Klaus von der Mark

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054 Erlangen, Germany
    Matrix Biol 27:693-9. 2008
  2. pmc BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054, Erlangen, Germany
    Histochem Cell Biol 127:183-94. 2007
  3. doi request reprint Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix
    Klaus von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University at Erlangen Nuremberg, Germany
    Cell Tissue Res 339:131-53. 2010
  4. doi request reprint Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation
    Svitlana Golovchenko
    Dept of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    Bone 55:102-12. 2013
  5. doi request reprint Ucma is not necessary for normal development of the mouse skeleton
    Nicole Eitzinger
    Department of Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Bone 50:670-80. 2012
  6. doi request reprint Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue
    Patricia Klinger
    Department of Orthopaedic Trauma Surgery, University Erlangen Nuremberg and University Hospital Erlangen, Erlangen, Germany
    Arthritis Rheum 63:2721-31. 2011
  7. ncbi request reprint A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054, Germany
    Matrix Biol 23:309-22. 2004
  8. ncbi request reprint Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 283:7082-93. 2008
  9. ncbi request reprint Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo
    Martina Schmidl
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 281:31790-800. 2006
  10. doi request reprint Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Germany
    J Cell Sci 122:3627-37. 2009

Collaborators

Detail Information

Publications32

  1. pmc Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054 Erlangen, Germany
    Matrix Biol 27:693-9. 2008
    ..The BAC-Col10-Cre lines should thus provide a valuable tool to get further insight into the role of genes involved in endochondral ossification by allowing their specific deletion in the hypertrophic zone of the growth plate...
  2. pmc BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054, Erlangen, Germany
    Histochem Cell Biol 127:183-94. 2007
    ..The Col10a1 specific BAC recombination vector described here will enable the specific analysis of effector gene functions in hypertrophic cartilage during skeletal development, endochondral ossification, and fracture callus healing...
  3. doi request reprint Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix
    Klaus von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University at Erlangen Nuremberg, Germany
    Cell Tissue Res 339:131-53. 2010
    ..The new technologies allowing the construction of a geometrically defined microenvironment for cells at the nanoscale should facilitate the investigation of nanotopography-dependent mechanisms of integrin-mediated cell signaling...
  4. doi request reprint Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation
    Svitlana Golovchenko
    Dept of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    Bone 55:102-12. 2013
    ....
  5. doi request reprint Ucma is not necessary for normal development of the mouse skeleton
    Nicole Eitzinger
    Department of Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Bone 50:670-80. 2012
    ....
  6. doi request reprint Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue
    Patricia Klinger
    Department of Orthopaedic Trauma Surgery, University Erlangen Nuremberg and University Hospital Erlangen, Erlangen, Germany
    Arthritis Rheum 63:2721-31. 2011
    ..To investigate the effect of chondromodulin 1 on the phenotype of osteochondral progenitor cells in cartilage repair tissue...
  7. ncbi request reprint A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054, Germany
    Matrix Biol 23:309-22. 2004
    ..These established transgenic lines should facilitate the genetic analysis of regulatory pathways of chondrocyte maturation and Col10a1 gene expression in the future...
  8. ncbi request reprint Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 283:7082-93. 2008
    ..These findings suggest that Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface...
  9. ncbi request reprint Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo
    Martina Schmidl
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 281:31790-800. 2006
    ..The data suggest that TSG is an important modulator of BMP-regulated cartilage development and chondrocyte differentiation...
  10. doi request reprint Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Germany
    J Cell Sci 122:3627-37. 2009
    ..These results identify Wif-1 as a novel extracellular Wnt modulator in cartilage biology...
  11. doi request reprint Thrombospondin-1 prevents excessive ossification in cartilage repair tissue induced by osteogenic protein-1
    Kolja Gelse
    Department of Orthopaedic Trauma Surgery, University Hospital Erlangen, Erlangen, Germany
    Tissue Eng Part A 17:2101-12. 2011
    ..While OP-1 induces chondrogenesis of the ingrowing cells, TSP-1 prevents their further hypertrophic differentiation and prevents excessive endochondral ossification within the lesions...
  12. doi request reprint Stable subclones of the chondrogenic murine cell line MC615 mimic distinct stages of chondrocyte differentiation
    Cordula Surmann-Schmitt
    Department Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Biochem 108:589-99. 2009
    ..Thus, the newly established MC615 subclones may serve as a potent new tool for investigations on the regulation of chondrocyte differentiation and function...
  13. doi request reprint Narrow window in nanoscale dependent activation of endothelial cell growth and differentiation on TiO2 nanotube surfaces
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nano Lett 9:3157-64. 2009
    ..These findings indicate that fine-tuning of TiO(2) surfaces at nanoscale will be an essential parameter in optimizing endothelial cell and smooth muscle cell responses to vascular implants...
  14. doi request reprint Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis
    Kolja Gelse
    University Hospital Erlangen, Erlangen, Germany
    Arthritis Rheum 58:475-88. 2008
    ..To investigate the potential of transgene-activated periosteal cells for permanently resurfacing large partial-thickness cartilage defects...
  15. doi request reprint Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University of Erlangen Nuremberg, Glueckstrasse 5, 91054 Erlangen, Germany
    Small 8:98-107. 2012
    ....
  16. doi request reprint The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Zentrum für Molekulare Medizin, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Physiol 227:2207-16. 2012
    ..Conversely, CTGF does not interfere with Wif-1-dependent inhibition of Wnt signalling. These results indicate that Wif-1 may be a multifunctional modulator of signalling pathways in the cartilage compartment...
  17. pmc Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage
    Jung Park
    Dept Exp Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany Department of Pediatrics, Division of Molecular Pediatrics, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Biol Open 4:608-21. 2015
    ..These findings add to current concepts of chondrocyte-osteocyte lineages and give new insight into the complex cartilage-bone transition process in the growth plate. ..
  18. doi request reprint Electric Field-Induced Osteogenic Differentiation on TiO2 Nanotubular Layer
    Jung Park
    1 Division of Molecular Pediatrics, Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Tissue Eng Part C Methods 22:809-21. 2016
    ....
  19. doi request reprint Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking
    Takako Sasaki
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany Department of Biochemistry II, Faculty of Medicine, Oita University, Oita 879 5593, Japan Electronic address
    Matrix Biol 50:53-66. 2016
    ..The finding suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase which has a pivotal role in cross-linking of collagen and elastin. ..
  20. ncbi request reprint Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer
    Silvia Riemer
    Department of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    J Cell Biochem 86:688-99. 2002
    ..These results indicate the presence of a PTH/PTHrP responsive element in the human COL10A1 enhancer, which may be represented by multiple putative AP-1 sites located in this region...
  21. doi request reprint Covalent functionalization of TiO2 nanotube arrays with EGF and BMP-2 for modified behavior towards mesenchymal stem cells
    Sebastian Bauer
    Department of Materials Science, WW4 LKO, Friedrich Alexander University of Erlangen Nuremberg, Martensstrasse 7, D 91058 Erlangen, Germany
    Integr Biol (Camb) 3:927-36. 2011
    ..This demonstrates that the strong diameter dependence on cell activity in the range between 15 and 100 nm observed in prior work can be compensated by coating of the nanotube surfaces with EGF...
  22. ncbi request reprint Sustained delivery of therapeutic concentrations of human clotting factor IX--a comparison of adenoviral and AAV vectors administered in utero
    Holm Schneider
    Children s Hospital, University of Erlangen Nuernberg, Germany
    J Gene Med 4:46-53. 2002
    ....
  23. doi request reprint Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa
    Takako Sasaki
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany Department of Biochemistry II, Faculty of Medicine, Oita University, Oita 879 5593, Japan Electronic address
    Matrix Biol 56:132-149. 2016
    ....
  24. ncbi request reprint Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms
    Helga von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    J Mol Biol 371:1188-203. 2007
    ..In conclusion, specific surface epitopes containing charged and hydrophobic residues are essential for ligand binding and define specific interactions with laminin isoforms...
  25. ncbi request reprint Nanosize and vitality: TiO2 nanotube diameter directs cell fate
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Germany
    Nano Lett 7:1686-91. 2007
    ..Thus, on a TiO2 nanotube surface, a lateral spacing geometry with openings of 30-50 nm represents a critical borderline for cell fate...
  26. doi request reprint Protein interactions with layers of TiO2 nanotube and nanopore arrays: Morphology and surface charge influence
    Mukta Kulkarni
    Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia Department of Materials Science and Engineering, WW4 LKO, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Biomater 45:357-366. 2016
    ....
  27. doi request reprint A dual role for UCMA in osteoarthritis-Inhibition of aggrecanases and promotion of bone turnover
    Michael Stock
    Department of Internal Medicine 3 Rheumatology and Immunology, Friedrich Alexander University Erlangen Nürnberg FAU and Universitätsklinikum Erlangen, Erlangen, Germany
    Arthritis Rheumatol . 2017
    ..How these processes are interlinked is however incompletely understood to date. Here, we investigate the mechanistic role of the cartilage-derived protein UCMA in osteoarthritis-related cartilage and bone changes...
  28. pmc Annexin A5 is not essential for skeletal development
    Bent Brachvogel
    Universitat Erlangen Nurnberg, Nikolaus Fiebiger Zentrum, Experimentelle Medizin I, Erlangen, Germany
    Mol Cell Biol 23:2907-13. 2003
    ....
  29. ncbi request reprint Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells
    Kolja Gelse
    University of Erlangen Nuernberg, Erlangen, Germany
    Arthritis Rheum 48:430-41. 2003
    ..To investigate the repair of partial-thickness lesions in rat articular cartilage by combining cell transplantation with transfer of growth factor complementary DNA (cDNA)...
  30. pmc Gene expression analysis of ischaemia and reperfusion in human microsurgical free muscle tissue transfer
    Adrian Dragu
    Department of Plastic and Hand Surgery, Friedrich Alexander University of Erlangen Nurnberg, University Hospital, Erlangen, Germany
    J Cell Mol Med 15:983-93. 2011
    ..When inflammatory and apoptotic proteins are expressed at high levels, flap damage might occur and flap loss is likely. The sole expression on mRNA level might explain why flap loss is unlikely...
  31. ncbi request reprint Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family
    Bent Brachvogel
    Department of Experimental Medicine I, Friedrich Alexander University Erlangen Nuremberg, Glueckstrasse 6, Germany
    Gene 288:203-10. 2002
    ..5-week-old mice. These data indicate a correlation between testase 4 expression and spermatogenesis and/or fertilization...
  32. ncbi request reprint c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1
    Birgit M Jehn
    Friedrich Alexander University, Erlangen Nuremberg, Department of Experimental Medicine I, 91054 Erlangen, Germany
    J Biol Chem 277:8033-40. 2002
    ..Our data suggest a regulatory mechanism down-regulating Notch1 protein levels already at the cellular surface, possibly with consequences for Notch-dependent signal transduction during terminal differentiation processes...