Ernst Wellnhofer

Summary

Country: Germany

Publications

  1. ncbi request reprint Is contrast-related vasodilatation after intra-coronary iodixanol and iopromide in vivo endothelium-dependent?
    E Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur J Echocardiogr 2:285-91. 2001
  2. ncbi request reprint Shear stress and vascular remodeling: study of cardiac allograft coronary artery disease as a model of diffuse atherosclerosis
    Ernst Wellnhofer
    Departments of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 21:405-16. 2002
  3. ncbi request reprint High fidelity correction of pressure signals from fluid-filled systems by harmonic analysis
    E Wellnhofer
    Charite, Campus Virchow Klinikum and Deutsches Herzzentrum Berlin, Humboldt University, Berlin, Germany
    J Clin Monit Comput 15:307-15. 1999
  4. doi request reprint Novel non-dimensional approach to comparison of wall shear stress distributions in coronary arteries of different groups of patients
    E Wellnhofer
    German Heart Institute of Berlin, Berlin, Germany
    Atherosclerosis 202:483-90. 2009
  5. ncbi request reprint Progression of coronary atherosclerosis quantified by analysis of 3-D reconstruction of left coronary arteries
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Atherosclerosis 160:483-93. 2002
  6. ncbi request reprint Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery
    Ernst Wellnhofer
    German Heart Institute, Internal Medicine Cardiology, Berlin, Germany
    Circulation 109:2172-4. 2004
  7. doi request reprint A decade of percutaneous coronary interventions in cardiac transplant recipients: a monocentric study in 160 patients
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 27:17-25. 2008
  8. ncbi request reprint Evaluation of new software for angiographic determination of right ventricular volumes
    Ernst Wellnhofer
    Department of Internal Medicine and Cardiology, German Heart Institute, Augustenburger Platz 1, 13353, Berlin, Germany
    Int J Cardiovasc Imaging 21:575-85. 2005
  9. doi request reprint Regional right ventricular function and timing of contraction in healthy volunteers evaluated by strain-encoded MRI
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Magn Reson Imaging 28:1379-85. 2008
  10. doi request reprint Quilty in biopsy is associated with poor prognosis after heart transplantation
    Nicola Erika Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Transpl Immunol 19:209-14. 2008

Detail Information

Publications44

  1. ncbi request reprint Is contrast-related vasodilatation after intra-coronary iodixanol and iopromide in vivo endothelium-dependent?
    E Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur J Echocardiogr 2:285-91. 2001
    ..Goals of the study were the assessment of the correlation between flow-dependent and contrast-related vasodilatation, comparison of iodixanol to iopromide and evaluation of the impact of plaque on vasodilatation in coronary arteries...
  2. ncbi request reprint Shear stress and vascular remodeling: study of cardiac allograft coronary artery disease as a model of diffuse atherosclerosis
    Ernst Wellnhofer
    Departments of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 21:405-16. 2002
    ..Flow-dependent remodeling is regulated by shear stress. Thus, normal levels of shear stress at baseline flow reflect adequate regulation and provide a functional assessment of flow-dependent remodeling...
  3. ncbi request reprint High fidelity correction of pressure signals from fluid-filled systems by harmonic analysis
    E Wellnhofer
    Charite, Campus Virchow Klinikum and Deutsches Herzzentrum Berlin, Humboldt University, Berlin, Germany
    J Clin Monit Comput 15:307-15. 1999
    ..Fluid-filled systems are generally used for invasive pressure measurements in cardiology, anesthesiology and intensive care medicine. Wave reflection and attenuation cause considerable signal distortion...
  4. doi request reprint Novel non-dimensional approach to comparison of wall shear stress distributions in coronary arteries of different groups of patients
    E Wellnhofer
    German Heart Institute of Berlin, Berlin, Germany
    Atherosclerosis 202:483-90. 2009
    ..Vessel size and flow rates are different between patients, however. To compare distribution patterns of WSS in analogy to fluid-dynamic modelling, non-dimensional WSS/area functions are calculated...
