Christoph Wanner

Summary

Country: Germany

Publications

  1. ncbi request reprint Fabry disease model: a rational approach to the management of Fabry disease
    Christoph Wanner
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Clin Ther 29:S2-5. 2007
  2. doi request reprint Wasting and sudden cardiac death in hemodialysis patients: a post hoc analysis of 4D (Die Deutsche Diabetes Dialyse Studie)
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Germany
    Am J Kidney Dis 58:599-607. 2011
  3. doi request reprint Differences in Fabry cardiomyopathy between female and male patients: consequences for diagnostic assessment
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    JACC Cardiovasc Imaging 4:592-601. 2011
  4. pmc Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes
    Vera Krane
    University Hospital Wurzburg, Department of Internal Medicine I, Division of Nephrology, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 5:874-81. 2010
  5. doi request reprint Two-dimensional speckle tracking as a non-invasive tool for identification of myocardial fibrosis in Fabry disease
    Johannes Krämer
    Department of Medicine, Department of Cardiology, University of Wurzburg, Oberdürrbacherstrasse 6, Wurzburg, Germany
    Eur Heart J 34:1587-96. 2013
  6. doi request reprint Department-related tasks and organ-targeted therapy in Fabry disease: an interdisciplinary challenge
    Frank Weidemann
    Department of Medicine, Würzburg University Medical Center, Wurzburg, Wurzburg, Germany
    Am J Med 123:658.e1-658.e10. 2010
  7. doi request reprint Cross-sectional baseline analysis of electrocardiography in a large cohort of patients with untreated Fabry disease
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    J Inherit Metab Dis 36:873-9. 2013
  8. doi request reprint Effect of atorvastatin on inflammation and outcome in patients with type 2 diabetes mellitus on hemodialysis
    Vera Krane
    Division of Nephrology, University Clinic, Wurzburg, Germany
    Kidney Int 74:1461-7. 2008
  9. doi request reprint Interdisciplinary approach towards female patients with Fabry disease
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Eur J Clin Invest 42:455-62. 2012
  10. doi request reprint The right ventricle in Fabry disease: natural history and impact of enzyme replacement therapy
    Markus Niemann
    Medizinische Klinik und Poliklinik I, Zentrum fur Innere Medizin, Oberdurrbacher Strasse 6, Wurzburg, Germany
    Heart 96:1915-9. 2010

Detail Information

Publications87

  1. ncbi request reprint Fabry disease model: a rational approach to the management of Fabry disease
    Christoph Wanner
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Clin Ther 29:S2-5. 2007
    ....
  2. doi request reprint Wasting and sudden cardiac death in hemodialysis patients: a post hoc analysis of 4D (Die Deutsche Diabetes Dialyse Studie)
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Germany
    Am J Kidney Dis 58:599-607. 2011
    ..This study examined the effects of wasting on the various components of cardiovascular outcome and deaths caused by infection in hemodialysis patients...
  3. doi request reprint Differences in Fabry cardiomyopathy between female and male patients: consequences for diagnostic assessment
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    JACC Cardiovasc Imaging 4:592-601. 2011
    ..We hypothesized that Fabry cardiomyopathy in female patients might differ substantially from that in male patients and sought to prove this hypothesis in a large cohort consisting of 104 patients with Fabry disease...
  4. pmc Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes
    Vera Krane
    University Hospital Wurzburg, Department of Internal Medicine I, Division of Nephrology, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 5:874-81. 2010
    ..Hemodialysis patients with type 2 diabetes exhibit an excessive cardiovascular risk and regularly receive heparin. We tested whether antibodies to the platelet factor 4-heparin complex (PF4-H-AB) contribute to outcome...
  5. doi request reprint Two-dimensional speckle tracking as a non-invasive tool for identification of myocardial fibrosis in Fabry disease
    Johannes Krämer
    Department of Medicine, Department of Cardiology, University of Wurzburg, Oberdürrbacherstrasse 6, Wurzburg, Germany
    Eur Heart J 34:1587-96. 2013
    ..Myocardial fibrosis is common in Fabry cardiomyopathy and is associated with disease progression and severe prognosis...
  6. doi request reprint Department-related tasks and organ-targeted therapy in Fabry disease: an interdisciplinary challenge
    Frank Weidemann
    Department of Medicine, Würzburg University Medical Center, Wurzburg, Wurzburg, Germany
    Am J Med 123:658.e1-658.e10. 2010
    ....
  7. doi request reprint Cross-sectional baseline analysis of electrocardiography in a large cohort of patients with untreated Fabry disease
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    J Inherit Metab Dis 36:873-9. 2013
    ..However, the value of electrocardiography (ECG) in relation to these two techniques remains largely unknown...
  8. doi request reprint Effect of atorvastatin on inflammation and outcome in patients with type 2 diabetes mellitus on hemodialysis
    Vera Krane
    Division of Nephrology, University Clinic, Wurzburg, Germany
    Kidney Int 74:1461-7. 2008
    ....
  9. doi request reprint Interdisciplinary approach towards female patients with Fabry disease
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Eur J Clin Invest 42:455-62. 2012
    ..Fabry disease (FD) is a rare X-linked lysosomal storage disorder leading to an accumulation of globotriaosylceramides in the lysosomes of various organs...
  10. doi request reprint The right ventricle in Fabry disease: natural history and impact of enzyme replacement therapy
    Markus Niemann
    Medizinische Klinik und Poliklinik I, Zentrum fur Innere Medizin, Oberdurrbacher Strasse 6, Wurzburg, Germany
    Heart 96:1915-9. 2010
    ..Storage of globotriaosylceramides is present in the left and right ventricles of patients with Fabry disease. Improvement of left ventricular morphology and function during enzyme replacement therapy (ERT) has previously been reported...
  11. doi request reprint Heart valve involvement in Fabry cardiomyopathy
    Frank Weidemann
    Department of Internal Medicine Centres of Rare Diseases and Cardiovascular Medicine, Wurzburg, Germany
    Ultrasound Med Biol 35:730-5. 2009
    ..Mild left ventricular valve regurgitations are frequent in Fabry disease. However, these valve abnormalities are not the major limitations for the Fabry heart...
  12. pmc Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Internal Medicine 1, University Hospital Wurzburg, University of Wurzburg, Oberdürrbacherstr 6, D 97080, Wurzburg, Germany
    Eur Heart J 34:578-87. 2013
    ..Sudden cardiac death is common and accounts largely for the excess mortality of patients on maintenance dialysis. It is unknown whether aldosterone and cortisol increase the incidence of sudden cardiac death in dialysis patients...
  13. doi request reprint Tei index in fabry disease
    Markus Niemann
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Am Soc Echocardiogr 24:1026-32. 2011
    ..The aim of this study was to investigate the diagnostic value of the Tei index, a marker for combined diastolic and systolic function, in patients with Fabry disease...
  14. doi request reprint [Females with Fabry's disease - an interdisciplinary diagnostic and therapeutic challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Med Klin (Munich) 105:627-34. 2010
    ..This synopsis wants to systematically review the typical organ involvement in female Fabry patients. Moreover, therapy recommendations especially for female patients are discussed...
  15. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  16. pmc High-Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease
    Nora Seydelmann
    Medizinische Klinik I, University Hospital Wurzburg, and Comprehensive Heart Failure Center, Wurzburg, Germany
    J Am Heart Assoc 5:. 2016
    ....
  17. pmc Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e63560. 2013
    ..We aimed to investigate the relation between homoarginine, kidney function and progression of chronic kidney disease (CKD)...
  18. pmc Predicting erythropoietin resistance in hemodialysis patients with type 2 diabetes
    Andreas Schneider
    Department of Medicine, Division of Nephrology, University Hospital Wuerzburg, Wuerzburg, Germany
    BMC Nephrol 14:67. 2013
    ..The aim of this study was to identify predictors for ESA resistance and to develop a prediction model for the risk stratification in these patients...
  19. ncbi request reprint The variation of morphological and functional cardiac manifestation in Fabry disease: potential implications for the time course of the disease
    Frank Weidemann
    Department of Internal Medicine I, Divisions of Cardiology and Nephrology, Medical University Clinic, University of Wurzburg, 97080 Wuerzburg, Germany
    Eur Heart J 26:1221-7. 2005
    ..The aim of this clinical cross-sectional study was to investigate the cardiac interrelation of morphological and functional abnormalities in patients with Fabry disease...
  20. doi request reprint Bisphenol A in chronic kidney disease
    Detlef H Krieter
    Department of Medicine, Division of Nephrology, University of Wurzburg, Oberdurrbacher Strasse 6, Wurzburg, Germany
    Artif Organs 37:283-90. 2013
    ..Due to high protein binding, the removal of BPA by hemodialysis is limited...
  21. doi request reprint Endogenous erythropoietin and the association with inflammation and mortality in diabetic chronic kidney disease
    Martin Wagner
    Department of Medicine I, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Clin J Am Soc Nephrol 6:1573-9. 2011
    ..In this cohort study, we aimed to identify factors associated with endogenous EPO levels and investigate their relation to all-cause mortality...
  22. pmc Copeptin levels associate with cardiovascular events in patients with ESRD and type 2 diabetes mellitus
    Wiebke Fenske
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    J Am Soc Nephrol 22:782-90. 2011
    ..Whether vasopressin receptor antagonists will improve these outcomes requires further studies...
  23. pmc Change in N-terminal-pro-B-type-natriuretic-peptide and the risk of sudden death, stroke, myocardial infarction, and all-cause mortality in diabetic dialysis patients
    Karl Winkler
    Division of Clinical Chemistry, Department of Medicine, University Medical Center Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
    Eur Heart J 29:2092-9. 2008
    ..This study examined the effect of baseline and change from baseline NT-pro-BNP on cardiovascular outcome and mortality in haemodialysis patients...
  24. doi request reprint Association of LDL cholesterol and inflammation with cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus
    Vera Krane
    Department of Medicine I, Division of Nephrology, University of Wurzburg, Germany
    Am J Kidney Dis 54:902-11. 2009
    ..In hemodialysis patients, the additive value is unknown. The association between LDL cholesterol level and outcome previously was suggested to be inverse and confounded by inflammation...
  25. ncbi request reprint A new echocardiographic approach for the detection of non-ischaemic fibrosis in hypertrophic myocardium
    Frank Weidemann
    Department of Medicine I Center of Cardiovascular Medicine, Universitat Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Eur Heart J 28:3020-6. 2007
    ..We investigated in a prospective study whether regional non-ischaemic fibrosis in hypertrophic myocardium can also be detected by ultrasonic strain-rate imaging based on specific visual features of the myocardial deformation traces...
  26. doi request reprint Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
    Hector Tamez
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:902-9.e2. 2012
    ..We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146)...
  27. pmc The effect of high-flux hemodialysis on hemoglobin concentrations in patients with CKD: results of the MINOXIS study
    Andreas Schneider
    Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Germany
    Clin J Am Soc Nephrol 7:52-9. 2012
    ..This study sought to determine whether high-flux dialysis would help improve markers of renal anemia, inflammation, and oxidative stress compared with low-flux dialysis...
  28. doi request reprint Glycemic control and cardiovascular events in diabetic hemodialysis patients
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital, Oberdürrbacherstrasse 6, D 97080 Wurzburg, Germany
    Circulation 120:2421-8. 2009
    ..Poor glycemic control is associated with cardiovascular comorbidities in the general population. This study investigated the impact of glycemic control on cardiac and vascular outcomes in diabetic hemodialysis patients...
