Dan Rujescu

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Current progress in the genetic research of schizophrenia: relevance for drug discovery?
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nußbaumstr 7, 80336 Munchen, Germany
    Curr Pharm Biotechnol 13:1614-21. 2012
  2. doi request reprint Schizophrenia genes: on the matter of their convergence
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nußbaumstr 7, 80336, Munchen, Germany
    Curr Top Behav Neurosci 12:429-40. 2012
  3. ncbi request reprint NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:42-8. 2008
  4. ncbi request reprint Dissecting the many genetic faces of schizophrenia
    Dan Rujescu
    Epidemiol Psichiatr Soc 18:91-5. 2009
  5. ncbi request reprint A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities
    Dan Rujescu
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 59:721-9. 2006
  6. ncbi request reprint Plexin B3 is genetically associated with verbal performance and white matter volume in human brain
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 12:190-4, 115. 2007
  7. ncbi request reprint Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system?
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Arch Suicide Res 11:17-40. 2007
  8. doi request reprint The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Psychiatry 25:272-4. 2010
  9. doi request reprint Estrogen receptor gene 1 variants are not associated with suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 160:1-7. 2008
  10. ncbi request reprint A monoamine oxidase B gene variant and short-term antidepressant treatment response
    Andre Tadic
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:1370-7. 2007

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Current progress in the genetic research of schizophrenia: relevance for drug discovery?
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nußbaumstr 7, 80336 Munchen, Germany
    Curr Pharm Biotechnol 13:1614-21. 2012
    ..New findings in schizophrenia will be summarized in this review and discussed in the light of a possible translation into the development of better treatment...
  2. doi request reprint Schizophrenia genes: on the matter of their convergence
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nußbaumstr 7, 80336, Munchen, Germany
    Curr Top Behav Neurosci 12:429-40. 2012
    ..All these studies showed up new avenues for the biology of common complex diseases and yielded a multitude of genes showing strong association with complex diseases...
  3. ncbi request reprint NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:42-8. 2008
    ..0002; sliding haplotype T-G, P = 0.002). In conclusion, our study suggests a possible involvement of NOS-I and NOS-III gene variants in suicidal behavior and related intermediate phenotypes...
  4. ncbi request reprint Dissecting the many genetic faces of schizophrenia
    Dan Rujescu
    Epidemiol Psichiatr Soc 18:91-5. 2009
    ....
  5. ncbi request reprint A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities
    Dan Rujescu
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 59:721-9. 2006
    ....
  6. ncbi request reprint Plexin B3 is genetically associated with verbal performance and white matter volume in human brain
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 12:190-4, 115. 2007
    ..These novel observations warrant further replication in independent samples...
  7. ncbi request reprint Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system?
    Dan Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Arch Suicide Res 11:17-40. 2007
    ..The aim of this article is to review molecular genetic studies in suicidal behavior and to emphasize findings on new genes...
  8. doi request reprint The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Psychiatry 25:272-4. 2010
    ..The aim of this article is to review molecular genetic studies in suicidal behavior beyond the serotonergic system and to emphasize findings on new genes...
  9. doi request reprint Estrogen receptor gene 1 variants are not associated with suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 160:1-7. 2008
    ..In conclusion, our study does not support the hypothesis that estrogen receptor alpha gene variants are major contributors to suicide or to anger- or aggression-related behaviors...
  10. ncbi request reprint A monoamine oxidase B gene variant and short-term antidepressant treatment response
    Andre Tadic
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:1370-7. 2007
    ..If replicated, the MAOB A644G polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression...
  11. ncbi request reprint Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Hum Psychopharmacol 23:115-20. 2008
    ..The aim of this study was to investigate the relationship between genetic variants of the COMT gene influencing synaptic dopamine levels and the LDAEP...
  12. doi request reprint Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  13. ncbi request reprint Tachykinin receptor 1 variants associated with aggression in suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:757-61. 2007
    ..In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features...
  14. doi request reprint Influence of ANKK1 and DRD2 polymorphisms in response to haloperidol
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:65-74. 2013
    ..Our findings support a possible role of ANKK1 and DRD2 variability on haloperidol efficacy. However, due to the discrepancies between the results in the two samples, our results need further validation...
