C W Reuter
Affiliation: University of Ulm
- Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?C W Reuter
Department of Internal Medicine III Hematology and Oncology, University of Ulm, Ulm, Germany
Blood 96:1655-69. 2000..Because Ras signaling plays a crucial role in the pathogenesis of some hematologic malignancies, the potential therapeutic usefulness of these inhibitors is discussed. (Blood. 2000;96:1655-1669)..
- Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signalingM A Morgan
Department of Hematology and Oncology, Section Molecular Biology, University of Ulm, Germany
Blood 97:1823-34. 2001..FTI-277 revealed strong toxicity toward normal purified CD34+ cells. The results suggest differences in the mechanisms of action and support a potential therapeutic usefulness of these inhibitors in the treatment of myeloid leukemias...