  29. doi request reprint Apolipoprotein E genotype predicts cardiovascular endpoints in dialysis patients with type 2 diabetes mellitus
    Karl Winkler
    Division of Clinical Chemistry, Department of Medicine, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Atherosclerosis 208:197-202. 2010
    ..Lipid metabolism is influenced by environmental and genetic factors. Among the latter, the apolipoprotein E (apoE) genotype is known to be associated with CVD risk and thus may affect cardiovascular outcome...
  30. pmc The association between parathyroid hormone and mortality in dialysis patients is modified by wasting
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Germany
    Nephrol Dial Transplant 24:3151-7. 2009
    ..We hypothesized that wasting, a common condition potentially related to adynamic bone disease, modifies the association of PTH with mortality and cardiovascular events (CVE), respectively...
  31. pmc Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients
    Christiane Drechsler
    Department of Internal Medicine 1, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Eur J Heart Fail 13:852-9. 2011
    ..Homoarginine deficiency may lead to decreased nitric oxide availability and endothelial dysfunction. Based on this rationale we assessed whether homoarginine deficiency is a risk factor for SCD in dialysis patients...
  32. doi request reprint Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry disease
    Johannes Krämer
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    Am J Cardiol 114:895-900. 2014
    ..In conclusion, myocardial fibrosis in Fabry disease is progressive, apparently not modified by ERT, and a crucial outcome determinant...
  33. doi request reprint Longitudinal assessments of erythropoietin-stimulating agent responsiveness and the association with specific clinical outcomes in dialysis patients
    Andreas Schneider
    Division of Nephrology, Department of Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Nephron Clin Pract 128:147-52. 2014
    ..We aimed to longitudinally assess ESA responsiveness over time and to investigate its association with specific clinical end points in a time-dependent approach...
  34. doi request reprint Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration
    Detlef H Krieter
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 25:212-8. 2010
    ..In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration...
  35. ncbi request reprint Fabry disease: diagnosis and treatment
    Frank Breunig
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Int Suppl . 2003
    ..Given the diagnostic and therapeutic potential today, it is of importance to identify patients at an early stage and to start therapeutic intervention before progression of organ damage is inevitable...
  36. doi request reprint Homoarginine and Clinical Outcomes in Renal Transplant Recipients: Results From the Assessment of Lescol in Renal Transplantation Study
    Christiane Drechsler
    1 Division of Nephrology, Department of Medicine, University Hospital Wurzburg, Wurzburg, Germany 2 Comprehensive Heart Failure Centre, University Hospital of Wurzburg, Wurzburg, Germany 3 Department of Organ Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway 4 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria 5 Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care, Research, VU University Medical Centre, Amsterdam, the Netherlands 6 Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical, University of Graz, Graz, Austria 7 Department of Cardiology, Medical University of Graz, Graz, Austria 8 Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria 9 Division of Nephrology, Department of Medicine, Sykehuset i Vestfold, Tønsberg, Norway 10 Division of Nephrology, Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden 11 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK 12 Department of Medicine V Nephrology, Frenchay Hospital
    Transplantation 99:1470-6. 2015
    ..The amino acid homoarginine exerts a variety of beneficial effects that may be relevant for cardiovascular and graft outcomes, which is investigated in the present study...
  37. doi request reprint Thyroid function, cardiovascular events, and mortality in diabetic hemodialysis patients
    Christiane Drechsler
    Department of Medicine 1, Division of Nephrology, University Hospital, University of Wurzburg, Wurzburg, Germany Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany Electronic address
    Am J Kidney Dis 63:988-96. 2014
    ..The aim of the present study was to analyze whether subclinical thyroid disorders were associated with CV events and mortality...
  38. pmc Potential role of vitamin D deficiency on Fabry cardiomyopathy
    Christiane Drechsler
    Department of Medicine 1, Divisions of Nephrology and Cardiology, University Hospital Wurzburg, Wurzburg, Germany
    J Inherit Metab Dis 37:289-95. 2014
    ..Whether vitamin D supplementation improves complications of Fabry disease, requires a randomized controlled trial...
  39. doi request reprint Endothelial progenitor cells in patients on extracorporeal maintenance dialysis therapy
    Detlef H Krieter
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 25:4023-31. 2010
    ..Chronic renal failure patients have a high cardiovascular disease burden, low numbers and impaired function of endothelial progenitor cells (EPCs). We hypothesized that enhanced uraemic toxin removal restores EPCs in haemodialysis patients...
  40. doi request reprint Matching efficacy of online hemodiafiltration in simple hemodialysis mode
    Detlef H Krieter
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Artif Organs 32:903-9. 2008
    ..Therefore, HD with PES may have beneficial effects on the outcome of maintenance dialysis patients similar to high-efficiency HDF...
  41. ncbi request reprint Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabry's cardiomyopathy
    Meinrad Beer
    Institut für Röntgendiagnostik, Wurzburg, Germany
    Am J Cardiol 97:1515-8. 2006
    ..Late enhancement may predict the effect of enzyme replacement therapy on left ventricular mass and cardiac function...
  42. pmc Organ manifestations and long-term outcome of Fabry disease in patients with the GLA haplotype D313Y
    Daniel Oder
    Department of Internal Medicine I and Comprehensive Heart Failure Center CHFC, University Hospital Wurzburg, Wurzburg, Germany Fabry Center for Interdisciplinary Therapy FAZIT, University Hospital Wurzburg, Wurzburg, Germany
    BMJ Open 6:e010422. 2016
    ..The severity of Fabry disease is dependent on the type of mutation in the α-galactosidase A (AgalA) encoding gene (GLA). This study focused on the impact of the GLA haplotype D313Y on long-term organ involvement and function...
  43. pmc Left Ventricular Geometry and Blood Pressure as Predictors of Adverse Progression of Fabry Cardiomyopathy
    Johannes Krämer
    Department of Medicine I, Cardiology Unit, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 10:e0140627. 2015
    ..In addition, the impact of blood pressure and alterations in geometry have not been systematically evaluated...
  44. pmc Galectin-3, Renal Function, and Clinical Outcomes: Results from the LURIC and 4D Studies
    Christiane Drechsler
    Division of Nephrology, Department of Internal Medicine 1 and Comprehensive Heart Failure Centre, University Hospital of Wurzburg, Wurzburg, Germany
    J Am Soc Nephrol 26:2213-21. 2015
    ..In conclusion, galectin-3 concentrations increased with progressive renal impairment and independently associated with cardiovascular end points, infections, and all-cause death in patients with impaired renal function. ..
  45. pmc Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial
    Andreas Schneider
    Department of Medicine, Division of Nephrology, University Hospital, Wurzburg, Germany
    PLoS ONE 10:e0128079. 2015
    ..Interventional strategies aiming to reduce levels of FGF-23 in HD patients are of particular interest. The purpose of the current study was to compare the impact of high-flux versus low-flux HD on circulating FGF-23 levels...
  46. pmc Hepcidin-25 in diabetic chronic kidney disease is predictive for mortality and progression to end stage renal disease
    Martin Wagner
    Division of Nephrology, Department of Medicine I, University Hospital Wurzburg, Wurzburg, Germany Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 10:e0123072. 2015
    ..In this cohort study, we evaluated the impact of hepcidin-25--the key hormone of iron-metabolism--on clinical outcomes in diabetic patients with CKD along with endogenous EPO levels...
  47. pmc Prognostic indicators of renal disease progression in adults with Fabry disease: natural history data from the Fabry Registry
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Clin J Am Soc Nephrol 5:2220-8. 2010
    ..These analyses were designed to characterize renal disease progression in untreated adults with Fabry disease...
