Volker Schmitz

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo
    Ludger Leifeld
    Departments of Internal Medicine I, University of Bonn, Bonn, Germany
    Am J Pathol 168:778-85. 2006
  2. ncbi request reprint Effective antitumour mono- and combination therapy by gene delivery of angiostatin-like molecule and interleukin-12 in a murine hepatoma model
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    Int J Colorectal Dis 20:494-501. 2005
  3. pmc Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice
    V Schmitz
    Division of Hepatology and Gene Therapy, Department of Medicine, Medical School, University of Navarra, Pamplona, Spain
    Gut 53:561-7. 2004
  4. pmc Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice
    Volker Schmitz
    Medizinische Klinik I, Sigmund Freud Str 25, Bonn 53105, Germany
    World J Gastroenterol 11:4332-6. 2005
  5. ncbi request reprint Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice
    V Schmitz
    Department of Internal Medicine I, University Hospital, Bonn, Germany
    Gene Ther 13:1198-205. 2006
  6. pmc Plasminogen fragment K1-5 improves survival in a murine hepatocellular carcinoma model
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Gut 56:271-8. 2007
  7. ncbi request reprint Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure
    Volker Schmitz
    Medizinische Klinik und Poliklinik I, Universitat Bonn, Bonn, Germany
    Hepatology 44:430-9. 2006
  8. ncbi request reprint Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    J Hepatol 40:787-91. 2004
  9. ncbi request reprint Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model
    Esther Raskopf
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Hepatology 41:1233-40. 2005
  10. doi request reprint Plasminogen derivatives encoding kringles 1-4 and kringles 1-5 exert indirect antiangiogenic and direct antitumoral effects in experimental lung cancer
    Volker Schmitz
    Department of Internal Medicine I, University of Bonn, Germany
    Cancer Invest 26:464-70. 2008

Collaborators

Detail Information

Publications58

  1. pmc Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo
    Ludger Leifeld
    Departments of Internal Medicine I, University of Bonn, Bonn, Germany
    Am J Pathol 168:778-85. 2006
    ..Moreover, selective expression of gelsolin in sinusoidal endothelial cells indicates a pivotal role for interactions between sinusoidal endothelial cells and liver parenchymal cells in Fas ligand-mediated liver failure...
  2. ncbi request reprint Effective antitumour mono- and combination therapy by gene delivery of angiostatin-like molecule and interleukin-12 in a murine hepatoma model
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    Int J Colorectal Dis 20:494-501. 2005
    ..We applied an experimental approach employing two recombinant adenoviral vectors (Ad) that express interleukin-12 (IL-12) and angiostatin-like molecule (K1-3) respectively to a subcutaneous hepatoma model in mice...
  3. pmc Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice
    V Schmitz
    Division of Hepatology and Gene Therapy, Department of Medicine, Medical School, University of Navarra, Pamplona, Spain
    Gut 53:561-7. 2004
    ....
  4. pmc Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice
    Volker Schmitz
    Medizinische Klinik I, Sigmund Freud Str 25, Bonn 53105, Germany
    World J Gastroenterol 11:4332-6. 2005
    ..Here, we tested a recombinant adenovirus, AdsFlt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice...
  5. ncbi request reprint Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice
    V Schmitz
    Department of Internal Medicine I, University Hospital, Bonn, Germany
    Gene Ther 13:1198-205. 2006
    ....
  6. pmc Plasminogen fragment K1-5 improves survival in a murine hepatocellular carcinoma model
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Gut 56:271-8. 2007
    ..The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, and new alternative treatments are needed...
  7. ncbi request reprint Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure
    Volker Schmitz
    Medizinische Klinik und Poliklinik I, Universitat Bonn, Bonn, Germany
    Hepatology 44:430-9. 2006
    ..This model suggests involvement of the CD40-CD40L system in FHF and might have important implications for future pathophysiological studies of this condition...
  8. ncbi request reprint Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    J Hepatol 40:787-91. 2004
    ..In this study we established an orthotopic tumour model for hepatocellular carcinoma and evaluated a non-invasive high resolution ultrasound technique for diagnosis and follow-up of intrahepatic HCC...
  9. ncbi request reprint Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model
    Esther Raskopf
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Hepatology 41:1233-40. 2005
    ..The data support the value of VEGF blockade as an effective target for HCC treatment...
  10. doi request reprint Plasminogen derivatives encoding kringles 1-4 and kringles 1-5 exert indirect antiangiogenic and direct antitumoral effects in experimental lung cancer
    Volker Schmitz
    Department of Internal Medicine I, University of Bonn, Germany
    Cancer Invest 26:464-70. 2008
    ..In addition our data supports the recent conclusion that plasminogen derivatives have a dual antitumor mechanism affecting both tumor angiogenesis and tumor cells...
  11. doi request reprint Plasminogen fragment K1-3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver
    Esther Raskopf
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Int J Colorectal Dis 24:837-44. 2009
    ..We tested a potential preventive, pre-operative strategy using plasminogen kringles 1-3 (K1-3) to overcome this hurdle...
  12. doi request reprint Increase of in vivo antitumoral activity by CD40L (CD154) gene transfer into pancreatic tumor cell-dendritic cell hybrids
    Carsten Ziske
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Pancreas 38:758-65. 2009
    ..Although there have been reports of clinical benefit, response rates have been limited and further improvements are warranted...
  13. pmc 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)-formulated, immune-stimulatory vascular endothelial growth factor a small interfering RNA (siRNA) increases antitumoral efficacy in murine orthotopic hepatocellular carcinoma with liver fibrosis
    Miroslaw Kornek
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Mol Med 14:365-73. 2008
    ..We expect that these results will help to direct and improve future experimental gene-silencing approaches and establish more efficient antitumoral therapies against HCC...
  14. doi request reprint Real-time high-resolution compound imaging allows percutaneous initiation and surveillance in an orthotopic murine pancreatic cancer model
    Carsten Ziske
    Medizinische Klinik und Poliklinik I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Pancreas 36:146-52. 2008
    ..Orthotopic tumor models are regarded as being suitable for preclinical research on pancreatic cancer. The anatomic localization of the tumor in the retroperitoneum, however, provides little possibility for monitoring tumor growth...
  15. doi request reprint CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo
    Maria A Gonzalez-Carmona
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 48:157-68. 2008
    ..Tumor-infiltrating lymphocytes were tumor-specific, as shown in interferon-gamma (IFN-gamma) enzyme-linked immunosorbent spot and T-cell proliferation assays...
  16. doi request reprint Accelerated orthotopic hepatocellular carcinomas growth is linked to increased expression of pro-angiogenic and prometastatic factors in murine liver fibrosis
    Miroslaw Kornek
    Department of Internal Medicine I, University Hospital, Bonn, Germany
    Liver Int 28:509-18. 2008
    ....
  17. ncbi request reprint Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1
    Miroslaw Kornek
    Department of Internal Medicine I, University Hospital Bonn, Germany
    J Hepatol 45:370-6. 2006
    ..Most experimental therapeutic studies are performed in mice without pre-damaged livers...
  18. doi request reprint siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo
    Esther Raskopf
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Hepatol 49:977-84. 2008
    ..We have investigated whether siRNA targeted against VEGF inhibits functional properties of endothelial cells in vitro and HCC tumor growth and blood vessel formation in vivo...
  19. ncbi request reprint Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor
    Lin Wang
    Division of Hepatology and Gene Therapy, Department of Medicine, Pamplona, Spain
    Mol Ther 8:72-9. 2003
    ..These data suggest that the antiangiogenic properties of PEDF can be exploited to inhibit the establishment of tumor neovasculature and reduce tumor growth...
  20. ncbi request reprint Combination of hypoxia and RNA-interference targeting VEGF induces apoptosis in hepatoma cells via autocrine mechanisms
    Esther Raskopf
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, Bonn Germany
    Curr Pharm Biotechnol 13:2290-8. 2012
    ..The direct impact on tumor cells further underscores the attractiveness of an anti-VEGF based siRNA treatment...
  21. ncbi request reprint A novel strategy for the generation of angiostatic kringle regions from a precursor derived from plasminogen
    V Schmitz
    Division of Hepatology and Gene Therapy, Department of Medicine, Medical School, University of Navarra, Pamplona, Spain
    Gene Ther 9:1600-6. 2002
    ..This strategy may have potential to develop angiostatic anti-cancer therapies...
  22. doi request reprint Association of socio-economic status and stage of pancreatic cancer at time of surgery in a German setting
    Jens Standop
    Department of Surgery, University of Bonn Medical Center, Bonn, Germany
    Hepatogastroenterology 59:2614-7. 2012
    ..We tested, in our population of pancreatic cancer patients, the hypothesis that surrogates representing a lower SES or demographic factors (DGF) linked to rural areas are associated with a more advanced disease stage at presentation...
  23. doi request reprint Anti-tumoural effects of PlgK1-5 are directly linked to reduced ICAM expression, resulting in hepatoma cell apoptosis
    Volker Schmitz
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Colorectal Dis 27:1029-38. 2012
    ..Therefore, we have analysed whether PlgK1-5 alters tumour cell functions and expression levels of cell adhesion molecules in murine and human hepatoma cells in vitro and in vivo...
  24. ncbi request reprint Gene therapy of hepatocellular carcinoma and gastrointestinal tumors
    Bruno Sangro
    Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Ann N Y Acad Sci 963:6-12. 2002
    ..In summary, a variety of gene therapy strategies have been effective against animal models of gastrointestinal tumors. Clinical trials should determine whether human patients can be treated safely and effectively by such strategies...
  25. ncbi request reprint Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model
    Tanja Schmidt
    Medizinische Klinik und Poliklinik I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Cancer Res 63:8962-7. 2003
    ..The antitumor effect was caused by induction of antigen-specific T lymphocytes as shown by additional in vitro studies. These results favor intratumoral injection of tumor RNA-pulsed DCs for immunotherapy of pancreatic cancer...
  26. doi request reprint Operative re-intervention following pancreatic head resection: indications and outcome
    Jens Standop
    Department of Surgery, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Gastrointest Surg 13:1503-9. 2009
    ..This study analyzed indication and outcome regarding operative re-intervention following pancreatoduodenectomy (PD) and pancreatogastrostomy (PG) with special emphasis on complications related to redo surgery...
  27. doi request reprint Emergency Kausch-Whipple procedure: indications and experiences
    Jens Standop
    Department of Surgery, University of Bonn Medical Center, Bonn, Germany
    Pancreas 39:156-9. 2010
    ..This study analyzed our experience with urgent pancreatoduodenectomies; special emphases were put on the evaluation of diagnostic means and the validation of existing indications for performance of this procedure...
  28. pmc Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures
    Hans Dieter Nischalke
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42141. 2012
    ..Here we analyze whether determination of target gene mRNA levels in intraductal brush cytology specimens may be used to improve the diagnosis of bile duct carcinoma...
  29. ncbi request reprint Intrahepatic activation of caspases in human fulminant hepatic failure
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Germany
    Liver Int 26:872-9. 2006
    ..Apoptosis has been implicated in the pathogenesis of fulminant hepatic failure (FHF) potentially involving caspases. Thus far, apoptosis in FHF has mainly been studied in animal models while human data are sparse...
  30. doi request reprint [Complications of liver cirrhosis, medical management]
    Frank Grunhage
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn
    Med Klin (Munich) 103:482-90. 2008
    ..At the same time, treatment of the underlying disease, the identification and treatment of triggering factors, and the possibility of liver transplantation should be kept in mind...
  31. pmc The conservative and interventional treatment of the complications of liver cirrhosis: Part 2 of a series on liver cirrhosis
    Tilman Sauerbruch
    Department of Internal Medicine I at the University Hospital of Bonn, Bonn, Germany
    Dtsch Arztebl Int 110:126-32, I. 2013
    ..The main complications of cirrhosis arise in turn: These include bleeding from collateral veins, ascites, hepatocellular carcinoma, encephalopathy, and infection leading to organ failure...
  32. ncbi request reprint An independent evaluation of modern prognostic scores in a central European cohort of 120 patients with hepatocellular carcinoma
    Christian Rabe
    Department of Medicine I, University of Bonn, Bonn, Germany
    Eur J Gastroenterol Hepatol 15:1305-15. 2003
    ..We therefore tested the ability of several newer scores to predict survival in comparison to the Okuda score in a European cohort of HCC patients...
  33. ncbi request reprint Adenovirus-mediated CD40 ligand gene therapy in a rat model of orthotopic hepatocellular carcinoma
    V Schmitz
    Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain
    Hepatology 34:72-81. 2001
    ..These data demonstrate that intratumoral administration of AdCMVmCD40L may provide an efficient and safe treatment for HCC...
  34. pmc Invasive fungal infections in neutropenic enterocolitis: a systematic analysis of pathogens, incidence, treatment and mortality in adult patients
    Marcus Gorschlüter
    Department of Internal Medicine I, University of Bonn, Germany
    BMC Infect Dis 6:35. 2006
    ..Fungi have also been reported, but their practical relevance remains unclear. The guidelines do not address concrete treatment recommendations for fungal neutropenic enterocolitis...
  35. ncbi request reprint Apoptotic potency of angiostatic compounds in the treatment of cancer
    Esther Raskopf
    Department of Inner Medicine I, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Curr Pharm Biotechnol 13:2283-9. 2012
    ....
  36. doi request reprint Endoscopy in patients with acute leukaemia after intensive chemotherapy
    Marcus Gorschlüter
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Bonn, Sigmund Freud Str 25, Bonn, Germany
    Leuk Res 32:1510-7. 2008
    ..5%) and gastritis (22.6%). Upper endoscopies had therapeutic consequences in 55%. Endoscopy could be performed relatively safely but the percentage of patients in whom endoscopic haemostasis was applicable and effective was low...
  37. ncbi request reprint Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma
    Christoph Jüngst
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 39:1663-72. 2004
    ..In conclusion, these data suggest that ROS generated by chronic inflammation contribute to human hepatocarcinogenesis. The role of DNA repair enzymes appears to be of reactive rather than causative manner...
  38. doi request reprint Inhibition of neuropilin-1 by RNA-interference and its angiostatic potential in the treatment of hepatocellular carcinoma
    E Raskopf
    Department of Inner Medicine I, University of Bonn, Medical School, Bonn Germany
    Z Gastroenterol 48:21-7. 2010
    ..In conclusion, inhibition of Nrp1 expression led to strong anti-endothelial effects, whereas tumor cells and tumor growth were not affected...
  39. pmc Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies
    V Schmitz
    Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Faculty of Medicine, Universidad de Navarra, Pamplona Spain
    Gut 50:130-5. 2002
    ..However, intense research is needed to evaluate the potential of gene therapy to improve efficacy and minimise the toxicity of the procedure...
  40. pmc Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
    Robert Hüneburg
    Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany
    Endosc Int Open 4:E164-9. 2016
    ..Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy...
  41. ncbi request reprint Does intubation really equal death in cirrhotic patients? Factors influencing outcome in patients with liver cirrhosis requiring mechanical ventilation
    Christian Rabe
    Department of Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Intensive Care Med 30:1564-71. 2004
    ..This study examines parameters both of chronic liver disease and of acute illness with regard to their influence on outcome in mechanically ventilated cirrhotic patients...
  42. pmc Toxic damage increases angiogenesis and metastasis in fibrotic livers via PECAM-1
    Esther Raskopf
    Department of Inner Medicine, University Hospital Bonn, Sigmund Freud Strase 25, 53107 Bonn, Germany
    Biomed Res Int 2014:712893. 2014
    ..Blockade of increased PECAM-1 expression could be a promising tool to inhibit fibrogenesis and metastasis in the liver...
  43. ncbi request reprint An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
    Ignacio Melero
    Gene Therapy Unit, Department of Medicine, University of Navarra School of Medicine, C Irunlarrea, I 31008 Pamplona, Spain
    Cancer Res 62:3167-74. 2002
    ....
  44. pmc Diagnosis and management of upper gastrointestinal bleeding
    Erwin Biecker
    Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Dtsch Arztebl Int 105:85-94. 2008
    ..Its clinical presentations are hematemesis, melena stool, or even fresh bleeding per rectum. This paper reviews the diagnosis and treatment of upper GI bleeding...
  45. doi request reprint Endoscopic management of anastomotic hemorrhage from pancreatogastrostomy
    Jens Standop
    Department of Surgery, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Surg Endosc 23:2005-10. 2009
    ..Hemorrhage from pancreatic-enteric anastomosis after pancreaticoduodenectomy (PD) is a critical condition due to its difficult accessibility and delicate condition, and therefore remains a major challenge for the surgeon in charge...
  46. ncbi request reprint Accumulation of 8-hydroxy-2'-deoxyguanosine adducts in HBx recombinant HepG2 cells and HBx transgenic mice
    Ralph Gehrke
    Department of Virus Research, Max Planck Institut fur Biochemie, Martinsried, Germany
    Digestion 70:117-26. 2004
    ..Therefore, we investigated whether HBx expression increases the level of the mutational precursor 8-hydroxy-2'-deoxyguanosine in hepatocellular DNA...
  47. doi request reprint Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice
    Gabriele Sass
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Int J Cancer 123:1269-77. 2008
    ..Livers and kidneys of treated animals did not reveal signs of damage by this treatment. In conclusion, a specific knockdown of HO-1 might represent a novel therapeutic approach in HCC therapy...
  48. ncbi request reprint Requirements for adeno-associated virus-derived non-viral vectors to achieve stable and site-specific integration of plasmid DNA in liver carcinoma cells
    Robin Steigerwald
    Department of Virus Research, Max Plank Institute for Biochemistry, Martinsried, Germany
    Digestion 68:13-23. 2003
    ..We therefore studied the minimal elements of gene therapy vectors necessary for stable integration and tested the effectiveness of this approach in hepatoma cells...
  49. ncbi request reprint The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice
    Kinya Okamoto
    Department of Medicine 1, University Hospital Erlangen, D 91054 Erlangen, Germany
    Int J Oncol 33:733-42. 2008
    ..Except for a reversible skin reaction and weight loss, no signs of toxicity were observed. AEE788 is a promising new option for the treatment of HCC...
  50. ncbi request reprint Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant
    Annemarie Musch
    Department of Medicine I, University of Bonn, Germany
    Digestion 71:78-91. 2005
    ..Hepatocellular carcinomas (HCC) often show resistance to the effects of transforming growth factor-beta (TGF-beta). This study focuses on molecular mechanisms of this resistance to explore ways to overcome it...
  51. ncbi request reprint Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation
    Volker Schmitz
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Eur Surg Res 38:388-98. 2006
    ..Since previous reports have indicated a benefit of combining histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solution, we evaluated the effects of initial flush with low viscosity HTK, followed by storage in UW...
  52. ncbi request reprint Functional interactions between P-glycoprotein and CYP3A in drug metabolism
    Uwe Christians
    University of Colorado Health Sciences Center, Clinical Research and Development, Department of Anesthesiology, Denver, Colorado 80262, USA
    Expert Opin Drug Metab Toxicol 1:641-54. 2005
    ..Future pharmacogenomic and pharmacokinetic studies will have to take all three components into account to allow for valid conclusions...
  53. ncbi request reprint Induction of long-term graft acceptance by a combination treatment of donor splenocytes and CTLA4Ig in a high responder rat liver transplantation model
    Volker Schmitz
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Augustenburger Platz, Berlin, Germany
    Transpl Int 18:1187-96. 2005
    ..The combination of CTLA4Ig and donor derived splenocytes is potent to induce long-term survival and graft acceptance. The mechanisms appear to involve the induction of an early inflammatory impulse and apoptosis...
  54. ncbi request reprint Vanishing bile duct syndrome associated with elevated pancreatic enzymes after short-term administration of amoxicillin
    Carolynne Schwarze
    Department of Internal Medicine, University of Bonn, Germany
    Eur J Gastroenterol Hepatol 14:1275-7. 2002
    ..The patient died after 18 months from progressive liver failure. This case illustrates that amoxicillin alone can be a cause of progressive and ultimately fatal vanishing bile duct syndrome...
  55. ncbi request reprint Simultaneous splenectomy increases risk for opportunistic pneumonia in patients after liver transplantation
    Ulf P Neumann
    Department of Surgery, Virchow Clinic, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Transpl Int 15:226-32. 2002
    ..Our study identified splenectomy as a major risk factor for the development of opportunistic pneumonia after liver transplantation. In these patients prophylactic protocols and early diagnosis may improve the long-term outcome...
  56. ncbi request reprint Low viscosity histidine-tryptophan-ketoglutarate graft flush improves subsequent extended cold storage in University of Wisconsin solution in an extracorporeal rat liver perfusion and rat liver transplantation model
    Gero Puhl
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
    Liver Transpl 12:1841-9. 2006
    ..Choosing low-viscosity HTK solution for the initial organ flush may represent a feasible improvement in liver preservation, which also further reduces the required amount of UW solution...
  57. ncbi request reprint Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS
    Jost Klawitter
    Clinical Research and Development, Department of Anesthesiology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Anal Biochem 365:230-9. 2007
    ..Avoidance of hypoxia during tissue retrieval is critical, and in vivo freeze clamping compares favorably with other tissue collection techniques...
  58. doi request reprint Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges
    Uwe Christians
    Eurofins Medinet, Aurora, CO 80045, USA
    Ther Drug Monit 30:151-8. 2008
    ....