  5. ncbi request reprint Progression of coronary atherosclerosis quantified by analysis of 3-D reconstruction of left coronary arteries
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Atherosclerosis 160:483-93. 2002
    ..We applied this technique to investigate diffuse luminal narrowing in patients with the clinical manifestation of progressive atherosclerosis...
  6. ncbi request reprint Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery
    Ernst Wellnhofer
    German Heart Institute, Internal Medicine Cardiology, Berlin, Germany
    Circulation 109:2172-4. 2004
    ..Low-dose dobutamine challenge (DSMR) by MRI was compared with delayed enhancement imaging with Gd-DTPA (SCAR) as a predictor of improvement of wall motion after revascularization (RECOVERY)...
  7. doi request reprint A decade of percutaneous coronary interventions in cardiac transplant recipients: a monocentric study in 160 patients
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 27:17-25. 2008
    ..Percutaneous transluminal coronary angioplasty (PCI) is a method of choice for local revascularization that is also increasingly used in heart transplant patients...
  8. ncbi request reprint Evaluation of new software for angiographic determination of right ventricular volumes
    Ernst Wellnhofer
    Department of Internal Medicine and Cardiology, German Heart Institute, Augustenburger Platz 1, 13353, Berlin, Germany
    Int J Cardiovasc Imaging 21:575-85. 2005
    ..The scope of the study was to evaluate a recent software for angiographic volume determination as compared to cardiovascular magnetic resonance imaging...
  9. doi request reprint Regional right ventricular function and timing of contraction in healthy volunteers evaluated by strain-encoded MRI
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Magn Reson Imaging 28:1379-85. 2008
    ..To prospectively determine the feasibility and accuracy of strain-encoded (SENC) magnetic resonance imaging (MRI) for the characterization of the right ventricular free wall (RVFW) strain and timing of contraction at 3.0 Tesla (3T) MRI...
  10. doi request reprint Quilty in biopsy is associated with poor prognosis after heart transplantation
    Nicola Erika Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Transpl Immunol 19:209-14. 2008
    ..28-0.77). Quilty is associated with graft loss and poor outcome post HTx. Index biopsy during the first post-transplant year is a useful tool to identify patients at risk and is recommended during routine post-transplant management...
  11. doi request reprint Quilty indicates increased risk for microvasculopathy and poor survival after heart transplantation
    Nicola E Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 27:289-96. 2008
    ..The impact of Quilty (sub-endocardial infiltration of lymphocytes) on the development of stenotic microvasculopathy and outcome after heart transplantation has not yet been evaluated...
  12. doi request reprint Everolimus prevents endomyocardial remodeling after heart transplantation
    Nicola E Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Transplantation 92:1165-72. 2011
    ..Endomyocardial remodeling is characterized by progressive fibrosis and scars and may develop after heart transplantation. The role of everolimus in preventing this process has not been evaluated as yet...
  13. doi request reprint Long-term prognostic value of dobutamine stress CMR
    Sebastian Kelle
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 4:161-72. 2011
    ..The aim of this study was to assess the long-term value of high-dose dobutamine cardiac magnetic resonance (DCMR) for the prediction of cardiac events in a large cohort of patients with known or suspected coronary artery disease...
  14. doi request reprint Beneficial effect of female gender on long-term survival after heart transplantation
    Nicola E Hiemann
    Deutsches Herzzentrum Berlin, Department of Cardiothoracic and Vascular Surgery, Berlin, Germany
    Transplantation 86:348-56. 2008
    ..We aimed to test whether stenotic microvasculopathy affects the more beneficial course in female cardiac transplant recipients...
