Christoph Schramm

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis
    Christoph Schramm
    Medizinische Klinik I, Universitätsulinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Rev Allergy Immunol 28:105-14. 2005
  2. doi request reprint Characteristics and long-term prognosis of the autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome
    Stefan Lüth
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 43:75-80. 2009
  3. doi request reprint Transient elastography in autoimmune hepatitis: Timing determines the impact of inflammation and fibrosis
    Johannes Hartl
    University Medical Centre Hamburg Eppendorf UKE, 1st Department of Medicine, Hamburg, Germany
    J Hepatol 65:769-75. 2016
  4. doi request reprint Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
    Antonella Carambia
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:112-8. 2013
  5. doi request reprint Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells
    Samuel Huber
    Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Immunol 182:4633-40. 2009
  6. doi request reprint Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
    Marcial Sebode
    I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 60:1010-6. 2014
  7. doi request reprint Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis
    Johannes Hartl
    University Medical Centre Hamburg Eppendorf UKE, Hamburg, Germany
    J Hepatol 62:642-6. 2015
  8. doi request reprint Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis
    Stefan Lüth
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 42:926-30. 2008
  9. ncbi request reprint Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    Katrin Presser
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Immunol 181:7751-8. 2008
  10. doi request reprint Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis
    Christina Weiler-Normann
    I Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:529-34. 2013

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis
    Christoph Schramm
    Medizinische Klinik I, Universitätsulinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Rev Allergy Immunol 28:105-14. 2005
    ..This article focuses on the prevalence, diagnosis, and treatment of the overlap syndrome of AIH and PBC or PSC...
  2. doi request reprint Characteristics and long-term prognosis of the autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome
    Stefan Lüth
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 43:75-80. 2009
    ..Our aim was to assess the clinical characteristics and long-term prognosis of the AIH/PSC overlap syndrome...
  3. doi request reprint Transient elastography in autoimmune hepatitis: Timing determines the impact of inflammation and fibrosis
    Johannes Hartl
    University Medical Centre Hamburg Eppendorf UKE, 1st Department of Medicine, Hamburg, Germany
    J Hepatol 65:769-75. 2016
    ..The aim of this study was to assess the diagnostic performance of transient elastography in patients with AIH and to investigate the impact of disease activity on its diagnostic accuracy...
  4. doi request reprint Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
    Antonella Carambia
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:112-8. 2013
    ..Here we investigated the role of liver sinusoidal endothelial cells (LSECs) in regulating the activity of inflammatory CD4 T cells...
  5. doi request reprint Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells
    Samuel Huber
    Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Immunol 182:4633-40. 2009
    ..Therefore, besides promoting inflammation, activin A may contribute to the regulation of inflammation via the expansion of peripheral Treg...
  6. doi request reprint Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
    Marcial Sebode
    I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 60:1010-6. 2014
    ..The aim of this study was to investigate Treg in patients with PSC and to associate their numbers with relevant gene polymorphisms...
  7. doi request reprint Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis
    Johannes Hartl
    University Medical Centre Hamburg Eppendorf UKE, Hamburg, Germany
    J Hepatol 62:642-6. 2015
    ..We therefore investigated, whether longer duration of treatment and proper patient selection could increase the long-term success rates after treatment withdrawal...
  8. doi request reprint Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis
    Stefan Lüth
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 42:926-30. 2008
    ..It is frequent clinical practice to follow disease by assessment of serologic markers. Here, we assessed the diagnostic fidelity of this clinical practice...
  9. ncbi request reprint Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    Katrin Presser
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Immunol 181:7751-8. 2008
    ..In conclusion, modulation of cytokine expression by Treg may have therapeutic potential for the treatment of AHR in asthma. The mechanisms of the effects of Treg on airway inflammation require further clarification...
  10. doi request reprint Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis
    Christina Weiler-Normann
    I Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:529-34. 2013
    ..We sought to analyze the safety and efficacy of off-label treatment with infliximab in a cohort of eleven patients with difficult-to-treat autoimmune hepatitis...
  11. doi request reprint WITHDRAWN: Reply
    Sina Hübener
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Gastroenterol Hepatol . 2016
    ..doi.org/10.1016/j.cgh.2016.03.013. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy...
  12. doi request reprint Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
    Antonella Carambia
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 62:1349-56. 2015
    ..Here, we explored whether the Treg-inducing potential of LSECs could be harnessed for the treatment of autoimmune disease...
  13. pmc Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis
    Kornelius Schulze
    I Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 10:e0140525. 2015
    ..Since there is no evidence to support this recommendation, we aimed to assess the criteria that guided clinicians in clinical practice to initiate IT in patients with previously diagnosed PSC...
  14. doi request reprint FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
    Moritz Peiseler
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 57:125-32. 2012
    ..However, the role of Treg in AIH is not clear, since earlier studies reporting Treg impairment had used only CD25 as marker that cannot unambiguously distinguish Treg from activated effector T cells...
  15. pmc Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
    Stefan Lüth
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 118:3403-10. 2008
    ..Our findings indicate that autoantigen expression in the liver may generate autoantigen-specific Tregs. Thus, targeting of autoantigens to hepatocytes may be a novel approach to prevention or treatment of autoimmune diseases...
  16. doi request reprint Efficacy of 6-Mercaptopurine as Second-Line Treatment for Patients With Autoimmune Hepatitis and Azathioprine Intolerance
    Sina Hübener
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Gastroenterol Hepatol 14:445-53. 2016
    ..We investigated whether 6-mercaptopurine (6-MP) is an effective second-line therapy for patients with AIH...
  17. doi request reprint Low risk of hepatocellular carcinoma in patients with primary sclerosing cholangitis with cirrhosis
    Roman Zenouzi
    First Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Gastroenterol Hepatol 12:1733-8. 2014
    ..We investigated the risk of HCC in patients with PSC with cirrhosis...
  18. doi request reprint Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis
    Janosch Katt
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 58:1084-93. 2013
    ..Th17 induction was also noted after stimulation of Toll-like receptor 5 or 7, but not of other pattern recognition receptors tested, pointing to signaling pathways potentially involved in Th17 induction in PSC...
  19. doi request reprint Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice
    Roja Barikbin
    Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 55:553-62. 2012
    ..Moreover, hepatocellular proliferation and signs of dysplasia were decreased after HO-1 induction...
  20. doi request reprint Mycophenolate mofetil as second line therapy in autoimmune hepatitis?
    Elke M Hennes
    First Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Am J Gastroenterol 103:3063-70. 2008
    ..The aim of this study was to examine the possible role of mycophenolate mofetil (MMF) as second line treatment of autoimmune hepatitis (AIH)...
  21. pmc P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg
    Samuel Huber
    I Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 3:e3302. 2008
    ..Our findings indicate that signaling via p38 MAP kinase seems to be important for the peripheral generation of iTreg; p38 MAP kinase could thus be a therapeutic target to enhance immunity to chronic viral infection or cancer...
  22. doi request reprint Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice
    Raluca Wroblewski
    I Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 64:508-21. 2016
    ..These results suggest that TNFR1 signaling in MDCs is a critical mediator of both the detrimental and the protective functions of TNF in T cell-induced hepatitis and bacterial infection, respectively...
  23. ncbi request reprint Diffusion-weighted MRI for detection of hepatic osteodystrophy in primary sclerosing cholangitis: a comparison study with dual-energy X-ray absorptiometry
    Sarah Keller
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf UKE, Martinistr 52, 20246, Hamburg, Germany
    Jpn J Radiol 34:677-683. 2016
    ..The aim was to test the feasibility of vertebral bone diffusion-weighted imaging (DWI) in routine liver MRI for detection of osteoporosis using dual-energy X-ray absorptiometry (DXA) as gold standard...
  24. doi request reprint Anti-TNF-α for necrotizing sarcoid granulomatosis of the liver
    Marcial Sebode
    1st Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Hepatology . 2016
    ..This article is protected by copyright. All rights reserved...
  25. doi request reprint Primary liver transplantation for autoimmune hepatitis: a comparative analysis of the European Liver Transplant Registry
    Christoph Schramm
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Liver Transpl 16:461-9. 2010
    ..It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database...
  26. ncbi request reprint Evaluation of F-actin ELISA for the diagnosis of autoimmune hepatitis
    Christian Frenzel
    The I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Am J Gastroenterol 101:2731-6. 2006
    ..We compared the diagnostic value of a new F-actin enzyme-linked immunosorbent assay (ELISA) with the current gold standard of detection of smooth muscle antibodies by indirect immunofluorescence (SMA-IFT)...
  27. ncbi request reprint Immunology of hepatic diseases during pregnancy
    Lars Bremer
    Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Semin Immunopathol 38:669-685. 2016
    ..This review intends to summarize current knowledge linking feto-maternal immunology and liver inflammation with a special emphasis on novel potential biomarkers...
  28. doi request reprint Litomosoides sigmodontis induces TGF-β receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice
    Wiebke Hartmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Eur J Immunol 45:2568-81. 2015
    ..Blockade of the same key suppression mediators, i.e. TGF-β- and IL-10 receptor, also ameliorated the suppression of IgG response to bystander antigen vaccination in L. sigmodontis-infected mice. ..
  29. doi request reprint Unmasking autoimmune hepatitis under immunomodulatory treatment of multiple sclerosis--not only beta interferon
    Vera von Kalckreuth
    Am J Gastroenterol 103:2147-8; author reply 2148. 2008
  30. doi request reprint Simplified criteria for the diagnosis of autoimmune hepatitis
    Elke M Hennes
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Germany
    Hepatology 48:169-76. 2008
    ..Based on the ROC curves, two cutoff points were chosen. The score was found to have 88% sensitivity and 97% specificity (cutoff > or =6) and 81% sensitivity and 99% specificity (cutoff > or =7) in the validation set...
  31. ncbi request reprint Pregnancy in autoimmune hepatitis: outcome and risk factors
    Christoph Schramm
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Gastroenterol 101:556-60. 2006
    ..Autoimmune hepatitis (AIH) may influence pregnancy outcome and pregnancy may affect AIH. We aimed at analyzing the disease course in pregnant AIH patients and at identifying disease-related risk factors for adverse pregnancy outcome...
  32. ncbi request reprint Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice
    Christoph Schramm
    First Department of Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 284:G525-35. 2003
    ..This suggests an important role for TGF-beta in immune homeostasis in the liver and may teleologically explain TGF-beta upregulation in response to T cell-mediated liver injury...