Genomes and Genes
Affiliation: University Hospital
- The Nlrp3 inflammasome regulates acute graft-versus-host diseaseDragana Jankovic
Department of Dermatology, University Hospital, CH 8091 Zurich, Switzerland
J Exp Med 210:1899-910. 2013..Thus, the identification of a crucial role for the Nlrp3 inflammasome sheds new light on the pathogenesis of GvHD and opens a potential new avenue for the targeted therapy of this severe complication. ..
- TrametinibRobert Zeiser
Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106, Freiburg, Germany
Recent Results Cancer Res 201:241-8. 2014..Future clinical trial in different solid tumor entities will define the therapeutic role of this targeted therapy approach, possibly as a combination with other targeted therapies such as BRAF inhibitors. ..
- A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine modelCarina A Bäuerlein
Department of Medicine II, Würzburg University Clinics, Zinklesweg 10, Wurzburg, D 97078, Germany
BMC Med 11:134. 2013..Here we address whether insights into the timing of the aGVHD initiation and effector phases could allow for the detection of migrating alloreactive T cells before clinical aGVHD onset to permit for efficient therapeutic intervention...
- Immunotherapy for malignant melanomaRobert Zeiser
Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
Curr Stem Cell Res Ther 7:217-28. 2012..This review summarizes different immunotherapeutical approaches against melanoma that have been applied in the past and focuses on CTLA-4 blockade with respect to its mechanism, clinical effectiveness and immunological side effects...
- Danger signals activating innate immunity in graft-versus-host diseaseRobert Zeiser
Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
J Mol Med (Berl) 89:833-45. 2011..This review covers both the impact of endogenous and exogenous danger signals activating innate immunity in GvHD...
- Regulation of different inflammatory diseases by impacting the mevalonate pathwayRobert Zeiser
Department of Haematology and Oncology, Albert Ludwigs University Freiburg, Freiburg, Germany
Immunology 127:18-25. 2009..This review discusses possible modes of action of statins in modulating immunity towards autoantigens and alloantigens...
- A potential role for P2X7R in allergic airway inflammation in mice and humansTobias Müller
Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
Am J Respir Cell Mol Biol 44:456-64. 2011..Our data suggest that targeting P2X₇R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
- Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissueChristoph Dürr
Department of Haematology and Oncology, Freiburg University Medical Centre, Albert Ludwigs University, Freiburg, Germany
Immunology 137:80-8. 2012..In conclusion, we demonstrate that GvHD-related inflammation reduced Treg-cell numbers at the tumour sites, which may in turn help to explain the observation that patients with GvHD have a lower risk of tumour relapse...
- Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammationRodolfo Paula Vieira
University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
Am J Respir Crit Care Med 184:215-23. 2011....
- Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivityFelix C Weber
Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
J Exp Med 207:2609-19. 2010..The lack of P2X(7) triggering prevents IL-1β release, which is an essential step in the sensitization process. Interference with P2X(7) signaling may be a promising strategy for the prevention of allergic contact dermatitis...
- Graft-versus-host disease is enhanced by extracellular ATP activating P2X7RKonrad Wilhelm
Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
Nat Med 16:1434-8. 2010..These data have major implications for transplantation medicine, as pharmacological interference with danger signals that act via P2X(7)R could lead to the development of tolerance without the need for intensive immunosuppression...
- MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activationSophia Chen
Department of Hematology and Oncology, Freiburg University Medical Center
Blood 126:103-12. 2015..Inhibiting proinflammatory miR-155 by antagomir treatment could help reduce this complication of allo-HCT. ..
- Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cellsAnne Kathrin Hechinger
Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
Haematologica 98:31-40. 2013....
- Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100Franziska Leonhardt
Department of Hematology and Oncology, FreiburgUniversity Medical Center, Albert Ludwigs University of Freiburg, Freiburg, Germany
Blood 121:3307-18. 2013..We identify negative regulation of GvHD-related neovascularization by miR-100, which indicates common pathomechanistic features of GvHD and ischemia...
- Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHDAnne Kathrin Hechinger
Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
Blood 125:570-80. 2015..We conclude that acute GVHD and chronic GVHD, caused by T cells activated by common γ-chain cytokines, each represent therapeutic targets for anti-CD132 mAb immunomodulation. ..
- SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancerKerstin Rönsch
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Stefan Meier Str 17, 79104 Freiburg, Germany Faculty of Biology, Albert Ludwigs University Freiburg, Schänzlestr 1, 79104 Freiburg, Germany
Mol Oncol 9:335-54. 2015..Altogether, our results identify EPHB3 as a novel target of SNAIL1 and suggest that disabling EPHB3 signaling is an important aspect to eliminate a roadblock at the onset of EMT processes...
- MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHDNatalie Stickel
Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Spemann Graduate School of Biology and Medicine, and Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
Blood 124:2586-95. 2014..Because miR-146a expression can be exogenously enhanced, our results provide a novel targeted molecular approach to mitigate GVHD. ..
- Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysemaSanja Cicko
Department of Pulmonary Medicine, University Hospital, Freiburg, Germany
J Immunol 185:688-97. 2010..We demonstrate, for the first time, that endogenous ATP contributes to smoke-induced lung inflammation and then development of emphysema via activation of the purinergic receptor subtypes, such as P2Y(2)R...
