R Voll

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases
    Reinhard E Voll
    IZKF Research Group 2, Nikolaus Fiebiger Center, Glückstrasse 6, 91054 Erlangen, Germany
    Curr Rheumatol Rep 10:341-2. 2008
  2. pmc Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE
    Vilma Urbonaviciute
    Interdisciplinary Center of Clinical Research IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    J Exp Med 205:3007-18. 2008
  3. pmc Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
    Barbara G Fürnrohr
    Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 69:1983-9. 2010
  4. ncbi request reprint High mobility group box 1 in the pathogenesis of inflammatory and autoimmune diseases
    Reinhard E Voll
    IZKF Research Group 2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Erlangen, Germany
    Isr Med Assoc J 10:26-8. 2008
  5. doi request reprint [Depletion of plasma cells - a novel strategy in the therapy of systemic lupus erythematosus in mice and man]
    R Voll
    Nikolaus Fiebiger Zentrum, IZKF N2 und Medizinische Klinik 3, Universitat Erlangen Nurnberg, Glückstr 6, 91054 Erlangen
    Z Rheumatol 68:150-3. 2009
  6. ncbi request reprint Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-beta1-induced down-regulation of leukocyte/endothelial cell adhesion
    F Roedel
    Department of Radiooncology, University of Erlangen Nuremberg, Universitätstrasse 27, D 91054 Erlangen, Germany
    Int J Radiat Biol 78:711-9. 2002
  7. ncbi request reprint Clearance deficiency and systemic lupus erythematosus (SLE)
    Udo S Gaipl
    Institute for Clinical Immunology, Department of Internal Medicine 3, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    J Autoimmun 28:114-21. 2007
  8. doi request reprint Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    Luis E Munoz
    University Hospital of Erlangen, Department of Radiation Oncology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:1733-42. 2009
  9. ncbi request reprint Defects in the disposal of dying cells lead to autoimmunity
    Udo S Gaipl
    Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    Curr Rheumatol Rep 6:401-7. 2004
  10. ncbi request reprint Blastic CD56+ natural killer-cell lymphoma with primary cutaneous manifestation
    Thomas G Berger
    Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany
    Acta Derm Venereol 84:53-6. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases
    Reinhard E Voll
    IZKF Research Group 2, Nikolaus Fiebiger Center, Glückstrasse 6, 91054 Erlangen, Germany
    Curr Rheumatol Rep 10:341-2. 2008
  2. pmc Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE
    Vilma Urbonaviciute
    Interdisciplinary Center of Clinical Research IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    J Exp Med 205:3007-18. 2008
    ..In conclusion, HMGB1-nucleosome complexes activate antigen presenting cells and, thereby, may crucially contribute to the pathogenesis of SLE via breaking the immunological tolerance against nucleosomes/dsDNA...
  3. pmc Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
    Barbara G Fürnrohr
    Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 69:1983-9. 2010
    ..Heat shock proteins (Hsps) play a role in the delivery and presentation of antigenic peptides and are thought to be involved in the pathogenesis of multifactorial diseases...
  4. ncbi request reprint High mobility group box 1 in the pathogenesis of inflammatory and autoimmune diseases
    Reinhard E Voll
    IZKF Research Group 2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Erlangen, Germany
    Isr Med Assoc J 10:26-8. 2008
    ..However, investigations of blood concentrations of HMGB1 and its relevance in human diseases are hindered by the lack of reliable routine test systems...
  5. doi request reprint [Depletion of plasma cells - a novel strategy in the therapy of systemic lupus erythematosus in mice and man]
    R Voll
    Nikolaus Fiebiger Zentrum, IZKF N2 und Medizinische Klinik 3, Universitat Erlangen Nurnberg, Glückstr 6, 91054 Erlangen
    Z Rheumatol 68:150-3. 2009
    ..These novel therapies may improve the future treatment of SLE and other antibody-mediated diseases...
  6. ncbi request reprint Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-beta1-induced down-regulation of leukocyte/endothelial cell adhesion
    F Roedel
    Department of Radiooncology, University of Erlangen Nuremberg, Universitätstrasse 27, D 91054 Erlangen, Germany
    Int J Radiat Biol 78:711-9. 2002
    ..To explore the role of inflammatory mediators in this process, we investigated the expression of Transforming growth factor beta(1) (TGF-beta(1)) and Interleukin 6 (IL-6) after LD-RT...
  7. ncbi request reprint Clearance deficiency and systemic lupus erythematosus (SLE)
    Udo S Gaipl
    Institute for Clinical Immunology, Department of Internal Medicine 3, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    J Autoimmun 28:114-21. 2007
    ..We conclude that impaired clearance in early phases of apoptosis leads to a secondary necrotic status of the cells. Danger signals are released; modified autoantigens are accessible, favouring an autoimmune reaction...
  8. doi request reprint Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    Luis E Munoz
    University Hospital of Erlangen, Department of Radiation Oncology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:1733-42. 2009
    ..The aim of this study was to investigate whether the remnants of apoptotic cells are involved in the induction of inflammatory cytokines in blood-borne phagocytes...
  9. ncbi request reprint Defects in the disposal of dying cells lead to autoimmunity
    Udo S Gaipl
    Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    Curr Rheumatol Rep 6:401-7. 2004
    ..Last but not least, the character and origin of clearance defects observed in some systemic lupus erythematosus patients is presented...
  10. ncbi request reprint Blastic CD56+ natural killer-cell lymphoma with primary cutaneous manifestation
    Thomas G Berger
    Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany
    Acta Derm Venereol 84:53-6. 2004
    ..Complicated of tuberculosis, the patient died within 9 months of diagnosis, despite aggressive polychemotherapy...
  11. ncbi request reprint Exposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal--implications for antiphospholipid syndrome and systemic lupus erythematosus
    Udo S Gaipl
    Institute for Clinical Immunology and Rheumatology, Department of Internal Medicine III, Erlangen, Germany
    Immunobiology 207:73-81. 2003
    ..In addition, accumulation of uncleared apoptotic debris in the germinal centres of lymph nodes may result in the survival of autoreactive B cells...
  12. ncbi request reprint Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis
    Vilma Urbonaviciute
    IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    Autoimmunity 42:305-7. 2009
    ..Also HMGB1 in plasma of patients with systemic lupus was reversibly oxidized. In conclusion, HMGB1 undergoes reversible oxidative modifications at cysteine residues during cell death, which may modulate its biological properties...
  13. ncbi request reprint Involvement of phosphatidylserine, alphavbeta3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages
    Andrea Böttcher
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 54:927-38. 2006
    ..Multiple receptors involved in the clearance of apoptotic cells have been described; however, little is known about the receptors and ligands involved in uptake of necrotic cells that release autoantigens as well...
  14. ncbi request reprint Cooperation between C1q and DNase I in the clearance of necrotic cell-derived chromatin
    Udo S Gaipl
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 50:640-9. 2004
    ..We analyzed the role of C1q and DNase I in the disposal of necrotic cell-derived chromatin because deficiencies in these serum factors predispose to the development of systemic autoimmune disorders, such as systemic lupus erythematosus...
  15. ncbi request reprint Apoptosis and systemic lupus erythematosus
    Ahmed Sheriff
    Institute for Clinical Immunology and Rheumatology, Medical Department III, University of Erlangen Nuremberg, Glueckstrasse 4a, 91054 Erlangen, Germany
    Rheum Dis Clin North Am 30:505-27, viii-ix. 2004
    ..Reflecting on the plethora of defects of clearance of apoptotic material already demonstrated in systemic lupus erythematosus, it is reasonable to argue that, for many patients, failure of clearance is at the heart of their disease...
  16. ncbi request reprint Impaired clearance of dying cells in systemic lupus erythematosus
    Udo S Gaipl
    Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    Autoimmun Rev 4:189-94. 2005
    ..We conclude that a failure of clearance in the early phase of apoptosis leads to a secondary necrotic status of the cells. Danger signals are released, modified autoantigens are accessible, and an autoimmune reaction gets started...
  17. ncbi request reprint Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    Irith Baumann
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 46:191-201. 2002
    ..To investigate the fate of apoptotic cells in the germinal centers (GCs) of patients with systemic lupus erythematosus (SLE)...
  18. doi request reprint Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
    Kristin Kruse
    Department for Internal Medicine 3, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Apoptosis 15:1098-113. 2010
    ..Up to date knowledge about these key elements may provide new insights that lead to the development of new treatment strategies of the disease...
  19. doi request reprint The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    Kirsten Neubert
    Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
    Nat Med 14:748-55. 2008
    ..Hence, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-mediated diseases...
  20. pmc Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells
    Silke Meister
    IZKF N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Neoplasia 12:550-61. 2010
    ..Thus, the combination of bortezomib with verapamil may improve the efficacy of proteasome inhibitory therapy...
  21. ncbi request reprint Impaired clearance of apoptotic cells in systemic lupus erythematosus: challenge of T and B cell tolerance
    Susanne Kuenkele
    Institute for Clinical Immunology and Rheumatology, Department of Internal Medicine III, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Curr Rheumatol Rep 5:175-7. 2003
  22. ncbi request reprint The CFSE distribution assay is a powerful technique for the analysis of radiation-induced cell death and survival on a single-cell level
    Franz Rodel
    Department of Radiooncology, University of Erlangen Nuremberg, Erlangen, Germany
    Strahlenther Onkol 181:456-62. 2005
    ..Here it is reported, that labeling of cells with 5-(and 6-)carboxyfluorescein diacetate succinimidyl ester (CFDASE) can be used as a highly sensitive assay to determine cellular response toward irradiation on a single-cell level...
  23. ncbi request reprint Do we need new treatment that goes beyond tumor necrosis factor blockers for rheumatoid arthritis?
    Reinhard E Voll
    Department of Internal Medicine III, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Ann N Y Acad Sci 1051:799-810. 2005
    ....
  24. ncbi request reprint Factors masking HMGB1 in human serum and plasma
    Vilma Urbonaviciute
    IZKF Research Group 2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nurnberg, and Department of Internal Medicine 3, University Hospital Erlangen, Germany
    J Leukoc Biol 81:67-74. 2007
    ..These HMGB1 interacting proteins are currently characterized and may contribute to complex formation, masking, and possibly, modulation of cytokine activity of HMGB1...
  25. ncbi request reprint Interaction of histones with phospholipids--implications for the exposure of histones on apoptotic cells
    Barbara G Fürnrohr
    IZKF Research Group 2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Erlangen, Germany
    Autoimmunity 40:322-6. 2007
    ..Moreover, histones/nucleosomes complexed to uningested apoptotic membrane structures may foster autoimmunity towards nuclear compounds...
  26. ncbi request reprint Sensitive detection of plasma/serum DNA in patients with systemic lupus erythematosus
    Justin A Chen
    Yale University School of Medicine, New Haven, CT, USA
    Autoimmunity 40:307-10. 2007
    ..To optimize the use of the fluorochromic PicoGreen assay for the sensitive detection and quantification of double stranded (ds) DNA in plasma/serum samples of patients with systemic lupus erythematosus (SLE)...
  27. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    ..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism...
  28. pmc Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    Attilio Bondanza
    Clinical Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Exp Med 200:1157-65. 2004
    ..Finally, AxV-coupled irradiated cells induced the regression of growing tumors. These data indicate that endogenous adjuvants that bind to dying tumor cells can be exploited to target tumors for immune rejection...
  29. ncbi request reprint Disposal of dying cells: a balancing act between infection and autoimmunity
    Udo S Gaipl
    Arthritis Rheum 48:6-11. 2003
  30. ncbi request reprint Apoptotic cells selectively suppress the Th1 cytokine interferon gamma in stimulated human peripheral blood mononuclear cells and shift the Th1/Th2 balance towards Th2
    Irute Girkontaite
    Institute of Immunology, University of Vilnius, Vilnius, Lithuania
    Autoimmunity 40:327-30. 2007
    ..This Th2 shift can largely be prevented by neutralizing IL-10, indicating an important role of this cytokine for modulating T cell cytokine secretion patterns...