Tillie Louise Hackett

Summary

Publications

  1. doi request reprint Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma
    Tillie Louise Hackett
    UBC James Hogg Research Centre, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Curr Opin Allergy Clin Immunol 12:53-9. 2012
  2. pmc Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus
    Pol Gomez
    UBC James Hogg Research Centre, Providence Heart Lung Institute, St, Paul s Hospital, Vancouver, BC, Canada
    BMC Genomics 11:358. 2010
  3. doi request reprint Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution
    Tillie Louise Hackett
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 45:1090-100. 2011
  4. pmc Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease
    Tillie L Hackett
    School of Medicine, University of Southampton, Southampton, UK
    Respir Res 11:180. 2010
  5. doi request reprint Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cells
    Stephanie M B Warner
    1 University of British Columbia James Hogg Research Centre, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 49:978-88. 2013
  6. pmc DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children
    Dorota Stefanowicz
    Department of Medicine, James Hogg Research Centre at the Heart and Lung Institute, University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 7:e44213. 2012
  7. doi request reprint Caveolin-1 controls airway epithelial barrier function. Implications for asthma
    Tillie Louise Hackett
    1 University of British Columbia James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada and
    Am J Respir Cell Mol Biol 49:662-71. 2013
  8. pmc Characterization of side population cells from human airway epithelium
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, Vancouver, British Columbia, Canada
    Stem Cells 26:2576-85. 2008
  9. pmc Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression
    Cleo Leung
    The James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 7:e40478. 2012
  10. doi request reprint The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A Hirota
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 129:1116-25.e6. 2012

