A Tannapfel

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    J Pathol 197:624-31. 2002
  2. ncbi request reprint [Pancreatic intraepithelial neoplasia in chronic pancreatitis]
    A Tannapfel
    Institut für Pathologie der Universität Leipzig, Germany
    Zentralbl Chir 126:879-83. 2001
  3. ncbi request reprint Adenoma of the papilla and ampulla--premalignant lesions?
    C Wittekind
    Institute of Pathology, University of Leipzig, Germany
    Langenbecks Arch Surg 386:172-5. 2001
  4. ncbi request reprint p16INK4A-alterations in primary angiosarcoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    J Hepatol 35:62-7. 2001
  5. ncbi request reprint Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    J Pathol 195:163-70. 2001
  6. ncbi request reprint INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Oncogene 20:7104-9. 2001
  7. ncbi request reprint Molecular findings in Barrett's epithelium
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Dig Dis 22:126-33. 2004
  8. ncbi request reprint [Gallbladder and bile duct carcinoma. Biology and pathology]
    A Tannapfel
    Institut fur Pathologie, Universitatsklinikum Leipzig
    Internist (Berl) 45:33-41. 2004
  9. ncbi request reprint Differential diagnosis of acute rejection versus hepatitis reinfection
    A Tannapfel
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Transplant Proc 35:2082-3. 2003
  10. pmc INK4a-ARF alterations in liver cell adenoma
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 51:253-8. 2002

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    J Pathol 197:624-31. 2002
    ..These findings indicate that the INK4a-ARF locus is frequently inactivated in cholangiocarcinoma of the liver and occurs independently of the status of p53 or pRb...
  2. ncbi request reprint [Pancreatic intraepithelial neoplasia in chronic pancreatitis]
    A Tannapfel
    Institut für Pathologie der Universität Leipzig, Germany
    Zentralbl Chir 126:879-83. 2001
    ..A better understanding of the molecular genetic changes occurring during neoplastic progression in the pancreas will form the basis for future strategies of early tumour detection and improved therapy...
  3. ncbi request reprint Adenoma of the papilla and ampulla--premalignant lesions?
    C Wittekind
    Institute of Pathology, University of Leipzig, Germany
    Langenbecks Arch Surg 386:172-5. 2001
    ..The full neoplastic spectrum, ranging from mild to high grade dysplasia, up to invasive carcinoma, resembles the adenoma-carcinoma sequence of the large bowels...
  4. ncbi request reprint p16INK4A-alterations in primary angiosarcoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    J Hepatol 35:62-7. 2001
    ..This study was performed to determine whether alterations of p16 are involved in the development of angiosarcoma of the liver...
  5. ncbi request reprint Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    J Pathol 195:163-70. 2001
    ..The increased expression of p63 (TAp63 and black triangleNp63) in less well differentiated gastric carcinomas may indicate that p63 can act to promote neoplastic growth in the gastric epithelium...
  6. ncbi request reprint INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Oncogene 20:7104-9. 2001
    ..The INK4a-ARF-/p53-pathway was disrupted in 86% of HCC, either by p53 mutations or by INK4a-ARF inactivation, and may have co-operative effects in hepatocarcinogenesis...
  7. ncbi request reprint Molecular findings in Barrett's epithelium
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Dig Dis 22:126-33. 2004
    ..Since these genetic or epigenetic alterations are neither tumor nor stage specific, they could not gain diagnostic significance as biomarkers until now...
  8. ncbi request reprint [Gallbladder and bile duct carcinoma. Biology and pathology]
    A Tannapfel
    Institut fur Pathologie, Universitatsklinikum Leipzig
    Internist (Berl) 45:33-41. 2004
    ..Histopathologically, the vast majority are adenocarcinomas; mesenchymal tumors and primary melanomas are extremely rare. Different genetic alterations are discussed to be of importance...
  9. ncbi request reprint Differential diagnosis of acute rejection versus hepatitis reinfection
    A Tannapfel
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Transplant Proc 35:2082-3. 2003
  10. pmc INK4a-ARF alterations in liver cell adenoma
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 51:253-8. 2002
    ..The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), whose functions are inactivated in many human cancers...
  11. ncbi request reprint Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Virchows Arch 440:345-52. 2002
    ..Recent results of high-output gene analysis using cDNA microarrays support the idea of different genetic alterations in HCC with or without cirrhosis...