  15. doi request reprint Influence of neuronal cell adhesion molecule (NCAM1) variants on suicidal behaviour and correlated traits
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 179:222-5. 2010
    ..However, independent studies are needed to validate these results...
  16. pmc Glutamatergic dysbalance and oxidative stress in in vivo and in vitro models of psychosis based on chronic NMDA receptor antagonism
    Just Genius
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    PLoS ONE 8:e59395. 2013
    ....
  17. doi request reprint Dysequilibrium of neuronal proliferation and apoptosis in a pharmacological animal model of psychosis
    Just Genius
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Methods 56:519-27. 2012
    ....
  18. doi request reprint NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 64:32-7. 2011
    ....
  19. doi request reprint Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychobiology 59:23-7. 2009
    ..Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question...
  20. doi request reprint Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene
    Georg Juckel
    Department of Psychiatry, Ruhr University, 44791 Bochum, Germany
    J Psychiatr Res 44:541-6. 2010
    ..To evaluate the genetic basis of this relationship, we studied whether the LDAEP is correlated with genetic variants within the BDNF gene...
  21. ncbi request reprint Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene
    Ina Giegling
    Molecular and Clinical Neurobiology, Department of Psychiatry, University of Munich, Germany
    J Affect Disord 96:75-81. 2006
    ....
  22. ncbi request reprint ABCG1 gene variants in suicidal behavior and aggression-related traits
    Anton Gietl
    Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    Eur Neuropsychopharmacol 17:410-6. 2007
    ..Given that these represent intermediate phenotypes of suicidal behavior, ABCG1 might also act on suicidal behavior through these traits. The observed associations warrant further replications...
  23. doi request reprint Lack of association between 71 variations located in candidate genes and response to acute haloperidol treatment
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychopharmacology (Berl) 214:719-28. 2011
    ..The antipsychotic pharmacological treatment effectiveness and side effects are at least partially driven by the genetic personal background...
  24. ncbi request reprint Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:454-8. 2008
    ....
  25. ncbi request reprint Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Psychiatry Res 153:183-7. 2007
    ..We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism...
  26. doi request reprint Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:434-8. 2009
    ..The main finding concerns the association between rs722207 and HA in the healthy sample. Further research is needed to replicate our findings and to investigate further ESR1 polymorphisms...
  27. doi request reprint Reduced early auditory evoked gamma-band response in patients with schizophrenia
    Gregor Leicht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, 7D 80336 Munich, Germany
    Biol Psychiatry 67:224-31. 2010
    ..power and phase-locking in schizophrenic patients?; and 2) Is this possible decrease a result of reduced activity in the auditory cortex and/or the anterior cingulate cortex (ACC), which were identified as sources of the GBR previously?..
  28. doi request reprint Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nußbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 45:234-41. 2011
    ..Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia...
  29. ncbi request reprint Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
    Isabella Braun
    Department of Psychiatry, Division of Molecular and Clinical Neurobiology, Ludwig Maximilians University of Munich, Germany
    Schizophr Res 97:254-63. 2007
    ..Moreover, this study provides further evidence for regional differences in the response of GABAergic interneurons to NMDA receptor antagonism and antipsychotic treatment...
  30. doi request reprint Personality and attempted suicide. Analysis of anger, aggression and impulsivity
    Ina Giegling
    Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 43:1262-71. 2009
    ..Such interactions could explain the correlation between temperament and suicidality but further research is needed. Anger and self-directedness appear to have some effects on suicide attempt...
  31. doi request reprint Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration
    Hanna Raeder
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Drug Alcohol Depend 96:16-21. 2008
    ..Our results demonstrate that long-term voluntary alcohol self-administration, affects the regulation of genes encoding the various subunits and splice variants of the NMDA receptor in a brain regional-specific manner...
  32. ncbi request reprint Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:308-15. 2008
    ..In conclusion, our study does not support the involvement of TH gene variants as major contributors to suicide, whereas DDC variants could mediate some features related to suicide and be involved in violent suicidal behavior...
  33. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
    ..Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties...
  34. doi request reprint Sociodemographic and treatment related variables are poor predictors of haloperidol induced motor side effects
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:74-7. 2011
    ....
  35. doi request reprint Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacogenet Genomics 21:206-16. 2011
    ..The glutamatergic system may be relevant to the pathophysiology of psychosis and to the effects of antipsychotic treatments...
  36. ncbi request reprint Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims
    Andreas Thalmeier
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:217-28. 2008
    ..The differentially expressed genes and significant biological processes might be involved in the pathophysiology of suicide and warrant further attention...
  37. ncbi request reprint A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits
    Dan Rujescu
    Department of Psychiatry, Division of Molecular Neurobiology, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:34-9. 2003
    ..Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. In this study, we examined the influence of a functional COMT (V158M) polymorphism on suicidal behavior and anger-related traits...
  38. doi request reprint Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms
    Gabriele Koller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 36:1230-6. 2012
    ..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
  39. doi request reprint Interaction of haloperidol plasma level and antipsychotic effect in early phases of acute psychosis treatment
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 44:487-92. 2010
    ..This finding could contribute to tailor more individualized treatment and highlights the need for early detection of non-responders...
  40. ncbi request reprint Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis
    Dan Rujescu
    Division of Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:465-73. 2003
    ..The most widely studied genetic variations in the TPH gene, which are located in intron 7, yielded conflicting results in individual studies on suicide-related behavior...
  41. doi request reprint Neuroanatomical correlates of executive dysfunction in the at-risk mental state for psychosis
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 123:160-74. 2010
    ....
  42. ncbi request reprint EEG-vigilance differences between patients with borderline personality disorder, patients with obsessive-compulsive disorder and healthy controls
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 258:137-43. 2008
    ....
  43. doi request reprint Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study
    Verena C Buschert
    Department of Psychiatry Ludwig Maximilians University, Munich, Germany
    J Alzheimers Dis 25:679-94. 2011
    ..In contrast, AD patients showed no significant benefit from intervention. The findings in this small sample support the use of the intervention in larger scales studies with an extended follow-up period to determine long-term effects...
  44. doi request reprint Antipsychotic response in the first week predicts later efficacy
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 66:100-5. 2012
    ..Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response...
  45. doi request reprint Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study
    Ulrich W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University, Halle Wittenberg, Julius Kühn Str 7, D 06112 Halle, Germany
    Addict Biol 16:323-33. 2011
    ....
  46. doi request reprint Inefficient neural activity in patients with schizophrenia and nonpsychotic relatives of schizophrenic patients: evidence from a working memory task
    Susanne Karch
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 43:1185-94. 2009
    ..In addition, compensatory strategies were demonstrated. These findings suggest that the genetic risk for schizophrenia is accompanied by neural inefficiency which is associated with cognitive deficits, especially in difficult tasks...
  47. doi request reprint Cholinergic impact on neuroplasticity drives muscarinic M1 receptor mediated differentiation into neurons
    Jens Benninghoff
    Department of Psychiatry, LMU University of Munich, Munich, Germany
    World J Biol Psychiatry 14:241-6. 2013
    ..Increasing evidence indicates that canonical neurotransmitters act as regulatory signals during neuroplasticity. Here, we report that muscarinic cholinergic neurotransmission stimulates differentiation of adult neural stem cells in vitro...
  48. ncbi request reprint Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents
    Doris Gohle
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 42:297-303. 2008
    ..Once again, our findings point to a hyperactivated cortical state also of temporo-parietal and hippocampal regions in OCD...
  49. doi request reprint No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression
    Richard Musil
    Department of Psychiatry and Psychotherapy, Psychiatric Clinic, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:405-12. 2013
    ..However, results showed a tendency towards significance. At this stage, we cannot support an influence of these three polymorphisms. Further studies in larger patient samples to increase sample sizes of subgroups are warranted...
  50. ncbi request reprint Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  51. doi request reprint Genetic findings in schizophrenia patients related to alterations in the intracellular Ca-homeostasis
    Ina Giegling
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Nußbaumstr 7, 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:1375-80. 2010
    ..Replications and functional studies will hopefully provide further insight into these genetic variants and the underlying processes...
  52. pmc Variation within the Huntington's disease gene influences normal brain structure
    Mark Mühlau
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 7:e29809. 2012
    ..Our study demonstrates that a certain trinucleotide repeat influences normal brain structure in humans. This result may have important implications for the understanding of both the healthy and diseased brain...
