Konstantinos N Fountoulakis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Treatment guidelines for bipolar disorder: a critical review
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 86:1-10. 2005
  2. ncbi Treatment of bipolar depression: an update
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 109:21-34. 2008
  3. pmc Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 8:27. 2009
  4. pmc Reliability and psychometric properties of the Greek translation of the State-Trait Anxiety Inventory form Y: preliminary data
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Psychiatry 5:2. 2006
  5. ncbi Beneficial effect of long-acting injectable risperidone on the neurocognitive deficit of a schizophrenic patient: A case report
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int J Clin Pharmacol Ther 44:589-92. 2006
  6. doi Personality disorders and violence
    Konstantinos N Fountoulakis
    Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Opin Psychiatry 21:84-92. 2008
  7. ncbi Comparison of depressive indices: reliability, validity, relationship to anxiety and personality and the role of age and life events
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 97:187-95. 2007
  8. doi No differences between drug naive and drug experienced unipolar depressed patients in terms of neurobiological testing: a cross sectional study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Medical School, Aristotle University of Thessaloniki, 1st Parodos Ampelonon Street, 55535 Pylaia, Thessaloniki, Greece Electronic address
    J Psychiatr Res 47:1984-90. 2013
  9. doi Development of the Risk Assessment Suicidality Scale (RASS): a population-based study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    J Affect Disord 138:449-57. 2012
  10. ncbi Peripheral thyroid dysfunction in depression
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Greece
    World J Biol Psychiatry 7:131-7. 2006

Collaborators

Detail Information

Publications80

  1. ncbi Treatment guidelines for bipolar disorder: a critical review
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 86:1-10. 2005
    ..The development of treatment guidelines emerged as an important element so as to standardize treatment and to provide clinicians with algorithms, which would be able to carry research findings to the everyday clinical practice...
  2. ncbi Treatment of bipolar depression: an update
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 109:21-34. 2008
    ..Bipolar depression seems to be a more difficult condition to treat than mania. Most patients need complex combination treatment although the published evidence on this type of treatment is limited...
  3. pmc Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 8:27. 2009
    ..We present a systematic review and meta-analysis of the available clinical trials concerning the usefulness of aripiprazole in the treatment of the psychotic symptoms in bipolar disorder...
  4. pmc Reliability and psychometric properties of the Greek translation of the State-Trait Anxiety Inventory form Y: preliminary data
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Psychiatry 5:2. 2006
    ..The State-Trait Anxiety Inventory form Y is a brief self-rating scale for the assessment of state and trait anxiety. The aim of the current preliminary study was to assess the psychometric properties of its Greek translation...
  5. ncbi Beneficial effect of long-acting injectable risperidone on the neurocognitive deficit of a schizophrenic patient: A case report
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int J Clin Pharmacol Ther 44:589-92. 2006
    ..The most impressive neurocognitive improvement concerned the clock drawing test, which was in parallel with her improvement in both the positive and negative symptoms of the PANSS...
  6. doi Personality disorders and violence
    Konstantinos N Fountoulakis
    Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Opin Psychiatry 21:84-92. 2008
    ..The review does not aim to address the issue of a possible etiological connection between previously being the victim of violent acts and later developing a personality disorder...
  7. ncbi Comparison of depressive indices: reliability, validity, relationship to anxiety and personality and the role of age and life events
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 97:187-95. 2007
    ..The current study aimed to compare the properties of some of the most popular of these scales...
  8. doi No differences between drug naive and drug experienced unipolar depressed patients in terms of neurobiological testing: a cross sectional study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Medical School, Aristotle University of Thessaloniki, 1st Parodos Ampelonon Street, 55535 Pylaia, Thessaloniki, Greece Electronic address
    J Psychiatr Res 47:1984-90. 2013
    ..Alternatively, they might suggest that our methodology assesses only a shallow and mainly state part of the pathophysiology of depression. ..
  9. doi Development of the Risk Assessment Suicidality Scale (RASS): a population-based study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    J Affect Disord 138:449-57. 2012
    ..The aim of the current study was to construct a self-report instrument with emphasis on items describing suicide-related behavior itself rather than strongly related clinical features on the basis of a general population study...
  10. ncbi Peripheral thyroid dysfunction in depression
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Greece
    World J Biol Psychiatry 7:131-7. 2006
    ..There is a strong possibility that the presence of a subtle thyroid dysfunction is a negative prognostic factor for depression and may demand specific therapeutic intervention...
  11. ncbi A seven- year follow-up of an extremely refractory bipolar I patient
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    CNS Spectr 12:733-4. 2007
  12. doi Obesity and smoking in patients with schizophrenia and normal controls: a case-control study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Psychiatry Res 176:13-6. 2010
    ..The results of the present study corroborate the increased prevalence of obesity in schizophrenia. The interpretation of this finding remains unclear...
  13. doi Development of a standardized scoring method for the Graphic Sequence Test suitable for use in psychiatric populations
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Cogn Behav Neurol 21:18-27. 2008
    ..The great advantage of this instrument is the fact that it is paper and pencil, easily administered and little time consuming. Further research is necessary to test its usefulness as a neuropsychologic test...
  14. doi Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 6 Odysseos str 1st Parodos Ampelonon str, Pylaia, Thessaloniki, Greece
    Eur Arch Psychiatry Clin Neurosci 262:1-48. 2012
    ..Combination therapy may improve the treatment outcome but it also carries more side-effect burden. Further research is necessary as well as the development of better guidelines and algorithms for the step-by-step rational treatment...
  15. doi Treatment of bipolar disorder: a systematic review of available data and clinical perspectives
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int J Neuropsychopharmacol 11:999-1029. 2008
    ..Combination therapy may improve treatment outcome but it also carries the burden of more side-effects. Further research as well as the development of better guidelines and algorithms for step-by-step rational treatment are necessary...
  16. ncbi Are dexamethasone suppression test nonsuppression and thyroid dysfunction related to a family history of dementia in patients with major depression? An exploratory study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Greece
    Can J Psychiatry 50:342-5. 2005
    ..This study aimed to search for correlations among Dexamethasone Suppression Test (DST) cortisol levels, thyroid indices, and family history of dementia in patients with depression...
  17. ncbi Life events and clinical subtypes of major depression: a cross-sectional study
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Psychiatry Res 143:235-44. 2006
    ..The question that arises is whether this finding is valid or whether these patients (who have higher personality psychopathology and interpersonal rejection sensitivity) tend to over-report life events...
  18. doi Antiepileptic drugs and suicidality
    Konstantinos N Fountoulakis
    13rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Psychopharmacol 26:1401-7. 2012
    ..Future randomised controlled trials should specifically focus on issues concerning depression and suicidal thoughts in patients with epilepsy...
  19. doi Aripiprazole monotherapy in the treatment of bipolar disorder: a meta-analysis
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 133:361-70. 2011
    ..The aim of the present work was to review and meta-analyze the findings of all the available randomized double-blind controlled trials (RCTs) on the efficacy of aripiprazole in the treatment of bipolar disorder...
  20. pmc Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Psychiatry 6:27. 2007
    ..Manic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment...
  21. pmc Relationship of suicide rates with climate and economic variables in Europe during 2000-2012
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 15:19. 2016
    ..The effect of economic variables has been extensively studied but not that of climate...
  22. ncbi Neurobiological and psychological correlates of suicidal attempts and thoughts of death in patients with major depression
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University, Thessaloniki, Greece
    Neuropsychobiology 49:42-52. 2004
    ..Further study is needed to test whether psychophysiological methods, which are noninvasive and easy to perform, are of value in the therapeutic planning and monitoring of responses...
  23. pmc Thyroid function in clinical subtypes of major depression: an exploratory study
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Thessaloniki, Greece
    BMC Psychiatry 4:6. 2004
    ..To our knowledge, this is the first study which explores the possible relationship of DSM-IV depressive subtypes and the medium term outcome, with thyroid function...
  24. doi A systematic review of the evidence on the treatment of rapid cycling bipolar disorder
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Bipolar Disord 15:115-37. 2013
    ..The aim of the present study was to review the existing published randomized trials investigating the effect of treatment on patients with rapid cycling bipolar disorder...
  25. pmc A standardized scoring method for the copy of cube test, developed to be suitable for use in psychiatric populations
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 10:19. 2011
    ..The aim of the current study was to develop a novel and detailed standardized method of administration and scoring this test...