  12. pmc Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    Gut 52:706-12. 2003
    ..The BRAF gene, one of the human isoforms of RAF, is activated by oncogenic Ras, leading to cooperative effects in cells responding to growth factor signals...
  13. ncbi request reprint [Carrent state of molecular pathology of stomach carcinomas]
    A Tannapfel
    Institut fur Pathologie, Universitatsklinikum Leipzig, Liebigstrasse 26, 04103 Leipzig
    Pathologe 22:37-43. 2001
    ..We discuss the mechanisms molecular pathology in relation to their potential clinical relevance...
  14. pmc Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 47:721-7. 2000
    ..Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and K-ras mutations are among the most frequent genetic alterations in human malignancies...
  15. ncbi request reprint Apoptosis and the expression of Fas and Fas ligand (FasL) antigen in rejection and reinfection in liver allograft specimens
    A Tannapfel
    Institute of Pathology, Departments of Surgery, University of Leipzig, Germany
    Transplantation 67:1079-83. 1999
    ....
  16. ncbi request reprint Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma
    A Tannapfel
    Institute of Pathology, Department of Internal Medicine, University of Leipzig, Germany
    J Natl Cancer Inst 91:1154-8. 1999
    ..This study was undertaken to investigate the expression of p73 in liver tissue of patients with hepatocellular carcinoma (HCC) and to determine whether this expression has any impact on prognosis...
  17. ncbi request reprint Tumor markers in squamous cell carcinoma of the head and neck: clinical effectiveness and prognostic value
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Eur Arch Otorhinolaryngol 258:83-8. 2001
    ..UICC tumor stage and patient's age and performance still remain the basis for therapeutic decisions. Further search for more sensitive and specific markers is needed to improve individual treatment and prognostic statements...
  18. ncbi request reprint Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma
    A Tannapfel
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Int J Cancer 89:350-5. 2000
    ..We conclude that evaluation of p27 in hepatocellular carcinoma is useful to predict stage of disease and may have clinical significance, e.g., in predicting optimal therapeutic regimes...
  19. ncbi request reprint Influence of a selective endothelin(A) receptor antagonist on the quantitative mRNA expression and the immunohistochemistry of vasoactive mediators after pancreas transplantation
    G Gabel
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Transplant Proc 35:2137-8. 2003
  20. pmc Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    Br J Cancer 80:1069-74. 1999
    ..We failed to establish p73 or p53 as independent prognostic factors in cholangiocellular carcinoma of the liver...
  21. ncbi request reprint Pathomorphologic and microcirculatory changes and endothelin-1 expression in UW-and Celsior-preserved pancreata in experimental pancreas transplantation
    S Ludwig
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Transplant Proc 34:2364-5. 2002
  22. pmc Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma
    I Tischoff
    Institute of Pathology, University of Bochum, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Gut 56:1047-53. 2007
    ..The suppressors of cytokine signalling (SOCS) are inhibitors of cytokine signalling; methylation of SOCS-3 has been implicated in the tumorigenesis of liver as well as head and neck cancer...
  23. ncbi request reprint Administration of a selective endothelin-a receptor antagonist (BSF 208075) improves hepatic warm ischemia/reperfusion injury in pigs
    H Witzigmann
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Transplant Proc 34:2387-8. 2002
  24. ncbi request reprint Apoptosis and proliferation in relation to histopathological variables and prognosis in hepatocellular carcinoma
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    J Pathol 187:439-45. 1999
    ..MIB-1 and PCNA immunostaining and AgNORs showed a good correlation among themselves. Apoptosis did not predict prognosis in hepatocellular carcinoma...
  25. ncbi request reprint Photodynamic therapy for advanced bile duct cancer: evidence for improved palliation and extended survival
    F Berr
    Department of Medicine II, University of Leipzig, Leipzig, Germany
    Hepatology 31:291-8. 2000
    ..Photodynamic therapy can prevent tumor occlusion of hilar bile ducts. The apparent benefit in survival time should be confirmed in a controlled trial versus palliation by endoprosthesis only...
  26. ncbi request reprint Sirolimus improves early microcirculation, but impairs regeneration after pancreatic ischemia-reperfusion injury
    F Serr
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Am J Transplant 7:48-56. 2007
    ..05) than the vehicle controls. In summary, our data indicate that administration of SRL improves microcirculation at a very early stage, but results in an impairment of the recovery phase after pancreatic ischemia-reperfusion injury...
