N B Tsavaris

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. pmc Neurotoxicity caused by the treatment with platinum analogues
    Sousana Amptoulach
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, 11527 Athens, Greece
    Chemother Res Pract 2011:843019. 2011
  2. pmc Prolonged survival after sequential multimodal treatment in metastatic renal cell carcinoma: two case reports and a review of the literature
    John Syrios
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, 75 Mikras Asias Street, Athens, 11527, Greece
    J Med Case Rep 6:303. 2012
  3. pmc Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter pylori infection
    John Syrios
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    BMC Cancer 12:264. 2012
  4. pmc Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report
    John Syrios
    Medical Oncology Unit, Department of Pathophysiology, Laikon General University Hospital, Athens University School of Medicine, Athens 11527, Greece
    J Med Case Reports 4:401. 2010
  5. pmc Pancreatic adenocarcinoma-associated polymyositis treated with corticosteroids along with cancer specific treatment: case report
    John Syrios
    Department of Pathophysiology, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
    BMC Gastroenterol 11:33. 2011
  6. ncbi request reprint Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphoma
    Nikolas Tsavaris
    Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Greece
    Anticancer Res 22:1845-8. 2002
  7. pmc Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes
    N Tsavaris
    Department of Pathophysiology Oncology Unit, Laikon General Hospital, Athens University School of Medicine, 11527 Athens, Greece
    Br J Cancer 87:21-7. 2002
  8. ncbi request reprint Etoposide, leucovorin (LV) and 5-fluorouracil (5-FU) in 5-FU+LV pre-treated patients with advanced colorectal cancer
    N Tsavaris
    Department of Pathophysiology, University of Athens, School of Medicine, Laikon General Hospital, Greece
    J Chemother 14:406-11. 2002
  9. pmc Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy
    Nicolas Tsavaris
    Medical Oncology Unit, Department of Pathophysiology, Medical School, Laikon University General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece
    Cancer Chemother Pharmacol 64:391-8. 2009
  10. ncbi request reprint Two different schedules of irinotecan (CPT-11) in patients with advanced colorectal carcinoma relapsing after a 5-fluorouracil and leucovorin combination. A randomized study
    N Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, University of Athens School of Medicine, 11527 Athens, Greece
    Cancer Chemother Pharmacol 52:514-9. 2003

Collaborators

Detail Information

Publications64

  1. pmc Neurotoxicity caused by the treatment with platinum analogues
    Sousana Amptoulach
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, 11527 Athens, Greece
    Chemother Res Pract 2011:843019. 2011
    ..Further studies on the prevention and treatment of neurotoxicity of platinum analogues are warranted...
  2. pmc Prolonged survival after sequential multimodal treatment in metastatic renal cell carcinoma: two case reports and a review of the literature
    John Syrios
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, 75 Mikras Asias Street, Athens, 11527, Greece
    J Med Case Rep 6:303. 2012
    ..abstract:..
  3. pmc Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter pylori infection
    John Syrios
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    BMC Cancer 12:264. 2012
    ..Palliative surgery followed by postoperative chemotherapy is a challenging approach in the treatment of stage IV gastric cancer yet patients must be carefully selected on the basis of likely clinical benefit...
  4. pmc Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report
    John Syrios
    Medical Oncology Unit, Department of Pathophysiology, Laikon General University Hospital, Athens University School of Medicine, Athens 11527, Greece
    J Med Case Reports 4:401. 2010
    ..This case report and short review discusses how long trastuzumab should be continued in metastatic breast cancer, the safety issues in case of pregnancy and the risk of relapse with trastuzumab cessation...
  5. pmc Pancreatic adenocarcinoma-associated polymyositis treated with corticosteroids along with cancer specific treatment: case report
    John Syrios
    Department of Pathophysiology, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
    BMC Gastroenterol 11:33. 2011
    ..Adenocarcinoma of the pancreas only rarely is associated with inflammatory myopathy. In this setting, polymyositis may be treated with glucocorticoids in combination with cancer specific treatment...
  6. ncbi request reprint Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphoma
    Nikolas Tsavaris
    Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Greece
    Anticancer Res 22:1845-8. 2002
    ....
