Thomas Steuber

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Serum markers for prostate cancer: a rational approach to the literature
    Thomas Steuber
    Department of Urology, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:31-40. 2008
  2. ncbi request reprint Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Prostate 63:13-8. 2005
  3. ncbi request reprint Circulating biomarkers for prostate cancer
    Thomas Steuber
    Department of Urology, University Clinic Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:111-9. 2007
  4. pmc Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 118:1234-40. 2006
  5. ncbi request reprint Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 120:1499-504. 2007
  6. ncbi request reprint Validation of a nomogram for prediction of side specific extracapsular extension at radical prostatectomy
    Thomas Steuber
    Department of Urology, Hamburg, Germany
    J Urol 175:939-44; discussion 944. 2006
  7. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
  8. doi request reprint Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study
    Thomas Steuber
    Martini Clinic, Prostate Cancer Center, Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1755-61. 2011
  9. doi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
  10. doi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010

Detail Information

Publications77

  1. doi request reprint Serum markers for prostate cancer: a rational approach to the literature
    Thomas Steuber
    Department of Urology, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:31-40. 2008
    ..Therefore, novel biomarkers are much needed to complement PSA by enhancing its diagnostic and prognostic performance...
  2. ncbi request reprint Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Prostate 63:13-8. 2005
    ....
  3. ncbi request reprint Circulating biomarkers for prostate cancer
    Thomas Steuber
    Department of Urology, University Clinic Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:111-9. 2007
    ..This article will briefly discuss current PSA-based strategies and review several novel biomarkers for prostate cancer, detectable in blood...
  4. pmc Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 118:1234-40. 2006
    ..Measurements of fPSA and hK2 improve on our ability to counsel patients prior to treatment as to their risk of BCR...
  5. ncbi request reprint Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 120:1499-504. 2007
    ..0.715, p=0.039). In this setting, hK2 did not add diagnostic information. Measurements of individual forms of suPAR and PSA isoforms contributed significantly to discrimination of men with PCa from those with no evidence of malignancy...
  6. ncbi request reprint Validation of a nomogram for prediction of side specific extracapsular extension at radical prostatectomy
    Thomas Steuber
    Department of Urology, Hamburg, Germany
    J Urol 175:939-44; discussion 944. 2006
    ..We developed a nomogram and compared the performance and discriminant properties of the tree regression and the nomogram in a contemporary cohort of European patients treated with radical retropubic prostatectomy...
  7. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
    ....
  8. doi request reprint Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study
    Thomas Steuber
    Martini Clinic, Prostate Cancer Center, Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1755-61. 2011
    ..Therapy (outcomes research)...
  9. doi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
    ..Diagnosis (case series)...
  10. doi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010
    ..To test the validity of an updated version of the preoperative Kattan nomogram for prediction of recurrence after radical prostatectomy (RP), published by Stephenson et al...
  11. doi request reprint Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer
    Sascha A Ahyai
    Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:478-83. 2010
    ....
  12. doi request reprint Risk assessment of metastatic recurrence in patients with prostate cancer by using the Cancer of the Prostate Risk Assessment score: results from 2937 European patients
    Lars Budaus
    Department of Urology, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 110:1714-20. 2012
    ..2 and 78.5, respectively, in European patients. Therefore, the CAPRA score also allows reliable prediction of the examined endpoints in European patients...
  13. ncbi request reprint High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany
    Eur Urol 50:498-505. 2006
    ..We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy...
  14. ncbi request reprint Development and internal validation of preoperative transition zone prostate cancer nomogram
    Thomas Steuber
    Department of Urology, University of Hamburg, Hamburg, Germany
    Urology 68:1295-300. 2006
    ..TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP...
  15. doi request reprint Unilateral prostate cancer cannot be accurately predicted in low-risk patients
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:784-7. 2010
    ..We tested the accuracy of unilaterally unremarkable biopsy findings in cases of low-risk PCa patients who are potential candidates for HAT...
  16. doi request reprint Biochemical recurrence after radical prostatectomy: multiplicative interaction between surgical margin status and pathological stage
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 184:1341-6. 2010
    ..We addressed the first degree of interaction between positive surgical margins and other established adverse predictors of biochemical recurrence after radical prostatectomy...
  17. doi request reprint Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score
    Jens Hansen
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 113:399-407. 2014
    ....
  18. doi request reprint Loss of pSer2448-mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers
    Julia Muller
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 132:1333-40. 2013
    ....
  19. doi request reprint External validation of the updated Briganti nomogram to predict lymph node invasion in prostate cancer patients undergoing extended lymph node dissection
    Jens Hansen
    Martini Clinic, Prostate Cancer Centre at University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Prostate 73:211-8. 2013
    ....
  20. doi request reprint Assessment of rates of lymph nodes and lymph node metastases in periprostatic fat pads in a consecutive cohort treated with retropubic radical prostatectomy
    Jens Hansen
    Martini Clinic, Prostate Cancer Center at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urology 80:877-82. 2012
    ....
  21. doi request reprint The presence of prostate cancer on saturation biopsy can be accurately predicted
    Sascha A Ahyai
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:636-41. 2010
    ..To improve the ability of our previously reported saturation biopsy nomogram quantifying the risk of prostate cancer, as the use of office-based saturation biopsy has increased...
  22. ncbi request reprint Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer
    Thomas Steuber
    Department of Surgery Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Chem 53:233-40. 2007
    ..We evaluated the association of total and free forms of serum human kallikrein 2 (hK2) and prostate-specific antigen (PSA) with prostate cancers of unfavorable prognosis...
  23. ncbi request reprint Contemporary prostate cancer prevalence among T1c biopsy-referred men with a prostate-specific antigen level < or = 4.0 ng per milliliter
    Sascha A Ahyai
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 53:750-7. 2008
    ..To investigate the prostate cancer (PCa) prevalence and risk factors of men with prostate-specific antigen (PSA) level< or =4.0 ng/ml and an unsuspicious digital rectal examination (DRE) in a large biopsy referral cohort...
  24. doi request reprint Nerve-sparing Surgery Technique, Not the Preservation of the Neurovascular Bundles, Leads to Improved Long-term Continence Rates After Radical Prostatectomy
    Uwe Michl
    Martini Clinic Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 69:584-9. 2016
    ..The effect of preservation of neurovascular bundles (NVBs) during radical prostatectomy (RP) on continence remains controversial...
  25. doi request reprint Long-term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate-specific antigen era
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:37-43. 2010
    ..Therapy (case series) Level of Evidence 4...
  26. ncbi request reprint Total and Gleason grade 4/5 cancer volumes are major contributors of human kallikrein 2, whereas free prostate specific antigen is largely contributed by benign gland volume in serum from patients with prostate cancer or benign prostatic biopsies
    Alexander Haese
    Department of Urology, University Clinic Eppendorf, Hamburg, Germany
    J Urol 170:2269-73. 2003
    ....
  27. doi request reprint Importance of baseline potency rate assessment of men diagnosed with clinically localized prostate cancer prior to radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University of Hamburg, Hamburg, Germany
    J Sex Med 6:498-504. 2009
    ..Knowledge about baseline potency is highly important in men undergoing treatment for prostate cancer (PCa) as it might influence judgments about impact of treatment and thereby treatment decisions...
  28. ncbi request reprint Comparative assessment of the 1992 and 2002 pathologic T3 substages for the prediction of biochemical recurrence after radical prostatectomy
    Thomas Steuber
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Cancer 106:775-82. 2006
    ....
  29. ncbi request reprint Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer
    Felix K H Chun
    Department of Urology, University Medical Center Eppendorf, Hamburg, Germany
    World J Urol 24:273-80. 2006
    ..Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery...
  30. ncbi request reprint Frozen section for the management of intraoperatively detected palpable tumor lesions during nerve-sparing scheduled radical prostatectomy
    Christian Eichelberg
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Eur Urol 49:1011-6; discussion 1016-8. 2006
    ..We investigated the use of frozen section (FS) analysis to monitor the safety and efficiency of NS during RP in patients with intraoperatively identified subcapsular tumor lesions...
  31. ncbi request reprint Discrimination of benign from malignant prostatic disease by selective measurements of single chain, intact free prostate specific antigen
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Germany
    J Urol 168:1917-22. 2002
    ..We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease...
  32. ncbi request reprint Zonal origin of localized prostate cancer does not affect the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 51:949-55; discussion 955. 2007
    ..To investigate whether transition zone (TZ) prostate cancers demonstrate different rates of biochemical recurrence after radical prostatectomy compared to peripheral zone (PZ) cancers...
  33. ncbi request reprint Development and internal validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 49:820-6. 2006
    ..We explored the rate of upgrading from biopsy to RP specimen in our contemporary cohort, and developed a model capable of predicting the probability of biopsy Gleason sum upgrading...
  34. ncbi request reprint Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    BJU Int 98:329-34. 2006
    ....
  35. doi request reprint Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) increases nerve-sparing frequency and reduces positive surgical margins in open and robot-assisted laparoscopic radical prostatectomy: experience after 11,069 consecutive patients
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 62:333-40. 2012
    ..Intraoperative frozen-section analysis allows real-time histologic assessment of surgical margins (SMs) and identification of candidates for nerve-sparing (NS) procedures...
  36. doi request reprint Inverse stage migration in patients undergoing radical prostatectomy: results of 8916 European patients treated within the last decade
    Lars Budaus
    Martiniclinic, Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 108:1256-61. 2011
    ..To investigate the stage migration patterns during the last decade in European men treated with radical prostatectomy (RP)...
  37. doi request reprint Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    Sarah Minner
    Institute of Pathology, Department of Urology, Prostate Cancer Center University Medical Center, Hamburg Eppendorf, Germany
    Clin Cancer Res 16:1553-60. 2010
    ..The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer...
  38. doi request reprint Effect of body mass index on histopathologic parameters: results of large European contemporary consecutive open radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Urology 73:615-9. 2009
    ..Studies, predominantly derived from the United States, have suggested that an increased BMI is a significant predictor of adverse pathologic findings in patients treated with open RP...
  39. doi request reprint Assessing the clinical benefit of a nomogram to predict specimen-confined disease at radical prostatectomy in patients with high-risk prostate cancer: An external validation
    Jens Hansen
    Department of Urology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany Department of Urology, Vivantes Auguste Viktoria Klinikum, Berlin, Germany Electronic address
    Urol Oncol 33:384.e1-8. 2015
    ..The nomogram allows improved decision making with curative intent within this heterogeneous patient cohort, which is important, as RP in patients with clinical HRPCa remains a topic of controversy...
  40. doi request reprint The effect of annual surgical caseload on the rates of in-hospital pneumonia and other in-hospital outcomes after radical prostatectomy
    Jan Schmitges
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int Urol Nephrol 44:799-806. 2012
    ..To examine the effect of annual surgical caseload (ASC) on contemporary in-hospital pneumonia (IHP) rates and three other in-hospital outcomes after radical prostatectomy (RP)...
  41. doi request reprint Accuracy of HistoScanning™ for the prediction of a negative surgical margin in patients undergoing radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University Medical Center Eppendorf, Hamburg, Germany
    BJU Int 111:60-6. 2013
    ..To assess the accuracy of HistoScanning™ (HS) as a visualization tool for preoperative treatment planning for nerve-sparing (NS) radical prostatectomy (RP)...
  42. doi request reprint Full functional-length urethral sphincter preservation during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Centre, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 60:320-9. 2011
    ..A key prerequisite for urinary continence after radical prostatectomy (RP) is the functional length of the urethral sphincter and the stabilisation of its anatomic position within the pelvic floor...
  43. doi request reprint Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:7838-42. 2008
    ..Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer...
  44. doi request reprint Limited prognostic value of preoperative circulating tumor cells for early biochemical recurrence in patients with localized prostate cancer
    Christian P Meyer
    Martini Clinic Prostate Cancer Center, Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urol Oncol 34:235.e11-6. 2016
    ..In contrast, the value of CTC detection in men with localized prostrate cancer before radical prostatectomy (RP) is unknown...
  45. doi request reprint Ten-year experience of robot-assisted radical prostatectomy: the road from cherry-picking to standard procedure
    Jonas Schiffmann
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Minerva Urol Nefrol 69:69-75. 2017
    ..Patients treated with robot-assisted radical prostatectomy (RARP) are frequently selected according to more favorable characteristics. Such patient selection might decrease according to increasing experience...
  46. doi request reprint Differences in Patient Characteristics Among Men Choosing Open or Robot-Assisted Radical Prostatectomy in Contemporary Practice at a European High-Volume Center
    Jonas Schiffmann
    Martini Clinic Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urol Int 97:8-15. 2016
    ..To examine the characteristics of robot-assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP) patients at a high-volume center...
  47. ncbi request reprint 10-year experience of robot-assisted radical prostatectomy: the road from cherry picking to standard procedure
    Jonas Schiffmann
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Minerva Urol Nefrol . 2016
    ..Patients treated with robot-assisted radical prostatectomy (RARP) are frequently selected according to more favorable characteristics. Such patient selection might decrease according to increasing experience...
  48. doi request reprint High Chance of Late Recovery of Urinary and Erectile Function Beyond 12 Months After Radical Prostatectomy
    Philipp Mandel
    Martini Klinik Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol . 2016
    ..8% at 24 mo and 36.5% at 36 mo after RP. Patients with postoperative UI or ED 12 mo after RP should be counseled about their good chance of achieving continence or potency in the course of time...
  49. ncbi request reprint Does low-risk prostate cancer detection change with repeat biopsies?
    Bobby B Najari
    Weill Cornell Medical College, New York, NY University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany Martini Clinic Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany Hubertus Wald Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 30:188. 2012
    ..Although higher rates of low grade PCa on repeat PBx have been reported, we hypothesize that a considerable risk of clinically significant PCa remains...
  50. doi request reprint A tertiary Gleason pattern in the prostatectomy specimen and its association with adverse outcome after radical prostatectomy
    Meike Adam
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    J Urol 192:97-101. 2014
    ..We tested the impact of a tertiary Gleason pattern on adverse histopathological features and biochemical recurrence rates after radical prostatectomy...
  51. doi request reprint Open and robot-assisted radical retropubic prostatectomy in men receiving ongoing low-dose aspirin medication: revisiting an old paradigm?
    Sami Ramzi Leyh-Bannurah
    Martini Clinic, Prostate Cancer Center at University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 114:396-403. 2014
    ..To assess blood loss, transfusion rates and 90-day complication rates in patients receiving ongoing 100 mg/day aspirin medication and undergoing open radical prostatectomy (RP) or robot-assisted RP (RARP)...
  52. doi request reprint Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients
    Georg Salomon
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 113:548-53. 2014
    ..To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy...
  53. doi request reprint CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer
    Lia Burkhardt
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer Res 73:2795-805. 2013
    ..Our study establishes CHD1 as the 5q21 tumor suppressor gene in prostate cancer and shows a key role of this chromatin remodeling factor in prostate cancer biology...
  54. doi request reprint High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 71:281-8. 2011
    ..This study was undertaken, to gain more insight on the role of PSMA in early prostate cancer and its distribution in various normal tissues...
  55. doi request reprint Current technique of open intrafascial nerve-sparing retropubic prostatectomy
    Lars Budaus
    Martini Clinic, Prostate Cancer Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 56:317-24. 2009
    ..Even though the principles of the technique and its oncological efficacy have often been published, ongoing refinements allow further improvements in functional outcome and morbidity...
  56. doi request reprint Salvage radical prostatectomy for recurrent prostate cancer: verification of European Association of Urology guideline criteria
    Philipp Mandel
    Martini Clinic Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 117:55-61. 2016
    ....
  57. doi request reprint Use of phosphodiesterase type 5 inhibitors may adversely impact biochemical recurrence after radical prostatectomy
    Uwe Michl
    Martini Clinic Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 193:479-83. 2015
    ..We studied the effect of phosphodiesterase type 5 inhibitors on biochemical recurrence after radical prostatectomy for prostate cancer...
  58. doi request reprint Oncological, functional and perioperative outcomes in transplant patients after radical prostatectomy
    Burkhard Beyer
    Martini Klinik Prostate Cancer Center, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    World J Urol 34:1101-5. 2016
    ..The aim of the present study was to analyse oncological, functional and perioperative outcomes in Tx patients following radical prostatectomy (RP)...
  59. doi request reprint Functional Outcomes and Quality of Life After Radical Prostatectomy Only Versus a Combination of Prostatectomy with Radiation and Hormonal Therapy
    Meike Adam
    Martini Klinik Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of Urology, University of Tuebingen, Tuebingen, Germany
    Eur Urol 71:330-336. 2017
    ..While the optimal use and timing of secondary therapy after radical prostatectomy (RP) remain controversial, there are limited data on patient-reported outcomes following multimodal therapy...
  60. doi request reprint Safe-R: a novel score, accounting for oncological safe nerve-sparing at radical prostatectomy for localized prostate cancer
    Andreas Becker
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    World J Urol 33:77-83. 2015
    ....
  61. doi request reprint Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
    Antje Krohn
    Institute of Pathology, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 181:401-12. 2012
    ....
