Jens Wiltfang

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi [Neurochemical early and differential diagnostics for Alzheimer's disease]
    J Wiltfang
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie Friedrich Alexander Universität Erlangen Nürnberg
    MMW Fortschr Med 146:38-40. 2004
  2. ncbi Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
  3. ncbi Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
  4. ncbi Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Mol Neurosci 23:115-22. 2004
  5. doi Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Brain Behav Immun 22:1044-8. 2008
  6. doi Distinct fractional Abeta release patterns in human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neuroimmunol 206:1-4. 2009
  7. ncbi Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
  8. ncbi Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy PL, TWG, JMM, JK, JW, University of Erlangen Nuremberg, Erlangen, Germany
    Biol Psychiatry 55:524-30. 2004
  9. ncbi Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Proteomics 7:3815-20. 2007
  10. doi Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009

Collaborators

Detail Information

Publications83

  1. ncbi [Neurochemical early and differential diagnostics for Alzheimer's disease]
    J Wiltfang
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie Friedrich Alexander Universität Erlangen Nürnberg
    MMW Fortschr Med 146:38-40. 2004
    ..As a result, future preventive drug treatment strategies can be employed early and selectively...
  2. ncbi Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
    ..We conclude that the amyloid beta concentration ratio should replace the 'raw' concentrations of corresponding A beta peptides to improve reliability of the neurochemical dementia diagnosis...
  3. ncbi Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
    ..Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed...
  4. ncbi Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Mol Neurosci 23:115-22. 2004
    ..The current literature regarding the physiological and pathological role of phosphorylated Tau proteins is reviewed, as well as the role of these proteins as promising biomarkers in the diagnosis of neurodegenerative disorders...
  5. doi Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Brain Behav Immun 22:1044-8. 2008
    ..Thus, mononuclear phagocytes might be one source of the N-truncated Abeta peptides regularly found in human plasma and are less likely to contribute substantially to plasma Abeta(1-42)...
  6. doi Distinct fractional Abeta release patterns in human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neuroimmunol 206:1-4. 2009
    ..MNP derived from early AD patients released significantly more total Abeta peptides than age-matched controls. The proportion of Abeta(1-42) was not altered...
  7. ncbi Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  8. ncbi Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy PL, TWG, JMM, JK, JW, University of Erlangen Nuremberg, Erlangen, Germany
    Biol Psychiatry 55:524-30. 2004
    ..The advent of new therapeutic avenues for Alzheimer's disease (AD) calls for an improved early and differential diagnosis...
  9. ncbi Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Proteomics 7:3815-20. 2007
    ..It might further help identifying plasma Abeta species suitable as biomarkers for the diagnosis of Alzheimer's disease (AD)...
  10. doi Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009
    ..The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments...
  11. pmc Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
    Philipp Spitzer
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neuroinflammation 7:59. 2010
    ..Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by perivascular macrophages. Both observations indicate a contribution of the mononuclear phagocyte system to the development of β-amyloid...
  12. doi Intrathecal IgG synthesis in patients with alterations in the neurochemical dementia diagnostics
    Rüdiger Zimmermann
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Erlangen, Germany
    J Alzheimers Dis 19:1199-203. 2010
    ..This, in turn, suggests that extended diagnosis should be performed in patients with "isolated" alterations of NDD biomarkers or intrathecal immunoglobulin synthesis...
  13. doi Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form
    Hans Wolfgang Klafki
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Alzheimers Dis 18:613-22. 2009
    ....
  14. doi Neurochemical dementia diagnostics: assays in CSF and blood
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Schwabachanlage 6, Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:44-9. 2008
    ..Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide...
  15. ncbi Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Brain Res 1052:156-62. 2005
    ..These results may provide a molecular explanation for beneficial effects of memantine on ethanol-induced glutamatergic hyperexcitability reflected in the ethanol withdrawal syndrome and on the development of ethanol dependence...
  16. ncbi International quality control survey of neurochemical dementia diagnostics
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurosci Lett 409:1-4. 2006
    ..Although the results of this quality control survey are promising, the quality of measurements has to be further optimized...