  7. pmc Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes
    N Tsavaris
    Department of Pathophysiology Oncology Unit, Laikon General Hospital, Athens University School of Medicine, 11527 Athens, Greece
    Br J Cancer 87:21-7. 2002
    ..Moreover, the effects of docetaxel are in all the above parameters more pronounced than those of paclitaxel...
  8. ncbi request reprint Etoposide, leucovorin (LV) and 5-fluorouracil (5-FU) in 5-FU+LV pre-treated patients with advanced colorectal cancer
    N Tsavaris
    Department of Pathophysiology, University of Athens, School of Medicine, Laikon General Hospital, Greece
    J Chemother 14:406-11. 2002
    ..The authors conclude that the combination of etoposide with LV+5-FU has limited activity when administered after failure of weekly LV+5-FU in patients with ACC and should not be recommended for further evaluation...
  9. pmc Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy
    Nicolas Tsavaris
    Medical Oncology Unit, Department of Pathophysiology, Medical School, Laikon University General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece
    Cancer Chemother Pharmacol 64:391-8. 2009
    ..In the present study, we correlate topo-I and -II expression and outcome after chemotherapy in primary and relapsed colorectal cancer...
  10. ncbi request reprint Two different schedules of irinotecan (CPT-11) in patients with advanced colorectal carcinoma relapsing after a 5-fluorouracil and leucovorin combination. A randomized study
    N Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, University of Athens School of Medicine, 11527 Athens, Greece
    Cancer Chemother Pharmacol 52:514-9. 2003
    ..To evaluate the efficacy and safety of irinotecan as second-line treatment in patients with advanced colorectal cancer (ACC) failing or relapsing after 5-fluorouracil (5-FU) plus leucovorin (LV) standard chemotherapy...
  11. ncbi request reprint Adenocarcinoma of the colon presenting as polymyositis: case report
    N Tsavaris
    Department of Pathophysiology, University of Athens School of Medicine, Laikon General Hospital, Greece
    J Chemother 14:102-5. 2002
    ..It has been suggested that tumors of the large bowel are rarely complicated by myositis. We describe a patient with adenocarcinoma of the colon presenting as polymyositis and review the available literature...
  12. ncbi request reprint Sequential administration of 5-fluorouracil (5FU)/leucovorin (LV) followed by irinotecan (CPT-11) at relapse versus CPT-11 followed by 5-FU/LV in advanced colorectal carcinoma. A phase III randomized study
    Nicolas Tsavaris
    Oncology Units, Department of Pathophysiology, University of Athens School of Medicine, Athens, Greece
    Chemotherapy 53:282-91. 2007
    ..The purpose of the present study was to evaluate the differences in the sequence of administration of 5-fluorouracil (5-FU)/leucovorin (LV) followed by irinotecan (CPT-11), or CPT-11 followed by 5-FU/LV in advanced colorectal cancer (ACC)...
  13. ncbi request reprint Second-line treatment with oxaliplatin, leucovorin and 5-fluorouracil in gemcitabine-pretreated advanced pancreatic cancer: A phase II study
    Nicolas Tsavaris
    Department of Pathophysiology, Oncology Unit, Metaxa Memorial Cancer Hospital, 18537 Piraeus, Greece
    Invest New Drugs 23:369-75. 2005
    ..The present study was conducted to evaluate the efficacy and safety of the combination of Oxaliplatin, Leucovorin and 5-FU as second line therapy, following relapse to Gemcitabine, in patients with advanced adenocarcinoma of the pancreas...
  14. ncbi request reprint A simplified premedication schedule for 1-hour paclitaxel administration
    Nicolas Tsavaris
    Medical Oncology Unit, Department of Pathophysiology, Laikon General Hospital, University of Athens, Greece
    J Support Oncol 3:77-81. 2005
    ..The present study supports the efficacy and safety of a short premedication schedule; with further study, this schedule might become a standard premedication protocol prior to paclitaxel administration...
  15. ncbi request reprint G-CSF in solid tumor chemotherapy: a tailored regimen reduces febrile neutropenia, treatment delays and direct costs
    Nicolas Tsavaris
    Medical Oncology Unit, Laikon General Hospital, Athens University School of Medicine, Athens 115 27, Greece
    Med Sci Monit 10:PI24-8. 2004
    ..Current guidelines do not recommend G-CSF for patients with risk factors for neutropenia...
  16. ncbi request reprint Breast cancer after curative chemotherapy in non-Hodgkin's lymphoma: examination of the role of drug resistance and retrospective comparison to the outcome of de novo breast cancer
    N Tsavaris
    Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, 11527 Athens, Greece
    Oncol Rep 11:899-903. 2004
    ....
  17. ncbi request reprint Irinotecan (CPT-11) in patients with advanced colon carcinoma relapsing after 5-fluorouracil-leucovorin combination
    N B Tsavaris
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, University of Athens, School of Medicine, Athens, Greece
    Chemotherapy 48:94-9. 2002
    ..However, further adequately powered phase II or III randomized studies might be required in order to confirm this observation...
  18. ncbi request reprint Raltitrexed (tomudex) administration in patients failing multiple prior chemotherapy regimens in advanced colorectal cancer: a pilot study
    N Tsavaris
    Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Greece
    Invest New Drugs 20:133-6. 2002
    ..To evaluate efficacy of Raltitrexed, a specific thymidilate synthase inhibitor, in patients with advanced colorectal cancer (ACC) failing multiple prior chemotherapy regimens (e.g. 5-FU+LV, CPT-11, etc)...
  19. ncbi request reprint Leucovorin and fluorouracil vs levamisole and fluorouracil as adjuvant chemotherapy in rectal cancer
    N Tsavaris
    Department of Pathophysiology, University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece
    Oncol Rep 12:927-32. 2004
    ..In conclusion, adjuvant chemotherapy in RC with LV + 5-FU for 6 months is equally effective and less toxic than LVZ + 5-FU for 12 months...
  20. doi request reprint Combined treatment with bevacizumab and standard chemotherapy restores abnormal immune parameters in advanced colorectal cancer patients
    Nikolaos Tsavaris
    Oncology Unit, Department of Pathophysiology, Athens University School of Medicine, Laikon General Hospital, 11527 Athens, Greece
    Invest New Drugs 30:395-402. 2012
    ..bevacizumab (B-IFL)...
  21. pmc Raltitrexed (Tomudex) administration in patients with relapsed metastatic colorectal cancer after weekly irinotecan/5-Fluorouracil/Leucovorin chemotherapy
    Nicolas Tsavaris
    Medical Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    BMC Cancer 2:2. 2002
    ....
  22. ncbi request reprint Comparative study of tropisetron with the addition of dexamethasone or alprazolam in breast cancer patients receiving adjuvant chemotherapy with CEF (cyclophosphamide, epirubicin and 5-fluorouracil)
    N Tsavaris
    Department of Pathophysiology, Oncology Unit, University of Athens, School of Medicine, Laiko Hospital, Greece
    J Chemother 13:641-7. 2001
    ..Addition of D or A improves the antiemetic effect, and A provides better coverage in women with stress, a finding worth exploration in larger confirmatory studies...
  23. ncbi request reprint Leucovorin + 5-fluorouracil plus dipyridamole in leucovorin + 5-fluorouracil-pretreated patients with advanced colorectal cancer: a pilot study of three different dipyridamole regimens
    N Tsavaris
    Department of Pathophysiology Oncologic Unit, University of Athens, School of Medicine, Laiko Hospital Athens, Greece
    Tumori 87:303-7. 2001
    ....
  24. pmc Evaluation of DNA ploidy in relation with established prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis
    Nikolas Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    BMC Cancer 9:264. 2009
    ..The aim of this study was to evaluate the prognostic significance of DNA ploidy in relation with established clinical and laboratory variables in such patients...