  53. pmc Disruption of the neurexin 1 gene is associated with schizophrenia
    Dan Rujescu
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:988-96. 2009
    ..24% of cases and 0.015% of controls). These were significantly associated with a high odds ratio (P = 0.0027; OR 8.97, 95% CI 1.8-51.9). We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia...
  54. ncbi request reprint The MAOA T941G polymorphism and short-term treatment response to mirtazapine and paroxetine in major depression
    Andre Tadic
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:325-31. 2007
    ..An independent replication of our finding is needed. If replicated, genotyping of this locus could become a promising tool to predict response to mirtazapine treatment in females suffering from major depression...
  55. ncbi request reprint A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials
    Christoph Mulert
    Department of Psychiatry, University of Munich, LMU, Munich, Germany
    Neuropsychopharmacology 31:1335-44. 2006
    ..Further studies should address the direct role of the DRD3 Ser9Gly polymorphism in attenuated P300 amplitudes in psychiatric disorders like schizophrenia or alcoholism...
  56. doi request reprint No association of alcohol dependence with HOMER 1 and 2 genetic variants
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010
    ..In conclusion, our results suggest that single SNPs, respectively, haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of AD...
  57. pmc Creatine protects against excitoxicity in an in vitro model of neurodegeneration
    Just Genius
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 7:e30554. 2012
    ....
  58. ncbi request reprint Kinematical analysis of motor function in schizophrenic patients: a possibility to separate negative symptoms from extrapyramidal dysfunction induced by neuroleptics?
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Pharmacopsychiatry 37:110-8. 2004
    ..In this prospective matched case-control study, hand movement analysis was conducted using a digitizing tablet (kinematical analysis)...
  59. doi request reprint KCNIP4 as a candidate gene for personality disorders and adult ADHD
    Lena Weißflog
    Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Eur Neuropsychopharmacol 23:436-47. 2013
    ..0079 to 0.049). Seven markers within the KCNIP4 gene showed an association with PD (p values from 0.0043 to 0.0437). The results of these studies suggest a role of KCNIP4 in the etiology of ADHD, PD and other co-morbid disorders...
  60. ncbi request reprint A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results
    Thomas Bronisch
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Suicide Res 9:19-26. 2005
    ..The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented...
  61. ncbi request reprint Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  62. ncbi request reprint Lack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behavior
    Dan Rujescu
    Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 116:69-71. 2003
    ..These findings suggest that the 5-HT1B polymorphism is unlikely to play a major role in the genetic susceptibility to suicide attempts...
  63. ncbi request reprint The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease
    Daniela C Glatz
    Molecular and Clinical Neurobiology, Department of Psychiatry Ludwig Maximilians University, Munich, Germany
    J Neurochem 96:635-44. 2006
    ..These findings suggest that a misregulation of alternative splicing seems to contribute to sporadic AD...
  64. doi request reprint Atypical parkinsonism due to a D202N Gerstmann-Sträussler-Scheinker prion protein mutation: first in vivo diagnosed case
    Annika Plate
    Department of Neurology, Ludwig Maximilians Universitat, Munich, Germany
    Mov Disord 28:241-4. 2013
    ..Parkinsonism with dopa-sensitivity and a correlating DaTSCAN turned out to be due to a D202N mutation which is associated with the Gerstmann-Sträussler-Scheinker (GSS) disease...
  65. doi request reprint Lack of association of the 5-HT(3A) receptor with schizophrenia
    Caroline Nothdurfter
    Department of Psychiatry, Psychotherapy, University of Regensburg, Regensburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:310-5. 2012
    ..In conclusion, our study does not support the hypothesis that the 5-HT(3A) receptor plays a major role in the pathogenesis of schizophrenia...
  66. doi request reprint Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment
    Philine Schneider
    Alzheimer Memorial Center, Department of Psychiatry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 70:145-51. 2011
    ..Midregional proatrial natriuretic peptide (MR-proANP), an inactive surrogate molecule of the mature atrial natriuretic peptide, is related to circulatory function and hypertension...
  67. pmc Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells
    Jens Benninghoff
    S Raffaele Scientific Institute, Stem Cell Research Institute HSR SCRI, Milan, Italy
    Neuropsychopharmacology 35:893-903. 2010
    ..Finally, we documented a 5-HT-induced increase of ANSC migration activity. In summary, we demonstrated a powerful serotonergic impact on ANSC functional features, which was mainly mediated by 5-HT1A receptors...
  68. ncbi request reprint Association of anger-related traits with SNPs in the TPH gene
    D Rujescu
    Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 7:1023-9. 2002
    ..These findings support the hypothesis that the A218C and the A779C SNP in the TPH gene may be associated with anger-related traits in German samples...
  69. ncbi request reprint Assessment of handedness using a digitizing tablet: a new method
    V Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Section of Clinical Neurophysiology, Nussbaumstr 7, 80336, Munich, Germany
    Neuropsychologia 39:1158-66. 2001
    ..According to our results handedness should be assessed not only with the EHI, but also with the computer-aided analysis of hand-movements...
  70. ncbi request reprint [Factor structure and validity of a german version of the barratt impulsiveness scale]
    U W Preuss
    Psychiatrische Klinik und Poliklinik Ludwig Maximilians Universität München
    Fortschr Neurol Psychiatr 71:527-34. 2003
    ..The aim of this study is to evaluate the BIS-5 in two German psychiatric inpatient samples and healthy controls proving the originally proposed four-factor structure as well as convergent and discriminate validity...
  71. doi request reprint 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  72. ncbi request reprint Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 42:22-5. 2000
    ..Furthermore, we found no association with suicidal behavior. These findings do not support the hypothesis that ABCG1 is a susceptibility gene for affective disorders or suicidal behavior...
  73. ncbi request reprint A polymorphism in the promoter of the serotonin transporter gene is not associated with suicidal behavior
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 11:169-72. 2001
    ....
  74. ncbi request reprint GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
    ..These findings support the hypothesis that the GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. This novel finding warrants replication...
  75. ncbi request reprint The neural basis of the P300 potential. Focus on the time-course of the underlying cortical generators
    C Mulert
    Laboratory for Clinical Neurophysiology, Department of Psychiatry, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:190-8. 2004
    ..In these selected regions, an analysis of the activation time-courses has been performed...
  76. doi request reprint The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review
    Jens Benninghoff
    Department of Psychiatry, LMU University of Munich, Munich, Germany
    World J Biol Psychiatry 13:240-7. 2012
    ..This is intriguing since neurogenesis is believed to play a decisive role in modulating the effect of selective serotonin reuptake inhibitors (SSRI), which are targeting SERT...
  77. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
    ....
  78. ncbi request reprint Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Biobehav Rev 31:89-102. 2007
    ....
  79. ncbi request reprint Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia
    E M Meisenzahl
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Am J Psychiatry 158:1316-9. 2001
    ..This study investigated the effect on brain morphology of an interleukin-1beta genetic polymorphism (C-->T transition at position -511) in patients with schizophrenia...
  80. ncbi request reprint Methionine homozygosity at codon 129 in the prion protein is associated with white matter reduction and enlargement of CSF compartments in healthy volunteers and schizophrenic patients
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, D 80336 Munich, Germany
    Neuroimage 15:200-6. 2002
    ..This, however, being a novel finding, should warrant further investigation...
  81. ncbi request reprint M129V variation in the prion protein may influence cognitive performance
    D Rujescu
    Division of Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 8:937-41. 2003
    ..In summary, we deliver evidence for an association of a common genetic variation in the prion protein gene with cognitive performance. However, independent replications are needed before firm conclusions can be drawn...
  82. doi request reprint Effect of transient blockade of N-methyl-D-aspartate receptors at neonatal stage on stress-induced lactate metabolism in the medial prefrontal cortex of adult rats: role of 5-HT1A receptor agonism
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930 0194, Japan
    Synapse 66:408-17. 2012
    ..The implications for the ability of 5-HT1A agonism to ameliorate impaired lactate production in the mPFC of this animal model are discussed...
  83. doi request reprint Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction
    A Mobascher
    Department of Psychiatry, Neuropsychiatric Research Laboratory, Heinrich Heine University, Duesseldorf, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:684-90. 2010
    ..Alternatively, variations in CHRM2 could modulate presynaptic auto-regulation in cholinergic systems and may thereby affect an individual's response to nicotine more specifically...
  84. doi request reprint Systems biology and complex neurobehavioral traits
    I Giegling
    Division of Molecular and Clinical Neurobiology, Munich, Germany
    Pharmacopsychiatry 41:S32-6. 2008
    ..New tools will be needed for a more complex and systemic view. The systems biology approach could be a pivotal tool in understanding of complex behavior and diseases in future...
  85. ncbi request reprint Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene
    M Schafer
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 158:802-4. 2001
    ..Pharmacogenetic influences on therapeutic response to neuroleptic treatment are poorly understood. This study investigates the association of response to short-term haloperidol treatment with a Taq I polymorphism in the DRD2 gene...
  86. ncbi request reprint Detection of TOAD-64 in adult rat brain as revealed by two-dimensional protein gel electrophoresis followed by MALDI mass spectrometry possible modulatory effect of chronic haloperidol treatment
    Norbert Dahmen
    Department of Psychiatry, University of Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:693-8. 2002
    ....
  87. ncbi request reprint The catechol-O-methyltransferase Val108/158Met polymorphism affects short-term treatment response to mirtazapine, but not to paroxetine in major depression
    A Szegedi
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Pharmacogenomics J 5:49-53. 2005
    ..Time course of response and antidepressant efficacy of mirtazapine, but not paroxetine, seem to be influenced in a clinically relevant manner by this allelic variation within the COMT gene...
  88. doi request reprint Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
    Edwin J C G van den Oord
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, PO Box 980533, Richmond, VA 23298 0533, USA
    Arch Gen Psychiatry 65:1062-71. 2008
    ..It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders...
  89. ncbi request reprint Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
    ..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies...
  90. ncbi request reprint HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:291-9. 2007
    ..In conclusion, our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample...
  91. ncbi request reprint Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens
    Andre Tadic
    Dept of Psychiatry, University of Mainz, 55131 Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 255:129-35. 2005
    ..Moreover, we hypothesized that another genetic variation within GRIN2B (rs1806191) may have an effect in the etiology of alcoholism or withdrawal-related traits...
  92. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  93. doi request reprint Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior
    Gunter Schumann
    Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
    Arch Gen Psychiatry 65:826-38. 2008
    ..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models...
  94. ncbi request reprint Association study of a SNP coding for a M129V substitution in the prion protein in schizophrenia
    Dan Rujescu
    Schizophr Res 62:289-91. 2003
  95. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  96. ncbi request reprint 5-HT2A SNPs and the Temperament and Character Inventory
    Alessandro Serretti
    Institute of Psychiatry University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 31:1275-81. 2007
    ..003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p=0.01) in the Italian sample. We conclude that 5-HT(2A) SNPs may marginally modulate personality traits but further studies are required...
  97. doi request reprint Association of functional polymorphisms in NOS1 and NOS3 with loudness dependence of auditory evoked potentials
    Wolfram Kawohl
    Research Group Clinical and Experimental Psychopathology, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Int J Neuropsychopharmacol 11:477-83. 2008
    ..Further studies are needed to fully clarify the relationship between nitrinergic transmission, LDAEP and complex disorders such as schizophrenia and affective disorders...
  98. ncbi request reprint Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior
    Erik Lauterbach
    University of Schleswig Holstein, Campus Luebeck, Department of Psychiatry and Psychotherapy, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Affect Disord 91:57-62. 2006
    ..A number of personality traits were assessed in order to provide a basis for a psychobiological model of suicidal behavior...
  99. ncbi request reprint Factor structure and external validity of the PANSS revisited
    Edwin J C G van den Oord
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, P O Box 980126, Richmond VA 23298 0126, USA
    Schizophr Res 82:213-23. 2006
    ..Our analyses also suggested that some of the controversy about the PANSS can possibly be attributed to methodological factors where the substantial cross-loadings of some PANSS items may play an important role...
  100. doi request reprint Failure to replicate effect of Kibra on human memory in two large cohorts of European origin
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:667-8. 2008
    ..These results suggest that Kibra does not have a strong and general effect on human memory...