Hermann Reichenspurner

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Overview of tacrolimus-based immunosuppression after heart or lung transplantation
    Hermann Reichenspurner
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:119-30. 2005
  2. doi request reprint Impact of patient-prosthesis mismatch after transcatheter aortic valve-in-valve implantation in degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    J Thorac Cardiovasc Surg 143:617-24. 2012
  3. doi request reprint Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 5:341-9. 2012
  4. doi request reprint Predictors and outcomes after transcatheter aortic valve implantation using different approaches according to the valve academic research consortium definitions
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Catheter Cardiovasc Interv 82:640-52. 2013
  5. ncbi request reprint Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Cardiology 108:128-37. 2007
  6. ncbi request reprint FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transpl Int 18:215-20. 2005
  7. doi request reprint Six-month results of a repositionable and retrievable pericardial valve for transcatheter aortic valve replacement: the Direct Flow Medical aortic valve
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 140:897-903. 2010
  8. ncbi request reprint FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy
    Sonja Schrepfer
    University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 26:70-7. 2007
  9. ncbi request reprint Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Martinistr, Germany
    Transpl Int 19:310-8. 2006
  10. doi request reprint Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation
    Volker Rudolph
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    Int J Cardiol 167:716-20. 2013

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Overview of tacrolimus-based immunosuppression after heart or lung transplantation
    Hermann Reichenspurner
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:119-30. 2005
    ..In particular, the lesser propensity of tacrolimus to cause hypertension and hyperlipidemia potentially offers decreased cardiovascular risk for heart and lung transplant recipients...
  2. doi request reprint Impact of patient-prosthesis mismatch after transcatheter aortic valve-in-valve implantation in degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    J Thorac Cardiovasc Surg 143:617-24. 2012
    ..Nevertheless, hemodynamic performance is limited by the previously implanted xenograft. We report our experience with patient-prosthesis mismatch (PPM) after valve-in-valve implantation in the aortic position...
  3. doi request reprint Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 5:341-9. 2012
    ..This study reports the results of a series of transapical mitral valve-in-valve implantations and aims to offer guidance on technical aspects of the procedure...
  4. doi request reprint Predictors and outcomes after transcatheter aortic valve implantation using different approaches according to the valve academic research consortium definitions
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Catheter Cardiovasc Interv 82:640-52. 2013
    ....
  5. ncbi request reprint Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Cardiology 108:128-37. 2007
    ..To investigate the efficacy of the malononitrilamide FK778 to prevent vascular smooth muscle cell (SMC) migration/proliferation, and vascular fibrosis, the key events in restenosis development using in vivo and in vitro studies...
  6. ncbi request reprint FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transpl Int 18:215-20. 2005
    ..Therefore, FK778 is a novel, highly desirable immunosuppressive drug for transplantation medicine...
  7. doi request reprint Six-month results of a repositionable and retrievable pericardial valve for transcatheter aortic valve replacement: the Direct Flow Medical aortic valve
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 140:897-903. 2010
    ..The Direct Flow Medical aortic valve (Direct Flow Medical, Inc, Santa Rosa, Calif) is a nonmetallic tissue valve prosthesis intended to treat patients with severe aortic stenosis at high risk for surgery...
  8. ncbi request reprint FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy
    Sonja Schrepfer
    University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 26:70-7. 2007
    ..This study examines the efficacy of FK778 regimens for prevention of different phases of xenograft rejection...
  9. ncbi request reprint Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Martinistr, Germany
    Transpl Int 19:310-8. 2006
    ..The anti-proliferative potency on SMCs seems to be an especially important mechanism for FK778. De novo combination regimens revealed no beneficial interaction and thus remain doubtful...
  10. doi request reprint Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation
    Volker Rudolph
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    Int J Cardiol 167:716-20. 2013
    ..We sought to assess the feasibility and effectiveness of bivalvular transcatheter therapy in patients with coexisting aortic stenosis and mitral regurgitation...
  11. doi request reprint Transapical implantation of a second-generation transcatheter heart valve in patients with noncalcified aortic regurgitation
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 6:590-7. 2013
    ..This study sought to report on the feasibility and early results of transcatheter aortic valve implantation employing a second-generation device in a series of patients with pure aortic regurgitation...
  12. doi request reprint Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease
    Ali Aydin
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Int J Cardiol 164:301-5. 2013
    ..The relationship of aortic valve dysfunction and ascending aortic aneurysm is unclear in adults with bicuspid aortic valve disease...
  13. doi request reprint Impact of MitraClip™ therapy on secondary mitral valve surgery in patients at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cardiothorac Surg 40:1521-6. 2011
    ..We report our experience with failed MitraClip™ therapy and its impact on subsequent surgical strategies, such as the feasibility of MVR in high-risk patients...
  14. doi request reprint The best of both worlds: staged hybrid approach to complex cardiac disease in a patient at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Thorac Cardiovasc Surg 61:421-4. 2013
    ..For the future, increasing clinical importance of interventional valve therapies either for stand-alone or hybrid procedures can be anticipated. ..
  15. ncbi request reprint FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:1844-54. 2005
    ..The effectiveness of the novel immunosuppressive agent FK778 and of tacrolimus to prevent the development of obliterative airway disease (OAD) was investigated in an animal model...
  16. doi request reprint A heart team's perspective on interventional mitral valve repair: percutaneous clip implantation as an important adjunct to a surgical mitral valve program for treatment of high-risk patients
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    J Thorac Cardiovasc Surg 143:78-84. 2012
    ..We sought to assess the feasibility of catheter-based mitral valve repair using a clip-based percutaneous edge-to-edge repair system in selected patients at high surgical risk with mitral regurgitation grade 3 or worse...
  17. doi request reprint Echocardiographic and clinical outcomes of MitraClip therapy in patients not amenable to surgery
    Volker Rudolph
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Am Coll Cardiol 58:2190-5. 2011
    ..The aim of this study was to assess the outcomes of patients at prohibitive surgical risk undergoing MitraClip therapy (Abbott Vascular, Redwood City, California) for severe mitral regurgitation (MR)...
  18. doi request reprint Series of transcatheter valve-in-valve implantations in high-risk patients with degenerated bioprostheses in aortic and mitral position
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    Catheter Cardiovasc Interv 76:608-15. 2010
    ..We report our experience with transcatheter valve-in-valve implantations in patients with degenerated bioprostheses in aortic and mitral position...
  19. ncbi request reprint The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Transpl Immunol 15:45-53. 2005
    ....
  20. doi request reprint Towards an integrated approach to mitral valve disease: implementation of an interventional mitral valve programme and its impact on surgical activity
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Cardiothorac Surg 44:324-8; discussion 328-9. 2013
    ..We sought to evaluate the impact of an interventional mitral valve programme on surgical mitral valve activity and to assess the risk profiles of the respective patient populations...
  21. doi request reprint Predictors for permanent pacemaker implantation after concomitant surgical ablation for atrial fibrillation
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany Electronic address
    J Thorac Cardiovasc Surg 147:984-8. 2014
    ..Pacemaker dependency is a known complication of AF ablation. We sought to determine independent predictors for pacemaker implantation after surgical AF ablation...
  22. doi request reprint Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545
    Tobias Deuse
    Transplant and Stem Cell Immunobiology Laboratory, University Heart Center Hamburg, Hamburg, Germany
    Transplantation 94:695-702. 2012
    ..This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection...
  23. doi request reprint Comparison of aortic root replacement in patients with Marfan syndrome
    Alexander M J Bernhardt
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Eur J Cardiothorac Surg 40:1052-7. 2011
    ....
  24. doi request reprint Transcatheter aortic valve implantation versus surgical aortic valve replacement: a propensity score analysis in patients at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 143:64-71. 2012
    ..In this propensity-score analysis we compared outcomes after TAVI to those after surgical aortic valve replacement (AVR)...
  25. ncbi request reprint The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 77:509-13. 2004
    ..The aim of this study was to evaluate the combination of FK778 and tacrolimus in a high-responder rat cardiac transplantation model...
  26. doi request reprint First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, Hamburg, Germany
    Clin Res Cardiol 100:311-6. 2011
    ..We investigated our experience with combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as an alternative strategy in high-risk patients...
  27. doi request reprint Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome
    Meike Rybczynski
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Am J Cardiol 107:268-74. 2011
    ..In conclusion, the same clinical determinants that predict outcomes in idiopathic mitral valve prolapse also predict outcomes in mitral valve prolapse associated with Marfan syndrome...
  28. doi request reprint First-in-man treatment of a degenerated mitral surgical valve with the mechanical expanding Lotus™ valve
    Ulrich Schaefer
    Division of Cardiology, University Heart Center Eppendorf, Hamburg, Germany
    EuroIntervention 12:515-8. 2016
    ..The case described demonstrates the very controlled feasibility of valve-in-valve treatment for a degenerated mitral bioprosthesis with a mechanically expanding Lotus valve. ..
  29. doi request reprint Applicability of next generation balloon-expandable transcatheter heart valves in aortic annuli exceeding formally approved dimensions
    Andreas Schaefer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrase 52, 20246, Hamburg, Germany
    Clin Res Cardiol 105:585-91. 2016
    ..Experience in patients receiving significantly undersized Sapien 3 (S3) THV (Edwards Lifesciences, Inc., Irvine, CA, USA) in aortic annuli up to 32 mm has not been reported so far...
  30. doi request reprint Transfemoral TAVI without pre-dilatation using balloon-expandable devices: a case-matched analysis
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Clin Res Cardiol 104:735-42. 2015
    ..This comparative case-matched analysis investigated feasibility and safety of direct transfemoral (TF) transcatheter aortic valve implantation (TAVI) without pre-dilatation using balloon-expandable devices...
  31. pmc Repeat transcatheter aortic valve implantation using a latest generation balloon-expandable device for treatment of failing transcatheter heart valves
    Andreas Schaefer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrase 52, D 20246, Hamburg, Germany
    J Cardiothorac Surg 11:2. 2016
    ..Herein we present initial experience with use of the latest generation balloon-expandable Edwards Sapien 3® (S3) transcatheter heart valve (THV) for treatment of failing THVs...
  32. doi request reprint First in human implantation of the mechanical expanding Lotus® valve in degenerated surgical valves in mitral position
    Ulrich Schaefer
    Division of Cardiology, University Heart Center Eppendorf, Hamburg, Germany
    Catheter Cardiovasc Interv 86:1280-6. 2015
    ..Although, CE mark of most THV is limited for native aortic valvular stenosis, transcatheter valve implantation into degenerated bioprostheses, even in mitral position is very intriguing...
  33. doi request reprint Single-centre experience with next-generation devices for transapical aortic valve implantation
    Moritz Seiffert
    Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 47:39-45; discussion 45. 2015
    ..We aimed to assess short-term outcomes of 200 consecutive patients who underwent transapical TAVI with next-generation THV at our institution...
  34. doi request reprint Surgical or percutaneous mitral valve repair for secondary mitral regurgitation: comparison of patient characteristics and clinical outcomes
    Lenard Conradi
    University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Cardiothorac Surg 44:490-6; discussion 496. 2013
    ..However, proof of a survival benefit for these patients is still pending. Percutaneous techniques of mitral valve repair (MVR) have become a viable treatment alternative for selected high-risk patients with severe secondary MR...
  35. doi request reprint FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression
    Kristin Kühne
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Int J Cardiol 168:953-9. 2013
    ..Until today, FBN1 gene mutation characteristics were not compared with clinical features for the prediction of mitral valve disease progression...
  36. doi request reprint Severe intraprocedural complications after transcatheter aortic valve implantation: calling for a heart team approach
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 44:478-84; discussion 484. 2013
    ..We sought to characterize severe intraprocedural complications during TAVI requiring immediate surgical or interventional bailout manoeuvres and evaluate outcomes...
  37. pmc The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease
    Xiaoqin Hua
    University of Hamburg, University Heart Center Hamburg, Transplant and Stem Cell Immunobiology Lab TSI, Cardiovascular Research Center Hamburg CVRC, Hamburg, Germany
    Transplantation 95:285-92. 2013
    ..We sought to investigate whether KCa3.1 contributes to the pathogenesis of obliterative airway disease (OAD) and whether knockout or pharmacologic blockade would prevent the development of OAD...
  38. doi request reprint Midterm stability and hemodynamic performance of a transfemorally implantable nonmetallic, retrievable, and repositionable aortic valve in patients with severe aortic stenosis. Up to 2-year follow-up of the direct-flow medical valve: a pilot study
    Klaudija Bijuklic
    Medical Care Center Prof Mathey, Prof Schofer, Hamburg University Cardiovascular Center, Hamburg University Heart Center, and Radiologische Allianz, Hamburg, Germany
    Circ Cardiovasc Interv 4:595-601. 2011
    ..We, therefore, analyzed the midterm stability of the position, shape, and hemodynamic performance of the DFM percutaneous aortic valve...
  39. ncbi request reprint The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Menopause 13:489-99. 2006
    ....
  40. doi request reprint Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction
    Olaf Franzen
    Department of General and Interventional Cardiology, University Heart Centre, Hamburg, Germany
    Eur Heart J 31:1373-81. 2010
    ..We sought to assess the feasibility of catheter-based mitral valve repair using the MitraClip system in high-surgical-risk patients with mitral regurgitation (MR) > or =grade 3+...
  41. doi request reprint Improving outcomes: case-matched comparison of novel second-generation versus first-generation self-expandable transcatheter heart valves
    Andreas Schaefer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 50:368-73. 2016
    ..We here present a case-matched analysis of acute 30-day outcomes using a novel nitinol-based THV (Symetis Acurate Neo TF™), which may overcome some limitations of currently used devices...
  42. doi request reprint Implantable loop recorder monitoring after concomitant surgical ablation for atrial fibrillation (AF): insights from more than 200 continuously monitored patients
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, 20246, Hamburg, Germany
    Heart Vessels 31:1347-53. 2016
    ..5 % at 1-year follow-up. Thus continuous rhythm monitoring provides reliable outcome data and helps to guide antiarrhythmic therapy. ..
  43. doi request reprint Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Heart Vessels 31:74-9. 2016
    ..The underlying mechanisms for these findings may potentially result from a complex imbalance of the autonomic nervous system with a continuous deregulation of the sympathetic and parasympathetic reflex arcs...
  44. doi request reprint Predicting Risk in Transcatheter Aortic Valve Implantation: Comparative Analysis of EuroSCORE II and Established Risk Stratification Tools
    Miriam Silaschi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 63:472-8. 2015
    ..However, no specific tools are available for risk prediction in transcatheter aortic valve implantation (TAVI). The recently introduced EuroSCORE II was compared with established risk scores...
  45. doi request reprint Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    J Cardiovasc Electrophysiol 25:1109-14. 2014
    ..However, limited data on feasibility and necessity of combined ICD and HVAD therapy are available. In this study we present our technical and clinical experience...
  46. doi request reprint Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue
    Mandy Stubbendorff
    1 Transplant and Stem Cell Immunobiology Lab, University Heart Center Hamburg, Hamburg, Germany
    Stem Cells Dev 22:2619-29. 2013
    ....
  47. ncbi request reprint Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve
    Fariba Chalajour
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, Hamburg, Germany
    Exp Cell Res 313:2326-35. 2007
    ..Hence, our findings might provide new insights into the process of pathological angiogenesis in cardiac valves...
  48. doi request reprint Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, Hamburg, Germany
    J Heart Lung Transplant 31:797-804. 2012
    ..In this study we assessed the efficacy and safety of two de novo immunosuppression protocols to prevent BOS...
  49. doi request reprint Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients
    Sven Meyer
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 91:1031-5. 2011
    ..Vaccination against the novel influenza A (H1N1) virus has generally been advocated. There is limited experience with AS03-adjuvanted A/H1N1 pandemic influenza vaccines in immunosuppressed patients...
  50. ncbi request reprint FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 78:71-7. 2004
    ..We investigated the effects of FK778 upon acute cardiac allograft rejection and upon adhesion molecule upregulation in experimental transplantation and by using in vitro cell culture...
  51. ncbi request reprint Laser lead extraction allows for safe and effective removal of single- and dual-coil implantable cardioverter defibrillator leads: A single-centre experience over 12 years
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg . 2016
    ..As adhesions are common at the side of the shock coils, we investigated success and procedural complication rates of laser lead extraction procedures in single- and dual-coil leads...
  52. pmc Coronary Sinus Lead Removal: A Comparison between Active and Passive Fixation Leads
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    PLoS ONE 11:e0153651. 2016
    ..Implantation of coronary sinus (CS) leads may be a difficult procedure due to different vein anatomies and a possible lead dislodgement. The mode of CS lead fixation has changed and developed in recent years...
  53. doi request reprint Valve-in-Valve Procedures in Failing Biological Xenografts Using a Novel Balloon-Expandable Device: Experience in Aortic, Mitral, and Tricuspid Positions
    Andreas Schaefer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 64:366-73. 2016
    ..In bioprostheses without any fluoroscopic landmarks, a balloon valvuloplasty may be necessary to identify the appropriate deployment position. ..
  54. doi request reprint Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation
    Moritz Seiffert
    Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Catheter Cardiovasc Interv . 2016
    ..Anemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid-term outcome after transcatheter aortic valve implantation (TAVI)...
  55. doi request reprint Thirty-day VARC-2 and performance data of a new self-expanding transcatheter aortic heart valve
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    EuroIntervention 11:785-92. 2015
    ..The BIOVALVE-I study aims to assess the safety and performance of a novel self-expanding transcatheter heart valve...
  56. doi request reprint Transcatheter valve-in-valve therapy using 6 different devices in 4 anatomic positions: Clinical outcomes and technical considerations
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    J Thorac Cardiovasc Surg 150:1557-65, 1567.e1-3; discussion 1565-7. 2015
    ..We report our cumulative experience using 6 types of transcatheter heart valves (THVs) in all anatomic positions...
  57. doi request reprint The challenge of valve-in-valve procedures in degenerated Mitroflow bioprostheses and the advantage of using the JenaValve transcatheter heart valve
    Lenard Conradi
    University Heart Center Hamburg, Department of Cardiovascular Surgery, Hamburg, Germany
    EuroIntervention 10:990-4. 2014
    ..In the present report we aimed to prove feasibility and safety of transapical valve-in-valve implantation of the JenaValve THV in two cases of degenerated Mitroflow bioprostheses...
  58. pmc Minimal access median sternotomy for aortic valve replacement in elderly patients
    Yousuf Alassar
    Department of Cardiovascular Surgery, Univeity Heart Center Hamburg, Martinistr, 52, Hamburg, 20246, Germany
    J Cardiothorac Surg 8:103. 2013
    ..It was especially performed in patients asking for an excellent cosmetic result, who did not qualifying for minimally-invasive AVR via partial upper sternotomy...
  59. doi request reprint MitraClip therapy in surgical high-risk patients: identification of echocardiographic variables affecting acute procedural outcome
    Edith Lubos
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    JACC Cardiovasc Interv 7:394-402. 2014
    ..The aim of the study was to assess predictors of acute procedural failure in surgical high-risk patients undergoing MitraClip (Abbott Vascular, Abbott Park, Illinois) therapy...
  60. doi request reprint Transapical transcatheter aortic valve implantation without prior balloon aortic valvuloplasty: feasible and safe
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 46:61-6. 2014
    ..Omitting BAV may therefore reduce neurological events after TAVI and facilitate the procedure while yielding non-inferior haemodynamic and clinical outcomes...
  61. doi request reprint Clinical outcomes through 12 months in patients with degenerative mitral regurgitation treated with the MitraClip® device in the ACCESS-EUrope Phase I trial
    Hermann Reichenspurner
    University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 44:e280-8. 2013
    ..We describe 12-month outcomes following treatment with the MitraClip device in DMR patients...
  62. doi request reprint Retrograde transarterial implantation of a nonmetallic aortic valve prosthesis in high-surgical-risk patients with severe aortic stenosis: a first-in-man feasibility and safety study
    Joachim Schofer
    Medical Care Center Prof Mathey, Prof Schofer and Hamburg University Cardiovascular Center, University Heart Center Hamburg, Hamburg, Germany
    Circ Cardiovasc Interv 1:126-33. 2008
    ....
  63. ncbi request reprint Angiogenic activation of valvular endothelial cells in aortic valve stenosis
    Fariba Chalajour
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Exp Cell Res 298:455-64. 2004
    ..These data provide new insights into the mechanisms of valvular disorders and open new perspectives for prevention and early treatment of calcified aortic stenosis...
  64. doi request reprint Distinction of non-ischemia inducing versus ischemia inducing coronary stenosis by fluorescent cardiac imaging
    Sabine Wipper
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, 20246, Hamburg, Germany
    Int J Cardiovasc Imaging 32:363-71. 2016
    ..FCI quantitative technology is capable of distinguishing between non-ischemia inducing NFLS and ischemia inducing FLS showing a good correlation compared to fluorescent microspheres...
