Reinhold Schmidt

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
  2. pmc Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration
    Reinhold Schmidt
    University of Giessen Lung Center, Medical Clinic II, Giessen, Germany
    Respir Res 8:55. 2007
  3. ncbi request reprint Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia
    Reinhold Schmidt
    Medizinische Klinik II, Zentrum fur Innere Medizin, Justus Liebig University, Giessen, Germany
    Free Radic Biol Med 36:78-89. 2004
  4. ncbi request reprint Alveolar antioxidant status in patients with acute respiratory distress syndrome
    R Schmidt
    Dept of Internal Medicine, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Eur Respir J 24:994-9. 2004
  5. ncbi request reprint Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations
    Philipp Markart
    Department of Internal Medicine, Med Klinik II, Justus Liebig University, Giessen, Germany
    J Heart Lung Transplant 24:1680-9. 2005
  6. doi request reprint Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Antioxid Redox Signal 11:227-40. 2009
  7. pmc Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Thorax 62:588-94. 2007
  8. ncbi request reprint Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome
    Reinhold Schmidt
    University of Giessen Lung Center, Germany
    Crit Care Med 34:2370-6. 2006
  9. ncbi request reprint Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration
    Andreas Gunther
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Thorac Cardiovasc Surg 127:344-54. 2004
  10. ncbi request reprint Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis
    Reinhold Schmidt
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Toxicol Appl Pharmacol 195:218-31. 2004

Collaborators

Detail Information

Publications30

  1. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
    ..So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time...
  2. pmc Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration
    Reinhold Schmidt
    University of Giessen Lung Center, Medical Clinic II, Giessen, Germany
    Respir Res 8:55. 2007
    ..We therefore examined the time-course of surfactant changes in 15 patients with direct ARDS (pneumonia, aspiration) over the first 8 days after onset of mechanical ventilation...
  3. ncbi request reprint Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia
    Reinhold Schmidt
    Medizinische Klinik II, Zentrum fur Innere Medizin, Justus Liebig University, Giessen, Germany
    Free Radic Biol Med 36:78-89. 2004
    ..This is paralleled by an increase rather than a decrease in alveolar antioxidant levels, suggested to reflect an adaptive response to oxidative stress during ischemia...
  4. ncbi request reprint Alveolar antioxidant status in patients with acute respiratory distress syndrome
    R Schmidt
    Dept of Internal Medicine, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Eur Respir J 24:994-9. 2004
    ..In conclusion, low molecular weight antioxidants are elevated in the alveolar compartment of patients with acute respiratory distress syndrome. Further research is warranted to elucidate the molecular mechanisms underlying this finding...
  5. ncbi request reprint Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations
    Philipp Markart
    Department of Internal Medicine, Med Klinik II, Justus Liebig University, Giessen, Germany
    J Heart Lung Transplant 24:1680-9. 2005
    ..We investigated the influence of ischemic and endotoxin pre-conditioning on gas exchange and surfactant properties in a canine model of ischemia/reperfusion injury...
  6. doi request reprint Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Antioxid Redox Signal 11:227-40. 2009
    ..This increase may be part of an adaptive response to oxidative stress. However, a leakage from the blood may also contribute to our findings...
  7. pmc Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Thorax 62:588-94. 2007
    ..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)...
  8. ncbi request reprint Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome
    Reinhold Schmidt
    University of Giessen Lung Center, Germany
    Crit Care Med 34:2370-6. 2006
    ..We analyzed pulmonary surfactant composition and function in bronchoalveolar lavage fluid (BALF) from ventilated and spontaneously breathing HIV-positive patients with PCP...
  9. ncbi request reprint Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration
    Andreas Gunther
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Thorac Cardiovasc Surg 127:344-54. 2004
    ..The aim of this study was to evaluate the influence of exogenous surfactant administration on surfactant properties in a model of single lung transplantation...
  10. ncbi request reprint Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis
    Reinhold Schmidt
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Toxicol Appl Pharmacol 195:218-31. 2004
    ..In conclusion, bleomycin caused marked abnormalities of pulmonary surfactant, with the profile of changes being different between the early ARDS and the late fibrotic phase...
  11. ncbi request reprint An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid
    Reinhold Schmidt
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 165:470-4. 2002
    ..We conclude that SP-C may be quantified with high specificity, reproducibility, and sensitivity in bronchoalveolar lavage samples by the presently described ELISA technique and that SP-C levels are significantly decreased in ARDS...
  12. ncbi request reprint Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion
    Clemens Ruppert
    University of Giessen Lung Center UGLC, Department of Internal Medicine, Medical Clinic II, Justus Liebig University, Giessen, Germany
    Biochem Biophys Res Commun 348:1449-54. 2006
    ..We conclude that SP-B plays a pivotal role during subtype conversion and represents the substrate for surfactant convertase...
  13. ncbi request reprint Changes in biochemical and biophysical surfactant properties with cardiopulmonary bypass in children
    Bernd Friedrich
    Department of Pediatrics, Justus Leibig University, Giessen, Germany
    Crit Care Med 31:284-90. 2003
    ..The aim of the present study was to characterize pulmonary surfactant properties in children undergoing cardiovascular surgery with cardiopulmonary bypass...
  14. ncbi request reprint Effect of pulmonary surfactant on TNF-alpha-activated endothelial cells and neutrophil adhesion in vitro
    Irwin Reiss
    Center of Pediatrics, Feulgenstrasse 12, D 35392 Giessen, Germany
    Immunobiology 209:235-44. 2004
    ..This might be explained by different fatty acid profiles, e.g. the presence of arachidonic acid in the natSF or higher concentrations of surfactant-associated protein-C in the synSF...
  15. ncbi request reprint Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration
    Anne Hilgendorff
    Department of Pediatrics and Neonatology, Justus Liebig University of Giessen, 35392, Giessen, Germany
    Intensive Care Med 29:2247-54. 2003
    ..The present study investigated the effect of two different surfactant preparations-recombinant surfactant protein C surfactant (rSP-C Surf) and natural bovine surfactant-on pulmonary gas exchange and inflammatory response...
  16. ncbi request reprint Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin
    Clemens Ruppert
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    Bioconjug Chem 13:804-11. 2002
    ..We conclude that urokinase and 8B5E can be cross-linked chemically, thus yielding a fibrinolytic enzyme with enhanced substrate specifity for surfactant-containing clots and higher PAI-1 resistance as compared to native u-PA...
  17. ncbi request reprint Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema
    A Gunther
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 153:176-84. 1996
    ..We conclude that pronounced surfactant abnormalities, comparable to those in ARDS in the absence of lung infection, occur in different entities of severe PNEU, but not in CLE...
  18. ncbi request reprint Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease
    R Schmidt
    Medizinische Klinik II, Zentrum fur Innere Medizin, Justus Liebig University, D 35392 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 283:L1079-85. 2002
    ..We conclude that significant alterations in the FA profile of pulmonary surfactant phospholipids occur predominantly in IPF and may contribute to the disturbances of alveolar surface activity in this disease...
  19. ncbi request reprint Host defence lectins in preterm neonates
    Anne Hilgendorff
    Department of Paediatrics and Neonatology, Immunology and Transfusion Medicine, and Medical Microbiology, Giessen Research Centre in Infectious Diseases GRID, Justus Liebig University Giessen, Germany
    Acta Paediatr 94:794-9. 2005
    ..The objective of this study was to determine serum concentrations of surfactant protein D (SP-D) and mannose-binding lectin (MBL) in preterm and term infants at birth...
  20. ncbi request reprint Surfactant subtype conversion is related to loss of surfactant apoprotein B and surface activity in large surfactant aggregates. Experimental and clinical studies
    A Gunther
    Departments of Internal Medicine and Anatomy, Justus Liebig University Giessen, Giessen, Germany
    Am J Respir Crit Care Med 159:244-51. 1999
    ..We conclude that an SP-B-related loss of LA integrity and function may substantially contribute to the decline of this surfactant subtype and the loss of its surface activity during cycling in vitro and in clinical ARDS...
  21. ncbi request reprint Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias
    P Markart
    Dept of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, Germany
    Eur Respir J 29:134-7. 2007
    ....
  22. pmc Surfactant alteration and replacement in acute respiratory distress syndrome
    A Gunther
    Department of Internal Medicine, Justus Liebig University Giessen, Germany
    Respir Res 2:353-64. 2001
    ..Here we summarize what is known about the kind and severity of surfactant changes occurring in ARDS, the contribution of these changes to lung failure, and the role of surfactant administration for therapy of ARDS...
  23. ncbi request reprint Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties
    A Gunther
    Dept of Internal Medicine II, Justus Liebig University, Giessen, Germany
    Eur Respir J 19:797-804. 2002
    ....
  24. ncbi request reprint In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFalpha impact of omega-3 versus omega-6 fatty acids
    Konstantin Mayer
    Medizinische Klinik II, Zentrum fur Innere Medizin, Justus Liebig University, Klinikstr 36, D 35392 Giessen, Germany
    J Lipid Res 43:944-51. 2002
    ....
  25. ncbi request reprint Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia
    R Schmidt
    Medizinische Klinik II, , Justus-Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 163:95-100. 2001
    ..The marked reduction of palmitic acid in the PC fraction may be related to changes in surfactant function under these conditions...
  26. ncbi request reprint Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type
    Clemens Ruppert
    Department of Internal Medicine, Justus Liebig University Giessen, Germany
    Am J Respir Cell Mol Biol 28:95-102. 2003
    ..Synthetic bis-benzamidine-type serine protease inhibitors may offer specific inhibition of this event...
  27. ncbi request reprint Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis
    Matthias Griese
    Children s Hospital, University of Munich, Munich, Germany
    Am J Respir Crit Care Med 170:1000-5. 2004
    ....
  28. ncbi request reprint Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin
    Clemens Ruppert
    Department of Internal Medicine, Justus Liebeg University Giessen, Germany
    Thromb Haemost 89:53-64. 2003
    ..We conclude that urokinase and SP-B can be chemically crosslinked, thereby yielding a fibrinolytic enzyme suitable for targeting alveolar fibrin...
  29. ncbi request reprint Bronchoscopic surfactant administration preserves gas exchange and pulmonary compliance after single lung transplantation in dogs
    Ivar Friedrich
    Department of Cardiothoracic Surgery, Martin Luther University, Halle, Germany
    J Thorac Cardiovasc Surg 127:335-43. 2004
    ..Surfactant abnormalities have been implicated in reperfusion injury and respiratory failure in lung transplantation...
  30. ncbi request reprint Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 33:2827-33. 2002
    ..We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale...