Christian Weber

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study
    Liselotte M Kornmann
    Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200, Maastricht, MD, The Netherlands
    Cardiovasc Ultrasound 13:1. 2015
  2. pmc Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet
    Cristiane Aoqui
    Department of Nephrology, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger St, 22, Munich 81675, Germany
    Cardiovasc Diabetol 13:31. 2014
  3. doi request reprint Atherosclerosis: current pathogenesis and therapeutic options
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    Nat Med 17:1410-22. 2011
  4. ncbi request reprint Anti-inflammatory therapeutic approaches to reduce acute atherosclerotic complications
    Isabella Kanzler
    Institute for Molecular Cardiovascular Research, Interdisciplinary Center for Clinical Research Aachen, RWTH Aachen University, Germany
    Curr Pharm Biotechnol 13:37-45. 2012
  5. pmc ApoE controls the interface linking lipids and inflammation in atherosclerosis
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    J Clin Invest 121:3825-7. 2011
  6. doi request reprint Differential role of monocyte subsets in atherosclerosis
    M Hristov
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    Thromb Haemost 106:757-62. 2011
  7. pmc MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
    Andreas Schober
    1 Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany 2 Institute for Molecular Cardiovascular Research, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany 3 DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany 4
    Nat Med 20:368-76. 2014
  8. doi request reprint The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis
    Yuanyuan Wei
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany
    Circulation 127:1609-19. 2013
  9. pmc Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes
    Oliver Soehnlein
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    EMBO Mol Med 5:471-81. 2013
  10. doi request reprint Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice
    Heidi Noels
    From the Institute for Molecular Cardiovascular Research H N, B Z, P V T, W T, X L, L P, S A, S S, E S, E A L and Institute of Biochemistry and Molecular Cell Biology C S, J B, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany Institute for Cardiovascular Prevention A S, Y D, C W and August Lenz Stiftung, Institute for Cardiovascular Research J B, Ludwig Maximilians University Munich, Munich, Germany Max Planck Institute for Molecular Biomedicine, University of Munster, Munster, Germany R H A Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands C W and German Centre for Cardiovascular Research Deutsches Zentrum für Herz Kreislauf Forschung, partner site Munich Heart Alliance, Munich, Germany C W
    Arterioscler Thromb Vasc Biol 34:1209-20. 2014

Detail Information

Publications69

  1. pmc Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study
    Liselotte M Kornmann
    Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200, Maastricht, MD, The Netherlands
    Cardiovasc Ultrasound 13:1. 2015
    ..The present study investigates in mice the potential of perfluorohexane (PFH) loaded macrophages to act as ultrasound contrast agent with high reflectivity and specifically targeted at (atherosclerotic) vascular lesions...
  2. pmc Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet
    Cristiane Aoqui
    Department of Nephrology, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger St, 22, Munich 81675, Germany
    Cardiovasc Diabetol 13:31. 2014
    ..We aimed to characterize microvascular function and some of its influencing factors in the course of MetS development...
  3. doi request reprint Atherosclerosis: current pathogenesis and therapeutic options
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    Nat Med 17:1410-22. 2011
    ..Here we aim to systematically survey recently identified molecular mechanisms, translational developments and clinical strategies for targeting lipid-related inflammation in atherosclerosis and CAD...
  4. ncbi request reprint Anti-inflammatory therapeutic approaches to reduce acute atherosclerotic complications
    Isabella Kanzler
    Institute for Molecular Cardiovascular Research, Interdisciplinary Center for Clinical Research Aachen, RWTH Aachen University, Germany
    Curr Pharm Biotechnol 13:37-45. 2012
    ..Therefore, many aspects should be considered and carefully scrutinized, when devising therapeutic strategies...
  5. pmc ApoE controls the interface linking lipids and inflammation in atherosclerosis
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    J Clin Invest 121:3825-7. 2011
    ..These findings could pave the way for the development of novel treatment strategies to control leukocyte homeostasis and atherosclerosis...
  6. doi request reprint Differential role of monocyte subsets in atherosclerosis
    M Hristov
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    Thromb Haemost 106:757-62. 2011
    ....
  7. pmc MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
    Andreas Schober
    1 Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany 2 Institute for Molecular Cardiovascular Research, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany 3 DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany 4
    Nat Med 20:368-76. 2014
    ..Administration of miR-126-5p rescued EC proliferation at predilection sites and limited atherosclerosis, introducing a potential therapeutic approach. ..
  8. doi request reprint The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis
    Yuanyuan Wei
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany
    Circulation 127:1609-19. 2013
    ..Because microRNAs (miRNAs) play a crucial role in cellular signaling by posttranscriptional regulation of gene expression, we studied the miRNA expression profiles during the progression of atherosclerosis...
  9. pmc Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes
    Oliver Soehnlein
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    EMBO Mol Med 5:471-81. 2013
    ..Collectively, these data establish the impact of classical monocytes on atheroprogression, identify a sequential role of CXCL1 in their mobilization and CCR1/CCR5 in their recruitment...
  10. doi request reprint Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice
    Heidi Noels
    From the Institute for Molecular Cardiovascular Research H N, B Z, P V T, W T, X L, L P, S A, S S, E S, E A L and Institute of Biochemistry and Molecular Cell Biology C S, J B, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany Institute for Cardiovascular Prevention A S, Y D, C W and August Lenz Stiftung, Institute for Cardiovascular Research J B, Ludwig Maximilians University Munich, Munich, Germany Max Planck Institute for Molecular Biomedicine, University of Munster, Munster, Germany R H A Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands C W and German Centre for Cardiovascular Research Deutsches Zentrum für Herz Kreislauf Forschung, partner site Munich Heart Alliance, Munich, Germany C W
    Arterioscler Thromb Vasc Biol 34:1209-20. 2014
    ..This study aimed to investigate the role of endothelial Cxcr4 in neointima formation...
  11. doi request reprint Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis
    Martin M N Schmitt
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany M M N S, R T A M, K B, R R K, C W the Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany M M N S, M A v Z the Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands M M N S, R T A M, N M v d A, T R, M A v Z, T M H, R R K, C W the Division of Vascular Biology, Department of Vascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany A Z and the German Centre for Cardiovascular Research DZHK, partner site Munich Heart Alliance, Munich, Germany A Z, C W
    Circulation 129:66-76. 2014
    ..Atherosclerosis develops at sites of disturbed flow in large arteries, but the mechanisms guiding inflammatory cells into these predilection sites remain unknown...
  12. doi request reprint Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice
    Yvonne Döring
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munchen, Munich, Germany
    Circ Res 110:1052-6. 2012
    ..Neutrophils have been reported to contribute to early atherosclerotic lesion formation. Mechanisms of neutrophil-driven atherosclerosis remain unclear so far...
  13. pmc Neutrophil-derived cathelicidin promotes adhesion of classical monocytes
    Sarawuth Wantha
    Institute for Cardiovascular Prevention, LMU Munich, Pettenkoferstrasse 9, Munich, Germany
    Circ Res 112:792-801. 2013
    ..Neutrophil-derived granule proteins were suggested to hold an important role in this cellular switch. The exact mechanisms by which neutrophils mediate these processes are only partially understood...
  14. doi request reprint CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice
    Shamima Akhtar
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstr 9, 80336 Munich, Germany
    Arterioscler Thromb Vasc Biol 33:679-86. 2013
    ..Moreover, treatment with SPCs stabilizes atherosclerotic lesions in mice. We investigated the role of CXCL12 in the treatment of unstable atherosclerotic lesions...
