Thorsten Sadowski

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint Minocycline inhibits the production of inducible nitric oxide synthase in articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    J Rheumatol 28:336-40. 2001
  2. ncbi request reprint Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Inflamm Res 51:427-33. 2002
  3. ncbi request reprint Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes
    Thorsten Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    Biochem Pharmacol 64:217-27. 2002
  4. ncbi request reprint Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Osteoarthritis Cartilage 9:407-15. 2001
  5. ncbi request reprint Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Inflamm Res 50:175-82. 2001
  6. ncbi request reprint Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface
    Simon Mauch
    Department of Immunology, University of Konstanz, Konstanz, Germany
    J Immunol 168:1244-51. 2002
  7. ncbi request reprint Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    Vance Matthews
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    J Biol Chem 278:38829-39. 2003
  8. pmc Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3
    Thorsten Sadowski
    Institute of Biochemistry, Christian Albrechts University of Kiel, D 24118 Kiel, Germany
    Mol Biol Cell 14:4569-80. 2003
  9. ncbi request reprint Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation
    Thorsten Sadowski
    Institute of Biochemistry, University of Kiel, Kiel, Germany
    J Invest Dermatol 121:989-96. 2003
  10. ncbi request reprint Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation
    Inken M Beck
    Institute of Biochemistry, University of Kiel, Kiel, Germany
    J Invest Dermatol 127:1107-14. 2007

Collaborators

  • Jurgen Steinmeyer
  • R Mentlein
  • Stefan Rose-John
  • Inken M Beck
  • Radislav Sedlacek
  • Vance Matthews
  • Simon Mauch
  • Ralf Paus
  • Matthias Muller
  • Markus S Mueller
  • Karl Josef Kallen
  • Ingo Bussmeyer
  • Andreas Ludwig
  • Christian Hundhausen
  • Paul Saftig
  • Björn Schuster
  • Stefan Schütze
  • Dieter Hartmann
  • Cornelia Kolb
  • Birgit Kolb

Detail Information

Publications10

  1. ncbi request reprint Minocycline inhibits the production of inducible nitric oxide synthase in articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    J Rheumatol 28:336-40. 2001
    ..To determine the in vitro effects of tetracyclines and nonsteroidal antiiflammatory drugs on interleukin 1alpha (IL-1alpha) induced NO production and biosynthesis of inducible NO synthase (iNOS) by articular chondrocytes...
  2. ncbi request reprint Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Inflamm Res 51:427-33. 2002
    ..To determine the in vitro effects of several nonsteroidal antiinflammatory drugs on the IL-1 altered expression and activity of tPA, uPA and PAI-1 by articular chondrocytes...
  3. ncbi request reprint Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes
    Thorsten Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    Biochem Pharmacol 64:217-27. 2002
    ..Due to their co-regulation of MMPs and TIMP(s) glucocorticoids should be carefully studied for their overall effect on extracellular matrix proteolysis...
  4. ncbi request reprint Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Osteoarthritis Cartilage 9:407-15. 2001
    ..To determine the in-vitro effects of several non-steroidal antiinflammatory drugs and the glucocorticoid dexamethasone on the IL-1 altered expression and activity of MMP-1, MMP-3 and TIMP-1 by bovine articular chondrocytes...
  5. ncbi request reprint Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1
    T Sadowski
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Inflamm Res 50:175-82. 2001
    ....
  6. ncbi request reprint Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface
    Simon Mauch
    Department of Immunology, University of Konstanz, Konstanz, Germany
    J Immunol 168:1244-51. 2002
    ....
  7. ncbi request reprint Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    Vance Matthews
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    J Biol Chem 278:38829-39. 2003
    ..For decades, high cholesterol levels have been considered harmful. This study indicates that low cholesterol levels may play a role in shedding of the membrane-bound IL-6R and thereby in the immunopathogenesis of human diseases...
  8. pmc Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3
    Thorsten Sadowski
    Institute of Biochemistry, Christian Albrechts University of Kiel, D 24118 Kiel, Germany
    Mol Biol Cell 14:4569-80. 2003
    ..This activity might have widespread consequences for the behavior of epidermal keratinocytes...
  9. ncbi request reprint Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation
    Thorsten Sadowski
    Institute of Biochemistry, University of Kiel, Kiel, Germany
    J Invest Dermatol 121:989-96. 2003
    ..The dysregulation of MMP-19 expression in epidermis suggests its possible involvement in the perpetuation of cutaneous infections and proliferative disorders such as psoriasis...
  10. ncbi request reprint Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation
    Inken M Beck
    Institute of Biochemistry, University of Kiel, Kiel, Germany
    J Invest Dermatol 127:1107-14. 2007
    ..Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes...