Peter Terness

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation
    Christian A Radu
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany
    Plast Reconstr Surg 119:2023-8. 2007
  2. pmc Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseases
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 105:18442-7. 2008
  3. ncbi Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?
    Peter Terness
    Institute of Immunology, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
    Blood 105:2480-6. 2005
  4. doi Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedside
    Peter Terness
    Institute of Immunology, University of Heidelberg, Department of Transplantation Immunology, Heidelberg, Germany
    Hum Immunol 70:506-12. 2009
  5. ncbi The immunoregulatory role of IDO-producing human dendritic cells revisited
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, INF 305, University of Heidelberg, 69120 Heidelberg, Germany
    Trends Immunol 27:68-73. 2006
  6. doi Melan-A/MART1 analog peptide triggers anti-myeloma T-cells through crossreactivity with HM1.24
    Olaf Christensen
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    J Immunother 32:613-21. 2009
  7. ncbi Inhibition of heart allograft rejection with mitomycin C-treated donor dendritic cells
    Lucian P Jiga
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:347-50. 2007
  8. doi Suppressive dendritic cells as a tool for controlling allograft rejection in organ transplantation: promises and difficulties
    Sandra Ehser
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 69:165-73. 2008
  9. ncbi Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in rats
    Daohu Wang
    Institute for Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:1537-40. 2006
  10. pmc Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma
    Sebastian Belle
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Eur J Haematol 81:26-35. 2008

