Danijela Gnjidic

Summary

Publications

  1. pmc De-adoption and its 43 related terms: harmonizing low-value care terminology
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    BMC Med 13:273. 2015
  2. ncbi request reprint Statin Therapy and Cognition in Older People: What is the Evidence?
    Danijela Gnjidic
    Lecturer and NHMRC Early Career Fellow, Faculty of Pharmacy, Bank Building A15, Science Rd, University of Sydney, The University of Sydney NSW 2006
    Curr Clin Pharmacol 10:185-93. 2015
  3. doi request reprint Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Ageing and Alzheimers Institute, Concord RG Hospital, Sydney, NSW, Australia Electronic address
    Int J Cardiol 192:49-55. 2015
  4. doi request reprint Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, NSW, Australia Sydney Medical School, University of Sydney, NSW, Australia
    Public Health Res Pract 25:e2521518. 2015
  5. doi request reprint Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: prescribing patterns according to pain prevalence and adherence to clinical guidelines
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing and Concord RG Hospital, Sydney, NSW, Australia Electronic address
    Pain 155:1814-20. 2014
  6. doi request reprint Clinical implications from drug-drug and drug-disease interactions in older people
    Danijela Gnjidic
    Faculty of Pharmacy and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 40:320-5. 2013
  7. pmc High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Bank Building A15, Science Rd, Sydney, NSW, Australia
    BMC Public Health 13:115. 2013
  8. pmc Mild cognitive impairment predicts institutionalization among older men: a population-based cohort study
    Danijela Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, New South Wales, Australia
    PLoS ONE 7:e46061. 2012
  9. doi request reprint Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes
    Danijela Gnjidic
    Department of Clinical Pharmacology, 11C Main Building, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 65:989-95. 2012
  10. doi request reprint Effects of drug burden index on cognitive function in older men
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    J Clin Psychopharmacol 32:273-7. 2012

Collaborators

Detail Information

Publications36

  1. pmc De-adoption and its 43 related terms: harmonizing low-value care terminology
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    BMC Med 13:273. 2015
    ..Please see related article: http://www.biomedcentral.com/1741-7015/13/255...
  2. ncbi request reprint Statin Therapy and Cognition in Older People: What is the Evidence?
    Danijela Gnjidic
    Lecturer and NHMRC Early Career Fellow, Faculty of Pharmacy, Bank Building A15, Science Rd, University of Sydney, The University of Sydney NSW 2006
    Curr Clin Pharmacol 10:185-93. 2015
    ..The objective of this narrative review is to analyse the current evidence in relation to statin therapy and cognition, and discuss challenges in translating the current evidence to older people. ..
  3. doi request reprint Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Ageing and Alzheimers Institute, Concord RG Hospital, Sydney, NSW, Australia Electronic address
    Int J Cardiol 192:49-55. 2015
    ..The study aimed to investigate the use of medications for IHD in older men with and without geriatric syndromes, and whether adherence to medication guidelines impacts on adverse outcomes...
  4. doi request reprint Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, NSW, Australia Sydney Medical School, University of Sydney, NSW, Australia
    Public Health Res Pract 25:e2521518. 2015
    ..Increasingly, automated methods are being used to code free-text medication data, but evidence on the validity of these methods is limited...
  5. doi request reprint Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: prescribing patterns according to pain prevalence and adherence to clinical guidelines
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing and Concord RG Hospital, Sydney, NSW, Australia Electronic address
    Pain 155:1814-20. 2014
    ..This difference between the guideline recommendations and what is happening in the real world should be explored further...
  6. doi request reprint Clinical implications from drug-drug and drug-disease interactions in older people
    Danijela Gnjidic
    Faculty of Pharmacy and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 40:320-5. 2013
    ..Clinical implications of interactions between drugs and geriatric syndromes such as frailty, falls, cognitive impairment, immobility and urinary incontinence should also be considered in older people...
  7. pmc High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Bank Building A15, Science Rd, Sydney, NSW, Australia
    BMC Public Health 13:115. 2013
    ..The aims of this project are to determine the prevalence, risk factors, clinical consequences, and costs of high risk prescribing, and to assess the impact of interventions on high risk prescribing in older people...
  8. pmc Mild cognitive impairment predicts institutionalization among older men: a population-based cohort study
    Danijela Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, New South Wales, Australia
    PLoS ONE 7:e46061. 2012
    ..There is a lack of evidence on the contribution of mild cognitive impairment (MCI) to institutionalization in older adults. This study aimed to evaluate a range of risk factors including MCI of institutionalization in older men...
  9. doi request reprint Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes
    Danijela Gnjidic
    Department of Clinical Pharmacology, 11C Main Building, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 65:989-95. 2012
    ..This study aimed to determine an optimal discriminating number of concomitant medications associated with geriatric syndromes, functional outcomes, and mortality in community-dwelling older men...
  10. doi request reprint Effects of drug burden index on cognitive function in older men
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    J Clin Psychopharmacol 32:273-7. 2012
    ..In this study of community-dwelling older men, DBI was not associated with limitations on objective cognitive performance measures or with a clinical diagnosis of mild cognitive impairment or dementia...
  11. doi request reprint Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, 11C Main Building, Royal North Shore Hospital, St Leonards NSW 2065, Australia
    Clin Geriatr Med 28:237-53. 2012
    ..Large RCTs evaluating multidisciplinary interventions and clinical outcomes of changes in medicines regimen across different settings are required to confirm the findings of the studies performed so far...
  12. doi request reprint High-risk prescribing and incidence of frailty among older community-dwelling men
    D Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, Australia
    Clin Pharmacol Ther 91:521-8. 2012
    ..45 (95% CI: 1.42-4.23) for polypharmacy, 2.50 (95% CI: 0.76-8.26) for hyperpolypharmacy, and 2.14 (95% CI: 1.25-3.64) for DBI exposure. High-risk prescribing may contribute to frailty in community-dwelling older men...
  13. pmc How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, Sydney, Australia
    BMJ 343:d7679. 2011
    ..To determine the speed at which the Grim Reaper (or Death) walks...
  14. pmc Drug Burden Index and physical function in older Australian men
    Danijela Gnjidic
    Department of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    Br J Clin Pharmacol 68:97-105. 2009
    ..The Drug Burden Index is a measure of total exposure to anticholinergic and sedative medications that incorporates the principles of dose-response and maximal effect...
  15. pmc Multiple, but not traditional risk factors predict mortality in older people: the Concord Health and Ageing in Men Project
    Vasant Hirani
    Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Hospital Road, Concord, NSW, Sydney, 2137, Australia
    Age (Dordr) 36:9732. 2014
    ....
  16. doi request reprint Prevalence of statin-drug interactions in older people: a systematic review
    Michele Thai
    Faculty of Pharmacy, The University of Sydney, Pharmacy and Bank Building A15, Sydney, NSW, 2006, Australia
    Eur J Clin Pharmacol 72:513-21. 2016
    ..The aim of this study was to conduct a systematic review of current evidence on the prevalence of statin-drug interactions in older people...
  17. doi request reprint Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    Fundam Clin Pharmacol 28:10-9. 2014
    ..Higher sedative load was not associated with poorer physical performance or cognitive impairment in older Australian men...
  18. doi request reprint Polypharmacy in older adults: Association Rule and Frequent-Set Analysis to evaluate concomitant medication use
    Fabian Held
    Charles Perkins Centre, University of Sydney, Sydney NSW, Australia
    Pharmacol Res . 2016
    ..This methodology may be a valuable pharmacovigilance approach to monitor large databases for the safety of medications...
  19. doi request reprint Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project
    Fabian P Held
    Charles Perkins Centre, University of Sydney, New South Wales, Australia
    J Gerontol A Biol Sci Med Sci 71:625-31. 2016
    ..Comorbidity and multimorbidity are common in older people. Here we used a novel analytic approach called Association Rules together with network analysis to evaluate multimorbidity (two or more disorders) and comorbidity in old age...
  20. doi request reprint Drug Burden Index associated with function in community-dwelling older people in Finland: a cross-sectional study
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Med 44:458-67. 2012
    ....
  21. ncbi request reprint Thinking through the medication list - appropriate prescribing and deprescribing in robust and frail older patients
    Sarah N Hilmer
    Northern Clinical School, Sydney Medical School, University of Sydney, New South Wales, Australia
    Aust Fam Physician 41:924-8. 2012
    ..Medicines in older patients have the potential to provide great gains as well as significant harms...
  22. doi request reprint A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people
    Danijela Gnjidic
    Clinical Pharmacology Department, University of Sydney, St Leonards, New South Wales, Australia
    Ann Pharmacother 44:1725-32. 2010
    ..Higher DBI has been associated with functional impairment in observational studies of older people...
  23. doi request reprint Prescription and administration of opioids to hospital in-patients, and barriers to effective use
    Bridin P Murnion
    Drug Health Services, Royal Prince Alfred Hospital, Royal North Shore Hospital, Sydney, NSW, Australia
    Pain Med 11:58-66. 2010
    ..Secondary aims were assessment of staff knowledge of opioid pharmacology and available preparations, and of perceived barriers limiting opioid use...
  24. doi request reprint Health Care Practitioners' Perspectives on Deprescribing Anticholinergic and Sedative Medications in Older Adults
    Lisa Kouladjian
    Kolling Institute of Medical Research, St Leonards, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia
    Ann Pharmacother 50:625-36. 2016
    ..Anticholinergic and sedative (ACh-Sed) medications are commonly prescribed for older adults and are associated with adverse events...
  25. doi request reprint Associations between drug burden index and mortality in older people in residential aged care facilities
    Nicholas M Wilson
    Kolling Institute of Medical Research, Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, NSW, Australia
    Drugs Aging 29:157-65. 2012
    ..In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls...
  26. doi request reprint Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults
    Sarah N Hilmer
    Department of Clinical Pharmacology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Gerontol A Biol Sci Med Sci 67:181-8. 2012
    ..Where possible, findings of pharmacoepidemiologic studies should be tested with well-conducted interventional randomized trials in relevant populations of older people...
  27. doi request reprint Development, validation and evaluation of an electronic pharmacological tool: The Drug Burden Index CalculatorĀ©
    Lisa Kouladjian
    Departments of Clinical Pharmacology and Aged Care, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, New South Wales 2065, Australia Sydney Medical School Northern, University of Sydney, New South Wales 2006, Australia Electronic address
    Res Social Adm Pharm 12:865-875. 2016
    ..A computerized clinical decision support system (CCDSS) for DBI has not been previously developed or evaluated...
  28. pmc Education and Assessment of Pharmacists on the Use of the Drug Burden Index in Older Adults Using a Continuing Professional Development Education Method
    Lisa Kouladjian
    Departments of Clinical Pharmacology and Aged Care, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, New South Wales, Australia Sydney Medical School Northern, University of Sydney, New South Wales, Australia
    Am J Pharm Educ 80:63. 2016
    ..This CPD intervention provided a practical medium for educating and assessing pharmacists' knowledge of the DBI. ..
  29. doi request reprint Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study
    Alexander Bennett
    University of Sydney, Northern Clinical School, Sydney, NSW, Australia
    Drugs Aging 31:225-32. 2014
    ..Several measures of medication exposure are associated with adverse outcomes in older people. Exposure to and the clinical outcomes of these measures in robust versus frail older inpatients are not known...
  30. doi request reprint Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia
    Katie Qi
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    Int J Clin Pharm 37:949-57. 2015
    ..Deprescribing of statins may be indicated for some older people, because the evidence for benefit in primary prevention of cardiovascular disease is limited and there is an increased risk of side effects in old age...
  31. doi request reprint Prevalence of Potential and Clinically Relevant Statin-Drug Interactions in Frail and Robust Older Inpatients
    Michele Thai
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia
    Drugs Aging 32:849-56. 2015
    ..A significant proportion of older people are prescribed statins and are also exposed to polypharmacy, placing them at increased risk of statin-drug interactions...
  32. pmc Gentamicin pharmacokinetics in old age and frailty
    Sarah N Hilmer
    Sydney Medical School, University of Sydney, Sydney, Australia
    Br J Clin Pharmacol 71:224-31. 2011
    ....
  33. pmc Impact of high risk drug use on hospitalization and mortality in older people with and without Alzheimer's disease: a national population cohort study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia Departments of Clinical Pharmacology and Aged Care, and Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia Centre for Education and Research on Ageing and Concord RG Hospital, Sydney, New South Wales, Australia
    PLoS ONE 9:e83224. 2014
    ..This retrospective cohort study investigated the relationship between cumulative exposure to anticholinergic and sedative drugs and hospitalization and mortality in people with and without AD in Finland...
  34. doi request reprint Drug burden index and beers criteria: impact on functional outcomes in older people living in self-care retirement villages
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, St Leonards, New South Wales, AustraliaSydney Medical School, University of Sydney, New South Wales, AustraliaCentre for Education and Research on Ageing, Concord Hospital, Concord, New South Wales, AustraliaOffice of Clinical Pharmacology, Food and Drug Administration, Silver Spring, USA
    J Clin Pharmacol 52:258-65. 2012
    ..Exposure to Beers criteria drugs was common; however, Beers criteria did not predict functional outcomes in this population of older adults. ..
  35. pmc Drug Burden Index in older adults: theoretical and practical issues
    Lisa Kouladjian
    Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, NSW, Australia
    Clin Interv Aging 9:1503-15. 2014
    ..This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing. ..