Jens Titze

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint Sodium sensing in the interstitium and relationship to hypertension
    Jens Titze
    Junior Research Group II, Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Curr Opin Nephrol Hypertens 19:385-92. 2010
  2. doi request reprint Water-free sodium accumulation
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Glückstrasse 6, Erlangen Nurnberg, Germany
    Semin Dial 22:253-5. 2009
  3. doi request reprint Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    Agnes Machnik
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 55:755-61. 2010
  4. doi request reprint Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats
    Agata Ziomber
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Glückstr 6, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 295:F1752-63. 2008
  5. ncbi request reprint Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats
    Markus Schafflhuber
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Am J Physiol Renal Physiol 292:F1490-500. 2007
  6. doi request reprint Water-free Na+ retention: interaction with hypertension and tissue hydration
    Jens Titze
    Department of Nephrology and Hypertension and Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Blood Purif 26:95-9. 2008
  7. pmc Agreement between 24-hour salt ingestion and sodium excretion in a controlled environment
    Kathrin Lerchl
    From the Interdisciplinary Center for Clinical Research K L, N R, U G, J T, Department of Nephrology and Hypertension A D, K U E, J T, and Department of Pediatrics M R, Friedrich Alexander University, Erlangen Nurnberg, Germany Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max Delbruck Center for Molecular Medicine, Berlin, Germany N R, F C L Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia M B, D F D Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany L B, B J State Scientific Center of Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia A A, I L, V B, B M, G V Fresenius Medical Care D GmbH, Bad Homburg, Germany P W, Montpellier
    Hypertension 66:850-7. 2015
  8. doi request reprint Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism
    Agnes Machnik
    Department of Nephrology and Hypertension, and Nikolaus Fiebiger Centre for Molecular Medicine, University Clinic and Friedrich Alexander University of Erlangen Nuremberg, Germany
    Nat Med 15:545-52. 2009
  9. pmc Quantitative assessment of muscle injury by (23)Na magnetic resonance imaging
    Anke Dahlmann
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Springerplus 5:661. 2016
  10. pmc Balancing wobbles in the body sodium
    Jens Titze
    Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Nephrol Dial Transplant 31:1078-81. 2016

Collaborators

Detail Information

Publications20

  1. doi request reprint Sodium sensing in the interstitium and relationship to hypertension
    Jens Titze
    Junior Research Group II, Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Curr Opin Nephrol Hypertens 19:385-92. 2010
    ....
  2. doi request reprint Water-free sodium accumulation
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Glückstrasse 6, Erlangen Nurnberg, Germany
    Semin Dial 22:253-5. 2009
    ..Besides the control of the body Na(+) content by the kidneys, redistribution of body electrolytes hence provides an extrarenal regulatory alternative in the maintenance of body fluid volume and blood pressure control...
  3. doi request reprint Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    Agnes Machnik
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 55:755-61. 2010
    ..Failure of this physiological extrarenal regulatory mechanism leads to a salt-sensitive blood pressure response...
  4. doi request reprint Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats
    Agata Ziomber
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Glückstr 6, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 295:F1752-63. 2008
    ..We conclude that excessive cellular electrolyte redistribution and/or intracellular Na(+) or Cl(-) accumulation may play an important role in the pathogenesis of salt-sensitive hypertension...
  5. ncbi request reprint Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats
    Markus Schafflhuber
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Am J Physiol Renal Physiol 292:F1490-500. 2007
    ....
  6. doi request reprint Water-free Na+ retention: interaction with hypertension and tissue hydration
    Jens Titze
    Department of Nephrology and Hypertension and Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Blood Purif 26:95-9. 2008
    ..Besides the control of the body Na(+) content by the kidneys, redistribution of body electrolytes hence provides an extrarenal regulatory alternative in the maintenance of body fluid volume and blood pressure control...
  7. pmc Agreement between 24-hour salt ingestion and sodium excretion in a controlled environment
    Kathrin Lerchl
    From the Interdisciplinary Center for Clinical Research K L, N R, U G, J T, Department of Nephrology and Hypertension A D, K U E, J T, and Department of Pediatrics M R, Friedrich Alexander University, Erlangen Nurnberg, Germany Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max Delbruck Center for Molecular Medicine, Berlin, Germany N R, F C L Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia M B, D F D Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany L B, B J State Scientific Center of Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia A A, I L, V B, B M, G V Fresenius Medical Care D GmbH, Bad Homburg, Germany P W, Montpellier
    Hypertension 66:850-7. 2015
    ..Repeated measurements of 24-hour UNaV improve precision. This knowledge could be relevant to patient care and the conduct of intervention trials. ..
  8. doi request reprint Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism
    Agnes Machnik
    Department of Nephrology and Hypertension, and Nikolaus Fiebiger Centre for Molecular Medicine, University Clinic and Friedrich Alexander University of Erlangen Nuremberg, Germany
    Nat Med 15:545-52. 2009
    ....
  9. pmc Quantitative assessment of muscle injury by (23)Na magnetic resonance imaging
    Anke Dahlmann
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Springerplus 5:661. 2016
    ..We now tested the utility of (23)Na-MRI technique in detecting and assessing sports-related acute muscular injury...
  10. pmc Balancing wobbles in the body sodium
    Jens Titze
    Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Nephrol Dial Transplant 31:1078-81. 2016
    ..We suggest that wobbles in expected outcomes can lead to novel clinical insights even with respect to banal salt questions. ..
  11. doi request reprint Skin sodium measured with ²³Na MRI at 7.0 T
    Peter Linz
    Interdisciplinary Center for Clinical Research, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nurnberg, Germany
    NMR Biomed 28:54-62. 2015
    ..0 T technology. The benefits of such improvements may have the potential to aid basic research and clinical applications designed to unlock questions regarding the Na(+) balance and Na(+) storage function of skin...
  12. doi request reprint Spooky sodium balance
    Jens Titze
    1 Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany 2 Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Kidney Int 85:759-67. 2014
    ..We are implementing (23)Na-magnetic resonance imaging (MRI) to pursue open questions on sodium balance in patients. Our findings could be relevant to therapeutic strategies for hypertension and target-organ damage...
  13. doi request reprint (23)Na magnetic resonance imaging of tissue sodium
    Christoph Kopp
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Hypertension 59:167-72. 2012
    ..We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible...
  14. doi request reprint Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance
    Natalia Rakova
    Interdisciplinary Center for Clinical Research, Friedrich Alexander University, Erlangen Nurnberg, Glückstrasse 6, D 91054 Erlangen, Germany
    Cell Metab 17:125-31. 2013
    ..Our findings define rhythmic Na(+) excretory and retention patterns independent of blood pressure or body water, which occur independent of salt intake...
  15. ncbi request reprint Salt and its effect on blood pressure and target organ damage: new pieces in an old puzzle
    Jens Titze
    Department of Nephrology and Hypertension, University of Erlangen, Erlangen, Germany
    J Nephrol 22:177-89. 2009
    ..Furthermore, salt promotes the secretion of cardiotonic steroids, i.e., mammalian "digitalis." Initial observations suggest a causal role for cardiotonic steroids in the genesis of cardiac abnormalities in advanced renal disease...
  16. ncbi request reprint Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 47:1101-7. 2006
    ..Extrarenal Na+ and volume balance seem to play an important role in long-term volume and MAP control...
  17. ncbi request reprint Internal sodium balance in DOCA-salt rats: a body composition study
    Jens Titze
    Forschungslabor der Medizinischen Klinik IV, Kreuzburger Strasse 2, 90471 Nürnberg, Germany
    Am J Physiol Renal Physiol 289:F793-802. 2005
    ..This "internal Na(+) escape" allows the maintenance of volume homeostasis despite increased total body Na(+)...
  18. doi request reprint Interstitial fluid homeostasis and pressure: news from the black box
    Jens Titze
    1 Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA 2 Junior Research Group 2, Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 84:869-71. 2013
    ..In this issue, Ebah and colleagues demonstrate a direct relationship between fluid overload and pressure in CKD patients. Surprise, instead of intravascular volume, interstitial fluids and pressures were measured. Finally! ..
  19. doi request reprint Cardiovascular and renal effects of high salt diet in GDNF+/- mice with low nephron number
    Julia Schlote
    Department of Pathology, IZKF Nachwuchsgruppe, Department of Nephrology and Hypertension, Department of Pediatrics, University of Erlangen Nurnberg, Germany
    Kidney Blood Press Res 37:379-91. 2013
    ..To test the suggested association of low nephron number and later development of renal and cardiovascular disease we investigated the effects of high sodium diet in heterozygous GDNF+/- mice...
  20. ncbi request reprint Bone mineral content and blood pressure: What is the pathophysiologic link?
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Hypertens 19:877-8. 2006