  17. ncbi Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau
    Piotr Lewczuk
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurobiol Aging 25:273-81. 2004
    ..Presence of the apolipoprotein E 4 allele, age or degree of mental disability did not significantly influence the parameters studied...
  18. doi Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm (Vienna) 115:1651-9. 2008
    ..Finally, CSF Abeta42 levels declined significantly in both groups within 12 months supporting the notion that CSF Abeta42 may be valid not only for diagnostic but also for prognostic purposes in AD...
  19. doi Neurochemical dementia diagnostics: State of the art and research perspectives
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Erlangen, Germany
    Proteomics 8:1292-301. 2008
    ....
  20. doi Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides
    Timo Jan Oberstein
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurobiol Dis 73:24-35. 2015
    ..The inhibition of BACE1 reduced the amount of Aβ 1-x in cell culture supernatants but not the amount of Aβ 2-x. ..
  21. ncbi Electrophoretic separation of amyloid beta peptides in plasma
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Molecular Neurobiology Lab, University of Erlangen Nuernberg, Erlangen, Germany
    Electrophoresis 25:3336-43. 2004
    ..Our method can be used to investigate the significance of plasma Abeta peptides in neurodegenerative disorders, and to monitor the efficiency of drugs with beta/gamma-secretase inhibitory potency...
  22. doi Neurochemical dementia diagnostics: a simple algorithm for interpretation of the CSF biomarkers
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Erlangen, Germany
    J Neural Transm (Vienna) 116:1163-7. 2009
    ....
  23. ncbi Memantine pharmacotherapy: a naturalistic study using a population pharmacokinetic approach
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Clin Pharmacokinet 46:599-612. 2007
    ..The objective of the present study was, therefore, to investigate the reasons for the observed variability of the pharmacokinetics of memantine in a representative patient population and to explore patient covariates on drug disposition...
  24. pmc Antidepressant drugs modulate growth factors in cultured cells
    Andreas W Henkel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    BMC Pharmacol 8:6. 2008
    ..In this study, antidepressant treatments are analyzed in a cell culture system, to study the modulation of growth factors...
  25. doi Confirmation rate of blinded (99m)Tc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease
    Daniela Schmidt
    Clinical Nuclear Medicine Unit, University of Erlangen Nurenberg, Erlangen, Germany
    J Neural Transm (Vienna) 117:1111-4. 2010
    ..80%). Both techniques showed no coherence (p = 0.17-0.47). Our results confirm that CSF biomarkers show higher sensitivity. SPECT has higher specificity and can also be used for other dementias without established CSF biomarkers...
  26. doi Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application
    Sabine Ott
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
    Mol Cell Biochem 349:169-77. 2011
    ....
  27. doi Validation of a Commercial Chemiluminescence Immunoassay for the Simultaneous Measurement of Three Different Amyloid-β Peptides in Human Cerebrospinal Fluid and Application to a Clinical Cohort
    Hans W Klafki
    Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Georg August University, Goettingen, Germany
    J Alzheimers Dis 54:691-705. 2016
    ....
  28. pmc Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia
    Philipp Spitzer
    Department of Psychiatry and Psychotherapy, Laboratory for Molecular Neurobiology, LVR Klinikum Essen, University of Duisburg Essen, Virchowstraße 174, 45147 Essen, Germany
    Int J Alzheimers Dis 2011:739847. 2011
    ..As a predictive diagnostic AD biomarker, CSF-ERK1/2 was inferior to tTau, pTau, and Aβ42...
  29. doi Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Med Chem 44:2667-72. 2009
    ..A low mu/MW is compatible with drug-cumulation in apolar lipid rafts. This study confirms that size-intensive descriptors allow the development of compact SPAR models...
  30. doi Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP
    Heinke Schieb
    Department of Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Klinikum, Essen, Germany
    Chemistry 16:14412-23. 2010
    ..Efficient inhibition of Aβ secretion by tripartite structures in the absence of appreciable neurotoxicity was confirmed in a primary neuronal cell culture, thus further supporting the concept...
  31. pmc Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, LVR Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Br J Pharmacol 159:474-83. 2010
    ..As moclobemide, an antidepressant, and also some antiepileptic drugs can reduce neuronal pHi in hippocampus slices in vitro, we screened a panel of currently used neuropsychopharmaca for comparable effects...
  32. ncbi Pharmacokinetic characterization of amantadine in human brain tissue
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Germany
    Ther Drug Monit 28:693-5. 2006
    ..The elimination half-life of amantadine from brain tissue is much longer than from blood and is comparable to the previously investigated neuroleptic drugs haloperidol and levomepromazine...
  33. doi N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models
    Adriana Savastano
    Georg August University Gottingen, University Medicine Gottingen, Department of Psychiatry and Psychotherapy, Gottingen, Germany
    J Alzheimers Dis 49:101-10. 2016
    ..Western blotting and a capillary isoelectric focusing immunoassay demonstrated the high specificity of the antibody pAb77 against Aβ-variants starting with the N-terminal Alanine-2. ..
  34. ncbi The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Rapid Commun Mass Spectrom 17:1291-6. 2003
    ..We conclude that SELDI-TOF offers a promising tool for dementia expression pattern profiling using a minute amount of a biological sample...
  35. pmc Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid
    Heinke Schieb
    Department of Psychiatry and Psychotherapy, LVR Klinikum, Essen, University of Duisburg Essen, D 45147 Essen, Germany
    J Biol Chem 286:33747-58. 2011
    ..Taken together, our findings suggest different underlying molecular mechanisms driving the amyloid deposition in transgenic mice and AD patients...
  36. ncbi Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder
    Christian Maihofner
    Department of Neurology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Brain Res 1129:200-5. 2007
    ..Therefore, we provide further functional neuroimaging evidence that the complex features of OCD have neural correlates, which may help in a future understanding of this disease...
  37. ncbi Non-drug therapies for dementia: an overview of the current situation with regard to proof of effectiveness
    Elmar Gräsel
    Clinic for Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Dement Geriatr Cogn Disord 15:115-25. 2003
    ....
  38. pmc Validation of the Erlangen Score Algorithm for the Prediction of the Development of Dementia due to Alzheimer's Disease in Pre-Dementia Subjects
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, and Friedrich Alexander Universität Erlangen Nürnberg, Erlangen, Germany
    J Alzheimers Dis 48:433-41. 2015
    ..With the previously published Erlangen Score Algorithm, we suggested a division of CSF patterns into five groups, covering all possible CSF result combinations based on the presence of pathologic tau and/or amyloid-β CSF values...
  39. doi Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay
    Ute Haußmann
    LVR Klinikum Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg Essen, D 45147 Essen, Germany
    Anal Chem 85:8142-9. 2013
    ..To assess the future possibility of absolute quantification, we have prepared the Aβ peptides Aβ(x-10), Aβ(x-16), and Aβ(5-38(D23S)) by using solid phase peptide synthesis as internal standards for the CIEF immunoassay...
  40. doi Association of systemic inflammation markers with the presence and extent of coronary artery calcification
    Dorette Raaz-Schrauder
    Department of Cardiology, University Hospital Erlangen, Erlangen, Germany
    Cytokine 57:251-7. 2012
    ..CAC is associated with atherosclerotic plaque burden, but it is still elusive if atherosclerosis-relevant cytokines and chemokines are also associated with CAC...
  41. doi A method to prevent cross contamination during 2-DE by β-amyloid peptides
    Heinke Schieb
    Department of Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Klinikum, Essen, Germany
    Proteomics 10:3539-43. 2010
    ..Surface catalysed amyloid aggregation" in the aluminium oxide ceramic trays is proposed as a possible underlying mechanism for the occurrence of proteinase K-resistant forms of Aβ...
  42. ncbi Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Germany
    J Med Chem 51:219-37. 2008
    ..During the course of the study, we characterized 26 new functional ASM inhibitors, including doxepine 63, fluoxetine 104, maprotiline 109, nortriptyline 114, paroxetine 118, sertraline 124, suloctidil 125, and terfenadine 127...