  48. ncbi request reprint Progression of Fabry cardiomyopathy
    Jörg Strotmann
    University of Wurzburg, Medical Clinic and Policlinic I, Center of Cardiovascular Disease, Wurzburg, Germany
    Clin Ther 29:S13-4. 2007
  49. doi request reprint The Fabry cardiomyopathy: models for the cardiologist
    Frank Weidemann
    Department of Medicine, Division of Cardiology, University Hospital, Wuerzburg, Germany
    Annu Rev Med 62:59-67. 2011
    ..As the models can be extrapolated to other diseases, they might contribute to more optimal clinical management of patients with other cardiac disorders...
  50. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
    ..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
  51. pmc Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients
    Christiane Drechsler
    Department of Internal Medicine 1, Division of Nephrology, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Eur Heart J 31:2253-61. 2010
    ..Accumulating evidence suggests a role of vitamin D for myocardial and overall health. This study investigated the impact of vitamin D status on cardiovascular outcomes and fatal infections in haemodialysis patients...
  52. doi request reprint Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy
    Jan Galle
    Department of Internal Medicine, University Hospital, Wurzburg, Germany
    Nephrol Dial Transplant 23:3174-83. 2008
    ..Experimental evidence demonstrates that angiotensin receptor blockers (ARBs) possess anti-inflammatory potential, which might contribute to reducing proteinuria and providing renoprotection...
  53. pmc Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis
    Vera Krane
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Clinic, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 4:394-400. 2009
    ..However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis...
  54. ncbi request reprint Improvement of cardiac function during enzyme replacement therapy in patients with Fabry disease: a prospective strain rate imaging study
    Frank Weidemann
    Department of Medicine, Division of Cardiology, University Hospital Wurzburg, Germany
    Circulation 108:1299-301. 2003
    ..Whether these results can be translated into an improvement of myocardial function has yet to be demonstrated...
  55. pmc Kidney function as an underestimated factor for reduced health related quality of life in patients with Fabry disease
    Martin Wagner
    Comprehensive Heart Failure Center, University of Wurzburg, Oberdürrbacherstr, 6, Wurzburg 97080, Germany
    BMC Nephrol 15:188. 2014
    ..This study aimed to explore the role of chronic kidney disease (CKD) in a large cohort of patients with FD...
  56. pmc Increased arterial diameters in the posterior cerebral circulation in men with Fabry disease
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany Würzburg Fabry Center for Interdisciplinary Therapy FAZIT, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 9:e87054. 2014
    ..001), but not from stroke patients. Enlarged arterial diameters of the posterior circulation are present only in men with Fabry disease independent of disease severity...
  57. doi request reprint Rationale and design of the Mineralocorticoid Receptor Antagonists in End-Stage Renal Disease Study (MiREnDa)
    Fabian Hammer
    Division of Cardiology, Department of Medicine, University Hospital Wuerzburg, Wuerzburg, Germany
    Nephrol Dial Transplant 29:400-5. 2014
    ..We here review the literature on CV effects of MRA in dialysis patients and report the design of the Mineralocorticoid Receptor antagonists in End-stage renal Disease (MiREnDa) trial...
  58. doi request reprint Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency
    Boris Betz
    Division of Nephrology, Department of Medicine I, University Hospital of Wurzburg, Germany
    Transl Res 162:67-76. 2013
    ..As a consequence, a pathologic renal L-arginine deficiency in ischemic acute kidney injury results. ..
  59. pmc Impaired small fiber conduction in patients with Fabry disease: a neurophysiological case-control study
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    BMC Neurol 13:47. 2013
    ..Fabry disease is an inborn lysosomal storage disorder which is associated with small fiber neuropathy. We set out to investigate small fiber conduction in Fabry patients using pain-related evoked potentials (PREP)...
  60. ncbi request reprint Update on Fabry disease: kidney involvement, renal progression and enzyme replacement therapy
    Frank Breunig
    Division of Nephrology, Department of Medicine I, University Hospital, Wurzburg, Germany
    J Nephrol 21:32-7. 2008
    ..Subsequent follow-up assessments should be carried out in all patients on a regular basis to evaluate treatment outcomes...
  61. pmc Lyso-Gb3 Indicates that the Alpha-Galactosidase A Mutation D313Y is not Clinically Relevant for Fabry Disease
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    JIMD Rep 7:99-102. 2013
    ..Our data for the first time not only clinically but also biochemically supports the hypothesis that the D313Y mutation is not a classical one, but a rare variant mutation...
  62. doi request reprint [Division-related function and organ-related therapy in Fabry's disease. An interdisciplinary challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Med Klin (Munich) 104:10-9. 2009
    ....
  63. doi request reprint Statins, inflammation and kidney disease
    Vera Krane
    Department of Medicine 1, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Nat Rev Nephrol 7:385-97. 2011
    ....
  64. pmc Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal Registry
    Martin Wagner
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 57:894-902. 2011
    ..No prediction tool is used widely in current clinical practice. We aimed to predict long-term mortality in incident dialysis patients using easily obtainable variables...
  65. doi request reprint Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism
    T Alp Ikizler
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Kidney Int 84:1096-107. 2013
    ....
  66. pmc Heart failure in a cohort of patients with chronic kidney disease: the GCKD study
    Hanna Beck
    Department of Medicine, Division of Nephrology, Medical Center University of Freiburg, Freiburg, Germany
    PLoS ONE 10:e0122552. 2015
    ..We therefore aimed to examine the prevalence and correlates of HF in the German Chronic Kidney Disease (GCKD) study, a large observational prospective study...
  67. ncbi request reprint Umbilical angiectases as the sole clinical sign of Fabry disease in a 9-year-old boy
    Andreas O Eggert
    Department of Dermatology, Julius Maximilians University Würzburg, Josef Schneider Str 2, 97080, Wurzburg, Germany
    Eur J Pediatr 165:205-6. 2006
  68. doi request reprint The challenge of sudden death in dialysis patients
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Germany
    Clin J Am Soc Nephrol 3:920-9. 2008
  69. doi request reprint A new synthetic dialyzer with advanced permselectivity for enhanced low-molecular weight protein removal
    Detlef H Krieter
    University of Wurzburg, Department of Medicine, Division of Nephrology, Wurzburg, Germany
    Artif Organs 32:547-54. 2008
    ..This improved performance may be regarded as a contribution to optimal dialysis therapy...
  70. doi request reprint Case Report: Atheroembolic renal disease in a 72-year-old patient through coronary intervention after myocardial infarction
    Anna Laura Herzog
    Department of Medicine, Division of Nephrology, Wurzburg, Germany
    Hemodial Int 12:406-11. 2008
    ..The case reported is a 72-year-old male patient with preexisting CKD stage 3 undergoing percutaneous coronary intervention after myocardial infarction and consecutive AERD with typical clinical appearance 6 weeks after the event...
  71. doi request reprint Prevention of cardiovascular disease in chronic kidney disease patients
    Christoph Wanner
    Department of Internal Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Semin Nephrol 29:24-9. 2009
    ....
  72. doi request reprint Results of the 4D study: ten years of follow-up?
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University Hospital of Würzburg and the Comprehensive Heart failure Center, Oberdürrbacherstr 2, 97080, Wurzburg, Germany
    Clin Exp Nephrol 18:274-7. 2014
    ..The latter may be especially true for dialysis patients in Japan...
  73. doi request reprint Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University Hospital Wurzburg, Josef Schneider Strasse 2, Würzburg D 97080, Germany
    Kidney Int 76:567-75. 2009
    ..Most likely, this rise is a counter-regulatory response to worsening health in keeping with adiponectin's potential to counteract inflammation...
  74. ncbi request reprint Down-regulation of MTUS1 in human colon tumors
    Christina Zuern
    Department of Medicine, Division of Nephrology, University Clinic of Wuerzburg, Wuerzburg, Germany
    Oncol Rep 23:183-9. 2010
    ..Since reduced expression of MTUS1 results in increased cellular proliferation, these data suggest that MTUS1 could be involved in the loss of proliferative control in human colon cancer...
