Nicolas Wentzensen

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Expression of an endogenous retroviral sequence from the HERV-H group in gastrointestinal cancers
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:1417-23. 2007
  2. doi p16 methylation does not affect protein expression in cervical carcinogenesis
    Kristina Nehls
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Eur J Cancer 44:2496-505. 2008
  3. doi Type-dependent integration frequency of human papillomavirus genomes in cervical lesions
    Svetlana Vinokurova
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 68:307-13. 2008
  4. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
  5. ncbi Analysis of p16INK4a and integrated HPV genomes as progression markers
    Svetlana Vinokurova
    Institute of Molecular Pathology, University of Heidelberg, Germany
    Methods Mol Med 119:73-83. 2005
  6. ncbi Triage of women with ASCUS and LSIL cytology: use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer 111:58-66. 2007
  7. pmc Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome
    Miriam Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Fam Cancer 9:173-9. 2010
  8. ncbi Clonal history of papillomavirus-induced dysplasia in the female lower genital tract
    Svetlana Vinokurova
    Department of Molecular Pathology Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Natl Cancer Inst 97:1816-21. 2005
  9. doi Cervical cancer control in the era of HPV vaccination and novel biomarkers
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Pathobiology 76:82-9. 2009
  10. doi Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer
    Gordana Halec
    Research Program Infection and Cancer, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:63-71. 2013

Collaborators

Detail Information

Publications31

  1. ncbi Expression of an endogenous retroviral sequence from the HERV-H group in gastrointestinal cancers
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:1417-23. 2007
    ..Further investigations of the HERV-H long terminal repeat and the HERV-H RNA are necessary to assess the functional relevance of the HERV-H expression...
  2. doi p16 methylation does not affect protein expression in cervical carcinogenesis
    Kristina Nehls
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Eur J Cancer 44:2496-505. 2008
    ..In cervical cancer, methylation of p16 does not seem to be an underlying pathogenic mechanism, but may be a result of increasing genetic and epigenetic instability...
  3. doi Type-dependent integration frequency of human papillomavirus genomes in cervical lesions
    Svetlana Vinokurova
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 68:307-13. 2008
    ....
  4. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
    ..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
  5. ncbi Analysis of p16INK4a and integrated HPV genomes as progression markers
    Svetlana Vinokurova
    Institute of Molecular Pathology, University of Heidelberg, Germany
    Methods Mol Med 119:73-83. 2005
    ..Integration of human papillomavirus DNA into the host genome is mainly found in high-grade dysplastic lesions and invasive cancers, and points to an increased progression potential...
  6. ncbi Triage of women with ASCUS and LSIL cytology: use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer 111:58-66. 2007
    ..The authors investigated the efficacy of p16INK4a as a biomarker to identify samples of patients with HGCIN among those with an ASCUS or LSIL result in Papanicolaou cytology...
  7. pmc Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome
    Miriam Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Fam Cancer 9:173-9. 2010
    ..Based on the high number of defined FSP antigens, measuring FSP-specific humoral immune responses is a highly promising tool for future diagnostic application in MSI-H cancer patients...
  8. ncbi Clonal history of papillomavirus-induced dysplasia in the female lower genital tract
    Svetlana Vinokurova
    Department of Molecular Pathology Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Natl Cancer Inst 97:1816-21. 2005
    ....
  9. doi Cervical cancer control in the era of HPV vaccination and novel biomarkers
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Pathobiology 76:82-9. 2009
    ..Several promising biomarkers have been described that might improve cervical cancer screening, but currently, high-quality studies on their efficiency are lacking...
  10. doi Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer
    Gordana Halec
    Research Program Infection and Cancer, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:63-71. 2013
    ....
  11. doi Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results
    Miriam Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Gynecol Oncol 119:98-105. 2010
    ..We evaluated HPV E6/E7 mRNA detection (APTIMA), p16(INK4a)-immunocytology (CINtec), and HPV DNA testing (HC2) to identify women with high grade cervical neoplasia in a disease-enriched cross-sectional cohort...
  12. doi Human papillomavirus infection in Ulaanbaatar, Mongolia: a population-based study
    Bolormaa Dondog
    Research Program Infection and Cancer, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1731-8. 2008
    ..Improving cervical cancer prevention, through screening and HPV vaccination, is an important public health issue for Mongolia...
  13. ncbi Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer
    Monika Hampl
    Department of Gynecology and Obstetrics, Institute of Pathology, University Hospital, Heinrich Heine University, Duesseldorf, Germany
    Obstet Gynecol 108:1361-8. 2006
    ..We assessed the prevalence of HPV (and the types) to estimate the possible effect of a HPV vaccine on lower genital tract disease prevention...
  14. pmc Semantic focusing allows fully automated single-layer slide scanning of cervical cytology slides
    Bernd Lahrmann
    Hamamatsu Tissue Imaging and Analysis Center TIGA, BIOQUANT, University Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e61441. 2013
    ..9±10.1 min with 29.1±15.5 focus points. In summary, the integration of semantic focus information into whole-slide imaging allows automatic high-quality imaging of LBC slides and subsequent biomarker analysis...
  15. ncbi Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract
    Nicolas Wentzensen
    Institute of Molecular Pathology, Department of Pathology, Heidelberg, Germany
    Cancer Res 64:3878-84. 2004
    ..No evidence for targeted disruption or functional alteration of critical cellular genes by the integrated viral sequences could be found...
  16. doi Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers
    Miriam Reuschenbach
    Department of Applied Tumor Biology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 123:2626-31. 2008
    ..9-11.1). In conclusion, despite the strong expression of p16 and the observed induction of cellular immune responses, antibody reactivity against p16 was observed only at very low levels independent of the disease background...
  17. ncbi No metastatic cervical adenocarcinomas in a series of p16INK4a-positive mucinous or endometrioid advanced ovarian carcinomas: an analysis of the AGO Ovarian Cancer Study Group
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Mannheim, Germany
    Int J Gynecol Pathol 27:18-23. 2008
    ..The p16 staining detected in many primary ovarian adenocarcinomas in the present series seems independent from HPV oncogene activity...
  18. ncbi Tetranucleotide repeats in coding regions: no evidence for involvement in EMAST carcinogenesis
    Matthias Kloor
    Institute of Molecular Pathology, University of Heidelberg, Germany
    J Mol Med (Berl) 84:329-33. 2006
    ..These data suggest that mutational inactivation of tetranucleotide-containing genes is very unlikely to contribute to the progression of EMAST tumors...
  19. ncbi Combined serial section-based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
    Nicolas Wentzensen
    Division for Applied Tumor Biology, Institute of Pathology, University Heidelberg, 69120 Heidelberg, Germany
    Cytometry A 71:327-33. 2007
    ..The present study analyzes the spatial organization of a cervical cancer and the relation of the tumor invasion front and the infiltration with CD3(+) T-cells...
  20. ncbi A large MSH2 Alu insertion mutation causes HNPCC in a German kindred
    Matthias Kloor
    Institute of Molecular Pathology, Department of Pathology, University of Heidelberg, INF 220 221, 69120, Heidelberg, Germany
    Hum Genet 115:432-8. 2004
    ..This is the first report of an Alu insertion in the coding sequence of a MMR gene as the cause of HNPCC. Our data thus further extend the spectrum of MMR gene mutations causative for HNPCC...
  21. pmc A systematic review of humoral immune responses against tumor antigens
    Miriam Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Cancer Immunol Immunother 58:1535-44. 2009
    ....
  22. pmc A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides
    Niels Grabe
    Institute of Medical Biometry and Informatics, Section Medical Informatics, University Hospital Heidelberg, Heidelberg, Germany
    Cell Oncol 32:109-19. 2010
    ..New biomarkers like p16 that specifically highlight abnormal cervical cells can improve cytology performance. Virtual microscopy offers an ideal platform for assisted evaluation and archiving of biomarker-stained slides...
  23. ncbi Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples
    Nicolas Wentzensen
    Institute of Molecular Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer 105:461-7. 2005
    ..The p16INK4a gene product is overexpressed strongly in abnormal cervical epithelia and may serve as a valuable biomarker to identify abnormal cells in cervical smears or liquid-based cytology samples...
  24. doi p16INK4a immunohistochemistry in cervical biopsy specimens: A systematic review and meta-analysis of the interobserver agreement
    Miriam Reuschenbach
    From the Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg and Clinical Cooperation Unit, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Pathol 142:767-72. 2014
    ..However, morphologic evaluation is subjective and has low interobserver agreement. Addition of p16(INK4a) immunohistochemistry may improve interpretation...
  25. ncbi Identification of high-grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer 107:2307-13. 2006
    ..p16(INK4a) is a cell-cycle regulator that has demonstrated strong overexpression in cervical precancer cells and cervical cancer induced by the deregulated expression of HPV oncogenes...
  26. ncbi Activating anti-CD40 antibodies induce tumour invasion by cytotoxic T-lymphocytes and inhibition of tumour growth in experimental liver cancer
    Eduard Ryschich
    Department of General Surgery, University of Heidelberg, Im Neunenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cancer 42:981-7. 2006
    ..Thus, the CD40/CD154 pathway is a worthwhile target for adjuvant immunotherapy...
  27. ncbi Identification of differentially expressed genes in colorectal adenoma compared to normal tissue by suppression subtractive hybridization
    Nicolas Wentzensen
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 24:987-94. 2004
    ..These genes might represent promising new candidates for colorectal cancer early detection...
  28. ncbi A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques
    Corina Ziegert
    Institute of Molecular Pathology, Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Oncogene 22:3977-84. 2003
    ..Disruption of cellular genes might support malignant transformation in rare cases; however, it is not a pathogenic prerequisite. The main function of HPV integration seems to be the stabilization of oncogene transcription...
  29. pmc Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling
    Stephan Grouls
    University of Heidelberg, Department of Nephrology, Im Neuenheimer Feld 162, 69120 Heidelberg, Baden Wurttemberg, Germany
    J Am Soc Nephrol 23:63-72. 2012
    ..Taken together, these findings demonstrate that β-catenin/Wnt signaling is important during the late stages of nephrogenesis and for the lineage specification of parietal epithelial cells...
  30. ncbi DNA aneuploidy and integration of human papillomavirus type 16 e6/e7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri
    Peter Melsheimer
    Department of Obstetrics, Gynecology and Gynecological Oncology, Medical School, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 10:3059-63. 2004
    ..This in turn leads to expression of viral cellular fusion transcripts and further enhanced expression of the E6-E7 oncoproteins. Chromosomal instability and aneuploidization thus seems to precede and favor integration of HR-HPV genomes...
  31. ncbi Characterization of viral-cellular fusion transcripts in a large series of HPV16 and 18 positive anogenital lesions
    Nicolas Wentzensen
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Oncogene 21:419-26. 2002
    ..These data demonstrate that target directed insertional mutagenesis might occur in few HPV-induced anogenital lesions, however, it is rather the exception than the rule...