Christos Reppas

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. doi request reprint Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen
    Igor E Shohin
    Sechenov First Moscow State Medical University, Moscow, Russia
    J Pharm Sci 101:3593-603. 2012
  2. ncbi request reprint Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 23:165-76. 2006
  3. doi request reprint Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    Pharm Res 27:2187-96. 2010
  4. ncbi request reprint Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Athens, Greece
    Pharm Res 23:1373-81. 2006
  5. ncbi request reprint Estimation of intragastric solubility of drugs: in what medium?
    Maria Vertzoni
    Faculty of Pharmacy, Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 24:909-17. 2007
  6. doi request reprint Stability of oleuropein in the human proximal gut
    Constantinos Markopoulos
    Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece
    J Pharm Pharmacol 61:143-9. 2009
  7. doi request reprint In vitro methods can forecast the effects of intragastric residence on dosage form performance
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Athens, Greece
    Eur J Pharm Sci 33:445-51. 2008
  8. doi request reprint In vitro and ex vivo investigation of the impact of luminal lipid phases on passive permeability of lipophilic small molecules using PAMPA
    Constantinos Markopoulos
    Faculty of Pharmacy Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 30:3145-53. 2013
  9. doi request reprint Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults
    Dimitrios Psachoulias
    Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
    Pharm Res 28:3145-58. 2011
  10. doi request reprint Characterization of the ascending colon fluids in ulcerative colitis
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    Pharm Res 27:1620-6. 2010

Collaborators

  • Maria Vertzoni
  • Erik Söderlind
  • J B Dressman
  • Filippos Kesisoglou
  • Joachim Brouwers
  • Patrick Augustijns
  • Wei Xu
  • Neil Parrott
  • Eva Persson
  • M Zahirul I Khan
  • Anders Carlsson
  • Alexandros Kourentas
  • Mira Symillides
  • Constantinos Markopoulos
  • Lida Kalantzi
  • Konstantinos Goumas
  • Bertil Abrahamsson
  • James Butler
  • Nikoletta Fotaki
  • Maria Dimopoulou
  • Chara Litou
  • Igor E Shohin
  • Dimitrios Psachoulias
  • Amalia Diakidou
  • Vasilios Kalioras
  • Ekarat Jantratid
  • Markus Vogt
  • Maria A Constantinou
  • Dragica Rausl
  • Britta Polentarutti
  • Sandra Klein
  • Gavin Halbert
  • Hugh Clark
  • Vassilis Vasdekis
  • Constantinos Goumas
  • Nick Stavrinoudakis
  • Alexandros Symillidis
  • Ibrahim Khadra
  • Canella Stefania Mourouti
  • Bart Hens
  • Robert Gibbon
  • Georgios Imanidis
  • D W Groot
  • Vinod P Shah
  • Sabine Kopp
  • Dirk M Barends
  • Galina V Ramenskaya
  • Peter Langguth
  • James E Polli
  • Julia I Kulinich
  • Stefania Beato
  • Apostolos Agalias
  • Prokopios Magiatis
  • Niels Janssen
  • Klaus Kunath
  • George Digenis
  • Richard Page
  • Eleftheria Nicolaides
  • Anna Tsantili-Kakoulidou
  • Emmanuel Mikros
  • Ruzica Zanoski
  • Biserka Cetina-Cizmek
  • Tamsin Albery
  • Dimitris Laitmer
  • John M Hempenstall

Detail Information

Publications34

  1. doi request reprint Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen
    Igor E Shohin
    Sechenov First Moscow State Medical University, Moscow, Russia
    J Pharm Sci 101:3593-603. 2012
    ..8 buffer; and (c) test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When one or more of these conditions are not fulfilled, BE should be established in vivo...
  2. ncbi request reprint Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 23:165-76. 2006
    ....
  3. doi request reprint Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    Pharm Res 27:2187-96. 2010
    ....
  4. ncbi request reprint Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Athens, Greece
    Pharm Res 23:1373-81. 2006
    ....
  5. ncbi request reprint Estimation of intragastric solubility of drugs: in what medium?
    Maria Vertzoni
    Faculty of Pharmacy, Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 24:909-17. 2007
    ....
  6. doi request reprint Stability of oleuropein in the human proximal gut
    Constantinos Markopoulos
    Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece
    J Pharm Pharmacol 61:143-9. 2009
    ..We aimed to assess the intralumenal stability of oleuropein in human gastric and small intestinal contents. We additionally aimed to assess the stability characteristics of oleuropein in media simulating the intralumenal conditions...
  7. doi request reprint In vitro methods can forecast the effects of intragastric residence on dosage form performance
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Athens, Greece
    Eur J Pharm Sci 33:445-51. 2008
    ..This work illustrates that recently proposed methods for simulating intragastric environment may be useful in predicting the performance of solid dosage forms...
  8. doi request reprint In vitro and ex vivo investigation of the impact of luminal lipid phases on passive permeability of lipophilic small molecules using PAMPA
    Constantinos Markopoulos
    Faculty of Pharmacy Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 30:3145-53. 2013
    ..9 ≤ clogP  ≤ 9.0) small molecules using biorelevant media and evaluate the impact of luminal coarse lipid particles on danazol permeability after oral administration of a triglyceride solution to fed adults using PAMPA...
  9. doi request reprint Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults
    Dimitrios Psachoulias
    Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
    Pharm Res 28:3145-58. 2011
    ..To evaluate precipitation in and supersaturation of intestinal contents after administration of pharmacologically relevant doses of dipyridamole and ketoconazole to 12 healthy adults...
  10. doi request reprint Characterization of the ascending colon fluids in ulcerative colitis
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    Pharm Res 27:1620-6. 2010
    ..To characterize the fluid composition in ascending colon of fasted adults with ulcerative colitis in relapse and in remission with a view to predicting variations on dosage form performance in the lower inflamed gut...
  11. ncbi request reprint Plasma profiles of lycopene after single oral and intravenous administrations in dogs
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    J Pharm Pharmacol 58:1211-7. 2006
    ..Estimation of the amount of lycopene reaching the systemic circulation after oral and after intravenous administration requires separate estimations of total body clearance of lycopene...
  12. ncbi request reprint The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels
    Lida Kalantzi
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece
    Int J Pharm 296:87-93. 2005
    ..However, for the products tested in this study, there was no correlation between intragastric disintegration and onset of plasma levels probably because gastric emptying in also delayed in the fed state...
  13. ncbi request reprint Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Athens, Athens, Greece
    Eur J Pharm Biopharm 60:413-7. 2005
    ..Accurate simulation of the fasting gastric contents may be crucial for the assessment of the absorption profile of lipophilic weak bases...
  14. doi request reprint Characterization of the contents of ascending colon to which drugs are exposed after oral administration to healthy adults
    Amalia Diakidou
    Faculty of Pharmacy, Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece
    Pharm Res 26:2141-51. 2009
    ..To characterize the contents of the ascending colon in healthy adults under fasting and fed state conditions, with a view to designing in vitro studies to explain/predict dosage form performance in the lower gut...
  15. doi request reprint An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation
    Alexandros Kourentas
    Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece
    Eur J Pharm Sci 82:106-14. 2016
    ....
  16. ncbi request reprint Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration
    Nikoletta Fotaki
    School of Pharmacy, Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Panepistimiopolis, 157 71 Zografou, Athens, Greece
    Eur J Pharm Sci 26:324-33. 2005
    ....
  17. doi request reprint Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults
    Alexandros Kourentas
    Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece
    Eur J Pharm Sci 91:11-9. 2016
    ..To evaluate the impact of dosage form relevant levels of a polymeric precipitation inhibitor and of lipid excipients on supersaturation of upper gastrointestinal contents with albendazole, a lipophilic weak base...
  18. doi request reprint In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT
    Alexandros Kourentas
    Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece
    Int J Pharm 515:352-358. 2016
    ..5 times. In most cases, supersaturation of contents in the upper small intestine was overestimated, partly due to underestimation of luminal solubility...
  19. doi request reprint Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System
    Alexandros Kourentas
    Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece
    J Pharm Sci 105:2896-903. 2016
    ....
  20. doi request reprint Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Zografou, Greece
    Mol Pharm 9:1189-98. 2012
    ..We conclude that drug dissolved in the coarse lipid particles formed after administration of a triglyceride solution can directly contribute to the flux of lipophilic drugs across the intestinal mucosa...
  21. doi request reprint Determination of intralumenal individual bile acids by HPLC with charged aerosol detection
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece
    J Lipid Res 49:2690-5. 2008
    ..Intra-day relative standard deviation in fasted gastric aspirates and in fed duodenal aspirates was less than 2.2% and 6.0%, respectively...
  22. ncbi request reprint 1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics
    Maria A Constantinou
    Department of Pharmaceutical Chemistry and Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Mol Pharm 4:258-68. 2007
    ..Moreover, it was shown that this approach has the potential to recognize subtle variations in the metabolic profile even if the administered xenobiotic itself could not be detected in the canine plasma by conventional HPLC methods...
  23. ncbi request reprint Solubilization and quantification of lycopene in aqueous media in the form of cyclodextrin binary systems
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece
    Int J Pharm 309:115-22. 2006
    ..Addition of the antioxidant sodium metabisulfite increased the stability of lycopene-HP-beta-CD binary system in water. At -20 degrees C, the lyophilized lycopene-cyclodextrin binary systems were stable for at least 2 weeks...
  24. doi request reprint Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug - Drug Interaction Studies
    Chara Litou
    Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 33:1399-412. 2016
    ..Evaluate the impact of reduced gastric acid secretion after administration of two acid-reducing agents on the physicochemical characteristics of contents of upper gastrointestinal lumen of fasted adults...
  25. doi request reprint Two-Stage Single-Compartment Models to Evaluate Dissolution in the Lower Intestine
    Constantinos Markopoulos
    Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece
    J Pharm Sci 104:2986-97. 2015
    ..The impact of type/intensity of fluid convection and viscosity of media on luminal performance of other APIs and drug products requires further exploration...
  26. doi request reprint Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed During Bioavailability/Bioequivalence Studies in Healthy Adults
    Christos Reppas
    Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71, Zografou, Greece
    Pharm Res 32:3338-49. 2015
    ..Characterize the contents of distal ileum and cecum in healthy adults under conditions simulating the bioavailability/bioequivelance studies of drug products in fasted and fed state...
  27. doi request reprint Degradation kinetics of metronidazole and olsalazine by bacteria in ascending colon and in feces of healthy adults
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian, University of Athens, Athens, Greece
    Int J Pharm 413:81-6. 2011
    ..To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of ascending colon and the bacteria of feces of healthy adults...
  28. doi request reprint In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts
    Maria Dimopoulou
    Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece
    J Pharm Pharmacol 68:579-87. 2016
    ..Evaluate the impact of salt and counterion identity on performance of solid immediate release dosage forms of miconazole and clopidogrel, respectively, in fasted upper gastrointestinal lumen using in-vitro methodologies...
  29. ncbi request reprint In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis
    Nikoletta Fotaki
    Laboratory of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
    Eur J Pharm Sci 24:115-22. 2005
    ....
  30. ncbi request reprint Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects
    Maria Vertzoni
    Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Athens, Greece
    J Pharm Pharmacol 56:453-62. 2004
    ..Finally, unless the drug is extremely lipophilic (ca. logP> 5), egg phosphatidylcholine can be substituted by partially hydrolysed soybean phosphatidylcholine...
  31. doi request reprint Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update
    Ekarat Jantratid
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Pharm Res 25:1663-76. 2008
    ....
  32. ncbi request reprint Media to simulate the postprandial stomach I. Matching the physicochemical characteristics of standard breakfasts
    Sandra Klein
    Department of Pharmaceutical Technology, Johann Wolfgang Goethe University, 9 Marie Curie Street, Frankfurt am Main 60439, Germany
    J Pharm Pharmacol 56:605-10. 2004
    ..By increasing the viscosity of Ensure Plus with 0.45% pectin, it was possible to obtain a medium that closely resembles the FDA standard breakfast...
  33. ncbi request reprint Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs
    Markus Vogt
    Department of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 68:338-45. 2008
    ..i.v. infusion). It was concluded that cogrinding can be a useful tool to improve the bioavailability of poorly soluble drugs from a solid dosage form format...
  34. ncbi request reprint Intestinal permeability and excretion into bile control the arrival of amlodipine into the systemic circulation after oral administration
    Dragica Rausl
    PLIVA Research and Development Ltd, Prilaz baruna Filipovica 29, 10 000 Zagreb, Croatia
    J Pharm Pharmacol 58:827-36. 2006
    ..Interestingly, in-vitro permeability data collected in this or in previous studies were inappropriate for simulating the mean actual plasma profile...