R H Straub

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Cytokines and hormones as possible links between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Hospital, 93042, Regensburg, Germany
    J Neuroimmunol 109:10-5. 2000
  2. pmc Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems
    P Harle
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Ann Rheum Dis 65:51-6. 2006
  3. ncbi request reprint The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages
    L E Miller
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Medical Center Regensburg, Germany
    FASEB J 14:2097-107. 2000
  4. pmc Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3
    P Sarzi-Puttini
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 65:301-5. 2006
  5. doi request reprint Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 57:911-21. 2008
  6. ncbi request reprint Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Neurochem 75:2464-71. 2000
  7. ncbi request reprint Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential beta-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions
    R H Straub
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    J Neuroimmunol 71:37-43. 1996
  8. ncbi request reprint Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 83:2012-7. 1998
  9. pmc Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    S Capellino
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Ann Rheum Dis 66:53-8. 2007
  10. ncbi request reprint In etanercept-treated psoriatic arthritis patients clinical improvement correlated with an increase of serum cortisol relative to other adrenal hormones
    F Atzeni
    Laboratory of Exp Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Clin Exp Rheumatol 26:103-8. 2008

Detail Information

Publications52

  1. ncbi request reprint Cytokines and hormones as possible links between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Hospital, 93042, Regensburg, Germany
    J Neuroimmunol 109:10-5. 2000
    ..Understanding of these bidirectional physiological mechanisms will help to define targets for therapeutical intervention to improve the health of aging people...
  2. pmc Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems
    P Harle
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Ann Rheum Dis 65:51-6. 2006
    ..To study in parallel the outflow of the sympathetic nervous system (SNS) and the hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  3. ncbi request reprint The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages
    L E Miller
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Medical Center Regensburg, Germany
    FASEB J 14:2097-107. 2000
    ..This demonstrates a loss of the influence of the sympathetic nervous system on the inflammation, accompanied by an up-regulation of the sensory inputs into the joint, which may contribute to the maintenance of the disease...
  4. pmc Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3
    P Sarzi-Puttini
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 65:301-5. 2006
    ..IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation...
  5. doi request reprint Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 57:911-21. 2008
    ..Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations...
  6. ncbi request reprint Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Neurochem 75:2464-71. 2000
    ..These experiments demonstrate the ambiguity of NPY, which functions as a cotransmitter of NE in the nerve-macrophage interplay...
  7. ncbi request reprint Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential beta-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions
    R H Straub
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    J Neuroimmunol 71:37-43. 1996
    ..The study demonstrates two different beta-adrenergic effects on IL-6 secretion of murine spleen slices under bacteria-rich or bacteria-free conditions...
  8. ncbi request reprint Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 83:2012-7. 1998
    ..Immunosenescence may be directly related to endocrinosenescence, which, in turn, may be a significant cofactor for the manifestation of inflammatory and age-related diseases...
  9. pmc Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    S Capellino
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Ann Rheum Dis 66:53-8. 2007
    ..Steroid hormone receptors such as glucocorticoid receptors, androgen receptors, and oestrogen receptors alpha (ERalpha) and beta (ERbeta) have been identified in synovial cells of patients with rheumatoid arthritis and osteoarthritis...
  10. ncbi request reprint In etanercept-treated psoriatic arthritis patients clinical improvement correlated with an increase of serum cortisol relative to other adrenal hormones
    F Atzeni
    Laboratory of Exp Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Clin Exp Rheumatol 26:103-8. 2008
    ..However, whether this is similar in psoriatic arthritis (PsA) is not known. The aim of this study was to assess the effect of 12 weeks of etanercept treatment upon the function of the HPA axis in patients with PsA...
  11. ncbi request reprint Differential age-related changes of hypothalamus - pituitary - adrenal axis hormones in healthy women and men - role of interleukin 6
    B Zietz
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:93-101. 2001
    ..This study underlines the hormone-like role of IL-6 in the aging process of the endocrine system in women...
  12. doi request reprint Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6
    R H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Ann Rheum Dis 68:572-8. 2009
    ..Acute stress in patients with rheumatoid arthritis (RA) should stimulate a strong stress response. After cryotherapy, we expected to observe an increase of hormones of the adrenal gland and the sympathetic nervous system...
  13. pmc Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus
    R H Straub
    Department of Internal Medicine I, University Hospital Regensburg, D 93042 Regensburg, Germany
    Ann Rheum Dis 63:961-8. 2004
    ..In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones...
  14. ncbi request reprint Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Z Rheumatol 59:II/108-18. 2000
    ..The importance of DHEAS deficiency will be demonstrated with respect to osteoporosis. As a consequence, we suggest a combined therapy with corticosteroids plus DHEA in chronic inflammatory diseases...
  15. ncbi request reprint A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-alpha and IL-6 secretion in the spleen
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University of Regensburg, Germany
    FASEB J 14:1380-8. 2000
    ..This suggests that activation of the sympathetic nervous system may be a forerunner for accumulation of bacteria in tissue and consecutively sepsis due to intensified inhibition of TNF-alpha secretion...
  16. pmc Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa
    R H Straub
    Laboratory of Neuro Endocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 54:1098-106. 2005
    ..In the intestinal tract, the role of sympathetic neurotransmitters has been largely ignored in mucosal neuroimmunology...
  17. doi request reprint Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases
    R H Straub
    From the Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Intern Med 267:543-60. 2010
    ..We propose that the presented pathophysiological framework may lead to new therapeutical approaches and to a better understanding of CID sequence...
  18. ncbi request reprint Treatment of pouchitis with dehydroepiandrosterone (DHEA) - a case report
    F H Klebl
    Department of Internal Medicine I, University of Regensburg, Germany
    Z Gastroenterol 41:1087-90. 2003
    ..In a pilot trial DHEA was effective for the treatment of active ulcerative colitis. Pouchitis is a common complication after proctocolectomy for ulcerative colitis and still a therapeutical challenge...
  19. doi request reprint Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps--a putative role of semaphorins 3F and 3A
    N Graf
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Neurogastroenterol Motil 24:120-8, e83. 2012
    ..Nerve fibers can exert trophic/anti-trophic effects on epithelial cells. Substance P (SP) is a pro-proliferative neuropeptide, whereas sympathetic noradrenaline is anti-proliferative at high concentrations...
  20. doi request reprint Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes
    H Bruhl
    Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Rheumatology (Oxford) 47:1771-4. 2008
    ..We have characterized the expression and the function of the chemokine receptor CCR7 on fibroblast-like synoviocytes (FLS) of patients with RA and OA and on dermal fibroblasts...
  21. doi request reprint [Rheumatism, jet lag and the body clock]
    G Pongratz
    Labor für experimentelle Rheumatologie und Neuroendokrinoimmunologie, Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum Regensburg, Franz Josef Straus Allee 11, 93042, Regensburg, Deutschland
    Z Rheumatol 70:305-12. 2011
    ..The impact of acute phase shifts as a result of transmeridian travel in subjects with rheumatic disorders, as well as strategies to prevent jet lag will be discussed in the following article...
  22. ncbi request reprint Favorable role of interleukin 10 in patients with polymyalgia rheumatica
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Rheumatol 26:1318-25. 1999
    ..To determine the relationship between the antiinflammatory molecule interleukin 10 (IL-10) and disease symptoms, IL-1beta, tumor necrosis factor (TNF), and IL-1 receptor antagonist (IL-1ra) in patients with polymyalgia rheumatica (PMR)...
  23. ncbi request reprint Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis
    M Dirmeier
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Rheumatology (Oxford) 47:36-40. 2008
    ..We demonstrated the increase of SP-positive NFs in RA as compared with OA. This study investigated the density of CGRP-positive NFs relative to SP-positive NFs or sympathetic NFs in synovial tissue of patients with RA and OA...
  24. ncbi request reprint The process of aging changes the interplay of the immune, endocrine and nervous systems
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Regensburg, Germany
    Mech Ageing Dev 122:1591-611. 2001
    ..Furthermore, it is demonstrated that chronic inflammatory diseases may accelerate the aging process. This review also reveals that new statistical and computational methods are necessary to unravel the complexity of the aging process...
