Christian G Ziegler

Summary

Country: Germany

Publications

  1. pmc Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells
    C G Ziegler
    University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany
    Mol Cell Endocrinol 371:189-94. 2013
  2. doi request reprint Direct effect of dehydroepiandrosterone sulfate (DHEAS) on PC-12 cell differentiation processes
    Christian G Ziegler
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 336:149-55. 2011
  3. ncbi request reprint Dehydroepiandrosterone induces a neuroendocrine phenotype in nerve growth factor-stimulated chromaffin pheochromocytoma PC12 cells
    Christian G Ziegler
    University Hospital Carl Gustav Carus, Medical Clinic III, University of Dresden, 01307 Dresden, Germany
    Endocrinology 149:320-8. 2008
  4. doi request reprint Dehydroepiandrosterone-sulphate (DHEA-S) promotes neuroendocrine differentiation of chromaffin pheochromocytoma PC12 cells
    Alexander W Krug
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Germany
    Mol Cell Endocrinol 300:126-31. 2009
  5. pmc Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate
    Flavie Sicard
    Department of Medicine, Carl Gustav Carus University Medical School, University of Technology, Dresden, Germany
    Proc Natl Acad Sci U S A 104:2007-12. 2007
  6. pmc Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase
    Janine Schmid
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 108:13722-7. 2011
  7. pmc Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model
    Martin Ullrich
    1 Dept of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany
    Theranostics 6:650-65. 2016
  8. ncbi request reprint DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells
    Christian G Ziegler
    Department of Medicine, Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann N Y Acad Sci 1073:306-11. 2006
  9. pmc Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 107:12623-8. 2010
  10. pmc In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma
    Martin Ullrich
    Department of Radiopharmaceutical and Chemical Biology M U, R B, J P, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany Department of Medicine III M U, N Q, M E B, G E, S R B, C G Z, University Hospital Carl Gustav Carus, 01307 Dresden, Germany Institute for Clinical Chemistry and Laboratory Medicine M P, N Q, G E, Technische Universitat Dresden, Germany Department of Radioimmunology M C, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, 01328 Dresden, Germany Department of Chemistry and Food Chemistry J P, Technische Universitat Dresden, Dresden, Germany and VA Medical Center Miami FL and Department of Pathology and Medicine N L B, A V S, Division of Endocrinology and Hematology Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136
    Endocrinology 155:4149-56. 2014

Collaborators

Detail Information

Publications11

  1. pmc Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells
    C G Ziegler
    University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany
    Mol Cell Endocrinol 371:189-94. 2013
    ..Studies of novel anti-tumor compounds on these mouse cell lines serve as an important basis for mouse models of metastatic pheochromocytoma, which we are currently establishing...
  2. doi request reprint Direct effect of dehydroepiandrosterone sulfate (DHEAS) on PC-12 cell differentiation processes
    Christian G Ziegler
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 336:149-55. 2011
    ..Furthermore, employing membrane-impermeable dehydroepiandrosterone-BSA indicates the involvement of plasma-membrane bound receptors...
  3. ncbi request reprint Dehydroepiandrosterone induces a neuroendocrine phenotype in nerve growth factor-stimulated chromaffin pheochromocytoma PC12 cells
    Christian G Ziegler
    University Hospital Carl Gustav Carus, Medical Clinic III, University of Dresden, 01307 Dresden, Germany
    Endocrinology 149:320-8. 2008
    ..DHEA drives NGF-stimulated cells toward a neuroendocrine phenotype, suggesting that the interaction of intraadrenal steroids and growth factors is required for the maintenance of an intact adrenal medulla...
  4. doi request reprint Dehydroepiandrosterone-sulphate (DHEA-S) promotes neuroendocrine differentiation of chromaffin pheochromocytoma PC12 cells
    Alexander W Krug
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Germany
    Mol Cell Endocrinol 300:126-31. 2009
    ..Our study provides support for the notion that adrenocortical-derived DHEA-S impacts adrenomedullary chromaffin cells during development and differentiation...
  5. pmc Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate
    Flavie Sicard
    Department of Medicine, Carl Gustav Carus University Medical School, University of Technology, Dresden, Germany
    Proc Natl Acad Sci U S A 104:2007-12. 2007
    ..In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors...
  6. pmc Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase
    Janine Schmid
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 108:13722-7. 2011
    ..Agonists of CRHR1 and GHRH-receptor, therefore, may play an important role as novel therapeutic tools in the treatment of diabetes mellitus...
  7. pmc Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model
    Martin Ullrich
    1 Dept of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany
    Theranostics 6:650-65. 2016
    ..Repeated treatment cycles, fractionated combinations of SSTR2-targeting radionuclide and cytotoxic therapies, and other adjuvant compounds addressing additional mechanisms may further enhance therapeutic outcome. ..
  8. ncbi request reprint DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells
    Christian G Ziegler
    Department of Medicine, Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann N Y Acad Sci 1073:306-11. 2006
    ..Hence, we speculate that DHEA might influence NGF-mediated chromaffin differentiation processes using the ERK1/2 MAP kinase pathway during adrenal tissue development...
  9. pmc Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 107:12623-8. 2010
    ..In conclusion, our study provides evidence that agonists of GHRH represent a promising pharmacological therapy aimed at promoting islet graft growth and proliferation in diabetic patients...
  10. pmc In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma
    Martin Ullrich
    Department of Radiopharmaceutical and Chemical Biology M U, R B, J P, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany Department of Medicine III M U, N Q, M E B, G E, S R B, C G Z, University Hospital Carl Gustav Carus, 01307 Dresden, Germany Institute for Clinical Chemistry and Laboratory Medicine M P, N Q, G E, Technische Universitat Dresden, Germany Department of Radioimmunology M C, Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden Rossendorf, 01328 Dresden, Germany Department of Chemistry and Food Chemistry J P, Technische Universitat Dresden, Dresden, Germany and VA Medical Center Miami FL and Department of Pathology and Medicine N L B, A V S, Division of Endocrinology and Hematology Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136
    Endocrinology 155:4149-56. 2014
    ..This animal model will allow for testing new treatment strategies for chromaffin cell tumors...
  11. ncbi request reprint Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice
    Valeria Lamounier-Zepter
    Department of Internal Medicine III, University Medical Center, University of Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 280:39-46. 2008
    ..In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes...