Johannes Schödel

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
    Johannes Schödel
    Medizinische Klinik 4 and Translational Research Center, Universitätsklinikum Erlangen und Friedrich Alexander Universität FAU Erlangen Nürnberg, Erlangen, Germany Electronic address
    Eur Urol 69:646-57. 2016
  2. doi request reprint Pan-genomic binding of hypoxia-inducible transcription factors
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Biol Chem 394:507-17. 2013
  3. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
  4. doi request reprint Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
    Jonathan Jantsch
    Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Leukoc Biol 90:551-62. 2011
  5. pmc Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts
    Ruth E Schietke
    Interdisciplinary Centre for Clinical Research, University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e31034. 2012
  6. doi request reprint Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
  7. doi request reprint Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
  8. pmc P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    Purinergic Signal 12:687-695. 2016
  9. doi request reprint Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    Tina Gimm
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 24:4443-58. 2010
  10. pmc Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
    Steffen Grampp
    Department of Nephrology and Hypertension, Universitätsklinikum Erlangen und Friedrich Alexander Universität FAU Erlangen Nürnberg, Ulmenweg 18, 91054 Erlangen, Germany
    Nat Commun 7:13183. 2016

Collaborators

Detail Information

Publications11

  1. pmc Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
    Johannes Schödel
    Medizinische Klinik 4 and Translational Research Center, Universitätsklinikum Erlangen und Friedrich Alexander Universität FAU Erlangen Nürnberg, Erlangen, Germany Electronic address
    Eur Urol 69:646-57. 2016
    ..Most clear cell renal cell carcinomas (ccRCC) are associated with loss of von Hippel-Lindau tumor suppressor (pVHL) function and deregulation of hypoxia pathways...
  2. doi request reprint Pan-genomic binding of hypoxia-inducible transcription factors
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Biol Chem 394:507-17. 2013
    ..This review summarizes recent pan-genomic analyses of HIF binding and HIF-dependent transcriptional regulation...
  3. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
    ..These results highlight the importance of the thick ascending limb in the pathogenesis of AKI and suggest that pharmacologically targeting the HIF system may have potential to prevent and mitigate AKI...
  4. doi request reprint Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
    Jonathan Jantsch
    Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Leukoc Biol 90:551-62. 2011
    ..Thus, TLR activation and hypoxia stabilize HIF1A via distinct signaling pathways, resulting in differential HIF1A-dependent gene expression...
  5. pmc Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts
    Ruth E Schietke
    Interdisciplinary Centre for Clinical Research, University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e31034. 2012
    ..However, HIF-2α overexpression alone is insufficient to induce tumors. Thus, our data bear implications for renal tumorigenesis, epithelial differentiation and renal repair mechanisms...
  6. doi request reprint Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  7. doi request reprint Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
    ....
  8. pmc P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    Purinergic Signal 12:687-695. 2016
    ..In conclusion, P2Y2R mediates ATP-dependent cyst growth and is transcriptionally regulated by HIF-1α. These findings provide further mechanistic evidence on how hypoxia promotes cyst growth...
  9. doi request reprint Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    Tina Gimm
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 24:4443-58. 2010
    ..HIG2 could be detected in atherosclerotic arteries and fatty liver disease, suggesting that this ubiquitously inducible HIF-1 target gene may play an important functional role in diseases associated with pathological lipid accumulation...
  10. pmc Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
    Steffen Grampp
    Department of Nephrology and Hypertension, Universitätsklinikum Erlangen und Friedrich Alexander Universität FAU Erlangen Nürnberg, Ulmenweg 18, 91054 Erlangen, Germany
    Nat Commun 7:13183. 2016
    ....
  11. doi request reprint Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis
    Jonathan Jantsch
    Institut für Klinische Mikrobiologie und Hygiene, Universitatsklinikum Regensburg, Germany Mikrobiologisches Institut Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich Alexander Universität FAU Erlangen Nürnberg, Erlangen, Germany Electronic address
    Immunobiology 220:305-14. 2015
    ..Furthermore, we will highlight effects of the master regulators of the cellular hypoxic response, hypoxia-inducible transcription factors (HIF), in myeloid cells in antimicrobial defense and tissue homeostasis. ..