Collaborators

Detail Information

Publications21

  1. doi request reprint Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma
    Tillie Louise Hackett
    UBC James Hogg Research Centre, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Curr Opin Allergy Clin Immunol 12:53-9. 2012
    ..In this review, we will discuss the mechanistic features of EMT and highlight recent descriptions of EMT in the airway to further define the role of the airway epithelium in the pathogenesis of asthma...
  2. pmc Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus
    Pol Gomez
    UBC James Hogg Research Centre, Providence Heart Lung Institute, St, Paul s Hospital, Vancouver, BC, Canada
    BMC Genomics 11:358. 2010
    ..fumigatus conidia expressing green fluorescent protein from cells without spores. Total RNA was then isolated and the transcriptome of 16HBE14o- cells was evaluated using Agilent Whole Human Genome microarrays...
  3. doi request reprint Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution
    Tillie Louise Hackett
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 45:1090-100. 2011
    ..05). This parallel ex vivo and in vitro study of the asthmatic epithelium demonstrates an intrinsically altered phenotype and aberrant inflammatory response to common environmental challenges, compared with nonasthmatic epithelium...
  4. pmc Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease
    Tillie L Hackett
    School of Medicine, University of Southampton, Southampton, UK
    Respir Res 11:180. 2010
    ..One current hypothesis is that the increased oxidant burden in these patients is not adequately counterbalanced by the lung antioxidant systems...
  5. doi request reprint Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cells
    Stephanie M B Warner
    1 University of British Columbia James Hogg Research Centre, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 49:978-88. 2013
    ..The role of ΔNp63α in epithelial barrier integrity requires further study to understand its role in health and disease. ..
  6. pmc DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children
    Dorota Stefanowicz
    Department of Medicine, James Hogg Research Centre at the Heart and Lung Institute, University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 7:e44213. 2012
    ..Epigenetic modifications, such as DNA methylation, can be influenced by the environment and result in changes to gene expression...
  7. doi request reprint Caveolin-1 controls airway epithelial barrier function. Implications for asthma
    Tillie Louise Hackett
    1 University of British Columbia James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada and
    Am J Respir Cell Mol Biol 49:662-71. 2013
    ..Together, our data demonstrate a crucial role for caveolin-1 in epithelial cell-cell adhesion, with important consequences for epithelial barrier function and the promotion of Th2 responses in asthma...
  8. pmc Characterization of side population cells from human airway epithelium
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, Vancouver, British Columbia, Canada
    Stem Cells 26:2576-85. 2008
    ..The number of SP cells is significantly greater in asthmatic airways, providing evidence of dysregulated resident SP cells in the asthmatic epithelium. Disclosure of potential conflicts of interest is found at the end of this article...
  9. pmc Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression
    Cleo Leung
    The James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 7:e40478. 2012
    ..The objectives of this study were to examine the expression of dysferlin and myoferlin within the human airway and determine the roles of these proteins in airway epithelial homeostasis...
  10. doi request reprint The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A Hirota
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 129:1116-25.e6. 2012
    ..The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses...
  11. doi request reprint IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells
    Samuel J Wadsworth
    UBC James Hogg Research Laboratories, Providence Heart and Lung Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 126:366-74, 374.e1-8. 2010
    ..Interaction of Fas receptor (CD95) with its ligand (FasL; CD95L) is an important mechanism of cell-mediated apoptosis. Bronchial epithelial FasL expression provides immune barrier protection from immune cell-mediated damage...
  12. pmc Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
    Farzian Aminuddin
    The University of British Columbia James Hogg Research Centre, Providence Heart Lung Institute, Vancouver, Canada
    BMC Pulm Med 13:64. 2013
    ....
  13. doi request reprint Mesenchymal stem cells for repair of the airway epithelium in asthma
    Darryl A Knight
    Providence Heart and Lung Institute at St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Expert Rev Respir Med 4:747-58. 2010
    ..This article focuses on the current knowledge about specific stem cell populations that may contribute to airway epithelial regeneration and discusses the use of mesenchymal stem cells as a potential therapeutic intervention...
  14. pmc Effect of gene environment interactions on lung function and cardiovascular disease in COPD
    Tillie Louise Hackett
    University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:277-87. 2011
    ....
  15. pmc Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects
    Dorota Stefanowicz
    UBC Centre for Heart Lung Innovation, St Paul s Hospital, 1081 Burrard Street, Vancouver, V6Z 1Y6, BC, Canada
    Respir Res 16:95. 2015
    ..It is important to establish in diseases like asthma how histone modifications affect tissue responses such as proliferation and differentiation...
  16. ncbi request reprint The role of epithelial injury and repair in the origins of asthma
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Curr Opin Allergy Clin Immunol 7:63-8. 2007
    ..We discuss the role of epithelial injury and wound repair in the origins of asthma...
  17. doi request reprint Modeling asthma in mice: what have we learned about the airway epithelium?
    Jeremy A Hirota
    University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 44:431-8. 2011
    ....
  18. doi request reprint Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 180:122-33. 2009
    ..The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal transition (EMT) may play a significant role...
  19. pmc Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study
    Tillie Louise Hackett
    School of Biological Sciences, University of Southampton, Southampton, UK
    Respir Res 9:47. 2008
    ..The aim of this study was to asses the kinetics of cytokine release from COPD parenchymal explants using an ex vivo model of lipopolysaccharide (LPS) induced acute inflammation...
  20. pmc Three dimensional imaging of paraffin embedded human lung tissue samples by micro-computed tomography
    Anna E Scott
    μ VIS Centre, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom
    PLoS ONE 10:e0126230. 2015
    ..However, non-destructive microstructural 3D imaging of formalin-fixed paraffin embedded (FFPE) tissues would facilitate retrospective analysis of extensive tissue archives of lung FFPE lung samples with linked clinical data...
  21. pmc MCL-1 localizes to sites of DNA damage and regulates DNA damage response
    Sarwat Jamil
    Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
    Cell Cycle 9:2843-55. 2010
    ..Together, these data indicate an important role for MCL-1 in coordinating DNA damage mediated checkpoint response, and have broad implications for the importance of MCL-1 in maintenance of genome integrity...