Jens Tyedmers

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Cellular strategies for controlling protein aggregation
    Jens Tyedmers
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D 69, 120 Heidelberg, Germany
    Nat Rev Mol Cell Biol 11:777-88. 2010
  2. pmc Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates
    Jens Tyedmers
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Prion 6:191-200. 2012
  3. doi request reprint Yeast as a model to understand mechanisms and consequences of protein modifications by metabolism derived toxic products
    J Tyedmers
    Center for Molecular Biology of the University of Heidelberg, DKFZ ZMBH Alliance, Germany
    Exp Clin Endocrinol Diabetes 120:179-81. 2012
  4. pmc Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
    Juliane Winkler
    Center for Molecular Biology of the University of Heidelberg and German Cancer Research Center, DKFZ ZMBH Alliance, Universitat Heidelberg, Heidelberg D 69120, Germany
    J Cell Biol 198:387-404. 2012
  5. doi request reprint Chaperone networks in protein disaggregation and prion propagation
    Juliane Winkler
    Center for Molecular Biology of the University of Heidelberg and German Cancer Research Center, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg D 69120, Germany
    J Struct Biol 179:152-60. 2012
  6. pmc Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae
    Harsha Garadi Suresh
    Center for Molecular Biology of the University of Heidelberg ZMBH and German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, D 69120 Heidelberg, Germany
    Mol Biol Cell 26:1601-15. 2015
  7. pmc Monitoring protein misfolding by site-specific labeling of proteins in vivo
    Tzung Yang Hsieh
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Deutsches Krebsforschungszentrum DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 9:e99395. 2014
  8. doi request reprint Coordination of translational control and protein homeostasis during severe heat stress
    Valeria Cherkasov
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Curr Biol 23:2452-62. 2013

Collaborators

  • Axel Mogk
  • Bernd Bukau
  • Howard Riezman
  • Juliane Winkler
  • Harsha Garadi Suresh
  • Tzung Yang Hsieh
  • Valeria Cherkasov
  • Wanda Kukulski
  • Aline Xavier da Silveira Dos Santos
  • Nadinath B Nillegoda
  • Gunter Kramer
  • Sarah Hofmann
  • Georg Stoecklin
  • Silke Druffel-Augustin

Detail Information

Publications8

  1. doi request reprint Cellular strategies for controlling protein aggregation
    Jens Tyedmers
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D 69, 120 Heidelberg, Germany
    Nat Rev Mol Cell Biol 11:777-88. 2010
    ..The organized aggregation of misfolded proteins might also allow their asymmetric distribution to daughter cells during cell division...
  2. pmc Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates
    Jens Tyedmers
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Prion 6:191-200. 2012
    ..Loss of the prion state is often characterized by reduced fragmentation of prion fibrils and fewer, larger aggregates...
  3. doi request reprint Yeast as a model to understand mechanisms and consequences of protein modifications by metabolism derived toxic products
    J Tyedmers
    Center for Molecular Biology of the University of Heidelberg, DKFZ ZMBH Alliance, Germany
    Exp Clin Endocrinol Diabetes 120:179-81. 2012
    ..Yeast has been used successfully to study the reaction of these toxic metabolites with proteins in vivo, which I will summarize with exemplified studies on 2 crucial reactions, protein carbonylation and protein glycation...
  4. pmc Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
    Juliane Winkler
    Center for Molecular Biology of the University of Heidelberg and German Cancer Research Center, DKFZ ZMBH Alliance, Universitat Heidelberg, Heidelberg D 69120, Germany
    J Cell Biol 198:387-404. 2012
    ..Our findings indicate a conserved mechanism of Hsp70-Hsp100 cooperation at the surface of protein aggregates and prion fibrils...
  5. doi request reprint Chaperone networks in protein disaggregation and prion propagation
    Juliane Winkler
    Center for Molecular Biology of the University of Heidelberg and German Cancer Research Center, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg D 69120, Germany
    J Struct Biol 179:152-60. 2012
    ....
  6. pmc Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae
    Harsha Garadi Suresh
    Center for Molecular Biology of the University of Heidelberg ZMBH and German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, D 69120 Heidelberg, Germany
    Mol Biol Cell 26:1601-15. 2015
    ....
  7. pmc Monitoring protein misfolding by site-specific labeling of proteins in vivo
    Tzung Yang Hsieh
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Deutsches Krebsforschungszentrum DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 9:e99395. 2014
    ..This experimental setup for the first time allows for the direct analysis of the folding state of a protein in living cells and may serve as valuable new tool for examining mechanisms of protein folding, misfolding and aggregation. ..
  8. doi request reprint Coordination of translational control and protein homeostasis during severe heat stress
    Valeria Cherkasov
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Curr Biol 23:2452-62. 2013
    ..How these two heat stress responses connect is unclear...