Julia Wilhelm

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:296-9. 2008
  2. ncbi request reprint Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 8:117-21. 2008
  3. ncbi request reprint Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
  4. doi request reprint Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
  5. doi request reprint Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
  6. doi request reprint Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    J Neural Transm (Vienna) 117:521-7. 2010
  7. ncbi request reprint Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
  8. doi request reprint Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 43:388-92. 2009
  9. doi request reprint Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
  10. doi request reprint Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009

Detail Information

Publications35

  1. doi request reprint Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:296-9. 2008
    ..Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism...
  2. ncbi request reprint Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 8:117-21. 2008
    ..We suggest that the disadvantageous effects of apolipoprotein E4 on alcohol-related brain volume loss are based on certain gene-environment interactions...
  3. ncbi request reprint Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
    ..Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures. These preliminary results must be validated in further studies...
  4. doi request reprint Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
    ..Further investigations in patients with depression as a sole diagnosis are needed to support its role in the pathogenesis of major depression...
  5. doi request reprint Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
    ..ANP mRNA expression was inversely associated with impaired impulse regulation. We conclude that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders...
  6. doi request reprint Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    J Neural Transm (Vienna) 117:521-7. 2010
    ..These findings add further evidence to the hypothesis that homocysteine might be involved in the pathophysiology of anorexia and bulimia nervosa...
  7. ncbi request reprint Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
    ....
  8. doi request reprint Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 43:388-92. 2009
    ..Furthermore, hypermethylation of the DAT-promoter may play an important role in dopaminergic neurotransmission and is associated with decreased alcohol craving...
  9. doi request reprint Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
    ....
  10. doi request reprint Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009
    ..Further studies focusing on longitudinal changes of epigenetic regulation and gene expression of both peptides are needed to clarify the pathophysiological role of these findings...
  11. ncbi request reprint Volume intake and craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:61-5. 2006
    ..The present study was undertaken to evaluate whether the daily volume intake of alcoholic beverages is associated with craving in patients undergoing alcohol withdrawal...
  12. ncbi request reprint Influence of beer, wine and spirits consumption on craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:181-6. 2005
    ..In addition, it is an important predictor for both obsessive and compulsive craving. Further studies are needed to clarify the pathophysiological basis of this finding...
  13. ncbi request reprint Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlagen, Germany
    J Psychiatr Res 42:83-6. 2008
    ..8; df = 42; P = 0.008). Presence of depressive symptoms may explain elevated homocysteine levels previously reported in patients with eating disorders or vice versa. Longitudinal studies are needed to unravel this hen or egg problem...
  14. ncbi request reprint Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 31:950-4. 2007
    ..Aim of this analysis was to search for differences regarding an association between these peptides and alcohol craving with respect to different subtypes and beverage consumption patterns in patients with alcohol dependence...
  15. ncbi request reprint Prolactin serum levels and alcohol craving - an analysis using Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 53:133-6. 2006
    ..Prolactin secretion is closely connected to dopaminergic transmission that is known to play a crucial role in mediating reinforcement and craving in alcoholism...
  16. doi request reprint Increased levels of adiponectin and resistin in alcohol dependence--possible link to craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 99:333-7. 2009
    ..Furthermore, adiponectin may be involved in the neurobiology of alcohol craving, possibly via its effects on the hypothalamic circuits...
  17. ncbi request reprint Evidence of an association of leptin serum levels and craving in alcohol dependence
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 32:87-90. 2007
    ..160, t=5.793, p<0.001) with a power of 1.00. In contrast to previous results describing an association only in female patients, this power-based analysis shows that leptin is associated with alcohol craving in both genders...
  18. doi request reprint Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
    ..The endocannabinoid system is involved in the regulation of appetite, food intake and energy balance...
  19. ncbi request reprint Recurrent detoxifications are associated with craving in patients classified as type 1 according to Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:66-9. 2006
    ..The aim of this investigation was to study the influence of preceding detoxifications on craving in patients with alcoholism classified according to Lesch's typology...
  20. ncbi request reprint Alteration of prolactin serum levels during alcohol withdrawal correlates with craving in female patients
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:337-43. 2005
    ....
  21. ncbi request reprint Elevated prolactin serum levels and history of alcohol withdrawal seizures
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Psychiatr Res 41:702-6. 2007
    ..Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures...
  22. ncbi request reprint Nicotine dependence is associated with compulsive alcohol craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addiction 101:892-7. 2006
    ..To investigate a possible association of nicotine dependence and alcohol craving...
  23. ncbi request reprint Association of catecholamine-O-methyltransferase and 5-HTTLPR genotype with eating disorder-related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Psychiatr Genet 16:205-8. 2006
    ..The aim of the present study was to evaluate, whether behavioral and attitudinal traits of the disorders can serve as phenotypes with a possible association with two common functional polymorphisms of the monoaminergic pathways...
  24. ncbi request reprint Plasma homocysteine concentrations do not influence craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 34:211-5. 2004
    ..Therefore, further research about alcohol craving should focus on neurobiologic factors other than homocysteine...
  25. ncbi request reprint Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Neurosci Lett 335:179-82. 2003
    ..001, multiple regression analysis). Raised plasma levels of homocysteine are associated with hippocampal (brain) atrophy in alcoholism...
  26. ncbi request reprint Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 110:401-11. 2003
    ..These findings indicate a genetic disposition for alcohol related brain atrophy in female carrying the ApoE4 genotype, which may also explain why female alcoholics are more susceptible to alcohol-induced brain damage...
  27. ncbi request reprint Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 113:357-63. 2006
    ..68, 95% CI=0.57-0.79, p=0.004). The present results show first evidence of an association between elevated plasma homocysteine levels in alcoholics and cognition deficits in patients undergoing alcohol withdrawal...
  28. ncbi request reprint Lack of association between hippocampal volume reduction and first-onset alcohol withdrawal seizure. A volumetric MRI study
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Alcohol Alcohol 38:40-4. 2003
    ..Until recently, no data as to whether hippocampal volume reductions in alcoholics might serve as a predictor of withdrawal seizures were available...
  29. doi request reprint Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Pharmacopsychiatry 41:134-7. 2008
    ..The aim of the present study was to assess the risk of different possible influencing factors...
  30. ncbi request reprint Homocysteine plasma levels are elevated in females with anorexia nervosa
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm (Vienna) 112:979-85. 2005
    ....
  31. ncbi request reprint Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Bad Oeynhausen, Germany
    J Neural Transm (Vienna) 112:1591-8. 2005
    ..566, OR=24.75, CI 2.89 - 212.23, P=0.003). These results indicate that under the special circumstances of eating disorders elevated homocysteine levels improve memory signaling possibly by facilitating long-term potentiation...
  32. ncbi request reprint Biological markers to predict previous alcohol withdrawal seizures: a risk assessment
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm (Vienna) 114:151-4. 2007
    ..001, OR = 9.23, 95%CI = 2.36-36.05). A combination of both, homocysteine and prolactin, may help to assess the individual risk of alcohol withdrawal seizures in clinical practice...
  33. ncbi request reprint Alcoholism, craving, and hormones: the role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake
    Friedrich Martin Wurst
    Christian Doppler Clinic, Department of Psychiatry and Psychotherapy II Addiction Medicine, Paracelsus Medical University, Salzburg, Austria
    Alcohol Clin Exp Res 31:1963-7. 2007
    ..The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses...
  34. ncbi request reprint Obsessive-compulsive alcohol craving is not associated with Apolipoprotein E genotype
    Thomas Hillemacher
    Psychiatr Genet 16:231-2. 2006
    ..Statistical analysis revealed no significant association between Apolipoprotein E polymorphism and obsessive-compulsive alcohol craving (analysis of variance: F=1.11, P=0.358)...
  35. ncbi request reprint Limited use of CK-MB as a screening parameter for acute coronary syndrome in patients with alcohol dependency
    Julia Wilhelm
    J Stud Alcohol 66:577-8. 2005