Collaborators

Detail Information

Publications33

  1. ncbi Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation
    Christian A Radu
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany
    Plast Reconstr Surg 119:2023-8. 2007
    ..In this study, the authors applied to composite tissue allotransplantation what nature has developed for pregnancy, and examined the immunosuppressive effect of tryptophan metabolites in a model of hind limb transplantation...
  2. pmc Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseases
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 105:18442-7. 2008
    ....
  3. ncbi Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?
    Peter Terness
    Institute of Immunology, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
    Blood 105:2480-6. 2005
    ..Our findings show that nonadherent CD123+/CCR6+ human DCs do not constitutively express IDO, and, even if they express the enzyme after IFN-gamma treatment, they possess only limited T-cell regulatory function...
  4. doi Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedside
    Peter Terness
    Institute of Immunology, University of Heidelberg, Department of Transplantation Immunology, Heidelberg, Germany
    Hum Immunol 70:506-12. 2009
    ..Although many questions remain, MMC-treated cells are a promising clinical tool for controlling allograft rejection and deleterious immune responses in autoimmune diseases...
  5. ncbi The immunoregulatory role of IDO-producing human dendritic cells revisited
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, INF 305, University of Heidelberg, 69120 Heidelberg, Germany
    Trends Immunol 27:68-73. 2006
    ..Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking...
  6. doi Melan-A/MART1 analog peptide triggers anti-myeloma T-cells through crossreactivity with HM1.24
    Olaf Christensen
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    J Immunother 32:613-21. 2009
    ..The current data demonstrate that Melan-A analog specific T-cells crossreact with HM1.24(aa22-30). They might be a tool for the future use in immunotherapy against MM...
  7. ncbi Inhibition of heart allograft rejection with mitomycin C-treated donor dendritic cells
    Lucian P Jiga
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:347-50. 2007
    ..We conclude that allogeneic MMC-DCs specifically inhibit the T-cell response in vivo and that downregulation of CD80, CD86, and ICAM-1 is a potential mechanism of this effect...
  8. doi Suppressive dendritic cells as a tool for controlling allograft rejection in organ transplantation: promises and difficulties
    Sandra Ehser
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 69:165-73. 2008
    ..Based on lessons learned from the use of DCs as tools in clinical vaccine trials in cancer, we discuss the unknown aspects and risks of DC therapy in transplantation...
  9. ncbi Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in rats
    Daohu Wang
    Institute for Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:1537-40. 2006
    ..Our findings indicate that the targeted perfusion of donor hearts with MMC-containing solution protects the graft from rejection...
  10. pmc Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma
    Sebastian Belle
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Eur J Haematol 81:26-35. 2008
    ..The aim of this study is the identification of HLA-A2 restricted T-cell epitopes in the conserved region of the immunoglobulin-G-heavy-chain (IgGH) that can be used for immunotherapy in multiple myeloma (MM) patients...
  11. ncbi Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo
    Thomas M Bauer
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    Transpl Int 18:95-100. 2005
    ..The metabolites induced a significant prolongation (P = 0.0018) of graft survival. We conclude that IDO-induced tryptophan metabolites suppress the T-cell response and prolong allograft survival in rats...
  12. doi Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation
    Christian Andreas Radu
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic and Hand Surgery, University of Heidelberg, Germany
    J Surg Res 176:e95-e101. 2012
    ..Mitomycin C (MMC) is an alkylating agent that suppresses allogeneic T-cell responses. MMC-treated dendritic cells/PBMCs have been shown to induce donor-specific tolerance in solid organ allograft transplantations...
  13. doi Role of human corneal endothelial cells in T-cell-mediated alloimmune attack in vitro
    Imad Lahdou
    University Hospital Heidelberg, Department of Immunology, Heidelberg, Germany
    Invest Ophthalmol Vis Sci 55:1213-21. 2014
    ....
  14. doi Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
    Hum Immunol 73:186-92. 2012
    ..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays...
  15. ncbi Generation of tolerogenic dendritic cells by treatment with mitomycin C: inhibition of allogeneic T-cell response is mediated by downregulation of ICAM-1, CD80, and CD86
    Lucian P Jiga
    Department of Transplantation Immunology, Heidelberg, Germany
    Transplantation 77:1761-4. 2004
    ..In this article, the authors study the effect of mitomycin C (MMC)-treated DC on rat T cells and delineate the mechanism of their conversion into tolerogenic cells...
  16. doi Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro
    Laura Dittmar
    Department of Transplantation Immunology, Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany Electronic address
    Hum Immunol 76:480-7. 2015
    ..In conclusion, human MMC-DC or MMC-monocytes are not or only weakly suppressive in vitro. When MMC-monocytes are differentiated to DC the resulting cells become suppressive. ..
  17. pmc Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis
    Christian Kleist
    Department of Transplantation Immunology, Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany
    J Transl Med 14:99. 2016
    ..This provides an approach for prophylactic vaccination against autoimmune diseases. For clinical application such DCs are difficult to generate and autoantigens hold the risk of exacerbating the disease...
  18. doi Generation of suppressive blood cells for control of allograft rejection
    Christian Kleist
    Department of Transplantation Immunology, Institute for Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    Clin Sci (Lond) 128:593-607. 2015
    ..Although the case report does not allow us to draw any conclusion about their therapeutic effectiveness, it shows that MICs can be easily generated and applied in humans...
  19. doi Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis
    Imad Lahdou
    Department of Transplantation Immunology, University of Heidelberg, Germany
    Hum Immunol 74:60-6. 2013
    ..Here we investigate whether the degree of systemic inflammation (QuinA, neopterin, CRP and IL-6) correlates with clinical liver dysfunction according to the MELD Score...
  20. pmc Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 196:447-57. 2002
    ....
  21. pmc Identification of a new HLA-A2-restricted T-cell epitope within HM1.24 as immunotherapy target for multiple myeloma
    Michael Hundemer
    Department of Internal Medicine V, University of Heidelberg, Germany
    Exp Hematol 34:486-96. 2006
    ..The aim of this study was identification of human leukocyte antigen (HLA)-A2-restricted T-cell epitopes within the HM1.24 antigen as target for multiple myeloma (MM)-directed specific peptide-based immunotherapy...
  22. doi Active-specific immunotherapy of human cancers with the heat shock protein Gp96-revisited
    Marco Randazzo
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 130:2219-31. 2012
    ..This review critically analyzes the current state of clinical immunotherapy with Gp96, with special attention to Vitespen...
  23. doi Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection
    Imad Lahdou
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 71:1067-72. 2010
    ..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients...
  24. doi Local administration of Mitomycin-C-Treated peripheral blood mononuclear cells (PBMCs) prolongs allograft survival in vascularized composite allotransplantation
    Christian Andreas Radu
    Department of Hand Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic and Hand Surgery University of Heidelberg, Heidelberg, Germany
    Microsurgery . 2015
    ..The aim of this study is to evaluate if local administration of MMC-PBMCs prolongs allograft survival in allogeneic hind limb transplantations of the rat...
  25. doi Cell therapy for immunosuppression after kidney transplantation
    Christian Morath
    Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 400:541-50. 2015
    ..To give an overview over cell therapeutic approaches to immunosuppression in clinical kidney transplantation. A focus is on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs)...
  26. ncbi Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipients
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 81:1227-33. 2006
    ..It is widely assumed that the graft-enhancing properties of antilymphocyte induction agents and their lymphoma-inducing potential are intimately related...
  27. ncbi Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives
    Dinara Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Int Immunopharmacol 3:1791-801. 2003
    ..The description of compounds without cardiac activity but with tumor-specific cytotoxicity suggests the potential of using them in cancer therapy...
  28. ncbi A simplified technique for heart transplantation in rats: abdominal vessel branch-sparing and modified venotomy
    Daohu Wang
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    Microsurgery 26:470-2. 2006
    ....
  29. doi Heat shock proteins purified from autologous tumors using antibody-based affinity chromatography
    Christian Kleist
    Department of Transplantation Immunology, Institute for Immunology, University of Heidelberg, Heidelberg, Germany
    Methods Mol Biol 1139:305-19. 2014
    ..Chromatographic columns are assembled and then used to simultaneously isolate various HSP from the supernatant of lysates of human tumor samples of different origin in a single chromatographic step...
  30. ncbi Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
    Peter Terness
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Reprod Immunol 58:238-54. 2007
    ..Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?..
  31. ncbi Single-chain Fv-based affinity purification of the cellular stress protein gp96 for vaccine development
    Christian Kleist
    Department of Transplantation Immunology, Institute for Immunology, University of Heidelberg, Germany
    Methods Mol Biol 207:393-420. 2003
  32. ncbi Comparison of six methods for the assessment of ischemia-reperfusion injury in skeletal muscle following composite tissue allotransplantation
    Steffen P Baumeister
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center, Ludwigshafen, University of Heidelberg, Germany
    J Reconstr Microsurg 20:253-9. 2004
    ..These findings help further researchers in their selection of reliable outcome parameters to measure I/R injury in skeletal muscle...
  33. ncbi Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Blood 111:2152-4. 2008
    ..Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study...