  65. doi request reprint Preoperative Ticagrelor administration leads to a higher risk of bleeding during and after coronary bypass surgery in a case-matched analysis
    Andreas Schaefer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 22:136-40. 2016
    ..To evaluate the effect of Ticagrelor on intra- and postoperative bleeding complications in patients undergoing coronary bypass surgery...
  66. doi request reprint Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery
    Yalin Yildirim
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Artif Organs 38:967-72. 2014
    ..75). IABP usage in chronic heart failure patients with severely reduced LVEF undergoing cardiac surgery was safe and resulted in shorter ICU and hospital stay but did not influence 7- and 30-day survival rates...
  67. doi request reprint Event recorder monitoring to compare the efficacy of a left versus biatrial lesion set in patients undergoing concomitant surgical ablation for atrial fibrillation
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany Electronic address
    J Thorac Cardiovasc Surg 148:2161-6. 2014
    ..We report results using continuous event recorder rhythm monitoring to compare more accurately the efficacy of a left versus biatrial lesion set to treat patients with persistent atrial fibrillation...
  68. doi request reprint Successful use of a left ventricular apical access and closure device for second-generation transapical aortic valve implantation
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 62:498-502. 2014
    ..We assessed safety and feasibility of a left ventricular apical access and closure device combined with second-generation transapical (TA) TAVI transcatheter heart valves (THV)...
  69. doi request reprint Kidney injury and mortality after transcatheter aortic valve implantation in a routine clinical cohort
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    Catheter Cardiovasc Interv 85:440-7. 2015
    ..We aimed at identifying predictors of renal impairment and its impact on long-term outcome after transcatheter aortic valve implantation (TAVI)...
  70. doi request reprint Safety and feasibility of concomitant surgical ablation of atrial fibrillation in patients with severely reduced left ventricular ejection fraction
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 46:67-71. 2014
    ..However, many surgeons are reluctant to perform it in patients with heart failure. We investigated the safety and efficacy of AF ablation in patients with a severely reduced left ventricular ejection fraction (LVEF <35%)...
  71. pmc Initial experience of pacemaker and implantable cardioverter defibrillator lead extraction with the new GlideLight 80 Hz laser sheaths
    Samer Hakmi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 18:56-60. 2014
    ..Use of new laser sheaths, which deliver a rate of 80 pulses per second, may probably reduce intraoperative adverse events by reduction of extraction force...
  72. pmc Concomitant surgical atrial fibrillation ablation and event recorder implantation: better monitoring, better outcome?
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 16:465-9. 2013
    ..We analysed the influence of event recorder (ER) implantation and therapy guidance by the results of continuous rhythm monitoring of consecutive postoperative follow-up by our department of electrophysiology...
  73. doi request reprint Shock efficacy of subcutaneous implantable cardioverter-defibrillator for prevention of sudden cardiac death: initial multicenter experience
    Ali Aydin
    Department of Electrophysiology, University Heart Center, Hamburg, Germany
    Circ Arrhythm Electrophysiol 5:913-9. 2012
    ..Recently, subcutaneous implantable cardioverter-defibrillator (S-ICD) has become available. The aim of our study was to assess the efficacy of S-ICD in a clinical setting...
  74. ncbi request reprint Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
    Tobias Deuse
    University Heart Center Hamburg, Department of Cardiovascular Surgery, Martinistr 52, 20246, Hamburg, Germany
    Transpl Immunol 17:255-61. 2007
    ..Here we describe the techniques of heterotopic and orthotopic tracheal transplantations in the rat, comparing the kinetics of systemic host immune response and of histopathologic OAD development...
  75. doi request reprint Valve-in-valve implantation of a novel and small self-expandable transcatheter heart valve in degenerated small surgical bioprostheses: the Hamburg experience
    Patrick Diemert
    Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Catheter Cardiovasc Interv 84:486-93. 2014
    ..We report on the feasibility and early results of VIV implantation using this novel device in a series of patients with degenerated small aortic bioprostheses...
  76. doi request reprint Rhythm outcome predictors after concomitant surgical ablation for atrial fibrillation: a 9-year, single-center experience
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany Electronic address
    J Thorac Cardiovasc Surg 148:428-33. 2014
    ..We performed a single-center data analysis to identify the predictors of rhythm outcome in such patients...
  77. doi request reprint Results of modern mitral valve repair in patients with Marfan syndrome
    Alexander Martin Bernhardt
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 62:35-41. 2014
    ..Valve pathology shares some features with myxomatous MV disease. Surgical treatment is still being debated and not well characterized in patients with MFS...
  78. doi request reprint MitraClip® therapy in patients with end-stage systolic heart failure
    Olaf Franzen
    Department of General and Interventional Cardiology, University Heart Centre, Hamburg, Germany
    Eur J Heart Fail 13:569-76. 2011
    ..To assess the feasibility, short-term durability and clinical outcomes of MitraClip® therapy for mitral regurgitation (MR) in patients with end-stage heart failure and a severely reduced left ventricular (LV) ejection fraction...
  79. doi request reprint Concomitant minimally invasive HVAD and transapical aortic valve implantation
    Andreas Schaefer
    From the Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    ASAIO J 61:209-12. 2015
    ..We believe this hybrid procedure could potentially reduce the risk for post-LVAD RVF because it preserves the pericardial geometry and obviates the need for cardioplegic arrest. ..
  80. doi request reprint Edwards Sapien XT valve placement as treatment option for aortic regurgitation after transfemoral CoreValve implantation: a multicenter experience
    Patrick Diemert
    Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany
    Clin Res Cardiol 103:183-90. 2014
    ..Here, we report a series of 11 patients from 3 German TAVI centers, suffering from moderate- to high-grade aortic regurgitation after CoreValve implantation, who were subsequently treated by Edwards Sapien XT implantation...
  81. ncbi request reprint [3-year results of the SYNTAX trial--stent or surgery? A surgeon's perspective]
    Lenard Conradi
    Klinik und Poliklinik für Herz und Gefäßchirurgie, Universitäres Herzzentrum Hamburg, Martinistrasse 52, Hamburg, Germany
    Clin Res Cardiol Suppl 6:43-8. 2011
    ..Final decision making should be a formal process as recommended in the recently updated guidelines on myocardial revascularization by the European Society of Cardiology...
  82. doi request reprint Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient
    Sven Meyer
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 29:585-6. 2010
    ..We present the first case of a young heart transplant recipient who remained asymptomatic despite positive polymerase chain reaction (PCR) after exposure to individuals with influenza A/H1N1...
  83. doi request reprint Surgical technique of lower lobe lung transplantation
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Ann Thorac Surg 92:e39-42. 2011
    ..Here we describe our surgical technique and discuss the benefits and risks of this procedure...
  84. ncbi request reprint Experimental orthotopic tracheal transplantation: The Stanford technique
    Sonja Schrepfer
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Microsurgery 27:187-9. 2007
    ..The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis...
  85. ncbi request reprint How to guide stent-graft implantation in type B aortic dissection? Comparison of angiography, transesophageal echocardiography, and intravascular ultrasound
    Dietmar H Koschyk
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 112:I260-4. 2005
    ..Despite growing interest in stent-graft implantation for type-B aortic dissection, there are no established recommendations to prepare and perform an implantation procedure...
  86. ncbi request reprint Minimally invasive valve surgery: different techniques and approaches
    Christian Detter
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Expert Rev Cardiovasc Ther 2:239-51. 2004
    ..This article will review the different minimally invasive techniques and approaches, as well as early results and outcomes for aortic and mitral valve surgery...
  87. ncbi request reprint Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment
    Eberhard Schulz
    University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    Circulation 105:1170-5. 2002
    ..However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO...
  88. ncbi request reprint New technique for chest opening in mice: U-sternotomy
    Sonja Schrepfer
    Department of Thoracic and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Microsurgery 23:274-5. 2003
    ..This U-sternotomy reduces the risk of animal death and therefore the amount of quite expensive virus solutions needed...
  89. ncbi request reprint Multidetector computed tomography (MDCT) in coronary surgery: first experiences with a new tool for diagnosis of coronary artery disease
    Hendrik Treede
    Department of Cardiac Surgery, Ludwig Maximilians University Munich, Germany
    Ann Thorac Surg 74:S1398-402. 2002
    ..Patients underwent CT scans in addition to SCA; findings were compared regarding location and degree of coronary artery stenosis...
  90. ncbi request reprint Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting
    Christian Detter
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilian University, Munich, Germany
    Ann Thorac Surg 74:497-501. 2002
    ..This study was designed to evaluate the efficacy of two different stabilizer concepts for off-pump coronary artery bypass grafting...
  91. ncbi request reprint Evaluation of acute traumatic changes of the coronary artery wall after robotically assisted endoscopic coronary artery bypass grafting
    Martin Arnold
    Department of Cardiac Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Heart Surg Forum 5:128-31. 2002
    ..Goleta, CA) in a laboratory setting...
  92. ncbi request reprint Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation
    Christian Detter
    Department of Thoracic and Cardiovascular Surgery, University Hospital Grosshadern, Munich, Germany
    Med Sci Monit 8:MT118-23. 2002
    ..Recently, the ZEUS(tm) Robotic Surgical System has been introduced to increase the precision of endoscopic cardiac surgery. This study investigated its clinical use for endoscopic coronary artery bypass grafting...
  93. ncbi request reprint Minimally invasive direct coronary artery bypass grafting (MIDCAB) and off-pump coronary artery bypass grafting (OPCAB): two techniques for beating heart surgery
    Christian Detter
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilian University, Munich, Germany
    Heart Surg Forum 5:157-62. 2002
    ..Coronary bypass surgery can be performed less invasively by avoiding cardiopulmonary bypass (CPB). We present our experiences with beating heart bypass surgery performed through a minithoracotomy or sternotomy...
  94. doi request reprint Implantation of a right ventricular implantable cardioverter-defibrillator lead in the right ventricular outflow tract in a patient with Ebstein anomaly and right ventricular lead dislocation
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 62:253-4. 2014
    ..So, we conducted positioning of the lead in the RV outflow tract where a stable position with good sensing and threshold parameters was found. ..
  95. doi request reprint Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device
    Yalin Yildirim
    From the Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    ASAIO J 60:124-6. 2014
    ..A mechanical irritation of the HVAD inflow touching the inferior-posterior wall was found to trigger these focal arrhythmias. The HVAD was explanted, and no further arrhythmias occurred. ..
  96. doi request reprint Isolated permanent right ventricular assistance using the HVAD continuous-flow pump
    Tobias Deuse
    University Heart Center Hamburg, Hamburg, Germany
    Ann Thorac Surg 95:1434-6. 2013
    ..No manipulations of the system were required to adapt the assist device to the pulmonary circulation...
  97. doi request reprint Transcutaneous lead implantation connected to an externalized pacemaker in patients with implantable cardiac defibrillator/pacemaker infection and pacemaker dependency
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, 20246 Hamburg, Germany
    Europace 15:1205-9. 2013
    ..In this study, a new therapy option with temporary pacing by ipsilateral implantation of a new active-fixation right ventricular (RV)-lead was evaluated...
  98. doi request reprint Concomitant transcatheter aortic valve and left ventricular assist device implantation
    Christina Baum
    University Heart Center Hamburg, 20246 Hamburg, Germany
    ASAIO J 59:90-2. 2013
    ..We believe concomitant transcatheter aortic valve implantation (TAVI) and LVAD implantation is a promising hybrid procedure, even in patients with pure AR...
  99. ncbi request reprint Prospective, randomized study comparing two different minimized versus conventional cardiopulmonary bypass systems
    Jeannette Schoenebeck
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Innovations (Phila) 5:270-7. 2010
    ..We aimed to assess the impact of two different minimized cardiopulmonary bypass systems (mini-CPB) with and without Bioline-coating compared with CCPB regarding organ function, inflammatory response, and early clinical outcome...
  100. ncbi request reprint Fluorescent cardiac imaging: a novel intraoperative method for quantitative assessment of myocardial perfusion during graded coronary artery stenosis
    Christian Detter
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Circulation 116:1007-14. 2007
    ..FCI is a novel technology to visualize coronary vessels and myocardial perfusion intraoperatively using the indocyanine green dye with an infrared-sensitive imaging device...
  101. doi request reprint Spontaneous coronary bypass rupture
    Jan Kaehler
    Department of Cardiology, University Hospital Hamburg, Hamburg, Germany
    Ann Thorac Surg 86:664. 2008