Aspasia Tsezou

Summary

Affiliation: University of Thessaly
Country: Greece

Publications

  1. pmc Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
    Dimitrios Iliopoulos
    Institute of Biomedical Research and Technology, Larissa, Greece
    PLoS ONE 3:e3740. 2008
  2. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
  3. doi request reprint Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes
    Aspasia Tsezou
    Department of Biology, Medical School, University of Thessaly, Mezourlo Hill, 41222 Larissa, Greece
    J Orthop Res 28:1033-9. 2010
  4. ncbi request reprint Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis
    Aspasia Tsezou
    Department of Biology, Laboratory of Cytogenetics and Medical Genetics, Medical School, University of Thessaly, 41 222 Larissa, Greece
    J Orthop Res 24:1900-5. 2006
  5. ncbi request reprint The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population
    Aspasia Tsezou
    University of Thessalia, Medical School, Department of Biology, 22 Papakyriazi Str, 41 222 Larissa, Greece
    J Orthop Res 26:136-40. 2008
  6. pmc Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis
    Aspasia Tsezou
    University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece
    Clin Vaccine Immunol 15:1888-90. 2008
  7. doi request reprint Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population
    Aspasia Tsezou
    Department of Biology, University of Thessalia, Medical School, 22 Papakyriazi str 41 222 Larisa, Greece
    J Orthop Res 26:1466-70. 2008
  8. ncbi request reprint The role of human telomerase catalytic subunit mRNA expression in cervical dysplasias
    A Tsezou
    Department of Biology, Medical School, University of Thessalia, 22 Papakyriazi Str, 41222 Larissa, Greece
    Exp Biol Med (Maywood) 230:263-70. 2005
  9. pmc Central role of SREBP-2 in the pathogenesis of osteoarthritis
    Fotini Kostopoulou
    Department of Cytogenetics and Molecular Genetics, University of Thessaly School of Medicine, Larissa, Greece
    PLoS ONE 7:e35753. 2012
  10. ncbi request reprint The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells
    Vassilis Papanikolaou
    Laboratory of Cytogenetics and Molecular Genetics, Medical School, University of Thessaly, 41110 Larissa, Greece
    Int J Oncol 35:1141-9. 2009

Collaborators

Detail Information

Publications65

  1. pmc Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
    Dimitrios Iliopoulos
    Institute of Biomedical Research and Technology, Larissa, Greece
    PLoS ONE 3:e3740. 2008
    ..Despite the high prevalence of the disease, the absence of large-scale molecular studies limits our ability to understand the molecular pathobiology of osteoathritis and identify targets for drug development...
  2. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  3. doi request reprint Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes
    Aspasia Tsezou
    Department of Biology, Medical School, University of Thessaly, Mezourlo Hill, 41222 Larissa, Greece
    J Orthop Res 28:1033-9. 2010
    ....
  4. ncbi request reprint Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis
    Aspasia Tsezou
    Department of Biology, Laboratory of Cytogenetics and Medical Genetics, Medical School, University of Thessaly, 41 222 Larissa, Greece
    J Orthop Res 24:1900-5. 2006
    ....
  5. ncbi request reprint The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population
    Aspasia Tsezou
    University of Thessalia, Medical School, Department of Biology, 22 Papakyriazi Str, 41 222 Larissa, Greece
    J Orthop Res 26:136-40. 2008
    ..Our data implied that the +104T/C; rs143383 GDF5 core promoter polymorphism is not a risk factor for OA etiology in Greek Caucasians. Our study highlights the heterogeneous nature of OA genetic susceptibility...
  6. pmc Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis
    Aspasia Tsezou
    University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece
    Clin Vaccine Immunol 15:1888-90. 2008
    ....
  7. doi request reprint Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population
    Aspasia Tsezou
    Department of Biology, University of Thessalia, Medical School, 22 Papakyriazi str 41 222 Larisa, Greece
    J Orthop Res 26:1466-70. 2008
    ..039) with knee OA in females only. For the first time, an association was observed between SNPs G395A and C2998T of the KLOTHO gene and knee osteoarthritis implicating KLOTHO in OA pathogenesis...