- CXCL12 mediates immunosuppression in the lymphoma microenvironment after allogeneic transplantation of hematopoietic cellsChristoph Dürr
Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
Cancer Res 70:10170-81. 2010..Blocking CXCR4 enhanced antitumor effects and prolonged survival of tumor-bearing mice by reducing local Treg accumulation, indicating that CXCR4 is a potential target to interfere with tumor escape after alloHCT...
- Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory responseAnnette Dorn
Department of Pathology, University Medical Centre Freiburg, Freiburg, Germany
Cell Immunol 276:187-95. 2012..In addition, in a hypersensitivity model rap1-deficient mice demonstrated reduced contact dermatitis compared to wildtype mice, demonstrating the impact of rap1-deficiency on the inflammatory response in vivo...
- Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantationWilfried Reichardt
Department of Diagnostic Radiology and Medical Physics, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
J Immunol 181:4770-9. 2008..This study is the first to delineate the impact of RAPA on DC migration and tolerogenic function after aHCT. Modification of the DC phenotype by mTOR inhibition may have therapeutic potential in an attempt to reduce GvHD following aHCT...
- P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysemaMonica Lucattelli
Department of Pulmonary Medicine, University of Freiburg, Germany
Am J Respir Cell Mol Biol 44:423-9. 2011..Inhibition of this receptor may be a new therapeutic target for the treatment of chronic obstructive pulmonary disease...
- Stem cell plasticity: the debate begins to clarifyAlexandros Spyridonidis
Freiburg University Medical Center, Department of Hematology Oncology, Hugstetter Strasse 55, Freiburg, Germany
Stem Cell Rev 1:37-43. 2005..This review discusses the current status of the "plasticity" debate and presents existing data on detection methodology, underlying mechanisms, physiological implications, and clinical significance...
- Capillary electrophoresis for chimerism monitoring by PCR amplification of microsatellite markers after allogeneic hematopoietic cell transplantationAlexandros Spyridonidis
Department of Hematology and Oncology, Albert Ludwigs University Medical Center, Freiburg, Germany
Clin Transplant 19:350-6. 2005..In the light of increasing numbers of non-myeloablative aHCT as a treatment modality sensitive, rapid, and accurate chimerism monitoring techniques acquire novel relevance...
- Fatal varicella zoster virus encephalitis in two patients following allogeneic hematopoietic stem cell transplantationBjörn Hackanson
Department of Hematology Oncology, Freiburg University Medical Center, Freiburg, Germany
Clin Transplant 19:566-70. 2005..Varicella zoster virus (VZV) reactivation in this setting most commonly manifests as dermatomal herpes zoster but in some cases life-threatening VZV encephalitis occurs...
- Ectonucleotidases in solid organ and allogeneic hematopoietic cell transplantationPetya Chernogorova
Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, 79106 Freiburg, Germany
J Biomed Biotechnol 2012:208204. 2012....
- MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive NeovascularizationFranziska Pankratz
From Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany F P, X B, S K, I Hi, C S, T H, J S E, M K, M M, C B, S G Department of Biology, Albert Ludwigs University, Freiburg, Germany F P, F L Department of Hematology and Oncology, University Hospital Freiburg, Germany R Z, F L and Experimental Cardiology Laboratory, University Medical Center Utrecht, The Netherlands I Ho
Circulation 131:1575-89. 2015..We now aimed to identify regulatory microRNAs involved in the modulation of neovascularization after femoral artery occlusion in mice...
- Vaccination of advanced prostate cancer patients with PSCA and PSA peptide-loaded dendritic cells induces DTH responses that correlate with superior overall survivalAnna K Thomas-Kaskel
Department of Hematology Oncology, Freiburg University Medical Center, D 79106 Freiburg, Germany
Int J Cancer 119:2428-34. 2006..Testing of DC-based vaccination is warranted for patients at earlier stages of prostate cancer...
- Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancerSabine Jägle
Institute of Molecular Medicine and Cell Research, Faculty of Biology, Institute of Pathology, University Medical Center, Department of Hematology and Oncology, University Medical Center, Freiburg Institute for Advanced Studies, and BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, D 79117 Freiburg, Germany
Proc Natl Acad Sci U S A 111:4886-91. 2014..In summary, our results uncover enhancer decommissioning as a mechanism for transcriptional silencing of the EPHB3 tumor suppressor and argue for an antitumorigenic function of Notch signaling in advanced colorectal cancer. ..
- Immunopathogenesis of acute graft-versus-host disease: implications for novel preventive and therapeutic strategiesRobert Zeiser
Department of Hematology and Oncology, Albert Ludwigs University Medical Center Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
Ann Hematol 83:551-65. 2004....
- The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemiaKonrad Aumann
Institute of Pathology, University Medical Center, 79106 Freiburg, Germany
Hum Pathol 42:719-26. 2011....
- Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapyRobert Zeiser
Division of Hematology and Oncology, Department of Medicine, Albert Ludwig University Freiburg, Freiburg, Germany
Cell Cycle 7:458-62. 2008..In this report we focus on the relevance of these pathways as well as the impact of immunosuppressive drugs that may affect or enhance Treg function by targeting IL-2R signalling...