Lars Gille

Summary

Publications

  1. pmc Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, A 1200 Vienna, Austria
    Ann Intensive Care 1:41. 2011
  2. doi request reprint Tocopheryl quinones and mitochondria
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Mol Nutr Food Res 54:601-15. 2010
  3. ncbi request reprint Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Austria
    Biofactors 25:87-95. 2005
  4. ncbi request reprint Ubichromanol: a prodrug to support mitochondrial ubiquinone functions?
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Natural Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Biofactors 32:83-90. 2008
  5. doi request reprint Modulation of the mitochondrial cytochrome bc1 complex activity by chromanols and related compounds
    Andrea Müllebner
    Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Chem Res Toxicol 23:193-202. 2010
  6. ncbi request reprint Antioxidant properties of natural and synthetic chromanol derivatives: study by fast kinetics and electron spin resonance spectroscopy
    Wolfgang Gregor
    Research Institute for Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Vienna, Austria
    J Org Chem 70:3472-83. 2005
  7. ncbi request reprint The protection of bioenergetic functions in mitochondria by new synthetic chromanols
    Katrin Staniek
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 70:1361-70. 2005
  8. ncbi request reprint Oxidized vitamin E and ubiquinone: competition for binding sites of the mitochondrial cytochrome bc1 complex?
    Lars Gille
    Research Institute of Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Ann N Y Acad Sci 1031:341-3. 2004
  9. ncbi request reprint The biomolecule ubiquinone exerts a variety of biological functions
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biofactors 18:23-31. 2003
  10. ncbi request reprint Distribution of tocopheryl quinone in mitochondrial membranes and interference with ubiquinone-mediated electron transfer
    Wolfgang Gregor
    Research Institute for Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Austria
    Biochem Pharmacol 71:1589-601. 2006

Collaborators

Detail Information

Publications20

  1. pmc Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, A 1200 Vienna, Austria
    Ann Intensive Care 1:41. 2011
    ..Collectively the data discussed in this review suggest that appropriate diagnosis and specific treatment of mitochondrial dysfunction in ICU patients may significantly improve the clinical outcome...
  2. doi request reprint Tocopheryl quinones and mitochondria
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Mol Nutr Food Res 54:601-15. 2010
    ..It is shown that the understanding of how tocopheryl quinones and tocopherols interfere with mitochondrial functions on the molecular level is still incomplete and that a better comprehension requires further research activities...
  3. ncbi request reprint Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Austria
    Biofactors 25:87-95. 2005
    ..Both cell lines were observed to increase VEGF and COX-II expression based on mRNA. Expression of VEGF was inhibited by caroverine and ubiquinon...
  4. ncbi request reprint Ubichromanol: a prodrug to support mitochondrial ubiquinone functions?
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Natural Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Biofactors 32:83-90. 2008
    ....
  5. doi request reprint Modulation of the mitochondrial cytochrome bc1 complex activity by chromanols and related compounds
    Andrea Müllebner
    Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Chem Res Toxicol 23:193-202. 2010
    ..This binding pose is similar but not identical to the potent inhibitor stigmatellin. The data suggest that chroman-2-ones are possible templates for modulatory molecules for the cyt bc(1) target...
  6. ncbi request reprint Antioxidant properties of natural and synthetic chromanol derivatives: study by fast kinetics and electron spin resonance spectroscopy
    Wolfgang Gregor
    Research Institute for Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Vienna, Austria
    J Org Chem 70:3472-83. 2005
    ..Finally, twin-chromanol can deliver twice as many reducing equivalents, which makes this compound a promising new candidate as artificial antioxidant in biological systems...
  7. ncbi request reprint The protection of bioenergetic functions in mitochondria by new synthetic chromanols
    Katrin Staniek
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 70:1361-70. 2005
    ..In conclusion, new chromanol-type antioxidants, especially twin-chromanol, were able to improve bioenergetic and biochemical parameters of mitochondria exposed to oxidative stress...
  8. ncbi request reprint Oxidized vitamin E and ubiquinone: competition for binding sites of the mitochondrial cytochrome bc1 complex?
    Lars Gille
    Research Institute of Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Ann N Y Acad Sci 1031:341-3. 2004
  9. ncbi request reprint The biomolecule ubiquinone exerts a variety of biological functions
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biofactors 18:23-31. 2003
    ..Furthermore, we have addressed the antioxidant role of ubiquinone and found that the efficiency of this activity is widely dependent on the type of biomembrane where ubiquinone exerts its chain-breaking activity...
  10. ncbi request reprint Distribution of tocopheryl quinone in mitochondrial membranes and interference with ubiquinone-mediated electron transfer
    Wolfgang Gregor
    Research Institute for Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Austria
    Biochem Pharmacol 71:1589-601. 2006
    ..On the other hand, both microsomal and mitochondrial enzymes contribute to the reduction of TQ to tocopheryl hydroquinone, which has been suggested to play an antioxidative role itself...
  11. ncbi request reprint A new ubiquinone metabolite and its activity at the mitochondrial bc1 complex
    Lars Gille
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinärpl 1, A 1210 Vienna, Austria
    Chem Res Toxicol 20:591-9. 2007
    ....
  12. ncbi request reprint The mystery of reactive oxygen species derived from cell respiration
    Hans Nohl
    Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Acta Biochim Pol 51:223-9. 2004
    ..However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc(1) redox complex such that ROS formation became possible...
  13. ncbi request reprint Lysosomal ROS formation
    Hans Nohl
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Redox Rep 10:199-205. 2005
    ..The role of this novel proton-pumping redox chain and the significance of the associated ROS formation has to be elucidated...
  14. ncbi request reprint Redox-interaction of alpha-tocopheryl quinone with isolated mitochondrial cytochrome bc1 complex
    Lars Gille
    Research Institute for Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinärpl 1, A 1210 Vienna, Austria
    Biochem Pharmacol 68:373-81. 2004
    ..These findings suggest that the irreversible oxidation of vitamin E to TQ in mitochondrial membranes causes a downregulation of respiratory activities as well as a lower O(2)(*)(-) formation rate by the cytochrome bc(1) complex...
  15. ncbi request reprint Intracellular generation of reactive oxygen species by mitochondria
    Hans Nohl
    Research Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 69:719-23. 2005
    ..However, if electron flow from ubiquinol to the bc(1) complex is hindered due to changes in lipid fluidity, single electrons may transfer to dioxygen and produce H(2)O(2) via superoxide radicals...
  16. ncbi request reprint Antioxidant properties of chromanols derived from vitamin E and ubiquinone
    Wolfgang Gregor
    Research Institute of Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Ann N Y Acad Sci 1031:344-7. 2004
  17. doi request reprint Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production
    Julia Gruber
    Institute of Pharmacology and Toxicology, Dept of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria University of Applied Sciences Wiener Neustadt FHWN, Wiener Neustadt, Austria
    Bioorg Med Chem 22:684-91. 2014
    ..In conclusion, this suggests that α-TNS although it has a structure similar to α-TOS is not acting via the same mechanism and that for α-TOS not only complex II but also complex III interactions are involved. ..
  18. doi request reprint Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock
    Johanna Catharina Duvigneau
    Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria
    Shock 33:289-98. 2010
    ..Although ER stress was not associated with depressed hepatocyte function, it may act as an early trigger of protracted cell death, thereby contributing to delayed organ failure after THS...
  19. ncbi request reprint Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, A 1210 Vienna, Austria
    Anticancer Res 25:2793-800. 2005
    ..Various radicals are formed on mixing LT97 or SW480 cells with LOOH. The expression of tumour-promoting factors was inhibited by caroverine and ubiquinone, which may be justified as active chemopreventive agents...
  20. ncbi request reprint Are mitochondria a spontaneous and permanent source of reactive oxygen species?
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Redox Rep 8:135-41. 2003
    ..Concomitantly superoxide radicals were released from these mitochondria, strongly suggesting the involvement of the ubiquinol/cytochrome bc(1) redox couple in this process...