  8. ncbi request reprint The role of human telomerase catalytic subunit mRNA expression in cervical dysplasias
    A Tsezou
    Department of Biology, Medical School, University of Thessalia, 22 Papakyriazi Str, 41222 Larissa, Greece
    Exp Biol Med (Maywood) 230:263-70. 2005
    ....
  9. pmc Central role of SREBP-2 in the pathogenesis of osteoarthritis
    Fotini Kostopoulou
    Department of Cytogenetics and Molecular Genetics, University of Thessaly School of Medicine, Larissa, Greece
    PLoS ONE 7:e35753. 2012
    ..Our aim was to test the hypothesis that SREBP-2, a gene that plays a key role in cholesterol homeostasis, is crucially involved in OA pathogenesis and to identify possible mechanisms of action...
  10. ncbi request reprint The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells
    Vassilis Papanikolaou
    Laboratory of Cytogenetics and Molecular Genetics, Medical School, University of Thessaly, 41110 Larissa, Greece
    Int J Oncol 35:1141-9. 2009
    ..We conclude, for the first time, that HER2 phenotype upregulates hTERT through c-myc activation and confers radio-resistance to breast cancer cells...
  11. doi request reprint hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells
    Vassilis Papanikolaou
    Department of Biology, Faculty of Medicine, University of Thessaly, Larissa, Greece
    Int J Radiat Biol 87:609-21. 2011
    ....
  12. doi request reprint Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction
    George Karayannis
    Department of Cardiology, University Hospital of Larissa, Larissa, Greece
    Angiology 61:737-43. 2010
    ..Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI...
  13. doi request reprint Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population
    Aspasia Tsezou
    Laboratory of Cytogenetics and Medical Genetics, Medical School, University of Thessaly Larissa, Larissa, Greece
    Genet Test Mol Biomarkers 13:143-6. 2009
    ....
  14. pmc Survivin regulation by HER2 through NF-κB and c-myc in irradiated breast cancer cells
    Vassilis Papanikolaou
    Medical School, Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly, Larissa, Greece
    J Cell Mol Med 15:1542-50. 2011
    ....
  15. doi request reprint Lack of association between the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphism and the risk of benign prostatic hyperplasia in Caucasian men
    Anastasios Karatzas
    Department of Urology, University of Thessaly School of Medicine, Mezourlo, 41110, Larissa, Greece
    Mol Biol Rep 40:6665-9. 2013
    ..TA(6)/TA(7) + TA(6)/TA(6)) (P = 0.31). Our data suggest that the TA repeat polymorphism of UGT1A1 is not associated with increased BPH risk susceptibility in Caucasian men. ..
  16. ncbi request reprint Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression
    Dimitrios Iliopoulos
    Institute of Biomedical Research and Technology, Larissa, Greece
    Oncol Rep 22:199-204. 2009
    ..0001). Our data suggest that the combination of hTERT, MGMT, DAPK promoter hypermethylation could have a potential function as molecular biomarker of cervical oncogenesis progression...
  17. ncbi request reprint Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma
    Danai Abazis-Stamboulieh
    Department of Biology, Medical School, University of Thessalia, Larissa, Greece
    Leuk Lymphoma 48:2196-203. 2007
    ..Moreover, genotypes IL1B -511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL1B +3954 CC with IL1B -511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them...
  18. pmc Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
    Evangelia E Tsironi
    Department of Ophthalmology, School of Medicine, University of Thessaly, Larissa, Greece
    Mol Vis 15:2890-5. 2009
    ..To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients...
  19. doi request reprint 1,25-Dihydroxyvitamin D(3) and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes
    Timoklia Orfanidou
    Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa 41110, Greece
    Exp Biol Med (Maywood) 237:241-53. 2012
    ..We propose that 1a,25(OH)(2)D(3) and Pi act synergistically through FGF23 signaling and ERK1/2 phosphorylation contributing to late hypertrophic events and impaired mineralization in osteoarthritic chondrocytes...
  20. doi request reprint Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population
    Aspasia Tsezou
    Department of Biology, Medical School, University of Thessaly, Larissa, Greece
    J Renin Angiotensin Aldosterone Syst 9:202-7. 2008
    ..Since the renin-angiotensin and the natriuretic peptide systems contribute to blood pressure regulation, variations in the relative genes are candidates for the development of hypertension...
  21. ncbi request reprint Genetic polymorphisms in the UGT1A1 gene and breast cancer risk in Greek women
    Aspasia Tsezou
    Department of Biology, University of Thessaly Medical School, Larissa, Greece
    Genet Test 11:303-6. 2007
    ..No significant associations were observed between the 7/7 genotype and breast cancer risk, indicating that further studies in Caucasian women are needed to elucidate the role of UGT1A1 polymorphism in breast cancer risk...
  22. doi request reprint Protective effect of atorvastatin in cultured osteoarthritic chondrocytes
    Theodora Simopoulou
    Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly Medical School, Larissa, Greece
    J Orthop Res 28:110-5. 2010
    ..Our findings suggest that atorvastatin may have potential chondroprotective effects mostly by reducing cartilage degradation...
  23. pmc Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
    Ioanna Papathanasiou
    Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly, School of Medicine, Mezourlo, Larissa, 41100, Greece
    Arthritis Res Ther 14:R82. 2012
    ..The aim of the study was to investigate the possible cross-talk between BMP-2 and Wnt/β-catenin pathways in OA progression...
  24. ncbi request reprint Epigenetic regulation of hTERT promoter in hepatocellular carcinomas
    Dimitrios Iliopoulos
    Institute of Biomedical Research and Technology, Larissa, Greece
    Int J Oncol 34:391-9. 2009
    ..05). Thus, we propose that hTERT is regulated by a combination of epigenetic mechanisms (DNA methylation and histone modifications) and by the transcription factor c-myc in HCC...
  25. doi request reprint Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men
    Anastasios Karatzas
    University of Thessaly, School of Medicine, Department of Urology, Mezourlo, Larissa, Greece
    Cancer Epidemiol 34:345-9. 2010
    ..The aim of our study was to investigate the possible correlation between UGT1A1 promoter gene polymorphisms and prostate cancer risk...
  26. doi request reprint The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells
    Maria Palianopoulou
    Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
    Exp Biol Med (Maywood) 236:70-6. 2011
    ....
  27. pmc Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes
    Timoklia Orfanidou
    Laboratory of Cytogenetics and Medical Genetics, University of Thessaly, Medical School, Larissa, Greece
    J Cell Mol Med 13:3186-94. 2009
    ....
  28. doi request reprint The catabolic role of toll-like receptor 2 (TLR-2) mediated by the NF-κB pathway in septic arthritis
    Ioanna Papathanasiou
    Medical School, Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly, Larissa, Greece
    J Orthop Res 29:247-51. 2011
    ..Modulation of TLR-mediated signaling may be a potential therapeutic strategy for the prevention of postinfectious cartilage degradation in articular joints...
  29. pmc Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase
    Nikolaos Stefanou
    University of Thessaly, Medical School, Department of Biology, Larissa, Greece
    BMC Cancer 10:442. 2010
    ....
  30. doi request reprint Lower fibroblast growth factor 23 levels in young adults with Crohn disease as a possible secondary compensatory effect on the disturbance of bone and mineral metabolism
    Konstantinos A Oikonomou
    Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Institute for Biomedical Research and Technology BIOMED, Centre for Research and Technology Thessaly CERETETH, Larissa, Greece
    J Clin Densitom 17:177-84. 2014
    ..The downregulation of serum FGF-23 levels in CD appears as a secondary compensatory effect on the bone and mineral metabolism induced by chronic intestinal inflammation...
  31. ncbi request reprint Quantitative determination of human telomerase reverse transcriptase messenger RNA expression in premalignant cervical lesions and correlation with human papillomavirus load
    Pagona Oikonomou
    Department of Cytogenetics and Medical Genetics, University of Thessalia Medical School, Larissa, Greece
    Hum Pathol 37:135-42. 2006
    ..However, the final diagnosis must rely on the inclusion of clinical evaluation and additional assessment data...
  32. doi request reprint Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration
    Ioannis Stefanidis
    Clinic of Nephrology, University of Thessaly, Larissa, Greece
    Artif Organs 39:756-64. 2015
    ..The underlying mechanism and clinical implications of our findings require further investigation. ..
  33. pmc DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
    Ioanna Papathanasiou
    Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly, Faculty of Medicine, Biopolis, Larissa, 41500, Greece
    Arthritis Res Ther 17:160. 2015
    ..Based on our previous findings on the interaction between Wnt/β-catenin pathway and BMP-2 in OA, we aimed to investigate the role of DNA methylation and BMP-2 on SOST's expression in OA chondrocytes...
  34. ncbi request reprint Correlation between radiation-induced telomerase activity and human telomerase reverse transcriptase mRNA expression in HeLa cells
    Maria Satra
    Department of Biology, University of Thessaly, Medical School, Larissa, Greece
    Int J Radiat Biol 82:401-9. 2006
    ..To quantify and correlate human telomerase reverse transcriptase (hTERT) mRNA expression with telomerase activity (TA) after ionizing irradiation of HeLa cells...
  35. doi request reprint Low-density lipoprotein receptor-related protein 5 (LRP5) expression in human osteoarthritic chondrocytes
    Ioanna Papathanasiou
    University of Thessaly, Medical School, Laboratory of Cytogenetics and Molecular Genetics, Larissa, Greece
    J Orthop Res 28:348-53. 2010
    ..Our findings suggest the catabolic role of LRP5 is mediated by the Wnt/beta-catenin pathway in human osteoarthritis...
  36. ncbi request reprint Leptin receptor isoforms mRNA expression in peripheral blood mononuclear cells from patients with chronic viral hepatitis
    Nikolaos Stefanou
    University of Thessaly, Faculty of Health Sciences, Medical School, Department of Biology, 22 Papakyriazi Street, 41222 Larissa, Greece
    Exp Biol Med (Maywood) 231:1653-63. 2006
    ..78, P < 0.001). In conclusion, our findings may suggest the involvement of the leptin system in the immunopathology of chronic viral hepatitis...
  37. doi request reprint MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux related genes in osteoarthritic chondrocytes
    Fotini Kostopoulou
    Department of Cytogenetics and Molecular Genetics, University of Thessaly, School of Medicine, Biopolis 41110, Larissa, Greece
    Arthritis Res Ther 17:556. 2015
    ....
  38. pmc MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes
    Fotini Kostopoulou
    Department of Cytogenetics and Molecular Genetics, School of Medicine, University of Thessaly, Biopolis, 41110, Larissa, Greece
    Arthritis Res Ther 17:42. 2015
    ....
  39. doi request reprint Recurrence of superficial vein thrombosis in patients with varicose veins
    Christos Karathanos
    Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, Larissa, Greece
    Phlebology 31:489-95. 2016
    ..To investigate which factors other than history of superficial vein thrombosis (SVT) are associated with recurrent spontaneous SVT episodes in patients with varicose veins (VVs)...
  40. pmc Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury
    Ioanna Papathanasiou
    Laboratory of Cytogenetics and Molecular Genetics, University of Thessaly, Faculty of Medicine, Biopolis, 41500, Larissa, Greece
    BMC Musculoskelet Disord 17:21. 2016
    ....
  41. ncbi request reprint DNA methylation is not likely to be responsible for hTERT expression in premalignant cervical lesions
    Pagona Oikonomou
    Department of Biology, Medical School, University of Thessalia, Larisa, Greece
    Exp Biol Med (Maywood) 232:881-6. 2007
    ..The observed lack of correlation suggests that other mechanisms might be involved in the regulation of hTERT expression. The correlation between hTERT mRNA and E6/E7 mRNA expression confirms the role of HPV infection in hTERT regulation...
  42. doi request reprint Lipid metabolism and osteoarthritis: lessons from atherosclerosis
    Vasiliki Gkretsi
    Institute of Biomedical Research and Technology, Center for Research and Technology, Thessaly CE RE TE TH, 51 Papanastasiou Street, 41222 Larissa, Greece
    Prog Lipid Res 50:133-40. 2011
    ..However, this may be an intriguing theory linking ATH and OA, which may open new avenues to novel therapeutic interventions for OA taking advantage of previous knowledge from ATH...