  15. pmc In-vivo coronary flow profiling based on biplane angiograms: influence of geometric simplifications on the three-dimensional reconstruction and wall shear stress calculation
    Ernst Wellnhofer
    Biofluid Mechanics Laboratory, Charite Universitatsmedizin Berlin, Berlin, Germany
    Biomed Eng Online 5:39. 2006
    ..Methodological simplifications are desirable in porting this approach from bench to bedside. The impact of such simplifications on the accuracy of geometry and wall shear stress calculations has to be investigated...
  16. ncbi request reprint CFD analysis in an anatomically realistic coronary artery model based on non-invasive 3D imaging: comparison of magnetic resonance imaging with computed tomography
    Leonid Goubergrits
    Biofluidmechanics Laboratory, Charite Universitaetsmedizin Berlin, Spandauer Damm 130, 14050, Berlin, Germany
    Int J Cardiovasc Imaging 24:411-21. 2008
    ..A comparison of the calculated mean WSS shows good correlation (r = 0.97) and good agreement among the three modalities with a WSS of 0.65 Pa in the original model, of 0.68 Pa in the CT based model and of 0.67 Pa in the MRI based model...
  17. doi request reprint Flow simulation studies in coronary arteries--impact of side-branches
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Atherosclerosis 213:475-81. 2010
    ..Wall shear stress (WSS) may induce local remodeling of the vascular wall and the WSS pattern in turn depends on vascular geometry. We aimed to elucidate the impact of side-branches on local WSS...
  18. ncbi request reprint Prognostic impact of microvasculopathy on survival after heart transplantation: evidence from 9713 endomyocardial biopsies
    Nicola E Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Circulation 116:1274-82. 2007
    ..Epicardial vasculopathy has been shown to be associated with poor outcome after heart transplantation. We demonstrate that histologically proven stenotic microvasculopathy is a novel prognostic factor for long-term survival...
  19. doi request reprint Magnetic resonance imaging versus computed tomography for characterization of pulmonary vein morphology before radiofrequency catheter ablation of atrial fibrillation
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, German Heart Institute Berlin, Berlin, Germany
    Am J Cardiol 104:1540-6. 2009
    ..75 to 0.99, p <0.001 for all) between the 2 imaging approaches. In conclusion, MRI and multislice CT of the PVs appear to provide similar and detailed anatomic and quantitative information before RFCA of AF...
  20. ncbi request reprint Early detection of left ventricular dysfunction related to transplant coronary artery disease
    Michael Dandel
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Heart Lung Transplant 22:1353-64. 2003
    ..We assessed left ventricular (LV) function in relation to severity of coronary lesions to improve both early diagnosis of TxCAD and evaluation of the severity of myocardial damage...
  21. doi request reprint Single-breathhold four-dimensional assessment of left ventricular volumes and function using k-t BLAST after application of extracellular contrast agent at 3 Tesla
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, German Heart Institute Berlin, Berlin, Germany
    J Magn Reson Imaging 27:1028-36. 2008
    ..0 Tesla (3T) MR system...
  22. doi request reprint Coronary flow reserve measurement detects transplant coronary artery disease in pediatric heart transplant patients
    Stephan Schubert
    Department of Congenital Heart Defects Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 27:514-21. 2008
    ..Systemic application of adenosine vs intracoronary testing for CFR has been validated in adults; however, its accuracy in pediatric patients has not yet been proven...
  23. ncbi request reprint Intravascular ultrasound assessment of longitudinal plaque distribution patterns in patients with angiographically silent coronary artery disease after heart transplantation
    Wolfgang Bocksch
    Department of Internal Medicine Cardiology, Humboldt University Berlin, Germany
    Coron Artery Dis 13:349-56. 2002
    ..The purpose of this three-dimensional intracoronary ultrasound (ICUS) study was to assess longitudinal plaque distribution patterns in patients with angiographically silent coronary artery disease (CAD) after heart transplantation (HTX)...
  24. doi request reprint A prospective study for comparison of MR and CT imaging for detection of coronary artery stenosis
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 4:50-61. 2011
    ..the purpose of the present study was to directly compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multislice computed tomography (CT) for the detection of coronary artery stenosis...
  25. doi request reprint Strain-encoded MRI to evaluate normal left ventricular function and timing of contraction at 3.0 Tesla
    Ashraf Hamdan
    Department of Internal Medicine Cardiology, Deutsche Herzzentrum Berlin, Berlin, Germany
    J Magn Reson Imaging 29:799-808. 2009
    ..To define the reproducibility of strain-encoded (SENC) magnetic resonance imaging (MRI) for assessment of regional left ventricular myocardial strain and timing of contraction in a 3T MRI system...
  26. doi request reprint Non-dimensional modeling in flow simulation studies of coronary arteries including side-branches: a novel diagnostic tool in coronary artery disease
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Atherosclerosis 216:277-82. 2011
    ..We performed non-dimensional modeling to discriminate different types of coronary artery remodeling based on WSS patterns and vessel morphology...
  27. doi request reprint Non-HLA antibodies targeting vascular receptors enhance alloimmune response and microvasculopathy after heart transplantation
    Nicola E Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Transplantation 94:919-24. 2012
    ..Non-human leukocyte antigen antibodies (Abs) targeting vascular receptors are implicated in the pathogenesis of renal allograft vascular rejection and in progressive vasculopathy in patients with systemic sclerosis...
  28. ncbi request reprint Noninvasive determination of coronary blood flow velocity with cardiovascular magnetic resonance in patients after stent deployment
    Eike Nagel
    Internal Medicine Cardiology, German Heart Institute, Augustenburger Platz 1, D 13353 Berlin, Germany
    Circulation 107:1738-43. 2003
    ..The purpose of the study was to determine coronary flow velocity reserve (CFVR) with MR after stent deployment...
  29. doi request reprint Clopidogrel pharmacokinetics and pharmacodynamics in out-of-hospital cardiac arrest patients with acute coronary syndrome undergoing target temperature management
    Jan Kaufmann
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany Electronic address
    Resuscitation 102:63-9. 2016
    ..Previous data point to an interaction between hypothermia and drug metabolism, potentially impacting on platelet function in patients on antiplatelet therapy...
  30. ncbi request reprint Prevalence of graft vessel disease after paediatric heart transplantation: a single centre study of 54 patients
    Nicola Erika Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Interact Cardiovasc Thorac Surg 4:434-9. 2005
    ..All patients dying due to cardiac related causes of death (N=6, 3-12 years after HTx) had evidence of GVD. The data show GVD to be an important cause of late cardiac related deaths in this population...
  31. ncbi request reprint Enhanced inotropic state of the failing left ventricle by cardiac contractility modulation electrical signals is not associated with increased myocardial oxygen consumption
    Christian Butter
    From the German Heart Institute Berlin, Berlin, Germany
    J Card Fail 13:137-42. 2007
    ..We examined the effects these same cardiac contractility modulating (CCM) electrical signals on myocardial oxygen consumption (MVO(2)) in both patients and dogs with chronic HF...
  32. ncbi request reprint Small vessel disease after heart transplantation: impact of immunologic and nonimmunologic risk factors
    Nicola E Hiemann
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Transpl Int 18:908-14. 2005
    ..No correlations were present to further demographical data. Microvascular alterations after HTx seem to be the result of an immunologic conflict rather than to depend on nonimmunologic factors...
  33. doi request reprint Angiographic assessment of cardiac allograft vasculopathy: results of a Consensus Conference of the Task Force for Thoracic Organ Transplantation of the German Cardiac Society
    Ernst Wellnhofer
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Transpl Int 23:1094-104. 2010
    ..331 (P=0.001). Angiographic evaluation of cardiac allograft vasculopathy, particularly of diffuse and peripheral disease and remodeling, needs standardization. This should be performed in a downward compatible improvement process...
  34. pmc Effects of Renal Denervation on Renal Artery Function in Humans: Preliminary Study
    Adelina Doltra
    Deutsches Herzzentrum Berlin, Department of Internal Medicine Cardiology, Berlin, Germany
    PLoS ONE 11:e0150662. 2016
    ..To study the effects of RD on renal artery wall function non-invasively using magnetic resonance...
  35. pmc Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity
    Kai Kappert
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    PLoS ONE 8:e70542. 2013
    ..Here we aimed to determine the role of serpinB8/furin in obesity-associated chronic inflammation...
  36. doi request reprint Soluble P-selectin level correlates with acetylsalicylic acid but not with clopidogrel response in patients with stable coronary artery disease after a percutaneous coronary intervention
    Jan Kaufmann
    Department of Internal Medicine Cardiology, German Heart Institute Berlin, 13353 Berlin, Germany
    Coron Artery Dis 24:312-20. 2013
    ..However, little is known about the relationship between platelet function and inflammation under dual antiplatelet therapy in patients with stable coronary artery disease...
  37. pmc Coronary artery distensibility assessed by 3.0 Tesla coronary magnetic resonance imaging in subjects with and without coronary artery disease
    Sebastian Kelle
    Department of Medicine, Division of Cardiology, German Heart Institute, Berlin, Germany
    Am J Cardiol 108:491-7. 2011
    ..006). In conclusion, 3.0-Tesla MRI, a reproducible noninvasive method to assess human coronary artery vessel wall distensibility, is able to detect significant differences in distensibility between healthy subjects and those with CAD...
  38. ncbi request reprint Time course of left ventricular volumes in severe congestive heart failure patients treated by optimized AV sequential left ventricular pacing alone--a 3-dimensional echocardiographic study
    Christian Butter
    German Heart Institute, Berlin, Germany
    Am Heart J 151:115-23. 2006
    ....
  39. pmc Incremental cost-effectiveness of dobutamine stress cardiac magnetic resonance imaging in patients at intermediate risk for coronary artery disease
    George Petrov
    Department of Internal Medicine Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 104:401-9. 2015
    ..The effectiveness of stress cardiac magnetic resonance (CMR) as a gatekeeper for coronary angiography (CA) has been established. Level five HTA studies according to the hierarchical model of diagnostic test evaluation are not available...
  40. ncbi request reprint X-ray-based flow visualization and measurement: application in multiphase flows
    Axel Seeger
    Biofluidmechanics Laboratory, Charite, Berlin, Germany
    Ann N Y Acad Sci 972:247-53. 2002
    ..Hence, in contrast to optical methods, both of these X-ray-based methods are independent of the void fraction and are applicable to opaque liquids...
  41. ncbi request reprint Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state free precession
    Holger Thiele
    Clinic of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    J Cardiovasc Magn Reson 4:327-39. 2002
    ..This may increase clinical utility of magnetic resonance by shorter acquisition and processing times...
  42. ncbi request reprint Noninvasive echocardiographic estimation of pulmonary wedge pressure in candidates for and recipients of heart transplantation
    Gero Tenderich
    Department of Cardio Thoracic Surgery, Heart Center North Rhine Westfalia, Ruhr University of Bochum, Bad Oeynhausen, Germany
    J Am Soc Echocardiogr 20:480-5. 2007
    ..We assessed the value of deceleration time (dt) of diastolic wave of pulmonary venous flow (PVF) (PVF_dt) as noninvasive estimation of pulmonary wedge pressure (PWP) in candidates for and recipients of heart transplantation...
  43. ncbi request reprint Association between acute rejection and cardiac allograft vasculopathy
    Michael Dandel
    J Heart Lung Transplant 22:1064-5. 2003
  44. ncbi request reprint Tissue Doppler imaging for the assessment of systolic and diastolic ventricular function
    Michael Dandel
    J Am Soc Echocardiogr 15:478. 2002