  62. ncbi request reprint Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, Department of Pathology and Urology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Clin Cancer Res 13:6579-84. 2007
    ..To determine its role in prostate cancer, we analyzed 2,497 prostate cancers on the DNA and protein level...
  63. doi request reprint Adjuvant radiation therapy is associated with better oncological outcome compared with salvage radiation therapy in patients with pN1 prostate cancer treated with radical prostatectomy
    Derya Tilki
    Martini Klinik Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int . 2016
    ....
  64. doi request reprint Prostate cancer in the elderly
    Hans Heinzer
    Martini Klinik, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urol Oncol 27:668-72. 2009
    ....
  65. doi request reprint A feasible and time-efficient adaptation of NeuroSAFE for da Vinci robot-assisted radical prostatectomy
    Burkhard Beyer
    The Martini Clinic Prostate Cancer Center, University Clinic Eppendorf, Hamburg, Germany
    Eur Urol 66:138-44. 2014
    ..In da Vinci robot-assisted prostatectomy (DVP), this approach is often avoided due to suspected difficulties in harvesting the prostate, loss in pneumoperitoneum, increased blood loss, and prolonged operating room (OR) time...
  66. pmc Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival
    Pauliina Helo
    Departments of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Chem 55:765-73. 2009
    ..e., prostate-specific antigen (PSA)] and KLK2 mRNAs. We also assessed the association of CTCs with disease characteristics and survival...
  67. doi request reprint Clinical significance of p53 alterations in surgically treated prostate cancers
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Mod Pathol 21:1371-8. 2008
    ..The rate of p53 alterations increases with prostate cancer progression...
  68. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
    ..However, transcript level patterns and RNA quality could rapidly change in response to ischemic and mechanical stress. Studies have shown that this occurs both perioperatively and after surgical removal of organs...
  69. doi request reprint Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Centre, Hamburg Eppendorf, Germany
    Eur Urol 55:394-401. 2009
    ..The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP...
  70. doi request reprint ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy
    Sarah Minner
    Institute of Pathology and Departments of Clinical Chemistry, Bone Marrow Transplantation with Section, Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 17:5878-88. 2011
    ..A secondary aim was to search for differences between these tumor classes...
  71. ncbi request reprint Extracorporeal shockwave lithotripsy compared with ureteroscopy for the removal of small distal ureteral stones
    Stefan Hautmann
    Department of Urology, University Hospital Hamburg, Eppendorf, Hamburg, Germany
    Urol Int 73:238-43. 2004
    ..The objective was to analyze the stone-free rate after treatment of distal ureteral stones with in situ SWL or URS...
  72. ncbi request reprint Surgical management of prostate cancer: advances based on a rational approach to the data
    Anoop M Meraney
    Glickman Urological Institute A 100, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Cancer 41:888-907. 2005
    ..Radical prostatectomy is also appropriate in selected patients with locally advanced disease and after failed radiation therapy...
  73. ncbi request reprint The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit and the Department of Urology, University of Montreal Health Center, Montreal, Canada
    Eur Urol 49:273-8; discussion 278-9. 2006
    ..We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients...
  74. ncbi request reprint Enhanced discrimination of benign from malignant prostatic disease by selective measurements of cleaved forms of urokinase receptor in serum
    Timo Piironen
    The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Clin Chem 52:838-44. 2006
    ..We assessed the ability of immunoassays for specific uPAR forms to discriminate PCa from benign conditions...
  75. ncbi request reprint Development and external validation of an extended 10-core biopsy nomogram
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    Eur Urol 52:436-44. 2007
    ..To test the accuracy of a previously externally validated sextant biopsy nomogram in referred men exposed to > or =10 or more biopsy cores. Moreover, we explored the hypothesis that a more accurate predictive tool could be developed...
  76. ncbi request reprint Surgical volume is related to the rate of positive surgical margins at radical prostatectomy in European patients
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 98:1204-9. 2006
    ..To assess the association between surgical volume (SV) and the rate of positive surgical margins (PSM) after radical prostatectomy (RP) in a large single-institution European cohort of patients...
  77. ncbi request reprint Development and external validation of an extended repeat biopsy nomogram
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    J Urol 177:510-5. 2007
    ..We hypothesized that the outcome of repeat biopsy could be accurately predicted. We tested this hypothesis in a contemporary cohort from 3 centers...