  43. doi request reprint Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study
    Alexandros Daponte
    Department of Obstetrics and Gynecology, University of Thessaly Medical School, Larissa, Greece
    Clin Chim Acta 415:145-51. 2013
    ....
  44. doi request reprint Chronic anterior cruciate ligament tears and associated meniscal and traumatic cartilage lesions: evaluation with morphological sequences at 3.0 T
    Marianna Vlychou
    Department of Radiology, Medical School of Thessaly, University Hospital of Larissa, Viopolis, Larissa, 41110, Greece
    Skeletal Radiol 40:709-16. 2011
    ..0 T MR imaging in detecting anterior cruciate ligament (ACL), meniscal pathology and traumatic cartilage legions in young patients with chronic deficient anterior cruciate ligament knees...
  45. ncbi request reprint Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions
    Georgios M Hadjigeorgiou
    Neurogenetics Unit, Department of Neurology, School of Medicine, University of Thessaly, Larissa 41222, Greece
    J Orthop Res 25:1087-93. 2007
    ..43; 95%CI = 1.04-1.97; p for trend = 0.03). We conclude that individuals with PON1 192QQ genotype may have increased risk for ONFH and WMLeOn...
  46. ncbi request reprint Telomerase reverse transcriptase mRNA expression in peripheral lymphocytes of patients with chronic HBV and HCV infections
    M Satra
    Department of Biology, Academic Liver Unit, Medical School, University of Thessaly, Larissa, Greece
    J Viral Hepat 12:488-93. 2005
    ..The observed low levels of hTERT mRNA expression in the above patients may suggest its involvement in the immunopathogenesis of chronic viral hepatitis...
  47. doi request reprint Evidence of deregulated cholesterol efflux in abdominal aortic aneurysm
    Evanthia Mourmoura
    University of Thessaly, Faculty of Medicine, Department of Cytogenetics and Molecular Genetics, Biopolis, Larissa 41100, Greece
    Acta Histochem 118:97-108. 2016
    ..Our study provides novel evidence for impaired cholesterol efflux in AAA associated with lipid accumulation in SMCs and macrophages, as well as switch of SMCs phenotype from contractile to synthetic form. ..
  48. doi request reprint Factors associated with the development of superficial vein thrombosis in patients with varicose veins
    Christos Karathanos
    Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessalia, Larissa, Greece
    Thromb Res 132:47-50. 2013
    ..The objective of this study was to investigate the prevalence of thrombophilia defects and to estimate the role of age, sex and body mass index (BMI) in patients with varicose veins (VVs) and SVT...
  49. doi request reprint Increased levels of oxidative DNA damage in pesticide sprayers in Thessaly Region (Greece). Implications of pesticide exposure
    Michalis Koureas
    Department of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 22 Papakyriazi Street, Larissa 41222, Greece
    Sci Total Environ 496:358-64. 2014
    ....
  50. ncbi request reprint Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee
    P Fytili
    Department of Orthopedics, University of Thessaly, Larissa, Greece
    Clin Exp Rheumatol 23:621-7. 2005
    ..To clarify and evaluate the possible role of interleukin-10G (IL-10G) and interleukin-10R (IL-10R) microsatellite polymorphisms of IL-10 gene in knee osteoarthritis (OA)...
  51. ncbi request reprint Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer
    A Tsezou
    Laboratory of Cytogenetics and Molecular Genetics, Medical School, University of Thessalia, University Hospital of Larissa, Larissa, Greece
    Breast 17:159-66. 2008
    ..In conclusion, an association for breast cancer risk between short (SS) alleles for the repeat variants of the ESR2 and AR genes was found in women of Greek descent...
  52. ncbi request reprint Steroid hormones polymorphisms and cholelithiasis in Greek population
    S Kitsiou-Tzeli
    Medical School, Department of Medical Genetics, Athens, University of Athens, Greece
    Liver Int 27:61-8. 2007
    ..Genetic variation in genes involved in steroid biosynthesis, metabolism and signal transduction have been suggested to play a role in gallstone disease...
