Barbara Walzog

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Midkine in inflammation
    Ludwig T Weckbach
    Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, 80336 Munich, Germany
    ScientificWorldJournal 11:2491-505. 2011
  2. pmc Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 2:e1132. 2007
  3. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
  4. ncbi request reprint The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
    Blood 108:3919-27. 2006
  5. doi request reprint The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions
    Ingrid Hepper
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Immunol 188:4590-601. 2012
  6. ncbi request reprint A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo
    Jurgen Schymeinsky
    Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    Blood 114:4209-20. 2009
  7. doi request reprint Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis
    Ludwig T Weckbach
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Heart Circ Physiol 303:H429-38. 2012
  8. ncbi request reprint Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Thromb Haemost 98:262-73. 2007
  9. ncbi request reprint The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    J Cell Physiol 204:614-22. 2005
  10. doi request reprint Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response
    Sascha M Jakob
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Blood 121:4184-94. 2013

Collaborators

Detail Information

Publications18

  1. pmc Midkine in inflammation
    Ludwig T Weckbach
    Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, 80336 Munich, Germany
    ScientificWorldJournal 11:2491-505. 2011
    ..Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology...
  2. pmc Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 2:e1132. 2007
    ..These data imply a novel role of Syk via PI3K p110delta signaling for beta2 integrin-mediated migration which is a prerequisite for efficient PMN recruitment in vivo...
  3. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
    ..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
  4. ncbi request reprint The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
    Blood 108:3919-27. 2006
    ..These findings indicate that Syk is critical for beta(2) integrin-mediated neutrophil migration in vitro and plays a fundamental role in neutrophil recruitment during the inflammatory response in vivo...
  5. doi request reprint The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions
    Ingrid Hepper
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Immunol 188:4590-601. 2012
    ..In conclusion, mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation...
  6. ncbi request reprint A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo
    Jurgen Schymeinsky
    Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    Blood 114:4209-20. 2009
    ..These unanticipated results define mAbp1 as a novel molecular player in integrin biology that is critical for phagocytosis and firm neutrophil adhesion under flow conditions...
  7. doi request reprint Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis
    Ludwig T Weckbach
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Heart Circ Physiol 303:H429-38. 2012
    ..01). These unanticipated results identified endothelial cells as the source of soluble MK in the vascular system during hypoxia and defined MK as a pivotal player of angiogenesis during ischemia in nonmalignant tissue...
  8. ncbi request reprint Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Thromb Haemost 98:262-73. 2007
    ....
  9. ncbi request reprint The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    J Cell Physiol 204:614-22. 2005
    ..Taken together, our data suggest a novel role for Syk in the maintenance of a bipolar phenotype by regulating lamellipodium formation, which is a critical prerequisite for site-directed migration of leukocytes...
  10. doi request reprint Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response
    Sascha M Jakob
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Blood 121:4184-94. 2013
    ..In summary, our results indicate that HPK1 is critically involved in LFA-1-mediated PMN trafficking during acute inflammation...
  11. doi request reprint The mammalian actin-binding protein 1 (mAbp1): a novel molecular player in leukocyte biology
    Jurgen Schymeinsky
    Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Trends Cell Biol 21:247-55. 2011
    ..Here, we review the current understanding of the molecular and cellular functions of mAbp1 with a focus on its impact in leukocyte biology...
  12. ncbi request reprint The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice
    Ruth Schruefer
    Department of Physiology, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 43:1-11. 2006
    ..Thus, PMN infiltration seems to facilitate inflammation-mediated angiogenesis which may be a consequence of the broad spectrum of proangiogenic factors expressed by these cells...
  13. doi request reprint Intraluminal crawling versus interstitial neutrophil migration during inflammation
    Robert Pick
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany
    Mol Immunol 55:70-5. 2013
    ..In this review, we will focus on the molecular mechanisms that control and fine-tune these migratory processes and discuss the role of adhesion molecules of the β2 integrin (CD11/CD18) family for these cellular functions...
  14. ncbi request reprint Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo
    Hanna Mannell
    Institute of Physiology, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 45:153-63. 2008
    ..Thus, SHP-2 exhibits a pivotal role in angiogenesis and may represent an interesting target for therapeutic approaches controlling vessel growth...
  15. ncbi request reprint Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8
    Ruth Schruefer
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstrasse 44, D 80336 Munich, Germany
    Am J Physiol Heart Circ Physiol 288:H1186-92. 2005
    ..These findings suggest that bacteria-derived tripeptides stimulate human PMN to release VEGF and IL-8, which activate endothelial cells and induce angiogenesis by a paracrine feedforward mechanism involving endothelial IL-8 upregulation...
  16. ncbi request reprint Identification of caspase-10 in human neutrophils and its role in spontaneous apoptosis
    Friederike Goepel
    Department of Physiology, Freie Universitat, Berlin, Germany
    J Leukoc Biol 75:836-43. 2004
    ..This finding may reveal that PMN apoptosis in different (patho-) physiological settings results from distinct molecular mechanisms...
  17. doi request reprint Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    Konstantin Stark
    Medizinische Klinik und Poliklinik I, Klinikum der Universitat, Ludwig Maximilians Universität and Deutsches Herzzentrum München, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 14:41-51. 2013
    ..Hence, our results identify a previously unknown role for NG2(+) pericytes as an active component of innate immune responses, which supports the immunosurveillance and effector function of extravasated neutrophils and macrophages...
  18. ncbi request reprint A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils
    Thomas Willeke
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Germany
    J Leukoc Biol 74:260-9. 2003
    ..Altogether, this suggests that Syk-kinase controls alternation of beta(2) integrin-mediated ligand binding with integrin detachment...