Carsten Willam

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc HIF activation protects from acute kidney injury
    Alexander Weidemann
    Medical Clinic 4, Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    J Am Soc Nephrol 19:486-94. 2008
  2. ncbi Inconsistent effects of acidosis on HIF-alpha protein and its target genes
    Carsten Willam
    Department of Nephrology and Hypertension, Medizinische Klinik IV, University of Erlangen Nuremberg, Germany
    Pflugers Arch 451:534-43. 2006
  3. pmc HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Pathol 174:1663-74. 2009
  4. ncbi Organ protection by hypoxia and hypoxia-inducible factors
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Methods Enzymol 435:221-45. 2007
  5. doi Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Immunol Methods 337:71-7. 2008
  6. doi Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
  7. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
  8. doi Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
  9. doi The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
    Christina Warnecke
    Department of Nephrology and Hypertension, University Clinic Erlangen, Germany
    Exp Cell Res 314:2016-27. 2008
  10. ncbi HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
    Thomas Hackenbeck
    Interdisciplinary Centre for Clinical Research IZKF, University of Erlangen Nuremberg, Erlangen, Germany
    Cell Cycle 8:1386-95. 2009

Collaborators

Detail Information

Publications27

  1. pmc HIF activation protects from acute kidney injury
    Alexander Weidemann
    Medical Clinic 4, Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    J Am Soc Nephrol 19:486-94. 2008
    ..Therefore, development of pharmacologic agents to induce renal HIF might provide a new approach to ameliorate cisplatin-induced nephrotoxicity...
  2. ncbi Inconsistent effects of acidosis on HIF-alpha protein and its target genes
    Carsten Willam
    Department of Nephrology and Hypertension, Medizinische Klinik IV, University of Erlangen Nuremberg, Germany
    Pflugers Arch 451:534-43. 2006
    ....
  3. pmc HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Pathol 174:1663-74. 2009
    ..These results implicate the non-uniform expression of HIF-regulating enzymes that modify the hypoxic response in the kidney under both regional and temporal conditions...
  4. ncbi Organ protection by hypoxia and hypoxia-inducible factors
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Methods Enzymol 435:221-45. 2007
    ..Oxygen-independent activation of HIF is therefore a promising therapeutic strategy for the prevention of organ injury and failure...
  5. doi Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Immunol Methods 337:71-7. 2008
    ..This new approach is superior to lipofection regarding detrimental effects of lipid-based transfection agents on BM-DC immunobiology...
  6. doi Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  7. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
    ..These results highlight the importance of the thick ascending limb in the pathogenesis of AKI and suggest that pharmacologically targeting the HIF system may have potential to prevent and mitigate AKI...
  8. doi Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
    ....
  9. doi The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
    Christina Warnecke
    Department of Nephrology and Hypertension, University Clinic Erlangen, Germany
    Exp Cell Res 314:2016-27. 2008
    ..Thus, HIF-2alpha effects are modulated by a number of intrinsic and extrinsic factors which may be most relevant in tumour cells...
  10. ncbi HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
    Thomas Hackenbeck
    Interdisciplinary Centre for Clinical Research IZKF, University of Erlangen Nuremberg, Erlangen, Germany
    Cell Cycle 8:1386-95. 2009
    ..Importantly, recent approaches to stabilize HIFalpha in normoxia could have deleterious effects on proliferating tissues...
  11. doi The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment
    Zhendi Wang
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 27:929-36. 2012
    ..It is also unknown whether HIF activation after the onset of ischaemia (postconditioning) is still able to protect the kidney...
  12. ncbi Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction
    Alexander Weidemann
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Biochem J 409:233-42. 2008
    ..Induction of BNP may therefore contribute to the potential benefits of pharmacological HIF inducers in the treatment of ischaemic heart disease and heart failure...
  13. ncbi Role of hypoxia in the pathogenesis of renal disease
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int Suppl . 2005
    ..Recent insights into the regulation of HIF increase our understanding of the role of hypoxia in disease progression and open new options to improve hypoxia tolerance and to induce nephroprotection...
  14. ncbi Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 180:4697-705. 2008
    ..Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen...
  15. doi Kidney injury is independent of endothelial HIF-1α
    Joanna Kalucka
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nürnberg FAU, Ulmenweg 18, 91054, Erlangen, Germany
    J Mol Med (Berl) 93:891-904. 2015
    ..This has implications for the development of pharmacological strategies targeting the endothelial hypoxic response pathways...
  16. ncbi Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia
    Michael S Wiesener
    Interdisciplinary Centre for Clinical Research IZKF, Friedrich Alexander University of Erlangen Nuremburg, Erlangen, Germany
    Int J Cancer 121:2434-42. 2007
    ..Further to the reported expression of EPO receptors in tumour tissues, the finding of widespread expression of EPO in RCC supports the recent notion of an involvement of this system in paracrine or autocrine effects of tumour cells...
  17. pmc Involvement of hypoxia-inducible transcription factors in polycystic kidney disease
    Wanja Michael Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Am J Pathol 170:830-42. 2007
    ..In conclusion, HIF accumulation in human and rat PKD seems to be responsible for increased EPO production and pericystic hypervascularity and may have an impact on progression of PKD...
  18. doi Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease
    Isabel N Schellinger
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA VA Palo Alto Health Care System, Palo Alto, California, USA Heart Center, Georg August University Gottingen, Gottingen, Germany German Center for Cardiovascular Research DZHK, Gottingen, Germany
    Kidney Int . 2016
    ..Thus, impaired ischemia-induced angiogenesis in rats with CKD can be improved by HIF stabilization, even if started after onset of ischemia...
  19. pmc Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 10:e0145042. 2015
    ..This study therefore directly compared the performance of AKI biomarkers in urine and plasma...
  20. ncbi Hypoxia-inducible transcription factors and their role in renal disease
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuernberg, Erlangen, Germany
    Semin Nephrol 27:363-72. 2007
    ..On the other hand, continuous activation of the HIF system occurs in kidney cancer and potentially promotes tumor growth. HIF therefore also is explored as a target for anticancer therapy...
  21. ncbi Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  22. doi Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
    Julian Aragones
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit K U Leuven, Leuven, B 3000, Belgium
    Nat Genet 40:170-80. 2008
    ..These findings delineate a new role of Phd1 in hypoxia tolerance and offer new treatment perspectives for disorders characterized by oxidative stress...
  23. pmc The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney
    Philipp Lechler
    Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen Nuremberg, Nuremberg, Germany
    Am J Pathol 171:1483-98. 2007
    ..Interventional strategies to inhibit survivin's function in malignancy need to be carefully (re)evaluated for renal side effects, as well as for other possible organ dysfunctions...
  24. ncbi HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation
    Carsten Willam
    Henry Wellcome Building for Molecular Physiology, Oxford, UK
    J Mol Cell Cardiol 41:68-77. 2006
    ..Inducibility of PHD2 and 3 by hypoxia and ischemia in vivo has important implications both for the pathophysiology of conditions where oxygen supply is deranged and for attempts to manipulate the HIF system therapeutically...
  25. ncbi The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha
    Carsten Willam
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Adv Enzyme Regul 44:75-92. 2004
  26. ncbi Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
    Christina Warnecke
    Department of Nephrology and Medical Intensive Care, Charite, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    FASEB J 17:1186-8. 2003
    ..In conclusion, structurally distinct inhibitors of prolyl hydroxylation are capable of inducing HIFalpha and HIF target genes in vitro and in vivo and induce adaptive responses to hypoxia, including angiogenesis...
  27. pmc Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis
    Carsten Willam
    Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 99:10423-8. 2002
    ..These results demonstrate the feasibility of using these polypeptides to enhance HIF activity, opening additional therapeutic avenues for ischemic diseases...