Matthias Zenkel

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Pathol 176:2868-79. 2010
  2. doi request reprint Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 52:8488-95. 2011
  3. ncbi request reprint Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 47:1982-90. 2006
  4. pmc Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 173:1724-35. 2008
  5. doi request reprint LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 119:1832-43. 2012
  6. ncbi request reprint Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:5558-66. 2007
  7. ncbi request reprint Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005
  8. pmc Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Hum Genet 19:186-93. 2011
  9. doi request reprint Extracellular matrix alterations in late-onset Fuchs' corneal dystrophy
    Julia M Weller
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 55:3700-8. 2014
  10. doi request reprint Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:2796-801. 2009

Collaborators

Detail Information

Publications21

  1. pmc Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Pathol 176:2868-79. 2010
    ..These findings support a role for a stress-induced, spatially, and temporally restricted subclinical inflammation in the onset of the fibrotic matrix process characteristic of PEX syndrome/glaucoma...
  2. doi request reprint Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 52:8488-95. 2011
    ..The aim of this study was to analyze the effect of various PEX-associated pathogenic factors on the genotype-correlated expression of LOXL1 and elastin-related genes...
  3. ncbi request reprint Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 47:1982-90. 2006
    ....
  4. pmc Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 173:1724-35. 2008
    ..Alterations of LOXL1 activation, processing, and/or substrate specificity may contribute to the abnormal aggregation of elastic fiber components into characteristic PEX fibrils...
  5. doi request reprint LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 119:1832-43. 2012
    ....
  6. ncbi request reprint Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:5558-66. 2007
    ..The expression of stress-related genes in eyes from patients with and without PEX syndrome/glaucoma was investigated to determine whether PEX syndrome is associated with an altered cellular stress response...
  7. ncbi request reprint Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005
    ..To identify and characterize genes differentially expressed in anterior segment tissues of eyes with pseudoexfoliation (PEX) syndrome and glaucoma...
  8. pmc Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Hum Genet 19:186-93. 2011
    ..Confirming efficiency of GWAS with DNA-pooling approach by detection of the known LOXL1 locus, our study data show evidence for association of CNTNAP2 with PEX syndrome and PEXG in German patients...
  9. doi request reprint Extracellular matrix alterations in late-onset Fuchs' corneal dystrophy
    Julia M Weller
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 55:3700-8. 2014
    ....
  10. doi request reprint Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:2796-801. 2009
    ..This study was focused on six functional candidate genes involved in PEX material deposition and the analysis of their potential association with PEX syndrome and PEX glaucoma (PEXG)...
  11. ncbi request reprint Selective upregulation of the A3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:2023-34. 2005
    ..In the current study, the role of the adenosine system in the pathophysiology of pseudoexfoliation (PEX) syndrome, which is typically associated with anterior chamber hypoxia and elevated intraocular pressure, was examined...
  12. doi request reprint Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations
    Bettina Krueger
    Department of Cellular and Molecular Physiology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 53:596-604. 2012
    ..However, the precise localization of ENaC in the human eye is still unclear. Here, the authors studied ENaC expression in 12 normal human donor eyes and in six eyes of patients with glaucoma...
  13. doi request reprint Reproducibility of graft preparations in Descemet's membrane endothelial keratoplasty
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 120:1769-77. 2013
    ..To assess the reproducibility of manual graft preparation and evaluate the incidence rate and nature of structural anomalies of Descemet's membrane (DM) preventing successful graft preparation in DM endothelial keratoplasty (DMEK)...
  14. ncbi request reprint Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma
    Ulrike B Kottler
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 80:121-34. 2005
    ....
  15. doi request reprint Cell Adhesion Molecules and Stem Cell-Niche-Interactions in the Limbal Stem Cell Niche
    Naresh Polisetti
    Department of Ophthalmology, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Stem Cells 34:203-19. 2016
    ..The findings provide a solid foundation for further functional studies and for advancement of our current therapeutic strategies for ocular surface reconstruction...
  16. pmc Variants in ASB10 are associated with open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Hospital Erlangen Nuremberg, Erlangen, Germany
    Hum Mol Genet 21:1336-49. 2012
    ..02). In conclusion, genetic and molecular analyses provide evidence for ASB10 as a glaucoma-causing gene...
  17. pmc Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells
    Ewa Anna Blazejewska
    Department of Ophthalmology, University of Erlangen Nuremberg, Germany
    Stem Cells 27:642-52. 2009
    ..Therefore, the HF may be an easily accessible alternative therapeutic source of autologous adult stem cells for replacement of the corneal epithelium and restoration of visual function in patients with ocular surface disorders...
  18. doi request reprint The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina
    Saadettin Sel
    Department of Ophthalmology, University Erlangen Nuremberg, Erlangen, Germany
    Gene Expr Patterns 13:280-6. 2013
    ..The expression pattern during development suggests that Foxk1 may have an important role in retinal cells...
  19. doi request reprint Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    J Glaucoma 23:S48-50. 2014
    ....
  20. doi request reprint The composition of exfoliation material and the cells involved in its production
    Matthias Zenkel
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    J Glaucoma 23:S12-4. 2014
    ....
  21. ncbi request reprint Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Invest Ophthalmol Vis Sci 43:1475-87. 2002
    ..To determine the expression and precise cellular and subcellular localization of the EP prostanoid receptor subtypes EP(1) through EP(4) and the FP receptor in normal human ocular tissues on the protein and mRNA levels...