Martin Wühr

Summary

Country: Germany

Publications

  1. pmc Evidence for an upper limit to mitotic spindle length
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1256-61. 2008
  2. pmc How does a millimeter-sized cell find its center?
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115 USA
    Cell Cycle 8:1115-21. 2009
  3. pmc A model for cleavage plane determination in early amphibian and fish embryos
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 20:2040-5. 2010
  4. doi request reprint Mitosis: new roles for myosin-X and actin at the spindle
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R912-4. 2008
  5. pmc Organization of early frog embryos by chemical waves emanating from centrosomes
    Keisuke Ishihara
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA Marine Biological Laboratory, Woods Hole, MA, USA
    Philos Trans R Soc Lond B Biol Sci 369:. 2014
  6. pmc Spatial organization of cytokinesis signaling reconstituted in a cell-free system
    Phuong A Nguyen
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Science 346:244-7. 2014
  7. pmc Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells
    Timothy Mitchison
    Department of Systems Biology, Harvard Medical School and Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    Cytoskeleton (Hoboken) 69:738-50. 2012
  8. doi request reprint Pronuclear migration: no attachment? No union, but a futile cycle!
    Phuong A Nguyen
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 22:R409-11. 2012
  9. pmc A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization
    Brian K Erickson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell . 2016
  10. pmc Size Scaling of Microtubule Assemblies in Early Xenopus Embryos
    Timothy J Mitchison
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115 Marine Biological Laboratory, Woods Hole, Massachusetts 02543
    Cold Spring Harb Perspect Biol 7:a019182. 2015

Collaborators

Detail Information

Publications14

  1. pmc Evidence for an upper limit to mitotic spindle length
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1256-61. 2008
    ..We conclude that early mitotic spindle length in Xenopus laevis is uncoupled from cell length, reaching an upper bound determined by mechanisms that are intrinsic to the spindle...
  2. pmc How does a millimeter-sized cell find its center?
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115 USA
    Cell Cycle 8:1115-21. 2009
    ....
  3. pmc A model for cleavage plane determination in early amphibian and fish embryos
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 20:2040-5. 2010
    ..Dynein anchored in the cytoplasm then generates length-dependent pulling forces, which move and orient centrosomes...
  4. doi request reprint Mitosis: new roles for myosin-X and actin at the spindle
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R912-4. 2008
    ....
  5. pmc Organization of early frog embryos by chemical waves emanating from centrosomes
    Keisuke Ishihara
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA Marine Biological Laboratory, Woods Hole, MA, USA
    Philos Trans R Soc Lond B Biol Sci 369:. 2014
    ..Large embryo cells provide valuable insights to how cells control chemical waves, which may be a general principle for cytoplasmic organization. ..
  6. pmc Spatial organization of cytokinesis signaling reconstituted in a cell-free system
    Phuong A Nguyen
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Science 346:244-7. 2014
    ..This system opens further approaches to understanding the biophysics of cytokinesis signaling. ..
  7. pmc Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells
    Timothy Mitchison
    Department of Systems Biology, Harvard Medical School and Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    Cytoskeleton (Hoboken) 69:738-50. 2012
    ..Studying these problems in extremely large cells is starting to reveal how general principles of cell organization scale with cell size...
  8. doi request reprint Pronuclear migration: no attachment? No union, but a futile cycle!
    Phuong A Nguyen
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 22:R409-11. 2012
    ..How do pronuclei migrate towards each other? The zebrafish futile cycle gene is shown to encode a maternally expressed membrane protein required for nuclear attachment and migration along the sperm aster...
  9. pmc A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization
    Brian K Erickson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell . 2016
    ..These data further elucidated a correlation between the expression of key proteins and their cellular response to drug treatment...
  10. pmc Size Scaling of Microtubule Assemblies in Early Xenopus Embryos
    Timothy J Mitchison
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115 Marine Biological Laboratory, Woods Hole, Massachusetts 02543
    Cold Spring Harb Perspect Biol 7:a019182. 2015
    ..These tasks are executed by the spindle in smaller cells. We end by discussing possible mechanisms that limit mitotic aster size and promote interphase aster growth to cell-spanning dimensions. ..
  11. pmc The Nuclear Proteome of a Vertebrate
    Martin Wühr
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 25:2663-71. 2015
    ..Thus, complex assembly and passive retention, rather than continuous active transport, is the dominant mechanism for the maintenance of nuclear and cytoplasmic proteomes...
  12. pmc Amyloid-like Self-Assembly of a Cellular Compartment
    Elvan Boke
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cell 166:637-50. 2016
    ..Prion-like domains are found in germ plasm organizing proteins in other species, suggesting that Balbiani body formation by amyloid-like assembly could be a conserved mechanism that helps oocytes function as long-lived germ cells. ..
  13. pmc On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development
    Leonid Peshkin
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 35:383-94. 2015
    ....
  14. doi request reprint Size and speed go hand in hand in cytokinesis
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:798-800. 2009
    ..2009) show in embryos of the worm Caenorhabditis elegans that the rate of ring constriction during cytokinesis is proportional to the initial cell perimeter, ensuring that the duration of cytokinesis is cell-size independent...