  25. ncbi request reprint Phase II study of paclitaxel, ifosfamide, and cisplatin as second-line treatment in relapsed small-cell lung cancer
    C Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, Athens, Greece
    J Clin Oncol 19:119-26. 2001
    ..The aim of the present phase II study was to evaluate the efficacy of the paclitaxel, ifosfamide, and cisplatin (PIC) combination in relapsed small-cell lung cancer (SCLC)...
  26. pmc Phase I study of dose-escalated paclitaxel, ifosfamide, and cisplatin (PIC) combination chemotherapy in advanced solid tumours
    C Kosmas
    Department of Medicine, Helena Venizelou Hospital, Athens, Greece
    Br J Cancer 82:300-7. 2000
    ..The PIC regimen appears to be feasible and safe in the outpatient setting. Care should be paid to neurotoxicity. Phase II studies are starting in non-small-cell lung cancer, ovarian cancer and head and neck cancer at DL-VI...
  27. ncbi request reprint Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review
    C Kosmas
    Department of Pathophysiology, Athens University School of Medicine, Laikon General Hospital, Greece
    Med Oncol 18:221-5. 2001
    ..All of these issues together with an extensive literature review are discussed in detail...
  28. ncbi request reprint Surgical adjuvant therapy of rectal carcinoma: a controlled evaluation of leucovorin, 5-fluorouracil and radiation therapy with or without interferon-alpha2b
    C Gennatas
    Second Department of Surgery, Areteion Hospital, University of Athens, Athens, Greece
    Ann Oncol 14:378-82. 2003
    ....
  29. ncbi request reprint Full dose paclitaxel plus vinorelbine as salvage chemotherapy in anthracycline-resistant advanced breast cancer: a phase II study
    A Polyzos
    Medical Oncology Unit, Laikon General Hospital, Athens University School of Medicine, 17 Agiou Thoma Street, Goudi, Athens, Greece
    J Chemother 15:607-12. 2003
    ..The combination at these doses and schedules should be considered in the design of regimens for advanced breast cancer...
  30. ncbi request reprint Immune changes in patients with colorectal cancer treated by adjuvant therapy with monoclonal antibody 17-1A: a pilot study
    O E Tsitsilonis
    Department of Animal and Human Physiology, School of Biology, University of Athens, Ilissia, Athens, Greece
    J Chemother 15:387-93. 2003
    ..The development of novel immunotherapeutic protocols using combinations of Mo17-1A with stimuli that enhance the lytic capacity of effector cells (e.g. cytokines), may improve clinical responses in these types of patients...
  31. ncbi request reprint Efficacy of tropisetron in patients with advanced non-small-cell lung cancer receiving adjuvant chemotherapy with carboplatin and taxanes
    N Tsavaris
    Department of Pathophysiology, Oncology Unit, Laiko General Hospital, University of Athens School of Medicine, Athens, Greece
    Eur J Cancer Care (Engl) 17:167-73. 2008
    ..However, the addition of D and, mainly, A improves its anti-emetic effect in patients with obvious stress...
  32. ncbi request reprint Methotrexate-paclitaxel-epirubicin-carboplatin (M-TEC) combination chemotherapy in patients with advanced bladder cancer: an open label phase II study
    N Tsavaris
    Department of Pathophysiology, Oncology Unit, Athens University School of Medicine, Laikon General Hospital, 115 27 Athens, Greece
    J Chemother 17:441-8. 2005
    ..The present pilot study indicates the feasibility of the M-TEC combination for bladder cancer with acceptable toxicity...
  33. ncbi request reprint Second-line chemotherapy with cisplatin-ifosfamide in patients with ovarian cancer previously treated with carboplatin-cyclophosphamide
    A Polyzos
    1st Dept of Propedeutic Medicine, Laikon Hospital, Athens University School of Medicine, Greece
    J Chemother 11:144-9. 1999
    ....
  34. ncbi request reprint Gemcitabine and docetaxel as second-line chemotherapy for patients with nonsmall cell lung carcinoma who fail prior paclitaxel plus platinum-based regimens
    C Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, Athens, Greece
    Cancer 92:2902-10. 2001
    ..In the current Phase II study, the authors evaluated the combination of gemcitabine and docetaxel in patients with recurrent NSCLC...
  35. ncbi request reprint Neutrophil 5-nucleotidase reaction in chronic myelogenous leukemia, myelofibrosis with myeloid metaplasia, and polycythemia vera
    N B Tsavaris
    Department of Pathophysiology, University of Athens School of Medicine, Laiko General Hospital, Greece
    Ann Hematol 76:1-5. 1998
    ..It appears that, apart from the already known activity of NAP in myeloproliferative disorders, other enzymes (e.g., N5N) can present a similar behavior with increased or decreased activity...
  36. ncbi request reprint A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma
    C Gennatas
    Medical Oncology Clinic Department of Surgery, Areteion Hospital, University of Athens, Greece
    J Chemother 18:538-44. 2006
    ..35% in group B; p=0.032) and mucositis (2% vs. 14%; p=0.017). The regimen containing irinotecan showed activity in advanced colorectal cancer. The overall safety data confirm this combination as a well-tolerated treatment...
  37. ncbi request reprint Treatment of pancreatic cancer with a combination of docetaxel, gemcitabine and granulocyte colony-stimulating factor: a phase II study of the Greek Cooperative Group for Pancreatic Cancer
    G P Stathopoulos
    Second Department of Internal Medicine, University of Athens, Ippokration Hospital, Greece
    Ann Oncol 12:101-3. 2001
    ..Six (11%) patients developed febrile neutropenia and one of them died from sepsis. CONCLUSIONS: This combination is a relatively well-tolerated out-patient regimen for patients with inoperable pancreatic cancer...
  38. ncbi request reprint Chemotherapy-induced complete regression of choroidal metastases and subsequent isolated leptomeningeal carcinomatosis in advanced breast cancer: a case report and literature review
    C Kosmas
    Department of Medicine, Helena Venizelou Hospital, Athens, Greece
    J Neurooncol 47:161-5. 2000
    ..This is the first case to our knowledge reporting complete regression of choroidal metastases with docetaxel-based chemotherapy as the only treatment modality and subsequent isolated leptomeningeal carcinomatosis recurrence...
  39. ncbi request reprint Gemcitabine and vinorelbine as second-line therapy in non-small-cell lung cancer after prior treatment with taxane+platinum-based regimens
    C Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, 21 Apolloniou Street, GR 163 41, Athens, Greece
    Eur J Cancer 37:972-8. 2001
    ..This regimen represents a tolerable and effective combination to apply in the palliative treatment of relapsed NSCLC...
  40. ncbi request reprint Efficacy of ondansentron treatment for acute emesis with different dosing schedules 8 vs 32 mg. A randomized study
    N Tsavaris
    Dept. of Pathophysiology, University of Athens, School of Medicine, Laiko Hospital, Greece
    J Exp Clin Cancer Res 20:29-34. 2001
    ..Retches (P 0.0001, P 0.005), and nausea (P 0.0001, P were also frequent in Group B. We concluded that reduced OND doses (8 mg) are inadequate in the prevention of emesis after high dose CDDP (100 mg/m2) and should be avoided...
  41. ncbi request reprint Chemotherapy of non small cell lung cancer. A prospectively randomized study of cisplatin-etoposide versus cisplatin-mitomycin-vinblastine
    A Polyzos
    Ist Dept of Propedeutic Medicine, Athens University School of Medicine, Laikon Hospital, Greece
    J Chemother 9:102-5. 1997
    ..Myelotoxicity and alopecia were more severe in the cisplatin-etoposide group. Compared to international experience both regimens exhibited a relatively low response rate. It seems that for NSCLC new agents are required...
  42. pmc Phase I-II study of docetaxel and ifosfamide combination in patients with anthracycline pretreated advanced breast cancer
    C Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, Athens, Greece
    Br J Cancer 88:1168-74. 2003
    ....
  43. ncbi request reprint Topoisomerase I protein expression in primary colorectal cancer and recurrences after 5-FU-based adjuvant chemotherapy
    P Gouveris
    Medical Oncology Unit, Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    J Cancer Res Clin Oncol 133:1011-5. 2007
    ..Our aim was to investigate whether chemotherapy with 5-FU induces an alteration in the levels of topoisomerase I (topo I) in colorectal neoplastic tissues..
  44. ncbi request reprint Combined epirubicin, 5-fluorouracil and folinic acid vs no treatment for patients with advanced pancreatic cancer: a prospective comparative study
    N Tsavaris
    Department of Pathophysiology, University of Athens, School of Medicine, Laiko Hospital, Greece
    J Chemother 10:331-7. 1998
    ..We conclude that the combination of EPI+FA+5-FU has moderate activity and increased toxicity in the treatment of advanced pancreatic cancer...
  45. ncbi request reprint Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience
    A Polyzos
    First Department of Propedeutic Medicine, Athens University Medical School, Laikon Hospital, Athens, Greece
    Oncology 61:129-33. 2001
    ..This is not the case when the intraperitoneal route of carboplatin administration is used when indicated...
  46. ncbi request reprint CEA and CA-19.9 serum tumor markers as prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis
    N Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    J Chemother 21:673-80. 2009
    ..Although certain clinical, biochemical and biological factors remain important predictors of survival in patients with advanced pancreatic cancer, CA-19.9 serum tumor marker levels retain independent prognostic value for poor survival...
  47. ncbi request reprint Screening of patients after colectomy: virtual colonography
    P Leonardou
    Department of Radiology, Geniko Kratiko Hospital G Genimatas, Athens, Greece
    Abdom Imaging 31:521-8. 2006
    ..Virtual colonography is a powerful new method of imaging the entire colon and is useful to assess polyps and diagnose colon cancer. We evaluated virtual colonography in the postoperative screening of patients who had colon cancer...
  48. ncbi request reprint Intramedullary spinal cord metastases in breast carcinoma: report of two cases and review of the literature
    C Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, Athens, Greece
    J Chemother 14:631-4. 2002
    ....
  49. ncbi request reprint Megestrol acetate in cancer patients with anorexia and weight loss. A Hellenic Co-operative Oncology Group (HeCOG) study
    D V Skarlos
    Agii Anargiri Cancer Center, Athens, Greece
    Acta Oncol 32:37-41. 1993
    ..MA at lower doses should be compared in a prospective trial to the dose used in this study...
  50. ncbi request reprint A phase II study of the docetaxel-ifosfamide-carboplatin combination in advanced non-small-cell lung cancer
    Christos Kosmas
    Department of Medicine, Second Division of Medical Oncology, Metaxa Memorial Hospital, Piraeus, and Athens University School of Medicine, Greece
    Oncology 69:333-41. 2005
    ..In the present phase II study we evaluated the docetaxel-ifosfamide-carboplatin (DICb) combination in the outpatient setting in patients with advanced non-small-cell lung cancer (NSCLC)...
  51. ncbi request reprint Amifostine, in a reduced dose, protects against severe diarrhea associated with weekly fluorouracil and folinic acid chemotherapy in advanced colorectal cancer: a pilot study
    Nicolas Tsavaris
    Department of Pathophysiology, Laikon General Hospital, University of Athens, 115 27 Athens, Greece
    J Pain Symptom Manage 26:849-54. 2003
    ..In this study, amifostine reduced the incidence and severity of diarrhea associated with 5-fluorouracil in patients with advanced colorectal cancer, with acceptable efficacy at a reduced dose that offered better tolerability...
  52. ncbi request reprint Etoposide added to weekly leucovorin (LV)/5-fluorouracil (5-FU) in LV/5-FU pre-treated patients with advanced colorectal cancer
    Nicolas Tsavaris
    Department of Pathophysiology, Medical Oncology Unit, University of Athens, School of Medicine, Laikon General Hospital, Greece
    Med Sci Monit 8:PI65-9. 2002
    ....
  53. ncbi request reprint Cardiotoxicity following different doses and schedules of 5-fluorouracil administration for malignancy -- a survey of 427 patients
    Nicolas Tsavaris
    Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, Greece
    Med Sci Monit 8:PI51-7. 2002
    ..We report on patients undergoing 5-FU chemotherapy who developed cardiac symptoms during its administration...
  54. ncbi request reprint Salvage chemotherapy with the gemcitabine/docetaxel combination in non-small cell lung cancer: an overview of recent phase II studies
    Christos Kosmas
    Department of Medicine, Medical Oncology Unit, Helena Venizelou Hospital, Athens, Greece
    Med Sci Monit 8:PI58-63. 2002
    ....
  55. ncbi request reprint A phase II study of the docetaxel-carboplatin chemotherapy regimen in advanced non-small-cell lung cancer
    Nicolas Tsavaris
    Medical Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, 115 21, Athens, Greece
    Lung 183:405-16. 2005
    ..The outpatient regimen of docetaxel-carboplatin is effective with acceptable toxicity in patients with advanced NSCLC...
  56. ncbi request reprint A phase I-II study of bi-weekly gemcitabine and irinotecan as second-line chemotherapy in non-small cell lung cancer after prior taxane + platinum-based regimens
    Christos Kosmas
    Second Division of Medical Oncology, Department of Medicine, Metaxa Cancer Hospital, Piraues, 21 Apolloniou Street, 16341, Athens, Greece
    Cancer Chemother Pharmacol 59:51-9. 2007
    ..In the present phase I-II study, we evaluated the feasibility and efficacy of bi-weekly gemcitabine (GEM) + irinotecan (CPT-11) in patients with relapsed NSCLC...
  57. ncbi request reprint A simplified premedication protocol for one-hour paclitaxel infusion in various combinations
    Christos Kosmas
    Department of Medicine, 2nd Division of Medical Oncology, Metaxa Cancer Hospital, Pireaus, Greece
    Med Sci Monit 12:CR462-6. 2006
    ..Using this rationale, the duration of administration was decreased to one hour, with a minimized premedication regimen...
  58. ncbi request reprint An overview of current results with the gemcitabine and docetaxel combination as initial and salvage chemotherapy regimen in advanced non-small cell lung cancer
    Christos Kosmas
    Second Division of Medical Oncology, Department of Medicine, Metaxa Memorial Hospital, Piraeus, Greece
    Crit Rev Oncol Hematol 45:265-75. 2003
    ....
  59. ncbi request reprint Docetaxel-ifosfamide combination in patients with HER2-non-overexpressing advanced breast cancer failing prior anthracyclines
    Christos Kosmas
    Department of Medicine, 2nd Division of Medical Oncology, Metaxa Cancer Hospital, Piraeus, Greece
    Invest New Drugs 25:463-70. 2007
    ....
  60. ncbi request reprint Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study
    Christos Kosmas
    Department of Medicine, 2nd Division of Medical Oncology, Metaxa Cancer Hospital, Piraues, 21 Apolloniou Street, 16341 Athens, Greece
    J Cancer Res Clin Oncol 134:75-82. 2008
    ..In the present study, patients undergoing 5FU-based and oral capecitabine (Xeloda-based chemotherapy were tested for the potential development of cardiac-related symptoms during their administration...
  61. ncbi request reprint Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases
    Nicolas Tsavaris
    Department of Pathophysiology, Oncology Unit, Laiko General Hospital, University of Athens School of Medicine, Athens, Greece
    Oncol Rep 16:871-5. 2006
    ..Our data show that intravenous calcitonin administered in a relatively high dose has a very limited therapeutic potential as an adjuvant analgesic for a short period of time in selected cancer patients with bone metastases...
  62. ncbi request reprint Aspects of the association between leishmaniasis and malignant disorders
    Petros Kopterides
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Department of Pathophysiology, Oncology Unit, Laiko General Hospital, University of Athens, School of Medicine, Athens, Greece
    Trans R Soc Trop Med Hyg 101:1181-9. 2007
    ....
  63. ncbi request reprint Retinol-binding protein, acute phase reactants and Helicobacter pylori infection in patients with gastric adenocarcinoma
    Nicolas Tsavaris
    Department of Patophysiology, Laiko University Hospital, University of Athens School of Medicine, Athens, Greece
    World J Gastroenterol 11:7174-8. 2005
    ....