Peter Zwanzger

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Anxiolytic effects of transcranial magnetic stimulation--an alternative treatment option in anxiety disorders?
    Peter Zwanzger
    Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, 49149 Munster, Germany
    J Neural Transm (Vienna) 116:767-75. 2009
  2. pmc Acute shift in glutamate concentrations following experimentally induced panic with cholecystokinin tetrapeptide--a 3T-MRS study in healthy subjects
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 38:1648-54. 2013
  3. ncbi request reprint Differences in saccadic eye movements in subjects at high and low risk for panic disorder
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry, University of Munster, Albert Schweitzer Campus 1, 48149 Muenster, Germany
    Curr Pharm Des 18:5685-90. 2012
  4. doi request reprint Auditory processing in remitted major depression: a long-term follow-up investigation using 3T-fMRI
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Campus 1, Building A9, 49149, Muenster, Germany
    J Neural Transm (Vienna) 119:1565-73. 2012
  5. doi request reprint Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin
    P Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Depress Anxiety 29:762-74. 2012
  6. doi request reprint Comparison of combined psycho- and pharmacotherapy with monotherapy in anxiety disorders: controversial viewpoints and clinical perspectives
    P Zwanzger
    Department of Psychiatry and Psychotherapy, University of Munster, Albert Schweitzer Strasse 11, 49149 Munster, Germany
    J Neural Transm (Vienna) 116:759-65. 2009
  7. doi request reprint Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder
    P Zwanzger
    Department of Psychiatry and Psychotherapy, University of Munster, Germany
    Pharmacopsychiatry 42:266-9. 2009
  8. ncbi request reprint [Anticonvulsants in the treatment of anxiety--an alternative treatment option?]
    P Zwanzger
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Munster, Albert Schweitzer Strasse 11, 49149 Munster
    Nervenarzt 78:1274-82. 2007
  9. doi request reprint Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations
    Peter Zwanzger
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychoneuroendocrinology 34:1586-9. 2009
  10. ncbi request reprint [Anxiety disorders. Causes, clinical picture and treatment]
    P Zwanzger
    Spezialambulanz für Angsterkrankungen und Forschungsbereich Angst, Klinik fur Psychiatrie und Psychotherapie, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 11, 48149 Munster
    Nervenarzt 78:349-59; quiz 360. 2007

Detail Information

Publications93

  1. doi request reprint Anxiolytic effects of transcranial magnetic stimulation--an alternative treatment option in anxiety disorders?
    Peter Zwanzger
    Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, 49149 Munster, Germany
    J Neural Transm (Vienna) 116:767-75. 2009
    ..However, to further elucidate the putative anxiolytic action of rTMS in patients with anxiety disorders future studies have to be conducted addressing in particular the limitations of the studies mentioned above...
  2. pmc Acute shift in glutamate concentrations following experimentally induced panic with cholecystokinin tetrapeptide--a 3T-MRS study in healthy subjects
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 38:1648-54. 2013
    ....
  3. ncbi request reprint Differences in saccadic eye movements in subjects at high and low risk for panic disorder
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry, University of Munster, Albert Schweitzer Campus 1, 48149 Muenster, Germany
    Curr Pharm Des 18:5685-90. 2012
    ..In the present study, we investigated saccadic eye movement (SEM) as an index of CNS inhibitory function in subjects at high risk for PD...
  4. doi request reprint Auditory processing in remitted major depression: a long-term follow-up investigation using 3T-fMRI
    Peter Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Campus 1, Building A9, 49149, Muenster, Germany
    J Neural Transm (Vienna) 119:1565-73. 2012
    ....
  5. doi request reprint Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin
    P Zwanzger
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Depress Anxiety 29:762-74. 2012
    ..This review article proposes an extended hypothetical model for human PD, which integrates preclinical and clinical findings on CCK in addition to existing theories of the pathogenesis of PD...
  6. doi request reprint Comparison of combined psycho- and pharmacotherapy with monotherapy in anxiety disorders: controversial viewpoints and clinical perspectives
    P Zwanzger
    Department of Psychiatry and Psychotherapy, University of Munster, Albert Schweitzer Strasse 11, 49149 Munster, Germany
    J Neural Transm (Vienna) 116:759-65. 2009
    ....
  7. doi request reprint Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder
    P Zwanzger
    Department of Psychiatry and Psychotherapy, University of Munster, Germany
    Pharmacopsychiatry 42:266-9. 2009
    ..Selective GABAergic treatment has been suggested as a new therapeutic strategy in PD. In this pilot-study anxiolytic effects of the GABA reuptake inhibitor tiagabine (TGB) were investigated in PD...
  8. ncbi request reprint [Anticonvulsants in the treatment of anxiety--an alternative treatment option?]
    P Zwanzger
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Munster, Albert Schweitzer Strasse 11, 49149 Munster
    Nervenarzt 78:1274-82. 2007
    ..This article gives an overview of investigations to date on the effects of various anticonvulsants in panic disorder, generalized anxiety disorder and social phobia...
  9. doi request reprint Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations
    Peter Zwanzger
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychoneuroendocrinology 34:1586-9. 2009
    ..Thus, it might be hypothesized that the anxiolytic effects of GABAergic treatment might in part be mediated by their influence on 3alpha,5alpha-THDOC concentrations...
  10. ncbi request reprint [Anxiety disorders. Causes, clinical picture and treatment]
    P Zwanzger
    Spezialambulanz für Angsterkrankungen und Forschungsbereich Angst, Klinik fur Psychiatrie und Psychotherapie, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 11, 48149 Munster
    Nervenarzt 78:349-59; quiz 360. 2007
    ..This review gives an overview of pathogenesis, clinical presentation and current treatment standards...
  11. doi request reprint Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression
    Katharina Domschke
    Dept of Psychiatry, University of Muenster, Germany
    Eur Neuropsychopharmacol 20:301-9. 2010
    ..The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing...
  12. ncbi request reprint The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
    ..Our investigation gives the first hint that the speed of onset of antidepressant therapies may be dependent on both variants of the ACE genes and the gender of the patients...
  13. ncbi request reprint Neuroactive steroids in responders and nonresponders to sleep deprivation
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Ann N Y Acad Sci 1032:216-23. 2004
    ..In contrast to antidepressant drugs which correct the dysequilibrium of neuroactive steroids in major depression within several weeks, PSD does not affect the concentrations of neuroactive steroids in either responders or nonresponders...
  14. ncbi request reprint Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
    ..This should result in earlier and more intense additional therapeutic interventions in this group of patients...
  15. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  16. ncbi request reprint Influence of sleep deprivation on neuroactive steroids in major depression
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 28:577-81. 2003
    ....
  17. ncbi request reprint Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine
    Cornelius Schule
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 166:271-5. 2003
    ..Mirtazapine acts as an antagonist at presynaptic alpha(2)-receptors and at postsynaptic 5-hydroxytryptamine (5-HT)(2), 5-HT(3) and histamine H(1) receptors. It has been shown acutely to inhibit cortisol secretion in healthy subjects...
  18. ncbi request reprint The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  19. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
    ....
  20. ncbi request reprint Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, Munich, 80336, Germany
    Psychopharmacology (Berl) 186:601-11. 2006
    ....
  21. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  22. ncbi request reprint Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  23. ncbi request reprint Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychopharmacology 30:1181-6. 2005
    ....
  24. doi request reprint Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation
    Katharina Domschke
    Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Campus 1, Gebaeude A9, 48149 Muenster, Germany
    Psychopharmacology (Berl) 222:533-41. 2012
    ..2006) and attenuating the stimulatory effects of NPS in rodents (Boeck et al., 2010)...
  25. doi request reprint Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany
    Neuroimage 60:2222-9. 2012
    ....
  26. doi request reprint Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, Munster, Germany
    Biol Psychiatry 71:286-93. 2012
    ....
  27. doi request reprint Norepinephrine and serotonin transporter genes: impact on treatment response in depression
    Anna Baffa
    Department of Psychiatry, University of Munster, Munster, Germany
    Neuropsychobiology 62:121-31. 2010
    ....
  28. ncbi request reprint Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers
    Daniela Eser
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 30:192-5. 2005
    ....
  29. ncbi request reprint No Influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:111-4. 2003
    ..Thus, the previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients...
  30. ncbi request reprint Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disorders
    Daniela Eser
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 186:373-87. 2006
    ..They are important endogenous modulators of depression and anxiety and may provide a basis for the development of novel therapeutic agents in the treatment of affective disorders...
  31. ncbi request reprint Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Munich, Germany
    Depress Anxiety 18:140-3. 2003
    ..Our results suggest anxiolytic properties of tiagabine in humans, which provide sufficient rationale to assess its putative anxiolytic effects in patients with panic disorder under controlled conditions...
  32. ncbi request reprint Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up study
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Psychiatr Res 37:145-53. 2003
    ....
  33. ncbi request reprint The influence of 4-week treatment with sertraline on the combined T3/TRH test in depressed patients
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:334-40. 2005
    ..07%) and after the 4-week treatment with sertraline (-58.92%). Apparently, the therapeutic efficacy of antidepressants such as sertraline is not related to the regulation of HPT axis activity in depressed patients...
  34. ncbi request reprint Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 52:147-50. 2005
    ..Tiagabine is a new antiepileptic drug which acts via selective blockade of GABA reuptake. Therefore, we examined the effects of tiagabine on saccade parameters...
  35. doi request reprint Amygdala responsiveness to emotional words is modulated by subclinical anxiety and depression
    Inga Laeger
    Department of Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Building A9, D 48149 Muenster, Germany
    Behav Brain Res 233:508-16. 2012
    ..These results suggest a modulation of negative-word processing by subclinical depression and anxiety, as well as possible prefrontal compensatory processes during unintentional emotion regulation in subjects with higher trait anxiety...
  36. doi request reprint Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation?
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany Department of Psychiatry, University of Wuerzburg, Germany Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:189-96. 2013
    ..Future studies are warranted to replicate the present finding in independent samples, preferably in a longitudinal design. ..
  37. doi request reprint Acute anxiolytic effects of quetiapine during virtual reality exposure--a double-blind placebo-controlled trial in patients with specific phobia
    Julia Diemer
    Department of Psychiatry, University of Muenster, Germany
    Eur Neuropsychopharmacol 23:1551-60. 2013
    ..The present results thus suggest a possible suitability of quetiapine in the acute treatment of anxiety, particularly with regard to somatic symptoms. ..
  38. doi request reprint Dopamine D₃ receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression
    Udo Dannlowski
    Department of Psychiatry, University of Muenster, Germany
    Int J Neuropsychopharmacol 16:1443-59. 2013
    ..002; sample 2: p=0.023). In summary, the present study suggests some impact of DRD3 gene variation on ECT response, potentially mediated by alteration of striatal engagement during the processing of emotionally rewarding stimuli...
  39. ncbi request reprint Effects of repetitive transcranial magnetic stimulation (rTMS) on panic attacks induced by cholecystokinin-tetrapeptide (CCK-4)
    Peter Zwanzger
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 10:285-9. 2007
    ..In contrast to the effects of pretreatment with alprazolam on CCK-4-induced panic in healthy subjects LF rTMS does not affect CCK-4-induced panic and cortisol or ACTH release...
  40. doi request reprint Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder?
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany
    Int J Neuropsychopharmacol 15:1217-28. 2012
    ..Future studies are warranted to replicate the present finding in independent samples, preferably in a longitudinal design...
  41. ncbi request reprint The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  42. ncbi request reprint Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  43. ncbi request reprint Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet 114:530-2. 2002
    ....
  44. pmc Early prefrontal brain responses to the Hedonic quality of emotional words--a simultaneous EEG and MEG study
    Kati Keuper
    Institute for Biomagnetism and Biosignalanalysis, University of Munster, Munster, Germany
    PLoS ONE 8:e70788. 2013
    ..The valence-specific recruitment of different networks might underlie fast adaptive responses to both approach- and withdrawal-related stimuli, be they acquired or biological. ..
  45. ncbi request reprint Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, D 80336, Munich, Germany
    Neuropsychopharmacology 27:874-8. 2002
    ..Changes in neuroactive steroid levels after antidepressant pharmacotherapy more likely reflect specific pharmacological effects of antidepressant drugs and are not necessary for the amelioration of depressive symptoms...
  46. pmc Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    PLoS ONE 7:e39709. 2012
    ....
  47. ncbi request reprint The influence of concomitant neuroleptic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:162-70. 2006
    ..In these cases, concomitant pharmacotherapy can be a useful augmentation strategy to improve clinical effectiveness. Interestingly, there is not much data about ECT and concomitant neuroleptic medication...
  48. pmc Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: associations with anhedonia
    Anja Stuhrmann
    Department of Psychiatry, University of Munster, Munster, Germany
    J Psychiatry Neurosci 38:249-58. 2013
    ..We investigated whether amygdala mood-congruent responses to emotional stimuli in depressed patients are correlated with anhedonic symptoms at automatic levels of processing...
