Nikos G Oikonomakos

Summary

Affiliation: National Hellenic Research Foundation
Country: Greece

Publications

  1. ncbi Advances in glycogen phosphorylase inhibitor design
    Nikos G Oikonomakos
    National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
    Curr Opin Investig Drugs 9:379-95. 2008
  2. ncbi Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    J Biol Chem 275:34566-73. 2000
  3. ncbi Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Biochim Biophys Acta 1647:325-32. 2003
  4. ncbi Glycogen phosphorylase as a molecular target for type 2 diabetes therapy
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Curr Protein Pept Sci 3:561-86. 2002
  5. ncbi Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, Athens, Greece
    Eur J Biochem 269:1684-96. 2002
  6. ncbi The 1.76 A resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Bioorg Med Chem 10:1313-9. 2002
  7. ncbi Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Bioorg Med Chem 10:261-8. 2002
  8. ncbi Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition
    Nikos G Oikonomakos
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens 11635, Greece
    J Med Chem 49:5687-701. 2006
  9. pmc Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
    Nikos G Oikonomakos
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens, Greece
    Protein Sci 14:1760-71. 2005
  10. ncbi Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyran
    Kyra Melinda Alexacou
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 116 35 Athens, Greece
    Proteins 71:1307-23. 2008

Collaborators

Detail Information

Publications50

  1. ncbi Advances in glycogen phosphorylase inhibitor design
    Nikos G Oikonomakos
    National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
    Curr Opin Investig Drugs 9:379-95. 2008
    ....
  2. ncbi Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    J Biol Chem 275:34566-73. 2000
    ....
  3. ncbi Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Biochim Biophys Acta 1647:325-32. 2003
    ....
  4. ncbi Glycogen phosphorylase as a molecular target for type 2 diabetes therapy
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Curr Protein Pept Sci 3:561-86. 2002
    ....
  5. ncbi Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, Athens, Greece
    Eur J Biochem 269:1684-96. 2002
    ..3-3.7 A (Calpha atoms) to accommodate Bzurea. Bzurea can also occupy the new allosteric site, some 33 A from the catalytic site, which is currently the target for the design of antidiabetic drugs...
  6. ncbi The 1.76 A resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Bioorg Med Chem 10:1313-9. 2002
    ..Structural comparison of MGPb--glucose--CP320626 complex with liver glycogen phosphorylase a (LGPa) complexed with a related compound (CP403700) show that the ligand binding site is conserved in LGPa...
  7. ncbi Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B
    Nikos G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Bioorg Med Chem 10:261-8. 2002
    ....
  8. ncbi Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition
    Nikos G Oikonomakos
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens 11635, Greece
    J Med Chem 49:5687-701. 2006
    ..The conformational change to the R state provides an explanation for previous findings that 5, unlike inhibitors that favor the T state, promotes phosphorylation of GPb in hepatocytes with sequential inactivation of glycogen synthase...
  9. pmc Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
    Nikos G Oikonomakos
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens, Greece
    Protein Sci 14:1760-71. 2005
    ..Our findings suggest that acyl ureas inhibit glycogen phosphorylase by direct inhibition of AMP binding and by indirect inhibition of substrate binding through stabilization of the T' state...
  10. ncbi Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyran
    Kyra Melinda Alexacou
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 116 35 Athens, Greece
    Proteins 71:1307-23. 2008
    ....
  11. ncbi Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b
    Theodoros Hadjiloi
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Ave, 11635 Athens, Greece
    Bioorg Med Chem 14:3872-82. 2006
    ....
  12. ncbi Halogen-substituted (C-β-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase
    Kyra Melinda Alexacou
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece
    Bioorg Med Chem 19:5125-36. 2011
    ..The differences in their inhibitory potency can be interpreted in terms of variations in the interactions with protein residues of the different substituents on the aromatic part of the inhibitors...
  13. ncbi The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors
    Kyra Melinda Alexacou
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
    Bioorg Med Chem 18:7911-22. 2010
    ..In addition, 14 out of the 15 studied inhibitors were found bound at the new allosteric site of the enzyme...
  14. ncbi Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex
    Magda N Kosmopoulou
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
    Eur J Biochem 271:2280-90. 2004
    ....
  15. pmc FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase
    Costas Tiraidis
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece
    Protein Sci 16:1773-82. 2007
    ..The ligand-binding mode is different from those of the potent phenoxy-phthalate and acyl urea inhibitors, previously described, illustrating the broad specificity of the allosteric site...
  16. ncbi Crystallographic studies on N-azidoacetyl-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine
    Evangelia I Petsalakis
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48, Vas Constantinou Ave, 116 35 Athens, Greece
    Bioorg Med Chem 14:5316-24. 2006
    ..The difference observed in the Ki values of the two analogues can be interpreted in terms of desolvation effects, subtle structural changes of protein residues and changes in water structure...
  17. pmc Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site
    Evangelia D Chrysina
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35 Athens, Greece
    Protein Sci 14:873-88. 2005
    ....
  18. ncbi Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies
    Evangelia D Chrysina
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vassileos Constantinou Ave, 11635 Athens, Greece
    Bioorg Med Chem 13:765-72. 2005
    ..4-4.3 A (main-chain atoms) to accommodate the phosphoramidate, but these conformational changes do not lead to increased contacts between the inhibitor and the protein that would improve ligand binding...
  19. ncbi The binding of IMP to ribonuclease A
    George N Hatzopoulos
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens, Greece
    FEBS J 272:3988-4001. 2005
    ..The binding of IMP suggests ways to develop more potent inhibitors of the pancreatic RNase superfamily using this nucleotide as the starting point...
  20. pmc High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors
    Demetres D Leonidas
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 11635 Athens, Greece
    Protein Sci 12:2559-74. 2003
    ..These inhibitors could be developed to therapeutic agents that could control the biological activities of EDN, ECP, and ANG, which play key roles in human pathologies...
  21. pmc The binding of beta- and gamma-cyclodextrins to glycogen phosphorylase b: kinetic and crystallographic studies
    Nikos Pinotsis
    Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Athens, Greece
    Protein Sci 12:1914-24. 2003
    ..The binding of alpha-cyclodextrin and octakis (2,3,6-tri-O-methyl)-gamma-cyclodextrin was also investigated, but none of them was bound in the crystal; moreover, the latter did not inhibit the phosphorylase reaction...
  22. ncbi Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
    Eleni Anagnostou
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48, Vas Constantinou Ave 116 35 Athens, Greece
    Bioorg Med Chem 14:181-9. 2006
    ....
  23. ncbi Structural basis for the carbohydrate recognition of the Sclerotium rolfsii lectin
    Demetres D Leonidas
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
    J Mol Biol 368:1145-61. 2007
    ..The features of the molecular recognition at the two sites are described in detail...
  24. pmc hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies
    Christina E Drakou
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece
    Proteins 80:206-20. 2012
    ..Our findings suggest that hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of CB assembly and disassembly in the nucleus of human cells...
  25. ncbi Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined
    Joseph M Hayes
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
    Proteins 79:703-19. 2011
    ....
  26. ncbi The binding of 3'-N-piperidine-4-carboxyl-3'-deoxy-ara-uridine to ribonuclease A in the crystal
    Demetres D Leonidas
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
    Bioorg Med Chem 14:6055-64. 2006
    ....
  27. ncbi Crystallization and preliminary X-ray crystallographic analysis of Sclerotium rolfsii lectin
    Demetres D Leonidas
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas Constantinou Ave, 11635 Athens, Greece
    Acta Crystallogr D Biol Crystallogr 59:363-5. 2003
    ..Preliminary crystallographic analysis showed that the crystals belong to the tetragonal space group P4(2)2(1)2, with unit-cell parameters a = b = 99.81, c = 63.99 A and two molecules per asymmetric unit...
  28. pmc Sulphate-activated phosphorylase b: the pH-dependence of catalytic activity
    S E Zographos
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Biochem J 310:565-70. 1995
    ..The results are discussed in the light of new structural data from crystallographic studies on binary complexes of the enzyme...
  29. ncbi Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol
    Katerina E Tsitsanou
    Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
    Food Chem Toxicol 61:14-27. 2013
    ..Further successful predictions using QM/MM-PBSA for the flavonoid quercetagetin (which binds at the allosteric site) leads us to propose the methodology as a useful and inexpensive tool to predict flavonoid binding...
  30. ncbi The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor
    S E Zographos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation 48, vas Constantinou Avenue, Athens, 11635, Greece
    Structure 5:1413-25. 1997
    ..The inhibitor has no structural similarity to the natural regulators of GP. We have carried out structural studies in order to elucidate the mechanism of inhibition...
  31. pmc Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Protein Sci 5:2416-28. 1996
    ..Structural comparisons suggest that the bound anions, in the position observed in the crystal, might have a structural role for effective catalysis...
  32. ncbi The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    J Mol Biol 254:900-17. 1995
    ....
  33. pmc Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research, Athens, Greece
    Protein Sci 8:1930-45. 1999
    ..The structures provide a rational for the potency of the inhibitor and explain GPa allosteric inhibition of activity upon W1807 binding...
  34. ncbi The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal
    N G Oikonomakos
    National Hellenic Research Foundation, Athens, Greece
    Arch Biochem Biophys 270:62-8. 1989
    ..A comparison of the positions of glycerol-2-P, AMP, glucose 6-phosphate, UDP-Glc, and Pi at the allosteric site is presented...
  35. pmc The binding of D-gluconohydroximo-1,5-lactone to glycogen phosphorylase. Kinetic, ultracentrifugation and crystallographic studies
    A C Papageorgiou
    Biological Research Center, National Hellenic Research Foundation, Athens, Greece
    Biochem J 274:329-38. 1991
    ..The results are discussed with reference to the ability of the catalytic site of the enzyme to distinguish between two or more conformations of the glucopyranose ring...
  36. ncbi Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug
    K E Tsitsanou
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, Athens, Greece
    Arch Biochem Biophys 384:245-54. 2000
    ..Caffeine binds at the purine inhibitor site by intercalating between the two aromatic rings of Phe285 and Tyr613 and stabilises the location of the 280s loop in the T state conformation...
  37. ncbi A new allosteric site in glycogen phosphorylase b as a target for drug interactions
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, Athens, 11635, Greece eie gr
    Structure 8:575-84. 2000
    ..Structural studies have been carried out in order to establish the mechanism of this unusual inhibitor...
  38. ncbi Sulphate activates phosphorylase b by binding to the Ser (P) site
    D D Leonidas
    Biological Research Center, National Hellenic Research Foundation, Athens, Greece
    Biochim Biophys Acta 1076:305-7. 1991
    ..The results show that this form of the enzyme is no longer activated by ammonium sulphate...
  39. ncbi The ammonium sulfate activation of phosphorylase b
    D D Leonidas
    Biological Research Center, National Hellenic Research Foundation, Athens, Greece
    FEBS Lett 261:23-7. 1990
    ..The data are consistent with the interpretation that sulfates bind to the Ser-14 site and the sulfate-protein interactions at this site are responsible for activation of phosphorylase b...
  40. pmc Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate
    D D Leonidas
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Protein Sci 1:1112-22. 1992
    ..The observed position in the crystal suggests that it is too far from the substrate site to represent a site for catalysis...
  41. pmc Kinetic properties of tetrameric glycogen phosphorylase b in solution and in the crystalline state
    D D Leonidas
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Protein Sci 1:1123-32. 1992
    ..However, large differences were found in the maximal velocities for both oligosaccharide or glucose-1-phosphate substrates between the soluble dimeric and crystalline tetrameric enzyme...
  42. ncbi Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
    Xiaoan Wen
    Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China
    J Med Chem 51:3540-54. 2008
    ..Pentacyclic triterpenes represent a promising class of multiple-target antidiabetic agents that exert hypoglycemic effects, at least in part, through GP inhibition...
  43. ncbi Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes
    Thomas Klabunde
    Sanofi Aventis Deutschland GmbH, Scientific and Medical Affairs, D 65926 Frankfurt am Main, Germany
    J Med Chem 48:6178-93. 2005
    ..These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes...
  44. pmc Recognition of ribonuclease A by 3'-5'-pyrophosphate-linked dinucleotide inhibitors: a molecular dynamics/continuum electrostatics analysis
    Savvas Polydoridis
    Department of Physics, University of Cyprus, Nicosia, Cyprus
    Biophys J 92:1659-72. 2007
    ....
  45. ncbi Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies
    Paul R O Whittamore
    AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    Bioorg Med Chem Lett 16:5567-71. 2006
    ..Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography...
  46. ncbi Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site
    Laura J Hampson
    School of Clinical Medical Sciences Diabetes, Newcastle University, The Medical School, Newcastle upon Tyne NE2 4HH, UK
    Bioorg Med Chem 14:7835-45. 2006
    ....
  47. ncbi The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features
    Christine M Lukacs
    Roche Pharmaceuticals, Discovery Chemistry, F Hoffmann La Roche, Nutley, New Jersey 07110, USA
    Proteins 63:1123-6. 2006
  48. ncbi Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase
    Kimberly A Watson
    Laboratory of Molecular Biophysics, University of Oxford, Oxford, United Kingdom
    Proteins 61:966-83. 2005
    ....
  49. ncbi Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
    Alan M Birch
    AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Bioorg Med Chem Lett 17:394-9. 2007
    ..X-ray crystallographic data are presented, showing an unexpected variety of binding orientations at the dimer interface site...
  50. ncbi New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase
    Hongqing Li
    UMR 7611, Laboratoire de Synthese Organique, Institut de Chimie Moleculaire FR 2769, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France
    Chembiochem 9:253-60. 2008
    ....