  15. doi request reprint Pathogenic arterial remodeling: the good and bad of microRNAs
    Yuanyuan Wei
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    Am J Physiol Heart Circ Physiol 304:H1050-9. 2013
    ..However, more in vivo studies on the functional roles of these miRNAs are required in the future...
  16. doi request reprint Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice
    Yvonne Döring
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Germany
    Arterioscler Thromb Vasc Biol 32:1613-23. 2012
    ..Inflammatory leukocyte accumulation drives atherosclerosis. Although monocytes/macrophages and polymorphonuclear neutrophilic leukocytes (PMN) contribute to lesion formation, sequelae of myeloproliferative disease remain to be elucidated...
  17. doi request reprint Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue
    Xiaofeng Li
    Institute for Molecular Cardiovascular Research X L, R R K, A T, K H, S A, Z W, M v Z, C W, A s, Core Facility Two Photon Imaging, Interdisciplinary Center for Clinical Research Aachen S K, and Experimental Molecular Imaging F G, F K, RWTH Aachen University, Aachen, Germany Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany M Z, R R K, K H, C W, A S ChemoCentryx Inc, Mountain View, CA M E P, T J S Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands M v Z, C W and Munich Heart Alliance, Munich, Germany C W, A s
    Circulation 129:1244-53. 2014
    ..CXCR7 is the alternative receptor of CXCL12, which regulates stem cell-mediated vascular repair and limits atherosclerosis via its receptor, CXCR4...
  18. pmc Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
    Petra Hartmann
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany
    Nat Commun 7:10521. 2016
    ..Overall, our study suggests that Dicer promotes endothelial maladaptation and atherosclerosis in part by miR-103-mediated suppression of KLF4. ..
  19. pmc Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication
    Yvonne Döring
    From Institute for Cardiovascular Prevention Y D, M M, B K, C N, D L, M D, R T A M, M L, H H, O S, C W, and Walter Brendel Centre of Experimental Medicine M S, Ludwig Maximilians University, Munich, Germany Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany H N, P V T, W T Center for Nanomedicine, Sanford Burnham Medical Research Institute, University of California, Santa Barbara, CA J D M DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany M S, O S, C W Academic Medical Center, Amsterdam, the Netherlands O S and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands R T A M, C W
    Circ Res 114:976-81. 2014
    ..Recent evidence suggests that sialylation also affects the binding of chemokines to their corresponding receptor...
  20. doi request reprint MicroRNAs in flow-dependent vascular remodelling
    Peter Neth
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstraße 9, 80336 Munich, Germany
    Cardiovasc Res 99:294-303. 2013
    ..Further elucidating the regulation of miRs by flow may allow future clinical applications of miRs as diagnostic and therapeutic tools. ..
  21. pmc Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation
    Manuela Mandl
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 10:e0134176. 2015
    ..Hence, we investigated the role of pDCs in atherogenesis vs atheroprogression by specifically depleting this cell population using the BDCA2-DTR mouse model bred to Apolipoprotein E (Apoe-/-) deficient mice...
  22. doi request reprint Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis
    Yuanyuan Wei
    From the Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Medical Faculty of Ludwig Maximilians University Munich, Munich, Germany Y W, M Z, J C C, K H, C W, A S Institute for Molecular Cardiovascular Research, Medical Faculty of RWTH Aachen University, Aachen, Germany Y W, J C C, K H, C W, A S and Munich Heart Alliance, Munich, Germany C W, A s
    Arterioscler Thromb Vasc Biol 35:796-803. 2015
    ..We hypothesized that the stage-dependent target selection of miR-155 in macrophages determines its effects on atherosclerosis...
  23. doi request reprint MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis?
    Yuanyuan Wei
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    Arterioscler Thromb Vasc Biol 33:449-54. 2013
    ..The discovery of the role of these miRNAs in atherosclerosis sheds light on the current concepts of atherogenesis and may provide novel treatment options for cardiovascular diseases...