  43. ncbi Therapeutic approaches to Alzheimer's disease
    Hans Wolfgang Klafki
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 129:2840-55. 2006
    ..In this review, currently available drugs as well as novel therapeutic strategies, in particular those targeting amyloid and tau pathologies, are discussed...
  44. doi No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment
    Katharina Bey
    Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
    Epigenomics 8:593-8. 2016
    ..In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI. ..
  45. pmc Spot quantification in two dimensional gel electrophoresis image analysis: comparison of different approaches and presentation of a novel compound fitting algorithm
    Jan M Brauner
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 091054 Erlangen, Germany
    BMC Bioinformatics 15:181. 2014
    ..Other methods use the optical density, i.e. the intensity of the most intense pixel of a spot, or calculate the volume from the parameters of a fitted function...
  46. ncbi Glutamate and the glutamate receptor system: a target for drug action
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Int J Geriatr Psychiatry 18:S33-40. 2003
    ....
  47. ncbi Abeta peptide 1-42, Tau protein and S-100B protein level in cerebrospinal fluid of three patients with primary progressive aphasia
    Lienhard Maeck
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, 37075 Gottingen, Germany
    Neurosci Lett 333:33-6. 2002
    ..In all patients Tau protein and S-100B level were slightly elevated, however, Abeta(1-42) was found to be in normal range. Thus, our first results point to PPA being neurochemically linked to frontotemporal degeneration...
  48. ncbi Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Gerontology 51:142-4. 2005
    ..There is evidence that homocysteine contributes to various neurodegenerative disorders...
  49. ncbi Neuroleptic drugs in the human brain: clinical impact of persistence and region-specific distribution
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:274-80. 2006
    ....
  50. ncbi Light-induced exocytosis in cell development and differentiation
    Andreas W Henkel
    Department of Psychiatry, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Cell Biochem 97:1393-406. 2006
    ....
  51. pmc Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay
    Inga Kraus
    1 LVR Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg Essen, Essen, Germany 2 German Center for Neurodegenerative Diseases DZNE, Research Site Goettingen, Germany 3 Dept of Psychiatry and Psychotherapy, University Medical Center Goettingen UMG, Georg August University Goettingen, Germany
    Sci Rep 5:12767. 2015
    ....
  52. pmc No Clear Association between Impaired Short-Term or Working Memory Storage and Time Reproduction Capacity in Adult ADHD Patients
    Christian Mette
    LVR Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg Essen, Essen, Germany
    PLoS ONE 10:e0133714. 2015
    ..Altered time reproduction is exhibited by patients with adult attention deficit hyperactivity disorder (ADHD). It remains unclear whether memory capacity influences the ability of adults with ADHD to reproduce time intervals...
  53. ncbi Memantine in moderate-to-severe Alzheimer's disease
    Stefan Bleich
    N Engl J Med 349:609-10; author reply 609-10. 2003
  54. ncbi Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    Jens Wiltfang
    Department of Psychiatry, University Erlangen Nurnberg, Germany
    Ann Neurol 54:263-7. 2003
    ..We conclude that the immunoblot shows disease-specific CSF Abeta peptide patterns in CJD and AD and suppose that measurement of the Abeta peptide pattern seems to be a promising diagnostic tool in the differential diagnosis of dementias...
  55. ncbi Cerebrospinal fluid amyloid beta peptide patterns in Alzheimer's disease patients and nondemented controls depend on sample pretreatment: indication of carrier-mediated epitope masking of amyloid beta peptides
    Mirko Bibl
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Electrophoresis 25:2912-8. 2004
    ..Remarkably, Abeta-SDS-PAGE/immunoblot measured threefold higher levels of Abeta1-42 in CSF than Abeta1-42-ELISA. In summary, our results indicate carrier-mediated epitope masking of Abeta1-42...
