Gerhard Schuler

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint How to improve endothelial repair mechanisms: the lifestyle approach
    Sven Mobius-Winkler
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Expert Rev Cardiovasc Ther 8:573-80. 2010
  2. doi request reprint Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, Leipzig 04289, Germany
    Eur Heart J 31:1398-403. 2010
  3. doi request reprint Randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus-eluting stenting in isolated proximal left anterior descending coronary artery stenosis
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 53:2324-31. 2009
  4. doi request reprint Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners
    Volker Adams
    Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:602-7. 2008
  5. ncbi request reprint Incidence, time course, and predictors of early malignant ventricular arrhythmias after non-ST-segment elevation myocardial infarction in patients with early invasive treatment
    Kazem Rahimi
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur Heart J 27:1706-11. 2006
  6. pmc Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
    Steffen Desch
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Trials 12:204. 2011
  7. pmc Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design
    Ahmed A Khattab
    Cardiology Department, Bern University Hospital, Bern, Switzerland
    Trials 12:56. 2011
  8. ncbi request reprint [Physical activity]
    G Schuler
    Innere Medizin Kardiologie, Herzzentrum, Universitatsklinikum Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Z Kardiol 94:III/11-4. 2005
  9. ncbi request reprint [Primary and secondary prevention: physical activity]
    G Schuler
    Herzzentrum Leipzig GmbH Russenstrasse 19 04289 Leipzig, Germany
    Z Kardiol 91:30-9. 2002
  10. ncbi request reprint Polymer-sirolimus-eluting stents in de novo lesions
    Gerhard Schuler
    Herzzentrum GmbH, University of Leipzig, Germany
    Herz 29:152-61. 2004

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. doi request reprint How to improve endothelial repair mechanisms: the lifestyle approach
    Sven Mobius-Winkler
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Expert Rev Cardiovasc Ther 8:573-80. 2010
    ..This review focuses on lifestyle interventions to correct endothelial dysfunction in different cardiovascular diseases...
  2. doi request reprint Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, Leipzig 04289, Germany
    Eur Heart J 31:1398-403. 2010
    ..To evaluate the outcome of transapical aortic valve implantation (TA-AVI) in comparison to conventional surgery...
  3. doi request reprint Randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus-eluting stenting in isolated proximal left anterior descending coronary artery stenosis
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 53:2324-31. 2009
    ....
  4. doi request reprint Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners
    Volker Adams
    Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:602-7. 2008
    ..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners...
  5. ncbi request reprint Incidence, time course, and predictors of early malignant ventricular arrhythmias after non-ST-segment elevation myocardial infarction in patients with early invasive treatment
    Kazem Rahimi
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur Heart J 27:1706-11. 2006
    ..With the limited intensive care facilities, knowledge of the total risk and predictors of acute life-threatening arrhythmias is of major interest to guide the decision on the intensity of care at the time of admission...
  6. pmc Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
    Steffen Desch
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Trials 12:204. 2011
    ..Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented...
  7. pmc Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design
    Ahmed A Khattab
    Cardiology Department, Bern University Hospital, Bern, Switzerland
    Trials 12:56. 2011
    ..The PC-Trial was set up to compare endovascular closure and best medical treatment for prevention of recurrent events...
  8. ncbi request reprint [Physical activity]
    G Schuler
    Innere Medizin Kardiologie, Herzzentrum, Universitatsklinikum Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Z Kardiol 94:III/11-4. 2005
    ..A great number of population-based risk factors were evaluated; in several randomized studies and meta-analyses concordant results were achieved with respect to direction and degree of the therapeutic effect (Level B)...
  9. ncbi request reprint [Primary and secondary prevention: physical activity]
    G Schuler
    Herzzentrum Leipzig GmbH Russenstrasse 19 04289 Leipzig, Germany
    Z Kardiol 91:30-9. 2002
    ..The recommendation of the German Society for Cardiology are based on the results of these studies; they call for regular physical exercise at intermediate or high intensity for 30 to 45 minutes on at least five days per week...
  10. ncbi request reprint Polymer-sirolimus-eluting stents in de novo lesions
    Gerhard Schuler
    Herzzentrum GmbH, University of Leipzig, Germany
    Herz 29:152-61. 2004
    ..5 mm. Registries containing several thousand patients, however, indicate that under realistic conditions the flawless results of the initial studies could not be reproduced in all patient groups...
  11. ncbi request reprint Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
    ..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)...
  12. doi request reprint Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
    ..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers...
  13. doi request reprint Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  14. doi request reprint Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial
    Claudia Walther
    Department of Cardiology, University of Leipzig, Heart Center, 4289 Leipzig, Germany
    Circulation 120:2251-9. 2009
    ....
  15. ncbi request reprint Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
    ..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF...
  16. doi request reprint Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study
    Marcus Sandri
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
    Eur Heart J 33:1758-68. 2012
    ..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)...
  17. doi request reprint Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease
    Ephraim B Beck
    Heart Center, Department of Cardiology, University of Leipzig, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:412-8. 2012
    ..The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD...
  18. ncbi request reprint Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
    ..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF...
  19. doi request reprint Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trial
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:452-9. 2011
    ....
  20. ncbi request reprint Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  21. ncbi request reprint Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
    ..This analysis was conducted, to evaluate the effects of ET on left ventricular function and haemodynamics in patients with advanced CHF (NYHA class III) fulfilling the inclusion criteria of the COPERNICUS trial...
  22. ncbi request reprint Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected]
    Peter B Sick
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Am Heart J 149:681-8. 2005
    ..The aim of this study was to compare a carbonized and high-grade stainless steel stent of identical design with regard to early and late adverse events...
  23. doi request reprint Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size
    Robert Höllriegel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Int J Cardiol 167:975-80. 2013
    ....
  24. ncbi request reprint ST-segment recovery and prognosis in patients with ST-elevation myocardial infarction reperfused by prehospital combination fibrinolysis, prehospital initiated facilitated percutaneous coronary intervention, or primary percutaneous coronary intervention
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Am J Cardiol 98:1132-9. 2006
    ..In addition, STR has been confirmed to predict prognosis in timely optimized reperfusion strategies...
  25. ncbi request reprint Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  26. doi request reprint Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
    ....
  27. doi request reprint Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: 10-year follow-up of a randomized trial
    Stephan Blazek
    Department of Internal Medicine, Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, Leipzig, Germany
    JACC Cardiovasc Interv 6:20-6. 2013
    ....
  28. doi request reprint The utility of trans-catheter aortic valve replacement after commercialization: does the European experience provide a glimpse into the future use of this technology in the United States?
    Axel Linke
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Catheter Cardiovasc Interv 75:511-8. 2010
    ..Despite of the progress in this field, we are still lacking an optimal transcatheter heart valve. Once it is available, we can take the plunge to compare transcatheter valve implantation with convention surgery in severe aortic stenosis!..
  29. ncbi request reprint Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Am Coll Cardiol 42:861-8. 2003
    ..The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF)...
  30. doi request reprint Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 30:346-55. 2009
    ..This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs)...
  31. ncbi request reprint Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
    ....
  32. doi request reprint Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction
    Ingo Eitel
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 55:2470-9. 2010
    ..The aim of the study was to determine the prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance (CMR) in reperfused ST-segment elevation myocardial infarction...
  33. ncbi request reprint Latest advances in transcatheter aortic valve implantation
    Jörg Kempfert
    Heart Center, University of Leipzig, Clinic for Cardiac Surgery, Leipzig, Germany
    Surg Technol Int 19:147-54. 2010
    ..Nevertheless, TAVI has already evolved into a routine procedure in selected specialized centers providing a safe and reproducible treatment option for high-risk elderly patients suffering from severe symptomatic aortic stenosis...
  34. doi request reprint Reliability of myocardial salvage assessment by cardiac magnetic resonance imaging in acute reperfused myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiovasc Imaging 28:263-72. 2012
    ..Further validation studies and trials showing the prognostic value of myocardial salvage by CMRI are needed before routine implementation as a surrogate endpoint in STEMI trials...
  35. doi request reprint Sex differences in myocardial salvage and clinical outcome in patients with acute reperfused ST-elevation myocardial infarction: advances in cardiovascular imaging
    Ingo Eitel
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circ Cardiovasc Imaging 5:119-26. 2012
    ....
  36. ncbi request reprint Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Am Heart J 146:280-5. 2003
    ..It remains unclear, however, whether the degree of endothelial dysfunction caused by oxidative stress differs between CAD and CHF because of ischemic (ICM) or dilated cardiomyopathy (DCM)...
  37. doi request reprint Transapical aortic valve implantation: analysis of risk factors and learning experience in 299 patients
    Jörg Kempfert
    Department of Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Circulation 124:S124-9. 2011
    ..Transapical aortic valve implantation has evolved to a reproducible therapeutic option for high-risk patients. The aim of the present study was to evaluate our learning experience over 4 years and to analyze outcome-related risk factors...
  38. ncbi request reprint Changes in myocardial perfusion due to physical exercise in patients with stable coronary artery disease
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 9a, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 32:813-9. 2005
    ..The aim of this study was to evaluate changes in myocardial stress perfusion after 1 year of exercise training in comparison with the effects of PTCA in patients with CAD...
  39. doi request reprint Transapical off-pump valve-in-valve implantation in patients with degenerated aortic xenografts
    Jörg Kempfert
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 89:1934-41. 2010
    ..We evaluated the off-pump beating heart concept of transapical aortic valve implantation using the valve-in-valve (VinV) concept...
  40. doi request reprint Transapical aortic valve implantation in patients requiring redo surgery
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 36:231-4; discussion 234-5. 2009
    ..To evaluate the results of minimally invasive transapical aortic valve implantation (TA-AVI) in patients requiring redo surgery...
  41. ncbi request reprint Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
    ..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF...
  42. doi request reprint Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives
    Gerhard Schuler
    University Leipzig Heart Center Leipzig, Strumpellstrasse 39, 4289 Leipzig, Germany
    Eur Heart J 34:1790-9. 2013
    ....
  43. doi request reprint Minimally invasive off-pump aortic valve implantation: the surgical safety net
    Joerg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1665-8. 2008
    ..Due to the "surgical safety-net," cardiopulmonary bypass was immediately established, and after coronary bypass grafting, the patient recovered and was discharged from the hospital...
  44. doi request reprint Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease
    Claudia Walther
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:107-12. 2008
    ..We investigated the impact of 2 years regular ET versus percutaneous intervention (PCI) on chronic inflammation and cardiovascular events...
  45. doi request reprint Long-term prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction
    Ingo Eitel
    Department of Internal Medicine, University of Leipzig, Heart Center, Leipzig, Germany
    Heart 97:2038-45. 2011
    ....
  46. pmc Exercise training prevents TNF-α induced loss of force in the diaphragm of mice
    Norman Mangner
    Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e52274. 2013
    ..Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are elevated in congestive heart failure and are known to induce the production of reactive oxygen species as well as to deteriorate respiratory muscle function...
  47. ncbi request reprint Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial)
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 33:2035-43. 2012
    ..The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction...
  48. doi request reprint Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
    ..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome...
  49. doi request reprint The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications
    Madlen Uhlemann
    Department of Internal Medicine Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    JACC Cardiovasc Interv 5:36-43. 2012
    ....
  50. doi request reprint Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty
    Michal Droppa
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Clin Res Cardiol 100:1037-43. 2011
    ....
  51. ncbi request reprint Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  52. ncbi request reprint Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 28:1433-9. 2007
    ..Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations...
  53. doi request reprint Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement
    Jörg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany
    Eur Heart J 29:2382-7. 2008
    ..This study was designed to evaluate the feasibility and haemodynamic performance of transcatheter valve-in-a-valve (VinV) implantation for failed mitral xenografts using a minimally invasive, transatrial, off-pump approach...
  54. doi request reprint Transapical aortic valve implantation: therapy of choice for patients with aortic stenosis and porcelain aorta?
    Jörg Kempfert
    Clinic for Cardiac Surgery, University of Leipzig, Heart Center, Leipzig, Germany
    Ann Thorac Surg 90:1457-61. 2010
    ..Minimally invasive off-pump transapical aortic valve implantation may be an optimal strategy to treat elderly patients with porcelain aorta requiring aortic valve replacement...
  55. doi request reprint Predictors of permanent pacemaker implantation after Medtronic CoreValve bioprosthesis implantation
    Thomas Schroeter
    Herzzentrum Leipzig GmbH, Department of Cardiac Surgery, Leipzig Heart Center, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Europace 14:1759-63. 2012
    ..The aim of this study was to identify pre-operative risk factors for PPM implantation after TAVI with the Medtronic CoreValve prosthesis (CVP)...
  56. doi request reprint New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  57. doi request reprint Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Circulation 121:759-67. 2010
    ..Regular exercise training (ET) slows the progression of atherosclerotic lesions, reduces oxidative stress, and increases nitric oxide bioavailability, all of which may be expected to improve degenerative aortic valve disease...
  58. ncbi request reprint Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction
    Sandra Erbs
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 23:1814-9. 2003
    ..Therefore, we aimed to determine the effects of these polymorphisms on endothelial function and endothelial response to physical exercise in patients with coronary artery disease (CAD)...
  59. ncbi request reprint Impact of diabetes mellitus type 2 on in-hospital outcome after cardiac catheterizations in a large cohort of octogenarians
    Josef Niebauer
    Department of Internal Medicine and Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiol 96:441-6. 2004
    ..To assess the impact of diabetes mellitus type 2 (DM) in 1085 octogenarians on in-hospital outcome after cardiac catheterization (CATH) and/or percutaneous coronary intervention (PCI)...
  60. doi request reprint Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model
    Karsten Lenk
    Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur J Heart Fail 11:342-8. 2009
    ..This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha)...
  61. ncbi request reprint Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
    ..The aim of this study was to investigate morphological, functional and electromyographical parameters of the skeletal muscle in CHF...
  62. ncbi request reprint Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells
    Nicolle Krankel
    Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 25:698-703. 2005
    ..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function...
  63. doi request reprint High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Int J Cardiol 146:56-63. 2011
    ..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...
  64. doi request reprint Growth-differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, Leipzig 04289, Germany
    Heart 97:632-40. 2011
    ....
  65. ncbi request reprint Correlation of exercise capacity with high-sensitive C-reactive protein in patients with stable coronary artery disease
    Kazem Rahimi
    Department of Internal Medicine, Cardiology, University of Leipzig, Herzzentrum, Leipzig, Germany
    Am Heart J 150:1282-9. 2005
    ..However, the association between fitness and CRP in patients with stable CAD treated with medications known to influence the inflammatory response, such as statins and aspirin, is not well known...
  66. ncbi request reprint Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure
    Thomas Peschel
    Herzzentrum der Universitat Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:609-14. 2003
    ..To test the hypothesis that during acute heart failure endotoxin might be increased in hepatic veins as a sign of bacterial or endotoxin translocation from the bowel into the blood stream...
  67. doi request reprint Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  68. ncbi request reprint Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions
    Stephan Gielen
    Universitat Leipzig, Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Heart Fail Monit 4:130-6. 2005
    ..In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored...
  69. ncbi request reprint Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 26:1276-83. 2005
    ..A newly developed percutaneous left ventricular assist device (VAD) (Tandem Heart, Cardiac Assist, Pittsburgh, PA, USA) with active circulatory support might have positive haemodynamic effects and decrease mortality...
  70. doi request reprint Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD
    Norman Mangner
    Heart Center Leipzig, University of Leipzig, Struempellstrasse 39, D 04289 Leipzig, Germany
    Muscle Nerve 45:544-51. 2012
    ..Mice that lack both the transcription factor MyoD and dystrophin display a more pronounced myopathic phenotype when compared with mdx mice. No data on skeletal muscle function and the impact of exercise training are available...
  71. doi request reprint Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease
    Sebastian Sixt
    Department of Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    Eur Heart J 31:112-9. 2010
    ....
  72. doi request reprint Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training
    Volker Adams
    Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:293-9. 2008
    ..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx...
  73. doi request reprint Human minimally invasive off-pump valve-in-a-valve implantation
    Thomas Walther
    Department of Cardiac Surgery, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 85:1072-3. 2008
    ..Hemodynamic function was excellent and the patient had a fast and uneventful recovery...
  74. ncbi request reprint Comparison of early and late results of a Carbofilm-coated stent versus a pure high-grade stainless steel stent (the Carbostent-Trial)
    Peter B Sick
    University of Leipzig, Heart Center, Department for Internal Medicine Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Am J Cardiol 93:1351-6, A5. 2004
    ..These results agree with other trials using inactive coatings on stents, which also could not demonstrate any advantage over pure stainless steel stents...
  75. ncbi request reprint Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression
    Nicolle Krankel
    Department of Cardiology, Heart Center, University of Leipzig, D 04289 Leipzig, Germany
    Mol Genet Metab 80:262-71. 2003
    ..The upregulation of PP2A, an important regulator in intracellular signaling and apoptosis, may be due to an increase of inflammatory cytokines...
  76. ncbi request reprint Transapical approach for sutureless stent-fixed aortic valve implantation: experimental results
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 29:703-8. 2006
    ..Percutaneous aortic valve implantation has been performed in patients with severe aortic stenosis judged as nonsurgical candidates. We evaluated a facilitated transapical antegrade approach for potential use in surgical high-risk patients...
  77. ncbi request reprint Exercise training in coronary artery disease and coronary vasomotion
    S Gielen
    , Herzzentrum GmbH, , Leipzig, Germany
    Circulation 103:E1-6. 2001
    ..Because endothelial dysfunction has been identified as a predictor of coronary events, exercise may contribute to the long-term reduction of cardiovascular morbidity and mortality...
  78. doi request reprint Anesthesia management for transapical transcatheter aortic valve implantation: a case series
    Jens Fassl
    Department of Anesthesiology and Intensive Care II, University of Leipzig, Heart Center, Leipzig, Germany
    J Cardiothorac Vasc Anesth 23:286-91. 2009
    ..The purpose of this study was to review the management of anesthesia for transapical transcatheter aortic valve implantation...
  79. doi request reprint Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance
    Axel Linke
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Atherosclerosis 205:207-13. 2009
    ..Adipose tissue is an important site of niacin action. Here we sought to determine potential pleiotropic effects of ER niacin on adipose tissue biology in patients with impaired glucose tolerance (IGT)...
  80. doi request reprint Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice
    Volker Adams
    Heart Center Leipzig, University Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    J Mol Biol 384:48-59. 2008
    ..However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known...
  81. doi request reprint Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells
    Claudia Walther
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:416-22. 2008
    ..In the context of primary prevention, the impact of regular physical activity on the amount and function of EPC has not yet been investigated in school children...
  82. ncbi request reprint Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Am Heart J 145:E3. 2003
    ..The aim of this consecutive study was to assess whether a home-based exercise program with reduced average training duration can sustain previously achieved effects on coronary endothelial function...
  83. ncbi request reprint Exercise training and endothelial dysfunction in coronary artery disease and chronic heart failure. From molecular biology to clinical benefits
    S Gielen
    University of Leipzig, Heart Center, Department of Internal Medicine, Cardiology, Leipzig, Germany
    Minerva Cardioangiol 50:95-106. 2002
    ..All these molecular effects converge on a reduction of myocardial ischemic events in CAD and a decrease of afterload in CHF...
  84. ncbi request reprint Color-encoded semiautomatic analysis of multi-slice first-pass magnetic resonance perfusion: comparison to tetrofosmin single photon emission computed tomography perfusion and X-ray angiography
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Int J Cardiovasc Imaging 20:371-84; discussion 385-7. 2004
    ....
  85. doi request reprint Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  86. ncbi request reprint Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 47:1641-5. 2006
    ..The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI)...
  87. doi request reprint Risk factor management: antiatherogenic therapies
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009
    ..In addition, it is essential not just to treat CV risk factors, but also to treat them to achieve the target values as set by the guidelines of European Society of Cardiology...
  88. doi request reprint Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention: design and rationale of the Abciximab Intracoronary versus intravenously Drug Application in ST-Elevation Myocardial Infarction (AIDA ST
    Holger Thiele
    Universität Leipzig Heart Center, Department of Internal Medicine Cardiology, Germany
    Am Heart J 159:547-54. 2010
    ..The hypothesis of this trial is that abciximab bolus intracoronary in comparison to standard intravenous application will improve the outcome of patients undergoing primary PCI in STEMI...
  89. ncbi request reprint [Lifelong after-care and secondary prevention after myocardial infarct]
    Peter B Sick
    Klinik für Innere Medizin Kardiologie, Universitat Leipzig, Herzzentrum GmbH, Leipzig
    Med Klin (Munich) 99:309-20; quiz 321. 2004
  90. ncbi request reprint Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase
    Volker Adams
    Clinic of Cardiology, Leipzig Heart Center, University Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:273-7. 2003
    ..The aim of this study was to assess whether NF-kappaB is activated in skeletal muscle of patients with CHF and linked to the expression of iNOS...
  91. ncbi request reprint Prospective randomized comparison of early and late results of 4 different stent designs
    Peter B Sick
    Heart Center, Department for Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Am Heart J 146:134-41. 2003
    ..So far, few data are available addressing the effect of stent design on this crucial variable and on early and late adverse events after stent implantation...
  92. ncbi request reprint Contemporary outcome of cardiac catheterizations in 1085 consecutive octogenarians
    Josef Niebauer
    Abteilung für Innere Medizin Kardiolgie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiol 93:225-30. 2004
    ..Since little is known about the overall safety of these procedures in this population, we assessed the procedure-related risks and determined predictors for complications...
  93. ncbi request reprint Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  94. doi request reprint New familial heterozygous c 4066_4068 delTT 2 bp deletion of the SCN5A gene causing Brugada syndrome
    Sven Mobius-Winkler
    University Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Heart Rhythm 8:1224-7. 2011
    ..Cardiac sodium channel alterations have been identified as the underlying condition in patients with Brugada syndrome...
  95. doi request reprint Shock in acute myocardial infarction: the Cape Horn for trials?
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, Leipzig, Germany
    Eur Heart J 31:1828-35. 2010
    ....
  96. doi request reprint Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 55:2201-9. 2010
    ....
  97. doi request reprint [Coronary artery bypass surgery for the treatment of acute coronary syndromes]
    Ardawan Julian Rastan
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum Leipzig, Leipzig, Germany
    Herz 35:70-8. 2010
    ..For all surgical candidates a close and direct communication between interventionalist and cardiac surgeon is mandatory to early identify the best treatment strategy and to achieve best possible revascularization results...
  98. doi request reprint Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from single center enrolment in the SYNTAX study
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center Leipzig, Struempellstrasse 39, Leipzig, Germany
    Eur J Cardiothorac Surg 34:376-82; discussion 382-3. 2008
    ....
  99. ncbi request reprint Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 26:1956-63. 2005
    ..This approach has been compared with pre-hospital combination-fibrinolysis only to determine whether either one of these methods offer advantages with respect to final infarct size...
  100. ncbi request reprint Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
    ..To evaluate initial multicenter results with minimally invasive transapical aortic valve implantation (TAP-AVI) for high risk patients with aortic stenosis...
  101. ncbi request reprint Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
    ..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha...