Ulrich O Wenzel

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. doi request reprint A pathogenic role of complement in arterial hypertension and hypertensive end organ damage
    Ulrich O Wenzel
    University Hospital Hamburg Eppendorf, Hamburg
    Am J Physiol Heart Circ Physiol . 2016
  2. pmc Immune Mechanisms in Arterial Hypertension
    Ulrich Wenzel
    Department of Medicine and
    J Am Soc Nephrol 27:677-86. 2016
  3. doi request reprint Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension
    Christian F Krebs
    III Medizinische Klinik, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Hypertension 63:565-71. 2014
  4. doi request reprint Treatment of arterial hypertension in obese patients
    Ulrich O Wenzel
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Semin Nephrol 33:66-74. 2013
  5. ncbi request reprint Chronic anti-Thy-1 nephritis is aggravated in the nonclipped but not in the clipped kidney of Goldblatt hypertensive rats
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 61:2119-31. 2002
  6. doi request reprint Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice
    Ralf A Benndorf
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Toxicology and Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 75:1039-49. 2009
  7. doi request reprint CCR5 deficiency does not reduce hypertensive end-organ damage in mice
    Christian Krebs
    Department of Medicine, Division of Nephrology, University Hospital Hamburg Eppendorf, Germany
    Am J Hypertens 25:479-86. 2012
  8. doi request reprint The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension
    Sebastian Weiss
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 310:F1356-65. 2016
  9. doi request reprint Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling
    Catherine Meyer-Schwesinger
    Department of Internal Medicine, University Hospital Hamburg, Hamburg, Germany
    Am J Physiol Renal Physiol 296:F1088-99. 2009
  10. ncbi request reprint Management of arterial hypertension in obese patients
    Ulrich O Wenzel
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Curr Hypertens Rep 9:491-7. 2007

Collaborators

  • Rolf A K Stahl
  • Ulf Panzer
  • Oliver M Steinmetz
  • Gunter Wolf
  • Ralf A Benndorf
  • Peter F Zipfel
  • David G Harrison
  • Genevieve Nguyen
  • Jörg Köhl
  • Edzard Schwedhelm
  • Hans Willi Mittrücker
  • Catherine Meyer-Schwesinger
  • Christian F Krebs
  • Alva Rosendahl
  • Christian Krebs
  • Sebastian Weiss
  • Hans Joachim Paust
  • Heimo Ehmke
  • Thorsten Wiech
  • Gianina Niemann
  • Jan Eric Turner
  • Sascha Lange
  • Joachim Velden
  • Matthias Janneck
  • Samuel Huber
  • Ulrich Steinhoff
  • Tobias Koyro
  • Sonja Krohn
  • Brigitta Stockinger
  • Nicole Fischer
  • Daniel Czesla
  • Patricia Bartsch
  • Laura Garcia Perez
  • Christian Kurts
  • Jan Hendrik Riedel
  • Silke R Brix
  • Nicola Gagliani
  • Jiabin Huang
  • Philipp Busch
  • Alexander Lehners
  • Erfan Ahadzadeh
  • Harry van Goor
  • Michael Schwake
  • Aurelie Contrepas
  • Judith Peters
  • Michael Bader
  • Andrea Tannapfel
  • Robin Schmidt-Haupt
  • Michael N Quang
  • Christoph Fraune
  • Claudia von Ruffer
  • Silke Dehde
  • Tobias N Meyer
  • Philipp Klug
  • Friedrich Thaiss
  • Stefan Gatzemeier