  56. ncbi CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
    Mirko Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Brain 129:1177-87. 2006
    ..Their distinct molecular phenotypes support the view of different pathophysiological pathways for each of these neurodegenerative diseases...
  57. ncbi Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases
    Petra Steinacker
    Department of Neurology, University Hospital, Robert Koch Str 40, 37075 Goettingen, Germany
    Neurosci Lett 370:36-9. 2004
    ..Our results suggest that H-FABP might be a useful biomarker for the differentiation between the dementias examined if levels in CSF and serum are determined in parallel...
  58. ncbi Blood-based neurochemical diagnosis of vascular dementia: a pilot study
    Mirko Bibl
    Department of Psychiatry University of Goettingen, von Siebold Str, Goettingen, Germany
    J Neurochem 103:467-74. 2007
    ..From the presented results, we consider the ratio of plasma Abeta1-38/Abeta1-40 peptides to be a blood-based biomarker candidate for VAD...
  59. ncbi Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies
    Brit Mollenhauer
    Department of Neurology, Georg August University Gottingen, Gottingen, Germany
    Dement Geriatr Cogn Disord 19:164-70. 2005
    ..We conclude that more specific markers have to be established for the differentiation of these diseases...
  60. doi Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
  61. ncbi Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies
    Brit Mollenhauer
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem Lab Med 44:192-5. 2006
    ..We conclude that more specific markers have to be established to differentiate between these diseases...
  62. ncbi Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms
    Mostafa Bentahir
    Neuronal Cell Biology and Gene Transfer, Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB4 and K U Leuven, Leuven, Belgium
    J Neurochem 96:732-42. 2006
    ..Finally, subtle differences in gamma-secretase complex assembly were observed. Overall, our results indicate that the different mutations in PS affect gamma-secretase structure or function in multiple ways...
  63. ncbi Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies
    Brit Mollenhauer
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neurodegener Dis 4:366-75. 2007
    ..Heart-type fatty acid-binding protein (H-FABP) was recently discovered in CSF and serum of patients with neurodegenerative diseases...
  64. ncbi Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurobiol Aging 27:10-5. 2006
    ..Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD...
  65. ncbi Tyr687 dependent APP endocytosis and Abeta production
    Sandra Rebelo
    Laboratorio de Neurociencias, Centro de Biologia Celular, Universidade de Aveiro, Aveiro 3810 193, Portugal
    J Mol Neurosci 32:1-8. 2007
    ..Our results provide novel insights into the role of direct APP phosphorylation on APP targeting, processing and Abeta production...
  66. ncbi Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome
    Hillevi Englund
    Department of Public Health and Caring Sciences, Section of Molecular Geriatrics, Uppsala University, and Department of Women s and Children s Health, Uppsala University Children s Hospital, Sweden
    Dement Geriatr Cogn Disord 24:369-74. 2007
    ..Individuals with Down syndrome (DS) invariably develop Alzheimer's disease (AD) during their life span. It is therefore of importance to study young DS patients when trying to elucidate early events in AD pathogenesis...
  67. ncbi Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
    Miriam Lotz
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurochem 94:289-98. 2005
    ..This suggests that not all TLR agonists enhance the stimulatory effect of A beta on innate immunity...
  68. ncbi Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease
    Kina Höglund
    Institute of Clinical Neuroscience, Section of Experimental Neurochemistry, Goteborg University, Neurolabb, SU Mölndal, 43180, Molndal, Sweden
    Exp Brain Res 164:205-14. 2005
    ..We also believe that the pleiotropic effects of statins should be investigated further in order to elucidate the connection between Alzheimer's disease and statin treatment...
  69. doi Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases
    Markus Otto
    Department of Neurology, University of Ulm, Ulm, Germany
    Methods 44:289-98. 2008
    ....
  70. ncbi Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    Lukas Cepek
    Department of Neurology, University of Gottingen, Gottingen, Germany
    Dement Geriatr Cogn Disord 19:376-82. 2005
    ..However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment...
  71. ncbi Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia
    Brit Mollenhauer
    Department of Neurology, Georg August University, Kassel, Germany
    Dement Geriatr Cogn Disord 22:200-8. 2006
    ..These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD...
  72. doi Applications in brain proteomics: 8(th) HUPO Brain Proteome Project Workshop 7 October 2007, Seoul, Korea
    Michael Hamacher
    Medizinisches Proteom Center, Ruhr Universitat Bochum, ZKF E 143, Bochum, Germany
    Proteomics 8:1750-3. 2008
    ..Around 100 scientists came together during the afternoon of 7 October, 2007, to discuss and to catch up on the latest results and strategies concerning Huntington's disease, glioblastoma and standardization...
  73. doi Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review
    Mirko Bibl
    Klinik fur Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universitat Duisburg Essen, Essen, Germany
    Dement Geriatr Cogn Disord 25:256-65. 2008
    ..The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (Abeta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD)...
  74. ncbi Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    Lukas Cepek
    Department of Neurology, University of Ulm, Ulm, Germany
    Dement Geriatr Cogn Disord 23:22-8. 2007
    ..We conclude that this proteomic approach can differentiate CJD from other diseases and may serve as a model for other neurodegenerative diseases...
  75. ncbi Effect of sample collection tubes on cerebrospinal fluid concentrations of tau proteins and amyloid beta peptides
    Piotr Lewczuk
    Clin Chem 52:332-4. 2006
  76. doi Diagnostic and prognostic needs in neurodegenerative disorders: focus on proteomics
    Mirko Bibl
    Expert Rev Proteomics 5:153-6. 2008
  77. ncbi Histologically confirmed amyloid deposition and low CSF Abeta42 in a cognitively normal subject
    Julius Popp
    J Neurol 254:970-1. 2007
  78. ncbi Increased transcranial magnetic motor threshold after ECT. A case report
    Martin Sommer
    Department Psychiatry, University of Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:250-2. 2002
    ..Resting motor thresholds were increased bilaterally after treatment, and the input/output curve less steep. These results point to a decreased excitability of the corticospinal motor tract after successful ECT...
  79. ncbi AIDS dementia complex and Hashimoto encephalopathy in a senescent woman
    Robert Waltereit
    Division of Geriatric Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Geriatr Psychiatry 22:1267-8. 2007
    ..We report here the first case of a patient who fulfils both, the criteria for AIDS dementia complex and Hashimoto encephalopathy, yet being unresponsive to steroid therapy. Diagnostic and therapeutic implications are discussed...
  80. ncbi Differential diagnosis of neurodegenerative diseases with special emphasis on Creutzfeldt-Jakob disease
    Markus Otto
    Department of Neurology, University of Goettingen, Germany
    Restor Neurol Neurosci 21:191-209. 2003
    ..This especially applies to some of the subtypes of CJD and Alzheimer's dementia (AD)...
  81. doi The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados
    Michael Hamacher
    Medizinisches Proteom Center, Ruhr Universitat Bochum, ZKF E 143, Bochum, Germany Michael
    Proteomics 8:2160-4. 2008
    ..Discussing the future HUPO BPP Roadmap, the attendees drafted the so called HUPO BPP wish list containing timelines, suggestions and missions. This wish list will be updated regularly and will serve as a guideline for the next phase...
  82. doi Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase
    Eva Czirr
    Molecular Neuropathology Group, Department of Neuropathology, Heinrich Heine University, D 40225 Duesseldorf, Germany
    J Biol Chem 283:17049-54. 2008
    ..These data provide evidence that Abeta42 and Abeta38 species can be independently generated by gamma-secretase and argue against a precursor-product relationship between these peptides...
  83. ncbi Tyrosine 687 phosphorylated Alzheimer's amyloid precursor protein is retained intracellularly and exhibits a decreased turnover rate
    Sandra Rebelo
    Laboratorio de Neurociencias, Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal
    Neurodegener Dis 4:78-87. 2007
    ..Our findings point to the direct phosphorylation of APP on Y687 as an important regulatory mechanism in terms of determining the subcellular localization of APP and modulating its processing via different proteolytic pathways...