Olaf Utermöhlen

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc Simian virus 40 large-T-antigen-specific rejection of mKSA tumor cells in BALB/c mice is critically dependent on both strictly tumor-associated, tumor-specific CD8(+) cytotoxic T lymphocytes and CD4(+) T helper cells
    O Utermohlen
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
    J Virol 75:10593-602. 2001
  2. ncbi request reprint Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase
    Olaf Utermöhlen
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center of the University of Cologne, Cologne, Germany
    J Immunol 170:2621-8. 2003
  3. doi request reprint Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes
    Jasmin Herz
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Germany
    Nat Immunol 10:761-8. 2009
  4. pmc Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
    Alexey Popov
    Molecular Tumor Biology and Tumor Immunology at the Clinic I for Internal Medicine, University of Cologne, Cologne, Germany
    J Clin Invest 116:3160-70. 2006
  5. doi request reprint Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes
    Michael Schramm
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Eur J Immunol 44:728-41. 2014
  6. doi request reprint Acid sphingomyelinase is required for efficient phago-lysosomal fusion
    Michael Schramm
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Centre of the University of Cologne, Cologne, Germany
    Cell Microbiol 10:1839-53. 2008
  7. ncbi request reprint Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
    Nikola Baschuk
    Institute for Medical Microbiology, Immunology und Hygiene, Medical Center of the University of Cologne, 50935, Cologne, Germany
    Cancer Immunol Immunother 56:1625-36. 2007
  8. pmc Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression
    Katussevani Bernardo
    Institute for Medical Microbiology, Immunology, and Hygiene, Medical Center, University of Cologne, Cologne, Germany
    Antimicrob Agents Chemother 48:546-55. 2004
  9. doi request reprint Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes
    Lukas P Frenzel
    Institute for Neurophysiology, University of Cologne, Cologne, Germany
    Stem Cells 27:307-16. 2009
  10. ncbi request reprint Activated virus-specific T cells are early indicators of anti-CMV immune reactions in liver transplant patients
    Christine Benz
    Department of Gastroenterology, Institute of Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany
    Gastroenterology 122:1201-15. 2002

Collaborators

Detail Information

Publications25

  1. pmc Simian virus 40 large-T-antigen-specific rejection of mKSA tumor cells in BALB/c mice is critically dependent on both strictly tumor-associated, tumor-specific CD8(+) cytotoxic T lymphocytes and CD4(+) T helper cells
    O Utermohlen
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
    J Virol 75:10593-602. 2001
    ..However, despite the support of CD4(+) T helper cells, the tumor-specific CTL response is so weak that only at the site of tumor cell inoculation and not in the spleen or in the regional lymph nodes can TAg-specific CTL be detected...
  2. ncbi request reprint Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase
    Olaf Utermöhlen
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center of the University of Cologne, Cologne, Germany
    J Immunol 170:2621-8. 2003
    ..monocytogenes in vitro. The results of this study suggest that ASMase is crucially required for the intracellular control of L. monocytogenes in macrophages and granulocytes by nonoxidative mechanisms...
  3. doi request reprint Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes
    Jasmin Herz
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Germany
    Nat Immunol 10:761-8. 2009
    ..In ASMase-KO CD8+ T cells, the contraction of secretory granules was markedly impaired. Thus, ASMase is required for contraction of secretory granules and expulsion of cytotoxic effector molecules...
  4. pmc Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
    Alexey Popov
    Molecular Tumor Biology and Tumor Immunology at the Clinic I for Internal Medicine, University of Cologne, Cologne, Germany
    J Clin Invest 116:3160-70. 2006
    ..These findings place IDO(+) DCs not only at the intersection of innate and adaptive immunity but also at the forefront of bacterial containment in granulomatous infections...
  5. doi request reprint Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes
    Michael Schramm
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Eur J Immunol 44:728-41. 2014
    ..Our results suggest that acute riboflavin deficiency immediately impairs priming of Nox2, which is of crucial relevance for an effective phagocytic immune response in vivo. ..
  6. doi request reprint Acid sphingomyelinase is required for efficient phago-lysosomal fusion
    Michael Schramm
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Centre of the University of Cologne, Cologne, Germany
    Cell Microbiol 10:1839-53. 2008
    ..The results of this study suggest that ASMase is required for the proper fusion of late phagosomes with lysosomes, which is crucial for efficient transfer of lysosomal antibacterial hydrolases into phagosomes...
  7. ncbi request reprint Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
    Nikola Baschuk
    Institute for Medical Microbiology, Immunology und Hygiene, Medical Center of the University of Cologne, 50935, Cologne, Germany
    Cancer Immunol Immunother 56:1625-36. 2007
    ..The data suggest that endogenous IL-4 can suppress the generation of CD8+ CTL expressing cytotoxic effector molecules especially when the antigen induces only a very weak CTL response...
  8. pmc Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression
    Katussevani Bernardo
    Institute for Medical Microbiology, Immunology, and Hygiene, Medical Center, University of Cologne, Cologne, Germany
    Antimicrob Agents Chemother 48:546-55. 2004
    ..aureus is especially sensitive to the inhibition of protein synthesis by linezolid, which should be an advantage in the treatment of infections with toxin-producing S. aureus...
  9. doi request reprint Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes
    Lukas P Frenzel
    Institute for Neurophysiology, University of Cologne, Cologne, Germany
    Stem Cells 27:307-16. 2009
    ..These data suggest that in the course of differentiation ESCM acquire resistance to NK cell-mediated lysis by downregulating the expression of ligands required for activation of NK cell cytotoxicity...
  10. ncbi request reprint Activated virus-specific T cells are early indicators of anti-CMV immune reactions in liver transplant patients
    Christine Benz
    Department of Gastroenterology, Institute of Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany
    Gastroenterology 122:1201-15. 2002
    ..Because cytotoxic T cells (CTLs) are crucial for the immune control of CMV, analysis of virus-specific CTLs could contribute to diagnosis and management of CMV infection...
  11. doi request reprint Immunologic hurdles of therapeutic stem cell transplantation
    Olaf Utermöhlen
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, D 50935 Cologne, Germany
    Biol Chem 390:977-83. 2009
    ....
  12. doi request reprint Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses
    Olaf Utermöhlen
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
    Immunobiology 213:307-14. 2008
    ..In light of the biochemical and biophysical properties of ceramide, we provide a model suggesting that ASMase regulates select vesicular fusion processes by modifying the steric conformation of cellular membranes...
  13. doi request reprint Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice
    Kristin Jakobshagen
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Am J Pathol 185:3025-38. 2015
    ..This study documents a physiological role of Il10 in the regulation of a balanced T-cell response limiting immunopathological damage. ..
  14. doi request reprint Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
    Benjamin Yazdanpanah
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Nature 460:1159-63. 2009
    ..The results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase...
  15. ncbi request reprint Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL
    Zeinab Abdullah
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
    J Immunol 178:3390-9. 2007
    ....
  16. doi request reprint Dual role of B cells with accelerated onset but reduced disease activity in P0₁₀₆₋₁₂₅-induced experimental autoimmune neuritis of IgH ⁰(/)⁰ mice
    Anna Brunn
    Department of Neuropathology, University Hospital of Cologne, Germany
    Acta Neuropathol 120:667-81. 2010
    ..e. suppressive and enhancing, role during induction and at height of EAN, respectively. The combined interaction of B cells as well as CD4(+) and CD8(+) T cells is required for the development of EAN...
  17. ncbi request reprint Regulation of the inflammatory response to Staphylococcus aureus-induced brain abscess by interleukin-10
    Werner Stenzel
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    J Neuropathol Exp Neurol 64:1046-57. 2005
    ..Collectively, these data outline the important role of IL-10 in vivo for the regulation of the IC host immune response in experimental S. aureus-induced brain abscess...
  18. pmc Accelerated wound closure in mice deficient for interleukin-10
    Sabine A Eming
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 170:188-202. 2007
    ..These results show for the first time that IL-10 can impede wound repair...
  19. pmc CD4 T cells mediate axonal damage and spinal cord motor neuron apoptosis in murine p0106-125-induced experimental autoimmune neuritis
    Anna Brunn
    Abteilung für Neuropathologie, Universitätsklinikum Köln, Kerpener Str 62, D 50924 Koln, Germany
    Am J Pathol 173:93-105. 2008
    ..In conclusion, P0(106-125)-induced experimental autoimmune neuritis is a CD4 T cell-mediated autoimmune disease that affects both the peripheral and central nervous systems...
  20. ncbi request reprint XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Blood 108:3434-40. 2006
    ..The results suggest that XIAP targeting by Smac agonists or XIAP-siRNA can be used as a synergistic strategy for cellular immunotherapy of Hodgkin lymphoma...
  21. doi request reprint Costimulatory molecule CD40 is essential for myelin protein 0 peptide 106-125-induced experimental autoimmune neuritis in mice
    Anna Brunn
    From the Department of Neuropathology, University Hospital of Cologne AB, MM, LS, ZF, As, MC, MM R, MD Institute for Medical Microbiology, Immunology, and Hygiene, Medical Center, University of Cologne OU and Center for Molecular Medicine OU, Cologne, Germany
    J Neuropathol Exp Neurol 73:454-66. 2014
    ..Thus, these experiments highlight the crucial role of CD40 as an important costimulatory molecule in EAN and suggest that it has potential as a therapeutic target in human neuritis. ..
  22. doi request reprint Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function
    Katharina Dannhausen
    Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany
    Biochem Biophys Res Commun 464:434-40. 2015
    ..In conclusion, the aSMase-deficient mouse is the first example in which microglial lipid inclusions are directly related to a loss of retinal function...
  23. pmc Strain-specific association of cytotoxic activity and virulence of clinical Staphylococcus aureus isolates
    Oleg Krut
    Institute for Medical Microbiology, Immunology, and Hygiene, Medical Center University of Cologne, 50935 Cologne, Germany
    Infect Immun 71:2716-23. 2003
    ..The results of our study unravel a previously unrecognized dichotomy of cytotoxic and noncytotoxic S. aureus isolates, which may play an important role in the dissemination of, and mortality induced by, S. aureus infection...
  24. pmc Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak
    Diana Corogeanu
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Cologne, Germany
    BMC Microbiol 12:160. 2012
    ....
  25. ncbi request reprint Survival of priceless cells: active and passive protection of embryonic stem cells against immune destruction
    Olaf Utermöhlen
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center of the University of Cologne, Cologne, Germany
    Arch Biochem Biophys 462:273-7. 2007
    ..These findings are discussed in view of their implications for using ES cell-derived transplants in regenerative medicine as well as for our understanding of early embryonic stages during invasion and implantation...