  24. doi request reprint Endothelial Hypoxia-Inducible Factor-1α Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a
    Shamima Akhtar
    From the Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany S A, P H, E K, F A R, P S, C W, S S, A S Institute for Molecular Cardiovascular Research S A, A s, Department of Experimental Molecular Imaging F G, F K, and European Vascular Center Aachen Maastricht J G, M J, RWTH Aachen University, Aachen, Germany European Vascular Center Aachen Maastricht, University Maastricht Medical Center, Maastricht, The Netherlands J G, M J Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands C W and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany C W, S S, A s
    Hypertension 66:1220-6. 2015
    ....
  25. doi request reprint Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice
    Ela Karshovska
    From the Institute for Cardiovascular Prevention IPEK E K, Z Z, X B, M M N S, K B, O S, P V H, R T A M, A s, C W, R R K and Division of Vascular and Endovascular Surgery Z Z, T A K, Ludwig Maximilians University Munich, Munich, Germany Department of Pathology, Academic Medical Center AMC, Amsterdam, The Netherlands O S German Centre for Cardiovascular Research DZHK, partner site Munich Heart Alliance, Munich, Germany O S, P V H, A s, C W and Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands N J M, J M E M C, R T A M, T M H, C W, R R K
    Circ Res 116:587-99. 2015
    ..In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin αIIbβ3-mediated outside-in signaling and its genetic knockdown resulted in hyperreactivity...
  26. doi request reprint Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment
    Birgit K Kramp
    Philipp von Hundelshausen, Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich, Munich, Germany, Tel 49 89 5160 4359, Fax 49 89 5160 4352, E mail
    Thromb Haemost 110:795-806. 2013
    ..Our data identify confined targetable regions of CCR1 specialised to facilitate CCL5-induced arrest and enhanced responsiveness to the CXCL4-CCL5 heteromer. ..
  27. doi request reprint Chemokines in atherosclerosis: proceedings resumed
    Alma Zernecke
    From the Institute of Clinical Biochemistry and Pathobiochemistry, University Hospital Wurzburg, Wurzburg, Germany A Z Department of Vascular Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany A Z DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany A Z, C W and Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany C W
    Arterioscler Thromb Vasc Biol 34:742-50. 2014
    ....
  28. pmc MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
    Maliheh Nazari-Jahantigh
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    J Clin Invest 122:4190-202. 2012
    ..Taken together, these data demonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and enhance vascular inflammation...
  29. pmc Neutrophil-derived cathelicidin protects from neointimal hyperplasia
    Oliver Soehnlein
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munchen, Munich 80336, Germany
    Sci Transl Med 3:103ra98. 2011
    ..This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy...
  30. doi request reprint Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes
    Norbert Gerdes
    From the Institute for Cardiovascular Prevention IPEK, Ludwig Maximilians University Munich, Munich, Germany N G, D L, H W, D P, R T A M, O S, C W, E L Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands T S, H H, L B, O S, E L Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands M J E K, J W M H, C W Bioceros BV, Utrecht, The Netherlands L B and Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, NH R J N
    Arterioscler Thromb Vasc Biol 36:482-90. 2016
    ..CD40, the receptor for CD40L, is present on platelets; however, the role of CD40 on this cell type is until now undefined...
  31. doi request reprint Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution
    Martin M N Schmitt
    Institute for Cardiovascular Prevention IPEK, Ludwig Maximilians University Munich, Munich, Germany Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Aachen, Germany Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Atherosclerosis 234:254-64. 2014
    ..Upon inflammatory stimulation, JAM-A relocates to the apical surface and might thereby facilitate the recruitment of leukocytes...
  32. pmc Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction
    Delia Projahn
    Institute for Molecular Cardiovascular Research IMCAR, Medical Faculty, RWTH Aachen University, Aachen, Germany Institute for Cardiovascular Prevention IPEK, University Hospital of the LMU Munich, Munich, Germany
    J Cell Mol Med 18:790-800. 2014
    ..This study demonstrates that time-controlled, biopolymer-mediated delivery of chemokines represents a novel and feasible strategy to support the endogenous reparatory mechanisms after MI and may compliment cell-based therapies...
  33. doi request reprint Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia
    Otilia Postea
    Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich, Munich, Germany
    Arterioscler Thromb Vasc Biol 32:1186-93. 2012
    ..Here, we evaluated the expression and role of platelet-CX(3)CR1 during hyperlipidemia and vascular injury...
  34. doi request reprint A flow cytometric protocol for enumeration of endothelial progenitor cells and monocyte subsets in human blood
    Mihail Hristov
    Institute for Cardiovascular Prevention, Ludwig Maximilians University LMU, Munich, Germany
    J Immunol Methods 381:9-13. 2012
    ..However, a general standard on their quantification is still elusive, thus precluding a routine monitoring and comparative interpretation of clinical studies...
  35. doi request reprint RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells
    Christian Mahl
    Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich, Pettenkoferstrasse 9b, 80336, Munich, Germany
    Cell Mol Life Sci 73:1489-501. 2016
    ..Our findings demonstrate that RECK is a regulator of hMSC functions suggesting that modulation of RECK may improve the development of hMSC-based therapeutical approaches in regenerative medicine. ..
  36. doi request reprint Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5
    Jean Eric Alard
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Sci Transl Med 7:317ra196. 2015
    ..These results establish the in vivo relevance of heteromers formed between proteins released from neutrophils and platelets and show the potential of targeting heteromer formation to resolve acute or chronic inflammation. ..
  37. doi request reprint Noninvasive molecular ultrasound monitoring of vessel healing after intravascular surgical procedures in a preclinical setup
    Adelina Curaj
    From the Institute for Experimental Molecular Imaging A C, Z W, S F, T L, F K, Institute for Molecular Cardiovascular Research A C, Z W, E A L, M v Z, University Clinic, RWTH Aachen University, Aachen, Germany Institute of Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany C W DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany C W Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, Bucharest, Romania A B Department of Controlled Drug Delivery, University of Twente, AE Enschede, The Netherlands T L and Department of Genetics and Molecular Cell Biology, School for Cardiovascular Diseases CARIM, Maastricht University, Maastricht, The Netherlands M v Z
    Arterioscler Thromb Vasc Biol 35:1366-73. 2015
    ....
  38. doi request reprint Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies
    Carlos Silvestre-Roig
    From the Departments of Pathology C S R, M D, O S and Biochemistry C S R, M D W, E L, Academic Medical Center, Amsterdam, The Netherlands Institute for Cardiovascular Prevention, Ludwig Maximilian University of Munich, Munich, Germany C W, E L, O S and Deutsches Zentrum für Herz Kreislauf Forschung e V DZHK German Centre for Cardiovascular Research, partner site of Munich Heart Alliance, Munich, Germany C W, O S
    Circ Res 114:214-26. 2014
    ....
  39. pmc Role of extracellular RNA in atherosclerotic plaque formation in mice
    Sakine Simsekyilmaz
    Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen, Aachen, Germany S S, E A L Department of Biochemistry, Medical School, Justus Liebig University, Giessen, Germany H A C F, K T P Department of Microbiology, Kazan Federal University, Kazan, Russian Federation H A C F Center for Cardiovascular Research, John A Burns School of Medicine, University of Hawaii, Honolulu, HI S M, Y B, W A B Core Lab for Molecular and Structural Biology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany S K Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany C W DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany C W, A Z Rudolf Virchow Center and Institute of Clinical Biochemistry and Pathobiochemistry, University Hospital Wurzburg, University of Wurzburg, Wurzburg, Germany A Z and Department of Vascular Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany A Z
    Circulation 129:598-606. 2014
    ..Here, we addressed the role of eRNA in high-fat diet-induced atherosclerosis and neointima formation after injury in atherosclerosis-prone mice...
  40. ncbi request reprint Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes
    Matthias Mack
    Medical Policlinic, University of Munich, Munich, Germany
    Eur J Immunol 32:1012-20. 2002
    ..Taken together, chondroitin sulfate A released from platelets appears to act as an important regulatory molecule for cellular responses to chemokines...
  41. ncbi request reprint JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes
    Georg Ostermann
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Nat Immunol 3:151-8. 2002
    ..Thus, JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment...
  42. ncbi request reprint Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma
    Wolfgang Erl
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
    Eur J Immunol 34:241-50. 2004
    ..Our findings show that PGA1 and PGJ2 induce apoptosis in endothelial cells independent of PPARgamma. As the synthesis of PGJ2 is increased at sites of inflammation, our results may suggest a possible mechanism for endothelial damage...
  43. ncbi request reprint Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation
    Stephan Segerer
    Medizinische Poliklinik Innenstadt, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 18:1835-44. 2007
    ..Both clusters of basic residues in CCL5 are necessary for sufficient binding of CCL5 to tissue sections...
  44. doi request reprint MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis
    Setareh Alampour-Rajabi
    Institute of Biochemistry and Molecular Cell Biology, Institute of Biochemistry and Molecular Biology, and Interdisziplinäres Zentrum für Klinische Forschung IZKF, Rhine Westphalia Technical University of Aachen RWTH, Aachen, Germany Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom INSERM, Unité Mixte de Recherche S 996, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Universite Paris Sud, Clamart, France Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, University of Tubingen, Tubingen, Germany Institute for Cardiovascular Prevention, Klinikum der Universitat Munchen, and August Lenz Stiftung, Ludwig Maximilians Universitat Munchen, Munich, Germany Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands and Deutches Zentrum für Herz Kreislauf Forschung DZHK, partner site Munich Heart Alliance, Munich, Germany
    FASEB J 29:4497-511. 2015
    ..Our findings provide biochemical and functional evidence that MIF is an alternative ligand of CXCR7 and suggest a functional role of the MIF-CXCR7 axis in B-lymphocyte migration...
  45. doi request reprint Optical imaging innovations for atherosclerosis research: multiphoton microscopy and optical nanoscopy
    Remco T A Megens
    From the Institute for Prevention of Cardiovascular Diseases IPEK, Ludwig Maximilians University Munich, Munich, Germany R T A M, M B, M M N S, C W Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands R T A M, C W and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany C W
    Arterioscler Thromb Vasc Biol 35:1339-46. 2015
    ..This review will discuss the current use of 2-photon microscopy and will provide an overview and outlook on options for introducing nanoscopic optical imaging modalities in atherosclerosis research. ..
  46. pmc Characterization of the CD14++CD16+ monocyte population in human bone marrow
    Manuela Mandl
    Institute for Cardiovascular Prevention, Ludwig Maximilians University LMU, Munich, Germany
    PLoS ONE 9:e112140. 2014
    ..Together, human monocytes obviously acquire their definitive CD14/CD16 signature in the bloodstream and the medullar monocytes probably transform into CD14(++)CD16- and CD14(+)CD16(++) subsets which appear enriched in the periphery...
  47. doi request reprint Neutrophils in atherosclerosis: from mice to man
    Yvonne Döring
    From the Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany Y D, M D, O S, C W Department of Pathology, Academic Medical Center, Amsterdam University, Amsterdam, the Netherlands M D, O S and German Centre for Cardiovascular Research DZHK, partner site Munich Heart Alliance, Munich, Germany O S, C W
    Arterioscler Thromb Vasc Biol 35:288-95. 2015
    ..This brief review will summarize latest findings on the role of neutrophils in atherosclerosis and will pay special attention to studies describing a translation approach by combining measurements in mouse and human. ..
  48. pmc CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Clin Invest 121:2898-910. 2011
    ..Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy...
  49. doi request reprint Chemokine-like functions of MIF in atherosclerosis
    Andreas Schober
    Cardiology Unit, Medical Policlinic City Center Campus, University of Munich, Munich, Germany
    J Mol Med (Berl) 86:761-70. 2008
    ..Detailed analysis of the interaction of MIF with its receptors could provide valuable information for drug development for the anti-inflammatory treatment of established and unstable atherosclerosis...
  50. doi request reprint MicroRNA-specific regulatory mechanisms in atherosclerosis
    Maliheh Nazari-Jahantigh
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    J Mol Cell Cardiol 89:35-41. 2015
    ..This article is part of a Special Issue entitled 'Non-coding RNAs'. ..
  51. doi request reprint Immune-mediated and lipid-mediated platelet function in atherosclerosis
    Maiwand Ahmadsei
    aInstitute for Cardiovascular Prevention IPEK, Ludwig Maximilians University Munich, Munich, Germany bDZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
    Curr Opin Lipidol 26:438-48. 2015
    ..Recent advances in molecular biology help to understand the complexity of atherosclerosis...
  52. doi request reprint Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential
    Charlotte Spitz
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstr 9, 80336, Munich, Germany
    Cell Mol Life Sci 73:901-22. 2016
    ..We then discuss experimental data and current knowledge pertaining to Tregs in atherosclerosis and perspectives on manipulating the adaptive immune system to alleviate atherosclerosis and cardiovascular disease. ..
  53. doi request reprint MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis
    Andreas Schober
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Pettenkoferstrasse 9, 80336 Munich, Germany
    Nat Rev Cardiol 12:361-74. 2015
    ..Elucidating miRNA-mediated regulatory mechanisms can aid the development of novel diagnostic and therapeutic strategies for atherosclerosis. ..
  54. pmc MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities
    Emiel P C van der Vorst
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    Front Immunol 6:373. 2015
    ..Ongoing research on CXCL12 points at a protective function of this chemokine in atherosclerotic lesion development. This review will focus on the role of CXCL12 and MIF and their differences and similarities in CAD of high risk patients...
  55. pmc Chemokines and microRNAs in atherosclerosis
    Petra Hartmann
    Institute for Cardiovascular Prevention, Ludwig Maximilians University LMU Munich, Munich, Germany
    Cell Mol Life Sci 72:3253-66. 2015
    ..Understanding the complex cross-talk of miRNAs controlling chemokine expression may open novel therapeutic options to treat atherosclerosis. ..
  56. doi request reprint β-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency
    Larisa Ring
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstraße 9, 80336 Munich, Germany Electronic address
    Cell Signal 26:260-7. 2014
    ..These data and extension of this experimental setup to the poorly characterized other WNTs should facilitate deeper insight into the complex WNT/FZD signalling system and its function. ..
  57. doi request reprint Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment
    Maik Drechsler
    From the Institute for Cardiovascular Prevention IPEK, LMU Munich, Munich, Germany M D, R d J, J R V, G L, J G, C W, Y D, O S Department of Pathology, Academic Medical Center AMC, Amsterdam University, Amsterdam, the Netherlands M D, O S Department of Anaesthesiology, University Munster, Munster, Germany J R, A Z Max Planck Institute, Munster, Germany J R, A Z Laboratory of Molecular Immunoregulation, NCI, Frederick, MD J M W European Vascular Center Aachen Maastricht, University Hospital RWTH Aachen, Aachen, Germany J G Medizinische Klinik und Poliklinik I, Klinikum Groshadern, LMU Munich, Munich, Germany R H, C K and DZHK, partner site Munich Heart Alliance, Munich
    Circ Res 116:827-35. 2015
    ..The contribution of FPR2 and its proresolving ligand annexin A1 to atherosclerotic lesion formation is largely undefined...
  58. ncbi request reprint Mechanisms of monocyte recruitment in vascular repair after injury
    Andreas Schober
    Division of Cardiology, Medizinische Poliklinik, University Hospital, Munich, Germany
    Antioxid Redox Signal 7:1249-57. 2005
    ..Understanding the complex molecular interactions of the injured vessel wall with circulating monocytes may enable therapeutic targeting to prevent the development of restenosis...
  59. doi request reprint The use of high-throughput technologies to investigate vascular inflammation and atherosclerosis
    Yvonne Döring
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum der Universitat Munchen, Pettenkoferstrasse 9, 80336 Munchen, Germany
    Arterioscler Thromb Vasc Biol 32:182-95. 2012
    ..This review exemplifies the use of high-throughput technologies-such as genomics, transcriptomics, proteomics, and epigenomics-and systems biology to explore pathomechanisms of vascular inflammation and atherosclerosis...
  60. pmc Chemokines: established and novel targets in atherosclerosis
    Rory R Koenen
    Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich, Munich, Germany
    EMBO Mol Med 3:713-25. 2011
    ..In this review, the current standing of this dynamic field is highlighted and the potential advantages and drawbacks of particular strategies are discussed...
  61. pmc Chemokines and their receptors in Atherosclerosis
    Emiel P C van der Vorst
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstr 9, 80336, Munich, Germany
    J Mol Med (Berl) 93:963-71. 2015
    ..However, results about this protective role are still quite debatable. Future research will further elucidate the precise role of these chemokines in atherosclerosis and determine the potential of chemokine-based therapies...
  62. doi request reprint Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia
    Janina Deppe
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    Toxicol Lett 244:81-7. 2016
    ....
  63. pmc Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies
    Janina Jamasbi
    Institute for the Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany
    J Am Coll Cardiol 65:2404-15. 2015
    ..Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential...
  64. pmc Touch of chemokines
    Xavier Blanchet
    Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich Munich, Germany
    Front Immunol 3:175. 2012
    ..In this review, we are interested in the role of chemokines in inflammatory disease and leukocyte trafficking with a focus on vascular inflammatory diseases, the operating synergism, and the emerging therapeutic approaches of chemokines...
  65. doi request reprint CD34+CD140b+ cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy
    Andreas Schober
    Medizinische Poliklinik Innenstadt, Kardiologie, University of Munich, Munich, Germany
    Eur Heart J 32:476-84. 2011
    ..We sought to determine whether circulating vascular progenitor cells, such as endothelial progenitor cells (EPCs) or smooth muscle progenitor cells (SPCs), were associated with the severity of cardiac allograft vasculopathy (CAV)...
  66. ncbi request reprint Peripheral CD34+ cells and the risk of in-stent restenosis in patients with coronary heart disease
    Andreas Schober
    Division of Cardiology, Medizinische Poliklinik, University Hospital, Munich, Germany
    Am J Cardiol 96:1116-22. 2005
    ..In conclusion, an increase in circulating CD34+ cells after coronary stenting constitutes an independent risk factor predicting in-stent restenosis and may be suggestive of their involvement in neointimal hyperplasia...
  67. pmc Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation
    Kiril Bidzhekov
    GSF National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Munich, Germany
    J Cell Mol Med 11:1395-407. 2007
    ..Thus, gain- and loss-of-function experiments point to distinct roles of B-Raf and C-Raf in regulating growth and differentiation of endothelial progenitor cells, which may harbour therapeutic implications...
  68. ncbi request reprint Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells
    Kristina Jostarndt
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Biochem Biophys Res Commun 290:988-93. 2002
    ..However, in our cellular model, the two induction processes appear to be causally unrelated...
  69. ncbi request reprint Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling
    Tobias Weber
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Biochemistry 42:4277-91. 2003
    ..These data provide an insight into the molecular mechanism, by which alpha-TOS kills malignant cells, and advocate its testing as a potential anticancer agent or adjuvant...