  53. ncbi request reprint Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis
    M Satra
    Department of Biology, Medical School, University of Thessaly, Larissa, Greece
    J Viral Hepat 14:41-7. 2007
    ..Real-time quantification of hTERT mRNA expression as a diagnostic/prognostic marker in patients with chronic hepatitis B and C and its relationship with hepatocarcinogenesis needs further evaluation...
  54. ncbi request reprint Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes
    T Simopoulou
    Laboratory of Cytogenetics and Medical Genetics, University of Thessalia, Larissa, Greece
    Clin Exp Rheumatol 25:605-12. 2007
    ..In addition, the effect of ox-LDL on chondrocyte viability and the effect of ascorbic acid (a well-known anti-oxidant) on LOX-1 expression were studied...
  55. doi request reprint Use of real-time PCR to detect human papillomavirus-16 viral loads in vaginal and urine self-sampled specimens
    A Daponte
    Department of Obstetrics and Gynaecology, Medical School, University of Thessalia, Larissa, Greece
    Clin Microbiol Infect 14:619-21. 2008
    ..The vaginal and urine viral loads correlated with HPV-16 positivity according to both conventional and QRT-PCR, and were proportional to the cervical viral load...
  56. pmc Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention
    D Iliopoulos
    University of Thessalia, Medical School, Department of Biology, 22 Papakyriazi str 41 222 Larisa, Greece
    Ann Rheum Dis 66:1616-21. 2007
    ..To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes...
  57. ncbi request reprint Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
    M Tzetis
    Department of Medical Genetics, Medical School, Athens University, Athens, Greece
    Clin Genet 71:451-7. 2007
    ....
  58. ncbi request reprint Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
    P Fytili
    Department of Orthopedics, Medical School, University of Thessaly, Universit Hospital of Larissa, Larissa, Greece
    Clin Genet 68:268-77. 2005
    ..002 and 0.001). An association between c.1092+3607(CA)(13-27) and c.172(CAG)(8-34) repeat polymorphisms of the ER-beta and AR genes and knee OA was found in individuals of Greek descent...
  59. ncbi request reprint Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism
    T Simopoulou
    Department of Biology, University of Thessalia, Medical School, Larissa, Greece
    Osteoarthritis Cartilage 15:872-83. 2007
    ..To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA)...
  60. doi request reprint A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility
    Kay Chapman
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    Hum Mol Genet 17:1497-504. 2008
    ..0004, OR = 1.21) and the dominant model (P < 0.0001, OR = 1.48). These findings represent the first highly significant evidence for a risk factor for the development of OA which affects two highly diverse ethnic groups...
  61. doi request reprint Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin
    Myrto Poulou
    Department of Medical Genetics, Athens University, Aghia Sophia Children s Hospital, Athens, Greece
    Genet Test 12:263-5. 2008
    ..Our objective was to assess whether this SNP was also associated with knee OA (KOA) in a Greek Caucasian population sample...
  62. ncbi request reprint Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
    Qing Jiang
    Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, China
    J Hum Genet 53:42-7. 2008
    ..06). The powers for European and Asian replication studies were less than 0.8. Our results suggest that there is no association between LRCH1 and knee OA. However, lack of association should be concluded by further replication studies...
  63. doi request reprint Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis
    Julio Rodriguez-Lopez
    Hospital Clinico Universitario Santiago, Santiago de Compostela, Spain
    Arthritis Rheum 58:435-41. 2008
    ....
  64. ncbi request reprint Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children
    Sofia Kitsiou-Tzeli
    Haematologica 88:1193-4. 2003
    ..05) in a group of 30 children with cholelithiasis than in a control group of 40 healthy children, indicating that this genotype might be an underlying factor for gallstone initiation in otherwise healthy children...
  65. ncbi request reprint Meta-analysis of association between the ASPN D-repeat and osteoarthritis
    Takahiro Nakamura
    Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo 108 8639, Japan
    Hum Mol Genet 16:1676-81. 2007
    ..The present results suggest that the association of the ASPN D14 allele and knee OA has global relevance, but that its effect has ethnic differences...