  26. ncbi The contemporary face of bipolar illness: complex diagnostic and therapeutic challenges
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    CNS Spectr 13:763-74, 777-9. 2008
    ..Treatment includes the careful combination of lithium, antiepileptics, atypical antipsychotics, and antidepressants, but not all of the agents in these broad categories are effective for the treatment of bipolar disorder...
  27. ncbi Amisulpride-induced tardive dyskinesia
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Schizophr Res 88:232-4. 2006
    ..To our knowledge, his is the first case report in the literature of tardive dyskinesia induced by amisulpride...
  28. doi Treatment of mixed bipolar states
    Konstantinos N Fountoulakis
    Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Int J Neuropsychopharmacol 15:1015-26. 2012
    ..New, randomized prospective trials involving homogeneous cohorts of mixed bipolar patients are needed in order to delineate the appropriate pharmacological treatment of mixed states...
  29. doi An update of evidence-based treatment of bipolar depression: where do we stand?
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 6 Odysseos Str Parodos Ampelonon Str, Pylaia, Thessaloniki, Greece
    Curr Opin Psychiatry 23:19-24. 2010
    ..The current article attempts to summarize the current status of our knowledge and practice in the treatment of bipolar depression and suggests future directions...
  30. doi Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int J Neuropsychopharmacol 14:405-12. 2011
    ..The drug effect is always present and is unrelated to depression severity, while this is not true for placebo...
  31. pmc The standardised copy of pentagons test
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 10:13. 2011
    ..Although it is a widely used test, its method of scoring is crude and its psychometric properties are not adequately known. The aim of the present study was to develop a sensitive and reliable method of administration and scoring...
  32. ncbi A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int J Neuropsychopharmacol 11:269-87. 2008
    ..It is desirable to keep lithium blood levels as low as feasible with prophylaxis...
  33. doi The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Dr Fountoulakis Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King s College, London, UK Dr Young Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Vancouver, Canada Dr Yatham Paracelsus Medical University, Salzburg, Austria Dr Grunze Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain Dr Vieta The Royal Institute of Mental Health Research, Department of Psychiatry, University of Ottawa, Ottawa, Canada Dr Blier Psychiatric Department, Ludwig Maximilians University, Munich, Germany Dr Moeller Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Vienna, Austria Dr Kasper
    Int J Neuropsychopharmacol . 2016
    ....
  34. ncbi Ecchymoses as an adverse effect of fluoxetine treatment
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, 1 Kyriakidi Street, 54636 Thessaloniki, Greece
    Psychiatry Res 152:91-2. 2007
    ..After substitution of sertraline, her depression resolved after 4 weeks and ecchymoses 1.5 months latter. This is an unexplored side-effect with unknown long-term consequences that warrants further study...
  35. doi Climate change but not unemployment explains the changing suicidality in Thessaloniki Greece (2000-2012)
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece Electronic address
    J Affect Disord 193:331-8. 2016
    ....
  36. doi Report of the WPA section of pharmacopsychiatry on the relationship of antiepileptic drugs with suicidality in epilepsy
    Konstantinos N Fountoulakis
    a 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Int J Psychiatry Clin Pract 19:158-67. 2015
    ..This report from the World Psychiatric Association Section on Pharmacopsychiatry examines the possible relationship of antiepileptic drugs with suicide-related clinical features and behaviors in patients with epilepsy...
  37. doi Standardization of the TEMPS-A in the Greek general population
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Pylaia, Thessaloniki 55535, Greece Electronic address
    J Affect Disord 158:19-29. 2014
    ..The current study evaluates the reliability and factor-structure replicability of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) in its Greek Version...
  38. doi Nonsensory hallucinations or obsessive symptoms?: a diagnostic and therapeutic dilemma in a psychotic patient
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Nerv Ment Dis 201:818-23. 2013
    ....
  39. doi Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue
    Konstantinos N Fountoulakis
    Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Psychopharmacol 26:744-50. 2012
    ..While the response in the placebo group is due to unstable 'noise' and 'artefacts', the medication effect is reliable, valid and stable...
  40. doi Tardive Tourette-like syndrome: a systematic review
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Clin Psychopharmacol 26:237-42. 2011
    ..Forty-one cases were identified, caused by antipsychotics, antiepileptics, stimulants and other medication. A number of treatment options are reported in the literature but no systematic study of the syndrome has been done yet...
  41. doi Psychotherapeutic intervention and suicide risk reduction in bipolar disorder: a review of the evidence
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 113:21-9. 2009
    ..The aim of our study was to systematically review the literature concerning the efficacy of psychosocial interventions in reducing the risk for attempting or committing suicide...
  42. pmc Clinical and neuroimaging correlates of abnormal short-latency Somatosensory Evoked Potentials in elderly vascular dementia patients: A psychophysiological exploratory study
    Iacovos Tsiptsios
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Hosp Psychiatry 2:8. 2003
    ..The results of the current study locate the abnormal SEPs in the white matter, and are in accord with the literature...
  43. pmc Revisiting the Dexamethasone Suppression Test in unipolar major depression: an exploratory study
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 7:22. 2008
    ..The aim of the present study was to explore the feasibility of an alternative way of interpreting DST results...
  44. pmc Is there a dysfunction in the visual system of depressed patients?
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thesssaloniki, Greece
    Ann Gen Psychiatry 4:7. 2005
    ..DISCUSSION: The findings of the current study provide empirical data in order to assist in the understanding of the international literature and to explain the mechanism of action of therapies like sleep deprivation and light therapy...
  45. pmc Report of three cases that received maintenance treatment with risperidone as a mood stabilizer
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Hosp Psychiatry 3:10. 2004
    ..She was free of symptoms for the following 9 months until her last follow-up. DISCUSSION: The current study provides preliminary evidence concerning the long term efficacy of risperidone in the treatment of bipolar patients..
  46. pmc Unipolar late-onset depression: A comprehensive review
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Hosp Psychiatry 2:11. 2003
    ..CONCLUSION: A significant number of questions regarding the assessment and treatment of geriatric depression remain unanswered, empirical data are limited, and further research is necessary...
  47. doi Trends in suicidality amid the economic crisis in Greece
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur Arch Psychiatry Clin Neurosci 263:441-4. 2013
    ..Community interventions reduce stigma and enhance help-seeking. However, only those including the creation of social support networks are essential in the fight against suicidality. ..
  48. doi Receptor targets for antidepressant therapy in bipolar disorder: an overview
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    J Affect Disord 138:222-38. 2012
    ....
  49. doi Assessing the role of cingulate cortex in bipolar disorder: neuropathological, structural and functional imaging data
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Brain Res Rev 59:9-21. 2008
    ..We provide here a review of currently available data regarding the CC neuroimaging and neuropathological alterations in BD...
  50. pmc Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Ann Gen Psychiatry 10:8. 2011
    ..The present article explores the possible existence of a true 'class effect' for agents available for the treatment of bipolar disorder...
  51. pmc Treatment implications of predominant polarity and the polarity index: a comprehensive review
    André F Carvalho
    Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil Dr Carvalho Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, Houston, TX Dr Quevedo Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil Dr Quevedo Departments of Psychiatry and Pharmacology and Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, ON, Canada Dr McIntyre Mood Disorders Unit GRUDA, Department and Institute of Psychiatry, School of Medicine, University of Sao Paulo IPq FMUSP, Sao Paulo, Brazil Dr Souza 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece Dr Fountoulakis IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia Dr Berk Department of Psychiatry, The Florey Institute of Neuroscience and Mental Health, and Orygen Youth Health Research Centre, University of Melbourne, Parkville, Australia Dr Berk Department of Psychiatry, Medical School, University of Ioaninna, Ioaninna, Greece Dr Hyphantis Bipolar Disorders Unit, Jackson 39216
    Int J Neuropsychopharmacol 18:. 2014
    ..Notwithstanding its potential clinical utility, predominant polarity was not included in the DSM-5 as a BD course specifier...
  52. pmc No role for initial severity on the efficacy of antidepressants: results of a multi-meta-analysis
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 6, Odysseos str 1st Parodos Ampelonon str, Pylaia, Thessaloniki 55535, Greece
    Ann Gen Psychiatry 12:26. 2013
    ..During the last decade, a number of meta-analyses questioned the clinically relevant efficacy of antidepressants. Part of the debate concerned the method used in each of these meta-analyses as well as the quality of the data set...
  53. pmc Psychophysiology and psychoacoustics of music: Perception of complex sound in normal subjects and psychiatric patients
    Stefanos A Iakovides
    3rd Department of Psychiatry, Neuroscience Division, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
    Ann Gen Hosp Psychiatry 3:6. 2004
    ..Perception of auditory signals is analyzed by the science of psychoacoustics. Differences in complex sound perception have been found between normal subjects and psychiatric patients and between different types of psychopathologies...
  54. pmc The Greek translation of the symptoms rating scale for depression and anxiety: preliminary results of the validation study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    BMC Psychiatry 3:21. 2003
    ..The scale consists of 42 items and permits the calculation of the scores of the Beck Depression Inventory (BDI)-21, the BDI 13, the Melancholia Subscale, the Asthenia Subscale, the Anxiety Subscale and the Mania Subscale..
  55. pmc Season of birth, clinical manifestations and Dexamethasone Suppression Test in unipolar major depression
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Ann Gen Psychiatry 6:20. 2007
    ..The aim of the current paper was to study the possible relationship of the season of birth and current clinical symptoms in unipolar major depression...
  56. doi Rate of suicide and suicide attempts and their relationship to unemployment in Thessaloniki Greece (2000-2012)
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece Electronic address
    J Affect Disord 174:131-6. 2015
    ....
  57. doi Rapid cycling in bipolar disorder: a systematic review
    André F Carvalho
    47 49, Pontou Str, 55133, Kalamaria, Thessaloniki, Greece
    J Clin Psychiatry 75:e578-86. 2014
    ..The purpose of this study was to synthesize data regarding prevalence, clinical correlates, and familial/genetic aspects related to rapid cycling in bipolar disorder...
  58. pmc The media and intellectuals' response to medical publications: the antidepressants' case
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 54636, Thessaloniki, Greece
    Ann Gen Psychiatry 12:11. 2013
    ..It seems that this line of thought represents another aspect of the stigma attached to people suffering from mental illness...
  59. doi Refractoriness in bipolar disorder: definitions and evidence-based treatment
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    CNS Neurosci Ther 18:227-37. 2012
    ..Conclusively there are only limited and sometimes confusing data on the treatment of refractory bipolar patients. Further focused research is necessary on this group of patients...
  60. doi Life events and dementia: what is the nature of their relationship?
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Psychiatry Res 190:156-8. 2011
    ..On the contrary, demented patients even the last few months before the clinical onset of dementia experience low life-events-related stress, possibly because of subclinical impairment which is already present...
  61. ncbi Late-life depression, religiosity, cerebrovascular disease, cognitive impairment and attitudes towards death in the elderly: interpreting the data
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, 1 St Kyriakidi Street, 546 36 Thessaloniki, Greece
    Med Hypotheses 70:493-6. 2008
    ..The above have profound implications in the understanding of late-life depression and to the therapeutic design, especially in the primary care setting...
  62. ncbi Personality disorders: new data versus old concepts
    Konstantinos N Fountoulakis
    Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Opin Psychiatry 19:90-4. 2006
    ..The purpose of this paper is to review the most recent literature on personality disorders...
  63. doi Suicide prevention programs through community intervention
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    J Affect Disord 130:10-6. 2011
    ..Very short duration interventions don't seem to have even this slight effect...
  64. doi Relationship of suicide rates to economic variables in Europe: 2000-2011
    Konstantinos N Fountoulakis
    Konstantinos N Fountoulakis, MD, Associate Professor of Psychiatry, 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece Wolfram Kawohl, MD, Center for Social Psychiatry, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland Pavlos N Theodorakis, MD, Mental Health Hospitals Trust of Attica Dafni and Dromokaiteio and WHO National Counterpart for Mental Health, Athens, Greece Ad J F M Kerkhof, MD, Faculty of Psychology and Education, Department of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands Alvydas Navickas, MD, PhD, Associate Professor, Psychiatric Clinic, Vilnius University Medical Faculty, Vilnius, Lithuania Cyril Höschl, MD, Prague Psychiatric Center NIMH, Czech Republic Dusica Lecic Tosevski, MD, Professor of Psychiatry, Belgrade University School of Medicine and Institute of Mental Health, WHO Collaborating Centre, Belgrade, Serbia Eliot Sorel, MD, The George Washington University
    Br J Psychiatry 205:486-96. 2014
    ..It is unclear whether there is a direct link between economic crises and changes in suicide rates...
  65. doi The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in bipolar disorder
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece Electronic address
    Eur Neuropsychopharmacol 25:335-42. 2015
    ..Overall the properties of lurasidone fit well the model and add to its validity. A point that needs clarification is norepinephrine reuptake inhibition which is not yet studied for lurasidone...
  66. doi Burning issues in the meta-analysis of pharmaceutical trials for depression
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Psychopharmacol 28:106-17. 2014
    ..Otherwise, meta-analysis risks alienation from clinical reality and thus risks becoming the 21(st) century psychoanalysis. ..
  67. ncbi The possible involvement of NMDA glutamate receptor in the etiopathogenesis of bipolar disorder
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece
    Curr Pharm Des 18:1605-8. 2012
    ....
  68. pmc Development of the Global Disability Scale (Glo.Di.S): preliminary results
    Konstantinos N Fountoulakis
    Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Pylaia 55535, Greece
    Ann Gen Psychiatry 11:14. 2012
    ..The aim of the current study was to develop such a self-report instrument on the basis of a review of the literature, and compatible with the WHO approach...
  69. pmc Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 8:16. 2009
    ..The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder...
  70. ncbi Acute dystonia with low-dosage aripiprazole in Tourette's disorder
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Pharmacother 40:775-7. 2006
    ..To report a case of an acute dystonic episode in a patient with Tourette's disorder (TD) treated with the partial dopamine agonist aripiprazole...
  71. ncbi Focus on bipolar illness
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    CNS Spectr 13:762. 2008
  72. ncbi The validation of the short form of the Geriatric Depression Scale (GDS) in Greece
    K N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Aging (Milano) 11:367-72. 1999
    ..The two diagnostic groups differed on all 4 factors scores at p-value <0.001...
  73. pmc Reliability, validity and psychometric properties of the Greek translation of the Major Depression Inventory
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    BMC Psychiatry 3:2. 2003
    ..The aim of the current preliminary study was to assess the reliability, validity and psychometric properties of the Greek translation of the MDI...
  74. ncbi Validation of the epidemiological dementia index in geriatric outpatients
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int Psychogeriatr 12:195-208. 2000
    ..The aim of the current study was to test the properties of a scale especially developed for use in epidemiological surveys in low sociocultural populations, and to determine whether this scale can be used in a clinical population...
  75. ncbi Comparison of the diagnosis of melancholic and atypical features according to DSM-IV and somatic syndrome according to ICD-10 in patients suffering from major depression
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Thessaloniki, Greece
    Eur Psychiatry 14:426-33. 1999
    ..The DSM demand that the existence of melancholic features be excluded first and then that diagnosis of atypical features be made was confirmed...
  76. pmc Reliability and cultural applicability of the Greek version of the International Personality Disorders Examination
    K N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    BMC Psychiatry 2:6. 2002
    ..The IPDE assesses pathological personality and is compatible both with DSM-IV and ICD-10 diagnosis. However it is important to test the reliability and cultural applicability of different IPDE translations...
  77. ncbi Is it possible to predict the long-term response to venlafaxine with the use of biological markers and psychophysiological methods?
    K N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thesssaloniki, Greece
    J Affect Disord 99:155-63. 2007
    ..The present study investigated whether it is possible to predict the medium term response to venlafaxine using biological markers and psychophysiological methods...
  78. ncbi Risperidone-induced sialorrhea responsive to biperiden treatment
    Panagiotis T Panagiotidis
    Schizophr Res 93:410-1. 2007
  79. doi Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence
    Norman Sartorius
    Chairperson of CINP Task Force, 14 Chemin Colladon, Geneva, Switzerland
    Int J Neuropsychopharmacol 10:S1-207. 2007
  80. ncbi Successful treatment of Tourette's disorder with amisulpride
    Konstantinos N Fountoulakis
    Ann Pharmacother 38:901. 2004