  27. pmc Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma
    J Rohloff
    Department of Medicine II, Leipzig University, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Br J Cancer 86:1270-5. 2002
    ..Our results suggest, that heparanase promotes cancer cell invasion in pancreatic carcinoma and could be used as a prognostic indicator for postoperative survival of patients...
  28. ncbi request reprint TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor
    Katja Spiesbach
    Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
    Int J Cancer 114:555-62. 2005
    ..TAp63gamma employs the same DNA recognition site for this activation as p53. We observe expression patterns of p53, p63 and maspin proteins in tumor tissue that may indicate also a function of maspin induction by p63 in tumors...
  29. ncbi request reprint Comparison of Celsior and UW solution in experimental pancreas preservation
    Dirk Uhlmann
    2nd Department of Surgery, University of Leipzig, 04103 Leipzig, Germany
    J Surg Res 105:173-80. 2002
    ..Recently, experimental and clinical experience has been reported on the application of CEL to abdominal organs. In this animal study, pancreas preservation with CEL was compared with that in UW solution...
  30. ncbi request reprint Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays
    Andrea Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    J Pathol 201:238-49. 2003
    ..These data indicate that the development of an array-based approach for the determination of protein profiles in HCC may facilitate the identification of new proteins associated with carcinogenesis or prognosis...
  31. doi request reprint Inverse association of p16 INK4a and p14 ARF methylation of the CDKN2a locus in different Gleason scores of prostate cancer
    B Verdoodt
    Institute of Pathology, Ruhr University Bochum, Bochum, Germany
    Prostate Cancer Prostatic Dis 14:295-301. 2011
    ..Recent studies suggest that the polycomb-group (PcG) protein BMI1 may have an impact on epigenetic regulation of several targets, including the CDKN2a locus...
  32. ncbi request reprint Apoptosis and cell proliferation in the metaplasia-dysplasia-carcinoma-sequence of Barrett's esophagus
    U Halm
    Department of Internal Medicine II, Institute of Pathology, University of Leipzig, Germany
    Hepatogastroenterology 47:962-6. 2000
    ..To investigate regulation of apoptosis, proliferation and the participation of the tumor suppressor gene p53, we examined these parameters in Barrett's metaplasia, dysplasia, and adenocarcinoma...
  33. ncbi request reprint Alloreactivity of natural killer cells in allogeneic liver transplantation
    M Oertel
    Department of Medicine II, Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany
    Transplantation 72:116-22. 2001
    ..Strategies to prevent or treat NK allospecific constellations after liver transplantation are not likely to reduce the incidence or severity of acute allograft rejection...
  34. ncbi request reprint Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma
    F Berr
    Department of Medicine II, University of Leipzig, Germany
    J Hepatol 32:352-7. 2000
    ..After 23 days the tumor was completely resected (adenocarcinoma pT2 pNO; G2)...
  35. ncbi request reprint Genetic and epigenetic alterations of 9p21 gene products in benign and malignant tumors of the head and neck
    Anette Weber
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Leipzig, Germany
    Pathol Res Pract 199:391-7. 2003
    ..P14ARF was found to be methylated in 8 out of 50 cases (16%). Our results demonstrate that alterations of the INK4a-ARF locus are frequent and important events not only in the carcinogenesis of malignant, but also in benign tumors...
  36. ncbi request reprint Cytology and mRNA expression analysis of fine needle aspirates of thyroid nodules in an East German region with borderline iodine deficiency
    S Karger
    III Medical Department, University of Leipzig, Ph Rosenthal Strasse 27, 04103 Leipzig, Germany
    Horm Metab Res 38:662-7. 2006
    ....
  37. ncbi request reprint [Anatomy and pathology of intrahepatic and extrahepatic bile duct tumors]
    A Tannapfel
    , , Liebigstrasse 26, 04103 Leipzig
    Pathologe 22:114-23. 2001
    ..Over 95% of bile duct tumors are adenocarcinomas. In the nomenclature of precursor lesions a two-grade classification of dysplasia (low-grade versus high-grade) has been found to be more reproducible...
  38. ncbi request reprint Effects of ET(A) receptor antagonism on proinflammatory gene expression and microcirculation following hepatic ischemia/reperfusion
    Dirk Uhlmann
    Department of Abdominal, Transplantation and Vascular Surgery, Leipzig, Germany
    Microcirculation 12:405-19. 2005
    ....
  39. ncbi request reprint Portal vein arterialisation as a technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigs
    Rudolf Ott
    Department of Surgery, University of Leipzig, Leipzig, Germany
    Liver Int 23:54-62. 2003
    ..Arterialisation of the portal vein has been propagated as a technical variant in liver transplantation. However, the consequences of this unphysiological vascular supply are insufficiently known...
  40. ncbi request reprint Alterations of the INK4a-ARF gene locus in pleomorphic adenoma of the parotid gland
    Anette Weber
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 18a, Germany
    J Pathol 198:326-34. 2002
    ....
  41. ncbi request reprint Role of epigenetic alterations in cholangiocarcinoma
    Iris Tischoff
    Institute of Pathology, University of Leipzig, D 04103, Leipzig, Germany
    J Hepatobiliary Pancreat Surg 13:274-9. 2006
    ..This review discusses the epi-genetic inactivation of different tumor suppressor genes in cholangiocarcinoma...
  42. ncbi request reprint Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors
    Iris Tischoff
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Int J Cancer 115:684-9. 2005
    ..In conclusion, our data indicate that 2-hit gene silencing of SEMA3B through epigenetic changes and allele loss is a common and important event in the carcinogenesis of malignant liver tumors...
  43. ncbi request reprint Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck
    Anette Weber
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany
    Int J Cancer 99:22-8. 2002
    ..p73 and p63 were rarely mutated in HNSCC, but both were expressed in a subset of tumours. The lack of correlation between p73/p63 and p53 protein expression suggests that neither p73 nor p63 can replace p53 when it is mutated...
  44. ncbi request reprint [Prognostic factors in head-neck carcinomas]
    A Weber
    Klinik für Hals Nasen Ohren Heilkunde, Plastische Operationen, Universitatsklinikum Leipzig, Liebigstrasse 18a, 04103 Leipzig
    HNO 50:35-42. 2002
    ..We discuss parameters that have been associated with prognosis of head and neck squamous cell carcinoma so far...
  45. ncbi request reprint Basement membrane component laminin-5 is a target of the tumor suppressor Smad4
    M Zapatka
    Department of Internal Medicine, Knappschaftskrankenhaus, IMBL, Ruhr University of Bochum, Bochum, Germany
    Oncogene 26:1417-27. 2007
    ..These data define the expression control of an essential BM component as a novel function for the tumor suppressor Smad4...
  46. ncbi request reprint [Role of epigenetics in the carcinogenesis of head and neck carcinomas - possible new targeted therapy?]
    A Weber
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Plastische Operationen, Universitatsklinikum Leipzig, Leipzig
    Laryngorhinootologie 86:9-13. 2007
    ..This presents a very promising new option for a targeted therapy...
  47. ncbi request reprint Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation
    H Lage
    Institute of Pathology, Charite Campus Mitte, Humboldt University Berlin, Germany
    Virchows Arch 438:567-73. 2001
    ..1 for normal hepatocytes, was significantly reduced to 1.2 for G1, 1.0 for G2, and 0.2 for G3 HCCs. These data suggest that neoplastic transformation is associated with a reduced p62 content...
  48. ncbi request reprint Relative versus absolute carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with acute alcoholic hepatitis
    U Halm
    Department of Medicine II, University of Leipzig, Germany
    Alcohol Clin Exp Res 23:1614-8. 1999
    ..This study investigated the usefulness of carbohydrate-deficient transferrin as a marker of alcohol consumption in acute alcoholic hepatitis...
  49. ncbi request reprint Evaluation of peroxisome proliferator-activated receptor-gamma expression in benign and malignant thyroid pathologies
    S Karger
    III Medical Department, University of Leipzig, Leipzig, Germany
    Thyroid 15:997-1003. 2005
    ..The marked downregulation of PPAR-gamma in GD warrants further investigation and could be linked, for example, with changes in apoptosis...
  50. ncbi request reprint Effects of salt loading and various therapies on cardiac hypertrophy and fibrosis in young spontaneously hypertensive rats
    Barbara Ziegelhöffer-Mihalovicová
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27 04103 Leipzig, Germany
    Life Sci 79:838-46. 2006
    ..Less pronounced effects were achieved with verapamil. These findings emphasize the cardioprotective role of captopril which may not be fully expressed in the presence of elevated salt intake...
  51. ncbi request reprint INK4a-ARF alterations and p53 mutations in primary and consecutive squamous cell carcinoma of the head and neck
    Anette Weber
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 18a, 04103 Leipzig, Germany
    Virchows Arch 441:133-42. 2002
    ....
