Andrea Tuettenberg

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint [Septic thrombosis of the cavernous sinus due to folliculitis]
    A Tuettenberg
    Universitätshautklinik Mainz
    Hautarzt 54:351-3. 2003
  2. ncbi request reprint Dendritic cell-based immunotherapy of malignant melanoma: success and limitations
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Dtsch Dermatol Ges 5:190-6. 2007
  3. doi request reprint CD40 signalling induces IL-10-producing, tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 19:44-53. 2010
  4. ncbi request reprint Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Int J Cancer 118:2617-27. 2006
  5. doi request reprint The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Immunol 182:3349-56. 2009
  6. ncbi request reprint Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC
    Andrea Tuettenberg
    Department of Dermatology, J Gutenberg University, Mainz, Germany
    J Immunol 172:1524-30. 2004
  7. doi request reprint Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells
    Susanne A Hahn
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Blood 122:1182-91. 2013
  8. ncbi request reprint Immune regulation by dendritic cells and T cells--basic science, diagnostic, and clinical application
    Andrea Tuettenberg
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Clin Lab 57:1-12. 2011
  9. ncbi request reprint Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    Exp Dermatol 16:171-8. 2007
  10. doi request reprint Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored after dendritic cell-based vaccination
    Anita Correll
    Department of Dermatology, Universitätsmedizin Mainz, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 19:e213-21. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint [Septic thrombosis of the cavernous sinus due to folliculitis]
    A Tuettenberg
    Universitätshautklinik Mainz
    Hautarzt 54:351-3. 2003
    ..The mainstays of therapy are heparinization and appropriate intravenous antibiotic therapy...
  2. ncbi request reprint Dendritic cell-based immunotherapy of malignant melanoma: success and limitations
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Dtsch Dermatol Ges 5:190-6. 2007
    ..These studies open a new way for "conditioning" of DC by TLRL and might significantly enhance the efficiency of DC-based melanoma vaccines in the future...
  3. doi request reprint CD40 signalling induces IL-10-producing, tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 19:44-53. 2010
    ..These data demonstrate that DC stimulated through CD40-CD40L interaction differentiate into tolerogenic DC with immunomodulatory function...
  4. ncbi request reprint Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Int J Cancer 118:2617-27. 2006
    ....
  5. doi request reprint The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Immunol 182:3349-56. 2009
    ..Taken together, these results indicate a crucial role for ICOS in the induction of peripheral tolerance maintained by tolerogenic DC mediated mostly via an IL-10-independent mechanism...
  6. ncbi request reprint Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC
    Andrea Tuettenberg
    Department of Dermatology, J Gutenberg University, Mainz, Germany
    J Immunol 172:1524-30. 2004
    ..These results have important implications for the use of genetically modified DC for therapeutic application...
  7. doi request reprint Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells
    Susanne A Hahn
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Blood 122:1182-91. 2013
    ....
  8. ncbi request reprint Immune regulation by dendritic cells and T cells--basic science, diagnostic, and clinical application
    Andrea Tuettenberg
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Clin Lab 57:1-12. 2011
    ....
  9. ncbi request reprint Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    Exp Dermatol 16:171-8. 2007
    ..Therefore, the therapeutic benefit of OMZ can be explained in part by its immunomodulating effects in the topical treatment of nasal inflammation...
  10. doi request reprint Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored after dendritic cell-based vaccination
    Anita Correll
    Department of Dermatology, Universitätsmedizin Mainz, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 19:e213-21. 2010
    ..These findings indicate that tumor progression in patients with melanoma result in general immunosuppression that is associated with Treg expansion in the periphery and can be overcome by DC-based vaccination...
  11. doi request reprint Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity
    Sandra Balkow
    Department of Dermatology, University of Mainz, Mainz, Germany
    Exp Dermatol 18:78-87. 2009
    ..These data indicate that maturation of DC with anti-CD40 plus IL-12 and IL-18 potently stimulates the generation of an anti-tumor immune response and may lead to improved immunotherapeutic capacity of DC vaccination...
  12. ncbi request reprint Dendritic cells: sentinels of immunity and tolerance
    Jan Kubach
    Department of Dermatology, University of Mainz, Germany
    Int J Hematol 81:197-203. 2005
    ..This brief review summarizes the current knowledge about the immunoregulatory role of DC as guardians for the induction of T-cell immunity and tolerance...
  13. pmc Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells
    Mario Hubo
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz Mainz, Germany
    Front Immunol 4:82. 2013
    ..Furthermore, we exemplarily describe protocols for the generation of two well-defined monocyte-derived DC subsets for their clinical use, immunogenic versus tolerogenic...
  14. doi request reprint Research in practice: Regulatory T cells - targets for therapeutic approaches?
    Helmut Jonuleit
    Department of Dermatology, University Medical Center Mainz, Germany
    J Dtsch Dermatol Ges 9:8-11. 2011
    ..Precise insight into the properties of Tregs may contribute to the development of innovative therapeutic approaches which directly affect Tregs in patients or use adoptive transfer of Tregs...
  15. ncbi request reprint Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy
    Andrea Tuettenberg
    Department of Dermatology and Research Center for Immunotherapy FZI University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Nanomedicine (Lond) 11:2735-2751. 2016
    ....
  16. doi request reprint Increased frequencies of CD11b(+) CD33(+) CD14(+) HLA-DR(low) myeloid-derived suppressor cells are an early event in melanoma patients
    Berenice M Rudolph
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 23:202-4. 2014
    ..T-cell proliferation assays revealed that MDSC critically contribute to suppressed antigen-specific T-cell reactivity and thus might explain the frequently observed transient effects of immunotherapeutic strategies in melanoma patients. ..
  17. pmc How Soluble GARP Enhances TGFβ Activation
    Sven Fridrich
    Cell and Matrix Biology, Institute of Zoology, JGU Mainz, Mainz, Germany
    PLoS ONE 11:e0153290. 2016
    ..TGFβ activation is enhanced by the non-covalent GARP-TGFβ complex already at low (nanomolar) concentrations, at which GARP alone does not show any effect. This supports the idea of soluble GARP acting as immune modulator in vivo. ..
  18. pmc Kinome Profiling of Regulatory T Cells: A Closer Look into a Complex Intracellular Network
    Andrea Tuettenberg
    Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 11:e0149193. 2016
    ....
  19. pmc A key role of GARP in the immune suppressive tumor microenvironment
    Susanne A Hahn
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Oncotarget 7:42996-43009. 2016
    ..Therefore, it may qualify as a promising target and a new checkpoint for cancer immunotherapy...
  20. pmc Diversity and recognition efficiency of T cell responses to cancer
    Tor B Stuge
    Division of Hematology, Department of Medicine, Stanford University, Stanford, California, USA
    PLoS Med 1:e28. 2004
    ..Understanding why vaccine-elicited responses are beneficial in some patients but not in others will be important to improve targeted cancer immunotherapies...