  49. pmc Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Munster, Germany
    Neuropsychopharmacology 36:1879-85. 2011
    ..Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity...
  50. ncbi request reprint Prefrontal cortex stimulation as antidepressant treatment: mode of action and clinical effectiveness of rTMS
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, D 80336 Munich, Germany
    Suppl Clin Neurophysiol 56:406-32. 2003
  51. doi request reprint Neuropeptide S receptor gene variation modulates anterior cingulate cortex Glx levels during CCK-4 induced panic
    Tillmann Ruland
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Germany
    Eur Neuropsychopharmacol 25:1677-82. 2015
    ..Our results underline the notion of a genetically driven rapid and dynamic response mechanism in the neural regulation of human anxiety and further strengthen the emerging role of the NPS system in anxiety...
  52. doi request reprint Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response
    Katharina Domschke
    Department of Psychiatry, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wurzburg, Germany
    J Neural Transm (Vienna) 122:99-108. 2015
    ....
  53. doi request reprint Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Germany
    World J Biol Psychiatry 15:17-25. 2014
    ....
  54. pmc Of 'disgrace' and 'pain'--corticolimbic interaction patterns for disorder-relevant and emotional words in social phobia
    Inga Laeger
    Department of Psychiatry, University of Munster, Munster, Germany Institute for Psychology, University of Munster, Munster, Germany
    PLoS ONE 9:e109949. 2014
    ..The findings clearly support the view of a hypersensitive threat-detection system, combined with disorder-related alterations in amygdala-prefrontal cortex connectivity in pathological anxiety. ..
  55. doi request reprint Amygdala excitability to subliminally presented emotional faces distinguishes unipolar and bipolar depression: an fMRI and pattern classification study
    Dominik Grotegerd
    Department of Psychiatry, University of Munster, Germany
    Hum Brain Mapp 35:2995-3007. 2014
    ....
  56. pmc Have we met before? Neural correlates of emotional learning in women with social phobia
    Inga Laeger
    The Department of Psychiatry, University of Muenster, Germany
    J Psychiatry Neurosci 39:E14-23. 2014
    ..The present study therefore examined whether patients with social phobia exhibit different patterns of neural activation when confronted with recently acquired emotional stimuli...
  57. ncbi request reprint Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensity
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 27:638-45. 2002
    ..These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficacy...
  58. doi request reprint Occurence of ultra-rapid cycling during electroconvulsive therapy in bipolar depression
    Maxim Zavorotnyy
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    World J Biol Psychiatry 10:987-90. 2009
    ..Moreover, during electroconvulsive therapy (ECT), which is considered a powerful antidepressant treatment, manic switches and episodes of rapid cycling can occur...
  59. pmc Magnetoencephalographic Correlates of Emotional Processing in Major Depression Before and After Pharmacological Treatment
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany Drs Domschke, Zwanzger, Knoke, and Arolt Department of Psychiatry, University of Wuerzburg, Germany Dr Domschke Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer Department of Radiology, University of Muenster, Germany Dr Kugel Department of Psychosomatic Medicine, University of Leipzig, Germany Dr Kersting
    Int J Neuropsychopharmacol 19:. 2015
    ....
  60. doi request reprint Emotional processing and rTMS: does inhibitory theta burst stimulation affect the human startle reflex?
    Nadja Vennewald
    School of Health, Muenster University of Applied Sciences, Leonardo Campus 8, 48149, Muenster, Germany
    J Neural Transm (Vienna) 123:1121-31. 2016
    ..Instead, we found accelerated habituation under verum TBS on a statistical trend-level. Hence, some preliminary hints for modulatory effects of inhibitory TBS on basic learning mechanisms could be found. ..
  61. doi request reprint SPIDER OR NO SPIDER? NEURAL CORRELATES OF SUSTAINED AND PHASIC FEAR IN SPIDER PHOBIA
    Anna Luisa Münsterkötter
    Department of Psychiatry, University of Munster, Munster, Germany
    Depress Anxiety 32:656-63. 2015
    ..We suggested that first, conditions of phasic and sustained fear would involve different neural networks and, second, that overall neural activity would be enhanced in a sample of phobic compared to nonphobic participants...
  62. pmc Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?
    Nils Opel
    Department of Psychiatry, University of Munster, Munster, Germany
    Neuropsychopharmacology 39:2723-31. 2014
    ....
  63. doi request reprint How 'love' and 'hate' differ from 'sleep': using combined electro/magnetoencephalographic data to reveal the sources of early cortical responses to emotional words
    Kati Keuper
    Institute for Biomagnetism and Biosignalanalysis, University of Muenster, D 48149 Muenster, Germany Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, D 48149 Muenster, Germany
    Hum Brain Mapp 35:875-88. 2014
    ..The EPN, as an index of natural selective attention, appears to reflect an elaborate interplay of distributed structures, related to cognitive functions, such as memory, attention, and evaluation of emotional stimuli...
  64. ncbi request reprint The combined T3/TRH test in depressed patients and healthy controls
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Psychoneuroendocrinology 30:341-56. 2005
    ....
  65. doi request reprint Associations between cognitive performance and cortisol reaction to the DEX/CRH test in patients recovered from depression
    Andreas Behnken
    Department of Psychiatry and Psychotherapy, University of Munster, 48149 Munster, Germany
    Psychoneuroendocrinology 38:447-54. 2013
    ..In the present study we were interested, whether these subtle impairments in cognitive functioning observed in patients recovered from depression compared to healthy control subjects are associated with HPA axis feedback sensitivity...
  66. doi request reprint Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Depress Anxiety 28:1048-57. 2011
    ..Thus, a gene-environment interaction (G × E) study was conducted with respect to anxiety sensitivity (AS) as a promising intermediate phenotype of anxiety disorders...
  67. doi request reprint Persistent non-verbal memory impairment in remitted major depression - caused by encoding deficits?
    Andreas Behnken
    Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Str 11, 48149 Muenster, Germany
    J Affect Disord 122:144-8. 2010
    ..This study investigates non-verbal memory functions in remitted MDD and whether nonverbal memory performance is mediated by organizational strategies whilst learning...
  68. ncbi request reprint Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: replication study in drug-free patients
    Eva Lotta Brakemeier
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Affect Disord 108:59-70. 2008
    ..Thus, this study aims to replicate previous findings and explore patterns of response in drug-free patients...
  69. doi request reprint Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response
    Katharina Domschke
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
    Int J Neuropsychopharmacol 17:1167-76. 2014
    ..This pharmaco-epigenetic approach could eventually aid in establishing epigenetic biomarkers of treatment response and thereby a more personalized treatment of MDD. ..
  70. doi request reprint Working-memory fMRI reveals cingulate hyperactivation in euthymic major depression
    Sonja Schöning
    Department of Psychiatry, University of Muenster, Germany
    Hum Brain Mapp 30:2746-56. 2009
    ..This could reflect a different speed of normalization in prefrontal and limbic cortices, persistent systematic changes in neuronal networks after an episode of MDD, or a compensatory mechanism to maintain working-memory performance...
  71. ncbi request reprint Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 40:307-14. 2006
    ..In future, this approach can be used to differentiate specific and non-specific reward-related effects of rTMS on dopaminergic neurotransmission...
  72. ncbi request reprint GABAA receptors as targets for novel anxiolytic drugs
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:231-7. 2006
    ..However, their clinical efficacy has still to be shown in clinical trials...
  73. doi request reprint COMT val158met influence on electroconvulsive therapy response in major depression
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:286-90. 2010
    ....
  74. doi request reprint Preferential responses to extinguished face stimuli are preserved in frontal and occipito-temporal cortex at initial but not later stages of processing
    Christian Steinberg
    Institute for Biomagnetism and Biosignalanalysis, University of Muenster, 48149, Muenster, Germany
    Psychophysiology 50:230-9. 2013
    ..These results suggest that previously acquired emotional memories can be accessed at initial processing stages but become ineffective in modulating processing at later stages as extinction proceeds...
  75. ncbi request reprint A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine
    Katja Koelkebeck
    University of Muenster, Department of Psychiatry, Muenster, Germany
    World J Biol Psychiatry 10:609-11. 2009
    ..Proposing further examination of the underlying pathomechanism of hyponatremia as a side effect of NaRIs, we discuss the importance of careful monitoring of serum sodium levels in patients treated with NaRIs...
  76. pmc Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder
    Peter Zwanzger
    Anxiety Research Unit and Anxiety Outpatient Clinic, Department of Psychiatry, Ludwig Maximilians Universitat, Munich, Germany
    J Psychiatry Neurosci 30:167-75. 2005
    ....