  52. pmc Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice
    Thomas Kamenz
    Department of Internal Medicine II, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    World J Gastroenterol 12:1583-90. 2006
    ..To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with extrahepatic cholangiocarcinoma (CC) and to evaluate the efficacy of in vitro and in vitro treatment with imatinib mesilate...
  53. ncbi request reprint Investigation of arthritic joint destruction by a novel fibroblast-based model
    U Sack
    Medical Faculty, Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Ann N Y Acad Sci 1051:291-8. 2005
    ..In vitro fibroblast/cartilage co-cultures present a convenient system for the assessment of novel therapeutic strategies toward reduction of articular destruction...
  54. doi request reprint [The current TNM system for gastrointestinal tumors part I]
    C Wittekind
    Institut fur Pathologie, Universitatsklinikum Leipzig, Liebigstr 26, 04103, Leipzig, Deutschland
    Pathologe 31:344-7. 2010
    ..The number of lymph nodes has been adapted to 16 to classify pN0. Only slight modifications have been introduced in tumors of the small bowel...
  55. ncbi request reprint Two somatic TSH receptor mutations in a patient with toxic metastasising follicular thyroid carcinoma and non-functional lung metastases
    D Fuhrer
    III Medical Department, University of Leipzig, Leipzig, Germany
    Endocr Relat Cancer 10:591-600. 2003
    ..No TSHR mutations were detected in the pulmonary metastases. This is the first case report of a patient with toxic follicular thyroid carcinoma harbouring two different TSHR mutations and presenting with non-functional lung metastases...
  56. ncbi request reprint Immunosuppression with sirolimus/tacrolimus combination in pancreas transplantation: 1-year results
    H Witzigmann
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Transplant Proc 34:3354-6. 2002
  57. ncbi request reprint Expression profiles of p53, p63, and p73 in benign salivary gland tumors
    Anette Weber
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Leipzig, Germany
    Virchows Arch 441:428-36. 2002
    ..The prevalence of p53 mutations and the observation of the expression of DeltaNp63 isoforms only in pleomorphic adenomas, myoepitheliomas, and also basal cell adenomas may reflect their possible malignant potential...
  58. ncbi request reprint C282Y and H63D mutation of the hemochromatosis gene in German porphyria cutanea tarda patients
    A Tannapfel
    Institute of Pathology, University of Leipzig, Germany
    Virchows Arch 439:1-5. 2001
    ..Inherited factors that may predispose to PCT include the C282Y mutation in the hemochromatosis (HFE) gene...
  59. pmc Multiple simultaneous gastric carcinomas
    C Wittekind
    Institute of Pathology, University of Leipzig, Germany
    Br J Cancer 76:1604-9. 1997
    ..Our results suggest that in at least a high proportion of patients with gastric cancer multiple primary tumours arise from precancerous conditions leading to similar genetic alterations...
  60. ncbi request reprint [Hepatocellular carcinoma: resection versus transplantation]
    D Uhlmann
    Chirurgische Klinik II Klinik für Abdominal, Transplantations und Gefässchirurgie, Universitat Leipzig
    Zentralbl Chir 125:624-8. 2000
    ..However, consequent patient selection is necessary for this treatment modality. Due to the limited donor resources liver transplantation is rarely justified in advanced tumors...
  61. ncbi request reprint [Massive space requirement by the parotid gland]
    J Machlitt
    Klinik fur Hals, Nasen, Ohrenheilkunde Plastische Operationen, Universitatsklinikum Leipzig AoR
    HNO 53:966-8. 2005
  62. ncbi request reprint [Musculoskeletal biopsies in an open 0.5-T-MR system]
    M Pretzsch
    Orthopädische Klinik und Poliklinik am Universitätsklinikum AöR Leipzig
    Z Orthop Ihre Grenzgeb 143:365-74. 2005
    ..The aim of this paper is to report our results with the application of MR-guided biopsies of musculoskeletal lesions using an open 0.5-T-MR scanner and further to discuss these results on the basis of the available literature...
  63. ncbi request reprint The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis
    V Keim
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Pancreas 19:248-54. 1999
    ..We conclude that there is a lack of PAP polymorphism in hereditary and alcoholic pancreatitis and that expression of the PAP in both groups of patients is related to the degree of cellular damage of the pancreas...
  64. ncbi request reprint [Mycosis fungoides and B-cell chronic lymphocytic leukemia: an extremely rare coincidence]
    A Suss
    Klinik und Poliklinik fur Dermatologie, Allergologie und Venerologie, Universitatsklinikum Leipzig, Germany
    Hautarzt 57:888-92. 2006
    ..A 72-year-old patient was diagnosed with coincident MF, stage Ib, and B-CLL, Binet stage A. Hypotheses on simultaneous occurrence of B- and T-cell malignancies as well as a new therapeutic option are discussed...
  65. ncbi request reprint Importance of microcirculatory disturbances in the pathogenesis of pancreatitis
    D Uhlmann
    Klinik für Abdominal, Transplantations und Gefässchirurgie der Universität Leipzig, Germany
    Zentralbl Chir 126:873-8. 2001
    ..Further studies are needed to clarify whether ischemia in chronic pancreatitis is more important in perpetuating the disease or as primary cause of the inflammatory processes...
  66. ncbi request reprint [Sporadic acute hepatitis E in Germany: an underdiagnosed phenomenon?]
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Z Gastroenterol 41:419-23. 2003
    ..These data indicate that community acquired hepatitis E virus infection may occur sporadically in Germany and should be considered as a cause of seronegative (non-A-non-B-non-C) hepatitis...
  67. ncbi request reprint [Treatment concept of adenomas of Vater's ampulla]
    H Witzigmann
    Klinik für Abdominal, Transplantations und Gefässchirurgie, Universitat Leipzig
    Chirurg 71:196-201. 2000
    ..The most common benign ampullary tumors are adenomas (80%). They are considered as premalignant lesions with a transformation rate to carcinoma of up to 30%...
  68. pmc Ectopic Cushing' syndrome caused by a neuroendocrine carcinoma of the mesentery
    Mathias Fasshauer
    Division of Endocrinology and Nephrology, University of Leipzig, Philipp Rosenthalstr 27, 04103 Leipzig, Germany
    BMC Cancer 6:108. 2006
    ..Moreover, diagnostic procedures and pitfalls associated with ectopic ACTH-secreting tumors are demonstrated and discussed...
  69. pmc Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma: palliative photodynamic therapy plus stenting is comparable to r1/r2 resection
    Helmut Witzigmann
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Ann Surg 244:230-9. 2006
    ..Second, to compare long-term outcome in patients undergoing surgical or palliative treatment, and third to evaluate the role of photodynamic therapy in this concept...
  70. ncbi request reprint Attenuation of proinflammatory gene expression and microcirculatory disturbances by endothelin A receptor blockade after orthotopic liver transplantation in pigs
    Dirk Uhlmann
    Department of Abdominal, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    Surgery 139:61-72. 2006
    ..Our aim was to evaluate the effect of a selective ET(A)-receptor antagonist (ET(A)-RA) on cold ischemia/reperfusion (I/R) injury in a pig model...
  71. ncbi request reprint p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix
    Lars Christian Horn
    Institute of Pathology, Division of Gynecopathology, and Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 25:182-6. 2006
    ..p14 inactivation is of high prevalence in SmCCs and detection rate of p53 is similar to other histologic types of cervical carcinomas...
  72. ncbi request reprint p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:193-6. 2006
    ..Factors known to play a pathogenetic role in types 1 and 2 of endometrial carcinomas are not associated with primary ESCC. However, prognostically, ESCCs are more related to type 1 cancers...
  73. ncbi request reprint Improvement of postischemic hepatic microcirculation after endothelinA receptor blockade--endothelin antagonism influences platelet-endothelium interactions
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, 04103 Leipzig, Germany
    J Gastrointest Surg 9:187-97. 2005
    ..The reduction in microcirculatory damages is responsible for better organ outcome...
  74. ncbi request reprint Changes of vasoregulatory gene expression following hepatic ischemia/reperfusion and treatment with endothelin-A receptor blockade
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, Leipzig, Germany
    J Cardiovasc Pharmacol 44:S100-2. 2004
    ....
  75. ncbi request reprint Vertebral osteomyelitis in an infant presenting with pseudotumor and narrowing of the spinal canal
    Ralf Bodo Tröbs
    Klinik und Poliklinik für Kinderchirurgie, Universitatsklinikum Leipzig AoR, Oststr 21 25, 04317 Leipzig, Germany
    Pediatr Surg Int 21:316-9. 2005
    ..A paraspinal mass and narrowing of the spinal canal due to vertebral osteomyelitis were present. Treatment with antibiotics and bracing was carried out with no evidence of neurologic disturbances over a follow-up period of 24 months...
  76. ncbi request reprint SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition
    Anette Weber
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Germany
    Oncogene 24:6699-708. 2005
    ..During its involvement in tumor growth, restoration of SOCS-3 may hold treatment potential for HNSCC...
  77. ncbi request reprint Assessment of hepatic ischemia-reperfusion injury by simultaneous measurement of tissue pO2, pCO2, and pH
    Dirk Uhlmann
    2nd Department of Surgery, University of Leipzig, 04103, Leipzig, Germany
    Microvasc Res 67:38-47. 2004
    ....
  78. ncbi request reprint Intrafascial nerve-sparing endoscopic extraperitoneal radical prostatectomy
    Jens Uwe Stolzenburg
    Department of Urology, University of Leipzig, Leipzig, Germany
    Urology 67:17-21. 2006
    ..To present a modification of our previously published technique of nerve-sparing endoscopic extraperitoneal radical prostatectomy (nsEERPE)...
  79. ncbi request reprint Norepinephrine-induced changes in cardiac transforming growth factor-beta isoform expression pattern of female and male rats
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Hypertension 44:410-8. 2004
    ..The increase in TGF-beta isoforms correlated with that of the mRNA expression of collagens, MMP-2 and TIMP-2...
  80. ncbi request reprint Endothelin A receptor blockade reduces hepatic ischemia/reperfusion injury after warm ischemia in a pig model
    Dirk Uhlmann
    Department of Abdominal Transplantation, University of Leipzig, Leipzig, Germany
    J Gastrointest Surg 7:331-9. 2003
    ....
  81. ncbi request reprint Catecholamine-induced pulmonary edema and pleural effusion in rats--alpha- and beta-adrenergic effects
    Beate Rassler
    Carl Ludwig Institute of Physiology, Liebigstr 27, D 04103, Leipzig, Germany
    Respir Physiol Neurobiol 135:25-37. 2003
    ..We conclude that both alpha- and beta-adrenergic stimulation contribute to pulmonary fluid shifts in rats, but alpha-adrenergic pathways cause more acute and more severe lung injury than beta-adrenergic mechanisms...
  82. ncbi request reprint TNP-470 fails to block the onset of angiogenesis and early tumor establishment in an intravital minimal disease model
    Grigore Cernaianu
    Department of Pediatric Surgery, University of Leipzig, 04317, Leipzig, Germany
    Int J Colorectal Dis 21:143-54. 2006
    ..Since little is known about the effects of TNP-470 at the minimal disease stage, we analyzed the effects of TNP-470 on the early stages of tumor establishment...
  83. ncbi request reprint [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 30:317-26. 2003
    ..This advantage of a faster reduction of unspecific binding, in light of similar or marginally lower tumor uptake, warrants further investigation of (18)FAZA as a marker of regional hypoxia in tumors...
  84. ncbi request reprint Pathophysiological role of platelets in acute experimental pancreatitis: influence of endothelin A receptor blockade
    Dirk Uhlmann
    2nd Department of Surgery, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Cell Tissue Res 327:485-92. 2007
    ..05). Thus, ET(A)-RA therapy was effective in reducing I/R-induced pancreatitis in this experimental model...
  85. ncbi request reprint [Efficient diagnosis of pathological fractures]
    Thomas Schulz
    Klinik und Poliklinik für Diagnostische Radiologie der Universität Leipzig, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
    Rontgenpraxis 56:75-92. 2006
    ....
  86. pmc Endothelin(A) receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantation
    Helmut Witzigmann
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Ann Surg 238:264-74. 2003
    ..The effect of prophylactic administration of a selective endothelin(A) receptor antagonist (ET(A)-RA) on ischemia/reperfusion injury in an experimental model of graft pancreatitis after pancreas transplantation was evaluated...
  87. ncbi request reprint Pulmonary edema and pleural effusion in norepinephrine-stimulated rats--hemodynamic or inflammatory effect?
    Beate Rassler
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 250:55-63. 2003
    ..Hence, we conclude that they are secondary factors which may contribute to maintain the fluid shifts over a longer period of time...
  88. ncbi request reprint Protein microarrays for the detection of biomarkers in head and neck squamous cell carcinomas
    Anette Weber
    Department of ENT, University of Leipzig, 04103 Leipzig, Germany
    Hum Pathol 38:228-38. 2007
    ..These data indicate that our protein arrays provide protein information in a systematic, reproducible, and also high-throughput fashion...
  89. ncbi request reprint Cardiac remodeling in erythropoietin-transgenic mice
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Cell Physiol Biochem 14:277-84. 2004
    ..This is accompanied by cardiac dysfunction and premature death. The aim of this study was to examine whether this cardiac dysfunction was accompanied by hypertrophy of the heart with remodeling of the extracellular matrix (ECM)...
  90. ncbi request reprint INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma
    Michael Vieth
    Institute of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Virchows Arch 445:135-41. 2004
    ..To study the contribution of each pathway to the carcinogenesis of Barrett's adenocarcinoma, we analysed the alterations of p14ARF and p16INK4a in preneoplastic and neoplastic lesions of this disease...
  91. ncbi request reprint Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib
    Marcus Wiedmann
    Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
    Anticancer Drugs 17:783-95. 2006
    ..Therefore, further clinical evaluation of this new drug for the treatment of biliary tract cancer is recommended...
  92. ncbi request reprint Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines
    Karel Caca
    Department of Medicine II, University of Leipzig, Leipzig, Germany
    Int J Cancer 97:481-8. 2002
    ..Other mechanisms than Tp53 mutations seems to be predominantly responsible for stabilization of nuclear p53 protein in bile duct cancers...
  93. ncbi request reprint Time course of hypoxia-induced lung injury in rats
    Beate Rassler
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Respir Physiol Neurobiol 159:45-54. 2007
    ..The time course of hypoxia-induced pulmonary injury resembled that previously observed after continuous norepinephrine infusion in rats...
  94. ncbi request reprint Management and outcome in patients with Klatskin-mimicking lesions of the biliary tree
    Dirk Uhlmann
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    J Gastrointest Surg 10:1144-50. 2006
    ..Clinical presentation and imaging assessment were similar for Klatskin tumors and benign fibrosing disease; therefore, an aggressive resectional approach is justified in any patient with suspicious obstruction of the liver hilum...
  95. ncbi request reprint Neuroendocrine tumours of the duodenum. Clinical aspects, pathomorphology and therapy
    Helmut Witzigmann
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    Langenbecks Arch Surg 386:525-33. 2002
    ..There are few studies concerning the biological characteristics and adequate therapy of these tumours...
  96. doi request reprint Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns
    Christian Mozet
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany
    Onkologie 32:655-60. 2009
    ....
  97. ncbi request reprint [Parapharyngeal space-occupying lesions. Differential diagnosis based on case examples]
    A Weber
    Klinik für Hals Nasen Ohren Heilkunde, Plastische Operationen, Universitatsklinikum Leipzig, Liebigstrasse 18a, 04103 Leipzig
    HNO 50:223-9. 2002
    ..Parapharyngeal tumors account for only 0.8% of all head and neck tumors which often presents the problem of preoperative diagnosis. Up to 80% of parapharyngeal tumors are benign...
  98. ncbi request reprint Alpha1-and beta2-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C
    W T Kassahun
    Faculty of Medicine, Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, OKL, University of Leipzig, Liebig Strasse 20a, 04103, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 372:171-81. 2005
    ..These quantitative changes may help to elucidate not fully understood pathogenetic mechanisms of disturbed hepatic metabolic processes, such as hypoglycemia during cancer in human liver...
  99. ncbi request reprint Carcinogen-induced site-specific mutagenesis and genetic susceptibility in squamous cell carcinoma of the head and neck
    A Weber
    Klinik für Hals Nasen Ohren Heilkunde Plastische Operationen, Universitatsklinikum Leipzig, Germany
    Onkologie 25:8-13. 2002
    ..In this review, we attempt to discuss the carcinogen-specific mutations as well as the genetic polymorphisms, which may transfer an enhanced susceptibility to suffer HNSCC...
  100. ncbi request reprint Identification of functional genes during Fas-mediated apoptosis using a randomly fragmented cDNA library
    M Hassan
    Institute of Pathology, Heinrich Heine University, Moorenstr 5, 40225, Dusseldorf, Germany
    Cell Mol Life Sci 62:2015-26. 2005
    ..Our gene discovery strategy provides a generally applicable procedure to identify functional genes that interfere with apoptosis, and may therefore be clinically relevant for tumor therapy...
  101. ncbi request reprint Attenuation of endothelin expression and histologic changes by administration of a selective endothelin-A receptor antagonist in pig pancreas transplantation
    D Uhlmann
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Transplant Proc 34:2362-3. 2002