Bastian Zimmer

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. doi request reprint Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
  2. doi request reprint Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
    Nina V Balmer
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, D 78457 Konstanz, Germany
    Hum Mol Genet 21:4104-14. 2012
  3. doi request reprint GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells
    Philipp B Kuegler
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Glia 60:218-28. 2012
  4. ncbi request reprint Compound selection for in vitro modeling of developmental neurotoxicity
    Suzanne Kadereit
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Front Biosci (Landmark Ed) 17:2442-60. 2012
  5. pmc Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Environ Health Perspect 120:1116-22. 2012
  6. pmc Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment
    Matthias K Weng
    Doerenkamp Zbinden Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e36708. 2012
  7. doi request reprint Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling
    Nadine Dreser
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Neurotoxicology 50:56-70. 2015
  8. ncbi request reprint Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing
    Philipp B Kuegler
    University of Konstanz, Germany
    ALTEX 27:17-42. 2010

Collaborators

Detail Information

Publications8

  1. doi request reprint Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
    ..Thus, transcriptional profiling in differentiating mESC identified a subpopulation of neurons affected by MeHg, and a pharmacological intervention was identified that specifically protected these cells...
  2. doi request reprint Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
    Nina V Balmer
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, D 78457 Konstanz, Germany
    Hum Mol Genet 21:4104-14. 2012
    ..The changes in these activating and silencing histone marks provide a more general mechanistic rational for the regulation of developmentally important genes at non-cytotoxic drug concentrations...
  3. doi request reprint GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells
    Philipp B Kuegler
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Glia 60:218-28. 2012
    ..In summary, we described here the generation and functional characterization of microglia-free murine astrocytes, displaying phenotypic heterogeneity as is commonly observed in brain astrocytes...
  4. ncbi request reprint Compound selection for in vitro modeling of developmental neurotoxicity
    Suzanne Kadereit
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Front Biosci (Landmark Ed) 17:2442-60. 2012
    ..A compilation of compound lists corresponding to the above-discussed principles supplement this review...
  5. pmc Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Environ Health Perspect 120:1116-22. 2012
    ..S. Environmental Protection Agency and others. Because impaired neural crest (NC) function is one of the known causes for teratologic effects, testing of toxicant effects on NC cells is desirable for a DT test battery...
  6. pmc Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment
    Matthias K Weng
    Doerenkamp Zbinden Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e36708. 2012
    ..Our findings suggest a hitherto unexpected extent of regulation, and a cell type-dependent specificity of epigenetic modifiers in neurodifferentiation...
  7. doi request reprint Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling
    Nadine Dreser
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Neurotoxicology 50:56-70. 2015
    ..Thus, incorporation of mechanistic markers in functional in vitro tests may support read-across procedures, also for structurally un-related compounds. ..
  8. ncbi request reprint Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing
    Philipp B Kuegler
    University of Konstanz, Germany
    ALTEX 27:17-42. 2010
    ..0), that may later include human induced pluripotent stem cells, and that are not designed for 1:1 replacement of animal experiments, but are rather intended to improve human risk assessment by using independent scientific principles...