Detail Information

Publications14

  1. doi request reprint A pathogenic role of complement in arterial hypertension and hypertensive end organ damage
    Ulrich O Wenzel
    University Hospital Hamburg Eppendorf, Hamburg
    Am J Physiol Heart Circ Physiol . 2016
    ..Herein, we will review canonical and non-canonical pathways of complement activation as the framework to understand the multiple roles of complement in arterial hypertension and hypertensive end organ damage...
  2. pmc Immune Mechanisms in Arterial Hypertension
    Ulrich Wenzel
    Department of Medicine and
    J Am Soc Nephrol 27:677-86. 2016
    ..This review briefly summarizes recent advances in immunity and hypertension as well as hypertensive end-organ damage. ..
  3. doi request reprint Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension
    Christian F Krebs
    III Medizinische Klinik, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Hypertension 63:565-71. 2014
    ..IL-17/IL-23 deficiency accelerates DOCA+Ang II-induced albuminuria and hypertensive renal but not cardiac end-organ damage. ..
  4. doi request reprint Treatment of arterial hypertension in obese patients
    Ulrich O Wenzel
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Semin Nephrol 33:66-74. 2013
    ..Therefore, treatment with a blocker of the renin-angiotensin-aldosterone-system and a thiazide diuretic should be considered as first-line antihypertensive drug therapy in obesity hypertension...
  5. ncbi request reprint Chronic anti-Thy-1 nephritis is aggravated in the nonclipped but not in the clipped kidney of Goldblatt hypertensive rats
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 61:2119-31. 2002
    ..To test whether a chronic model of the Thy-1 nephritis is more susceptible to high blood pressure, the repetitive hit model was evaluated in rats with 2-kidney, 1-clip Goldblatt hypertension...
  6. doi request reprint Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice
    Ralf A Benndorf
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Toxicology and Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 75:1039-49. 2009
    ..Whether activation of the AT2 receptor will have therapeutic benefit in chronic kidney disease will require further study...
  7. doi request reprint CCR5 deficiency does not reduce hypertensive end-organ damage in mice
    Christian Krebs
    Department of Medicine, Division of Nephrology, University Hospital Hamburg Eppendorf, Germany
    Am J Hypertens 25:479-86. 2012
    ..CCR5 is expressed on infiltrating T cells in hypertensive mice and CCR5 antagonists reduce hypertension making CCR5 an interesting target in treatment of hypertension...
  8. doi request reprint The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension
    Sebastian Weiss
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 310:F1356-65. 2016
    ..No effect was found on blood pressure. In summary, the C5a:C5aR1 axis drives end-organ damage in the kidney but protects from the development of cardiac fibrosis and hypertrophy in experimental ANG II-induced hypertension. ..
  9. doi request reprint Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling
    Catherine Meyer-Schwesinger
    Department of Internal Medicine, University Hospital Hamburg, Hamburg, Germany
    Am J Physiol Renal Physiol 296:F1088-99. 2009
    ..Together, these data suggest that Rho kinase inhibition by preventive or therapeutic treatment effectively reduced endotoxic kidney injury in part by attenuation of NF-kappaB p65 activation...
  10. ncbi request reprint Management of arterial hypertension in obese patients
    Ulrich O Wenzel
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Curr Hypertens Rep 9:491-7. 2007
    ..Therefore, an ACE inhibitor or diuretic should be considered as first-line antihypertensive drug therapy in obesity-hypertension...
  11. doi request reprint Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
    Christian F Krebs
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, 20251 Hamburg, Germany
    Immunity 45:1078-1092. 2016
    ..Thus, in some autoimmune settings, intestinal Th17 cells migrate into target organs, where they contribute to pathology. Targeting the intestinal Th17 cell "reservoir" may present a therapeutic strategy for these autoimmune disorders...
  12. ncbi request reprint Treatment of arterial hypertension in obese patients
    Ulrich O Wenzel
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Contrib Nephrol 151:230-42. 2006
    ..Sodium retention plays a central role in the development of obesity-related hypertension. Therefore, treatment with an ACE-inhibitors or a diuretic should be considered as first-line antihypertensive drug therapy in obesity-hypertension...
  13. doi request reprint Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice
    Alva Rosendahl
    Division of Nephrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Lab Invest 94:863-72. 2014
    ..Renin expression increased eightfold in the kidney but no renal injury could be detected. In conclusion, our results suggest no major role for PRR in organ damage per se or related to its function as a receptor of renin. ..
  14. ncbi request reprint Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Kidney Int 61:1020-9. 2002
    ..Inhibition of the renin-angiotensin system slows the progression of chronic renal disease...