  25. ncbi request reprint Serum BAFF strongly correlates with PsA activity in male patients only--is there a role for sex hormones?
    G Pongratz
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Clin Exp Rheumatol 28:813-9. 2010
    ..To determine the relationship between serum levels of B cell activating factor belonging to the TNF family (BAFF) and disease activity (DAS28) in psoriatic arthritis (PsA) patients...
  26. pmc Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis
    P Harle
    Laboratory of Neuro Endocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, D 93042 Regensburg, Germany
    Ann Rheum Dis 63:809-16. 2004
    ..Leptin is stimulated by TNF and is associated with hypoandrogenicity in non-inflammatory conditions...
  27. ncbi request reprint Surgical synovectomy decreases density of sensory nerve fibers in synovial tissue of non-inflamed controls and rheumatoid arthritis patients
    B Ossyssek
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    J Orthop Res 29:297-302. 2011
    ..This study can help to explain the positive effects of surgical synovectomy which usually leads to pain reduction and improved mobility...
  28. pmc Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium
    C Weidler
    Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 64:13-20. 2005
    ..To investigate the correlation between density of nerve fibres and the presence of BDNF(+) cells...
  29. doi request reprint Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    J Endocrinol 199:61-8. 2008
    ..Since androgens inhibit IL6 secretion, the activity-induced increase of these hormones might be an anti-atherogenic signal...
  30. ncbi request reprint Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Neuroimmunol 80:149-57. 1997
    ..05). Autonomic hyperreflexia was significantly associated with more severe inflammation and systemic disease in IBD. Hyperreflexia may be a response to inflammation or a pathogenetic element that drives mucosal inflammation...
  31. ncbi request reprint Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach
    P Harle
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Rheumatology (Oxford) 44:426-33. 2005
    ..Therefore, this review focuses on the multidisciplinary aspects of neuroendocrine-immune changes in RA...
  32. ncbi request reprint Early shifts of adrenal steroid synthesis before and after relief of short-term cholestasis
    B Zietz
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Hepatol 35:329-37. 2001
    ..CONCLUSIONS: Short-term cholestasis for 5-12 days induced marked alterations of adrenal steroidogenesis which partly resemble the changes observed in chronic inflammatory diseases...
  33. ncbi request reprint Alterations of the hypothalamic-pituitary-adrenal axis in systemic immune diseases - a role for misguided energy regulation
    R H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Clin Exp Rheumatol 29:S23-31. 2011
    ....
  34. ncbi request reprint Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Leukoc Biol 67:553-8. 2000
    ..These findings may explain the close association of nerves and macrophages in tissue and lymphoid organs and may thus be of functional relevance in neuroimmunomodulation...
  35. doi request reprint [Neuroendocrine immune interactions in rheumatic diseases]
    R H Straub
    Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum Regensburg, 93042, Regensburg, Deutschland
    Z Rheumatol 69:340-8. 2010
    ..These considerations could lead to novel therapeutic strategies for rheumatic diseases in the future...
  36. ncbi request reprint In vitro superfusion method to study nerve-immune cell interactions in human synovial membrane in long-standing rheumatoid arthritis or osteoarthritis
    L E Miller
    Department of Internal Medicine, University Medical Center, Regensburg, Germany
    Ann N Y Acad Sci 876:266-75. 1999
    ..The study demonstrates that local endogenous NE seem to play a minor role, which may be due to a depletion of NE or loss of noradrenergic fibers during chronic RA and OA...
  37. ncbi request reprint Low density of CD1+ cells in the synovial tissue of patients with rheumatoid arthritis
    C Weidler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Rheumatol 22:433-40. 2004
    ..This study was initiated to compare the density of CD1a+, CD1b+, and CD1c+ synovial cells in RA and OA patients...
  38. ncbi request reprint Involvement of the hypothalamic--pituitary--adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Arthritis Rheum 44:493-507. 2001
    ..This review reinforces the belief that combined therapeutic approaches on a neuroendocrine immune basis are of crucial importance in a pathogenetically oriented therapy of RA...
  39. pmc The role of the sympathetic nervous system in intestinal inflammation
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 55:1640-9. 2006
    ..This review attempts to integrate the different perspectives of the pro- and anti-inflammatory effects of the SNS on inflammatory disease of the gut...
  40. ncbi request reprint Molecular imaging: novel tools in visualizing rheumatoid arthritis
    A Wunder
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatology (Oxford) 44:1341-9. 2005
    ..With regard to their applicability in rheumatic diseases, we discuss potential molecular targets, current experimental approaches and the future prospects for molecular imaging in rheumatoid arthritis...
  41. doi request reprint Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis
    M Worlicek
    Department of Internal Medicine, School of Medicine, University Hospital, Regensburg, Germany
    Gut 59:1127-34. 2010
    ..However, the role of splanchnic SNS activity in bacterial translocation and bacterial spreading in cirrhosis remains unclear...
  42. ncbi request reprint Role of NPY for vasoregulation in the splanchnic circulation during portal hypertension
    R Wiest
    Department of Internal Medicine, School of Medicine, University Hospital, Regensburg 93042, Germany
    Peptides 28:396-404. 2007
    ....
  43. ncbi request reprint Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study
    T Andus
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Aliment Pharmacol Ther 17:409-14. 2003
    ..Dehydroepiandrosterone inhibits nuclear factor-kappaB and the secretion of interleukin-6 and interleukin-12 via the peroxisome proliferator-activated receptor alpha...
  44. pmc Benefit of pregnancy in inflammatory arthritis
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 64:801-3. 2005
  45. ncbi request reprint Estimation of the cut-off value in cardiovascular autonomic nervous function tests: not-age-related criteria or the age-related 5th percentile
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Diabetes Complications 11:145-50. 1997
    ..We therefore suggest that age-related normal values (percentiles) have to be applied when cANP is estimated...
  46. pmc Anti-tumour necrosis factor antibody treatment does not change serum levels of cortisol binding globulin in patients with rheumatoid arthritis but it increases androstenedione relative to cortisol
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg 93042, Germany
    Ann Rheum Dis 64:1353-6. 2005
    ..CBG serum levels are typically low during prolonged inflammatory processes. Thus, observed changes of cortisol during anti-tumour necrosis factor (TNF) treatment may be related to changes of CBG in rheumatoid arthritis (RA)...
  47. ncbi request reprint Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen caused by opioidergic transmission
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    Am J Physiol 274:R997-1003. 1998
    ..Inhibition of spontaneous IL-6 secretion from spleen macrophages is most probably due to a net inhibitory effect of opioidergic transmission under these conditions...
  48. ncbi request reprint Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 85:1340-4. 2000
    ..As IL-6 may be a pathogenetic factor in age-related diseases, HRT-related inhibition of IL-6 secretion could be an important element for the favorable effects of HRT in postmenopausal women...
  49. ncbi request reprint No alterations of serum levels of adrenal and gonadal hormones in patients with ankylosing spondylitis
    R H Straub
    Department of Internal Medicine I, University Hospital Regensburg, Germany
    Clin Exp Rheumatol 20:S52-9. 2002
    ..In conclusion, current data on sex steroid hormones provide no straightforward explanation for the male predominance in AS. At the moment, there is no rationale to treat AS patients with sex steroid hormones...
  50. doi request reprint Systemic metabolic signaling in acute and chronic gastrointestinal inflammation of inflammatory bowel diseases
    T Karrasch
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Horm Metab Res 46:445-51. 2014
    ..A major mechanism of the redirection program is insulin resistance. New therapeutic strategies might be developed in the future, directly impacting on the storage and utilization of energy-rich fuels. ..
  51. ncbi request reprint The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    J Endocrinol 175:467-74. 2002
    ..As in chronic inflammatory diseases, during an acute inflammatory response with endotoxin, these physiological hormone changes are probably necessary to achieve adequate cortisol levels at the expense of adrenal androgens...
  52. ncbi request reprint Efficient analysis of hepatic glucose output and insulin action using a liver slice culture system
    R Buettner
    Department of Internal Medicine I, University of Regensburg, Germany
    Horm Metab Res 37:127-32. 2005
    ..However, whether this method is suitable to measure hepatic glucose output is unknown...