  77. ncbi request reprint Analysis of polymorphisms in the olfactory G-protein Golf in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 12:17-22. 2002
    ..The results of this study agree with the reported parent-of-origin effects on chromosome 18, but do not support the hypothesis that the Golf gene is a major susceptibility factor for major depression...
  78. ncbi request reprint Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Biol Psychiatry 51:602-3. 2002
    ..Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potentially useful treatment for major depression. Nonpsychotic depressed patients appear to have a better outcome than those with psychotic symptoms...
  79. pmc ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 37:759-69. 2012
    ..The present findings may eventually aid in improving primary and secondary prevention by sharpening the risk profiles of anxiety-prone individuals...
  80. ncbi request reprint Relation between responses to repetitive transcranial magnetic stimulation and partial sleep deprivation in major depression
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 36:131-5. 2002
    ..Apparently, different subgroups of depressed patients respond to both interventions. Further studies are needed to characterize the response to rTMS by means of clinical and biological parameters...
  81. ncbi request reprint Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychoneuroendocrinology 27:385-99. 2002
    ....
  82. ncbi request reprint Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers
    P Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuropsychopharmacology 25:699-703. 2001
    ....
  83. pmc Prolonged apnea during electroconvulsive therapy in monozygotic twins: case reports
    Maxim Zavorotnyy
    Mood and Anxiety Disorders Research Unit, Department of Psychiatry, University of Muenster, Muenster, Germany
    Ann Gen Psychiatry 10:30. 2011
    ..These data show the potential risk of BCHE deficiency as a complication of anesthesia during ECT, and in particular underline the possible genetic contribution within a complex pathogenetic model...
  84. pmc Coincidence of paroxysmal supraventricular tachycardia and panic disorder: two case reports
    Katharina Domschke
    Department of Psychiatry, University of Munster, Munster, Germany
    Ann Gen Psychiatry 9:13. 2010
    ..As both PSVT and PD require different treatments, potentially helpful differential clinical diagnostic criteria are proposed...
  85. ncbi request reprint Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuropsychopharmacology 28:979-84. 2003
    ..In conclusion, our data show that alprazolam reduces CCK-4-induced panic, which supports the hypothesis of a possible interaction between the GABA and the CCK system...
  86. ncbi request reprint Plasma gamma-amino-butyric acid (GABA) levels in cholecystokinine-tetrapeptide (CCK-4) induced anxiety
    P Zwanzger
    Department of Psychiatry, University of Munich, Munich, Germany
    J Neural Transm (Vienna) 110:313-6. 2003
    ..To evaluate a possible relationship between plasma GABA and CCK-4 induced panic plasma GABA levels in healthy volunteers were investigated...
  87. ncbi request reprint Treatment of mitral valve prolapse and panic disorder with metoprolol
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:124-5. 2000
    ..This case report suggests that betablockers might represent a useful tool in the treatment of panic disorder and mitral valve prolapse...
  88. ncbi request reprint Neuroactive steroids as modulators of depression and anxiety
    D Eser
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuroscience 138:1041-8. 2006
    ..The modulation of GABA type A-receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds...
  89. doi request reprint Effects of experimentally induced panic attacks on neuroimmunological markers
    L de la Fontaine
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Neural Transm (Vienna) 116:699-702. 2009
    ..Herein we conducted for the first time a new approach to immunological research in panic disorder, suggesting immune changes are more related to long term disease stress...
  90. ncbi request reprint GABAergic and endocannabinoid dysfunction in anxiety - future therapeutic targets?
    K Domschke
    Department of Psychiatry, University of Munster, Munster, Germany
    Curr Pharm Des 14:3508-17. 2008
    ..Moreover, both systems will be discussed as potential therapeutic targets...
  91. ncbi request reprint Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS
    F Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychiatry Res 88:163-71. 1999
    ..In conclusion, this study further supported the safety of rTMS but does not show any clinically meaningful antidepressant efficacy of rTMS at 250 daily stimuli over 5 days in pharmacotherapy-refractory major depression...
  92. ncbi request reprint Vigabatrin and tiagabine might have antipanic properties
    P Zwanzger
    J Psychopharmacol 18:440. 2004
  93. ncbi request reprint [Significance of GABAA receptors for the pathophysiology and therapy of panic disorders]
    R Rupprecht
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München, Munich
    Nervenarzt 74:543-51. 2003
    ....