  75. doi request reprint Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study
    Nikolas Deubner
    Department of Internal Medicine I, Centre of Cardiovascular Medicine, University of Wurzburg, University Hospital Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
    Eur J Heart Fail 12:753-62. 2010
    ....
  76. ncbi request reprint Enzyme replacement therapy in Fabry disease: clinical implications
    Frank Breunig
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Nephrol Hypertens 12:491-5. 2003
    ..In this review we would like to give a current overview on recent advances in therapy and an outlook on future aspects in the management of Fabry disease...
  77. doi request reprint Recent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 34:209-17. 2011
    ..73 m(2) and with residual atherogenic dyslipidemia. The link between dyslipidemia treatment and diabetic retinopathy, nephropathy and neuropathy is an emerging new field and microvascular complications are targets for new treatments...
  78. ncbi request reprint Fabry disease: guidelines for the evaluation and management of multi-organ system involvement
    Christine M Eng
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genet Med 8:539-48. 2006
    ....
  79. doi request reprint Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults
    Alberto Ortiz
    Dialysis Unit, Universidad Autonoma de Madrid, Fundacion Jimenez Diaz, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    Nat Clin Pract Nephrol 4:327-36. 2008
    ..These organ-specific guidelines could be easier to implement than general guidelines, provided they are used in the context of an overall multisystem care approach...
  80. ncbi request reprint Fabry nephropathy and the case for adjunctive renal therapy
    Christoph Wanner
    J Am Soc Nephrol 18:2426-8. 2007
  81. ncbi request reprint Lipid changes and statins in chronic renal insufficiency
    Eberhard Ritz
    Ruperto Carola University Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:S226-30. 2006
    ..e. interference with proximal tubular reabsorption of protein) meanwhile has been well documented...
  82. ncbi request reprint Females with Fabry disease frequently have major organ involvement: lessons from the Fabry Registry
    William R Wilcox
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd SSB, Los Angeles, CA 90048, USA
    Mol Genet Metab 93:112-28. 2008
    ..Thus, females with FD have a significant risk for major organ involvement and decreased QoL. Females should be regularly monitored for signs and symptoms of FD, and considered for enzyme replacement therapy...
  83. doi request reprint Nephropathy in males and females with Fabry disease: cross-sectional description of patients before treatment with enzyme replacement therapy
    Alberto Ortiz
    Unidad de Dialisis, Fundacion Jimenez Diaz, Av Reyes Catolicos 2, 28040 Madrid, Spain
    Nephrol Dial Transplant 23:1600-7. 2008
    ..Fabry disease, an X-linked genetic disorder with deficient alpha-galactosidase A activity, is characterized by kidney disease and kidney failure. The spectrum of kidney disease has not been well defined, especially in female patients...
  84. ncbi request reprint Statins and aspirin in chronic kidney disease: what does the UK-HARP-I trial tell us?
    Vera Krane
    Am J Kidney Dis 45:607-9. 2005
  85. ncbi request reprint Enzyme replacement therapy for Fabry disease: proving the clinical benefit
    Frank Breunig
    Nephrol Dial Transplant 18:7-9. 2003
  86. doi request reprint Treatment of Fabry disease with different dosing regimens of agalsidase: effects on antibody formation and GL-3
    Anouk C Vedder
    Department of Internal Medicine Endocrinology and Metabolism, Academic Medical Center, F4 224, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Mol Genet Metab 94:319-25. 2008
    ..Infusion of a dose of 1.0mg/kg results in a more robust decline in GL-3, less impact, if any of antibodies, stable renal function and reduction of LVMass...
  87. ncbi request reprint Foreword. The 8th Annual European Round Table on Fabry Disease
    Christoph Wanner
    Clin Ther 30:S39. 2008