- Analysis of gene expression data with pathway scoresA Zien
Institute for Algorithms and Scientific Computing, GMD German National Research Center for Information Technology, Schloss Birlinghoven, Sankt Augustin
Proc Int Conf Intell Syst Mol Biol 8:407-17. 2000..This suggests that the combination of appropriate scoring functions with the systematic generation of pathways can be used in order to select the most interesting pathways based on gene expression measurements...
- A simple iterative approach to parameter optimizationA Zien
GMD German National Research Center for Information Technology, Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin
J Comput Biol 7:483-501. 2000..These results show the general validity of the optimized weights for the given threading program and the associated scoring contributions...
- Engineering support vector machine kernels that recognize translation initiation sitesA Zien
GMD SCAI, Schloss Birlinghoven, 53754 Sankt Augustin, Germany
Bioinformatics 16:799-807. 2000..In order to extract protein sequences from nucleotide sequences, it is an important step to recognize points at which regions start that code for proteins. These points are called translation initiation sites (TIS)...
- Centralization: a new method for the normalization of gene expression dataA Zien
SCAI Institute for Algorithms and Scientific Computing, GMD German National Research Center for Information Technology, Schloss Birlinghoven, Sankt Augustin, 53754, Germany
Bioinformatics 17:S323-31. 2001..First, for each pair of arrays the quotient of the constants of proportionality is estimated. Second, from the resulting matrix of pairwise quotients an optimally consistent scaling of the samples is computed...