Norbert Pfeiffer

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Central corneal thickness in the European Glaucoma Prevention Study
    Norbert Pfeiffer
    Department of Ophthalmology, University Hospital Mainz, Langenbeckstr 1, D 55131 Mainz, Germany
    Ophthalmology 114:454-9. 2007
  2. doi request reprint Timolol versus brinzolamide added to travoprost in glaucoma or ocular hypertension
    Norbert Pfeiffer
    Department of Ophthalmology, Mainz University, Langenbeckstr 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1065-71. 2011
  3. ncbi request reprint [Results of the "Ocular hypertension treatment study"]
    N Pfeiffer
    Augenklinik, Universitat, Mainz
    Ophthalmologe 102:230-4. 2005
  4. ncbi request reprint Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study
    N Pfeiffer
    Department of Ophthalmology, Mainz University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Ophthalmol 119:191-6. 2001
  5. ncbi request reprint Knowledge about glaucoma in the unselected population: a German survey
    Norbert Pfeiffer
    Department of Ophthalmology, University of Mainz, Germany
    J Glaucoma 11:458-63. 2002
  6. ncbi request reprint A comparison of the fixed combination of latanoprost and timolol with its individual components
    Norbert Pfeiffer
    Department of Ophthalmology, Mainz University, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 240:893-9. 2002
  7. ncbi request reprint Fine structural evaluation of the iris after unilateral treatment with latanoprost in patients undergoing bilateral trabeculectomy (the Mainz II study)
    Norbert Pfeiffer
    Department of Ophthalmology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Ophthalmol 121:23-31. 2003
  8. doi request reprint The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors
    Esther M Hoffmann
    Department of Ophthalmology, University Medical Center Mainz, Mainz, GermanyDepartment of Ophthalmology, University of Milan, Monza, ItalyLeuven University Hospitals, Leuven, BelgiumInstitute Mario Negri, Milan, ItalyDepartment of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal
    Acta Ophthalmol 91:e612-9. 2013
  9. doi request reprint Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens
    Panagiotis Laspas
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:8835-48. 2011
  10. pmc Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:7479-84. 2011

Collaborators

Detail Information

Publications152 found, 100 shown here

  1. ncbi request reprint Central corneal thickness in the European Glaucoma Prevention Study
    Norbert Pfeiffer
    Department of Ophthalmology, University Hospital Mainz, Langenbeckstr 1, D 55131 Mainz, Germany
    Ophthalmology 114:454-9. 2007
    ..This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma...
  2. doi request reprint Timolol versus brinzolamide added to travoprost in glaucoma or ocular hypertension
    Norbert Pfeiffer
    Department of Ophthalmology, Mainz University, Langenbeckstr 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1065-71. 2011
    ..To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension...
  3. ncbi request reprint [Results of the "Ocular hypertension treatment study"]
    N Pfeiffer
    Augenklinik, Universitat, Mainz
    Ophthalmologe 102:230-4. 2005
    ..This decision must be made on an individual basis after each patient's risk has been assessed...
  4. ncbi request reprint Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study
    N Pfeiffer
    Department of Ophthalmology, Mainz University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Ophthalmol 119:191-6. 2001
    ..To determine whether 3 months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma...
  5. ncbi request reprint Knowledge about glaucoma in the unselected population: a German survey
    Norbert Pfeiffer
    Department of Ophthalmology, University of Mainz, Germany
    J Glaucoma 11:458-63. 2002
    ..To determine the general population's knowledge about glaucoma...
  6. ncbi request reprint A comparison of the fixed combination of latanoprost and timolol with its individual components
    Norbert Pfeiffer
    Department of Ophthalmology, Mainz University, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 240:893-9. 2002
    ..To evaluate the intraocular pressure (IOP)-reducing effect of the fixed combination of 0.005% latanoprost and 0.5% timolol compared with the individual monotherapies...
  7. ncbi request reprint Fine structural evaluation of the iris after unilateral treatment with latanoprost in patients undergoing bilateral trabeculectomy (the Mainz II study)
    Norbert Pfeiffer
    Department of Ophthalmology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Ophthalmol 121:23-31. 2003
    ..To investigate by masked electron microscopy whether 6 months of topical latanoprost caused pathological changes in the peripheral iris of patients with glaucoma...
  8. doi request reprint The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors
    Esther M Hoffmann
    Department of Ophthalmology, University Medical Center Mainz, Mainz, GermanyDepartment of Ophthalmology, University of Milan, Monza, ItalyLeuven University Hospitals, Leuven, BelgiumInstitute Mario Negri, Milan, ItalyDepartment of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal
    Acta Ophthalmol 91:e612-9. 2013
    ..Furthermore, to examine the relationship between HRT optic disc topographic measurements and baseline demographic and ocular factors...
  9. doi request reprint Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens
    Panagiotis Laspas
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:8835-48. 2011
    ..The target of this study was to investigate the pathomechanism behind this decline and the serum antibody reactivity against ocular and neuronal tissues after immunization with glaucoma- and non-glaucoma-associated antigens...
  10. pmc Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:7479-84. 2011
    ..To identify the muscarinic acetylcholine receptor subtype that mediates cholinergic vasodilation in murine retinal arterioles...
  11. pmc Distribution of central corneal thickness and its association with ocular parameters in a large central European cohort: the Gutenberg health study
    Esther M Hoffmann
    University Medical Centre, Department of Ophthalmology, Mainz, Germany
    PLoS ONE 8:e66158. 2013
    ..To evaluate the distribution of central corneal thickness (CCT) in a large German cohort and to analyse its relationship with intraocular pressure and further ocular factors...
  12. ncbi request reprint Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor
    Stephanie C Joachim
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Curr Eye Res 32:501-9. 2007
    ..To show the existence of IgG antibodies against retinal antigens in aqueous humor of normal tension glaucoma patients...
  13. doi request reprint Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension
    Jan Reichelt
    Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Curr Eye Res 33:253-61. 2008
    ..The aim of this study was to show that complex antibody patterns against retinal antigens in sera of patients with glaucoma, found in previous studies, are autoantibodies against human antigens...
  14. doi request reprint Does autoimmunity play a part in the pathogenesis of glaucoma?
    Katharina Bell
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutewnberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Prog Retin Eye Res 36:199-216. 2013
    ..Early diagnosis and intervention in risk patients would offer the chance of early treatment and to slow down the progression of glaucoma and delay the resulting blindness. ..
  15. pmc Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina
    Oliver W Gramlich
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center Mainz, Germany
    PLoS ONE 8:e57557. 2013
    ..So far there has been no convincing evidence that autoantibodies are accumulated in the retina of glaucoma patients and that the local immune homeostasis might be affected...
  16. doi request reprint Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice
    Panagiotis Laspas
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Exp Eye Res 127:1-8. 2014
    ..However, the chronic lack of eNOS is functionally compensated by NOS-independent vasodilator mechanisms. The lack of a single NOS isoform does not appear to affect IOP or neuron density in the RGC layer. ..
  17. ncbi request reprint Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration
    Stephanie C Joachim
    Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 245:619-26. 2007
    ....
  18. doi request reprint Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens
    Stephanie C Joachim
    Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrabe 1, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:573-80. 2008
    ..We analyzed the complex autoantibody patterns against human optic nerve antigens in sera of patients with glaucoma and tried to identify important antigens...
  19. doi request reprint Role of α₁-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice
    Marcin L Kordasz
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 55:8295-301. 2014
    ..We tested the hypothesis that the α₁A-AR mediates pupil dilation and trophic effects in the mouse iris...
  20. doi request reprint Correlations between central corneal thickness and general anthropometric characteristics and cardiovascular parameters in a large European cohort from the Gutenberg Health Study
    Heike M Elflein
    Department of Ophthalmology, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany Institute of Medical Biostatistics, Epidemiology and Informatics IMBEI, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany and Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany
    Cornea 33:359-65. 2014
    ..The aim of this study was to evaluate the correlations between general anthropometric features and cardiovascular parameters and central corneal thickness (CCT) in an adult European cohort...
  21. doi request reprint Alterations in the tear proteome of dry eye patients--a matter of the clinical phenotype
    Nils Boehm
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 54:2385-92. 2013
    ..The aim of the present study was to analyze tear protein patterns of dry eye patients considering different clinical phenotypes in order to examine their influence on tear film protein composition...
  22. doi request reprint Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Exp Eye Res 109:60-6. 2013
    ..In contrast, pharmacological inhibition of nNOS and iNOS had no effect on acetylcholine-induced vasodilation. These findings suggest that dilation of murine retinal arterioles to acetylcholine is mediated predominantly by eNOS...
  23. pmc Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Germany
    Am J Physiol Heart Circ Physiol 300:H1602-8. 2011
    ..In contrast, neither M₁ nor M₅ receptors appear to be involved in cholinergic responses of the three vascular preparations tested...
  24. ncbi request reprint Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States
    Franz H Grus
    Universitaets Augenklinik, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 47:968-76. 2006
    ..The purpose of this study was to compare the antibody profiles against optic nerve antigens in patients with glaucoma in two different study populations from Germany and the United States...
  25. ncbi request reprint IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma
    Stephanie C Joachim
    Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Mol Vis 13:1573-9. 2007
    ....
  26. doi request reprint Ophthalmopathology in rats with MBP-induced experimental autoimmune encephalomyelitis
    Oliver W Gramlich
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrase 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1009-20. 2011
    ..The aim of our study was to examine the effects of myelin basic protein (MBP) immunization on survival of neurons, alteration of antibody reactivity, and microglia in the retinal ganglion cell layer...
  27. doi request reprint Direct cost and predictive factors for treatment in patients with ocular hypertension or early, moderate and advanced primary open-angle glaucoma: the CoGIS study in Germany
    Katrin Lorenz
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 251:2019-28. 2013
    ..The main objectives of this analysis were to assess the treatment costs and to identify major cost drivers and factors predicting direct costs in German patients with ocular hypertension (OHT) or primary open-angle glaucoma (POAG)...
  28. doi request reprint Long-term results after transconjunctival resuturing of the scleral flap in hypotony following trabeculectomy
    Judith Eha
    Department of Ophthalmology, University Medical Center, Mainz, Germany
    Am J Ophthalmol 155:864-9. 2013
    ..To present the 4-year follow-up results in the surgical treatment of hypotony following trabeculectomy with mitomycin C in glaucoma patients with additional flap sutures...
  29. doi request reprint Tolerability of 24-hour intraocular pressure monitoring of a pressure-sensitive contact lens
    Katrin Lorenz
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
    J Glaucoma 22:311-6. 2013
    ..To investigate tolerability and safety of a new diagnostic device for 24-hour intraocular pressure monitoring in healthy subjects and age-matched glaucoma patients...
  30. doi request reprint Structure-function relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients
    Julia Lamparter
    Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 53:7553-9. 2012
    ..It is the purpose of this study to investigate the structure-function relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma...
  31. doi request reprint New insights into autoantibody profiles from immune privileged sites in the eye: a glaucoma study
    Nils Boehm
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Brain Behav Immun 26:96-102. 2012
    ..Furthermore they indicate the necessity of analyzing not only up-regulated but also down-regulated antibody reactivities, which might be likewise relevant for the understanding of other diseases...
  32. doi request reprint Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork
    Giulia Renieri
    Department of Ophthalmology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1107-15. 2008
    ..This study investigates the role of ET-1 and its receptors ET-A and ET-B (ET-AR and ET-BR) in TM Ca(2+)-independent contractility...
  33. ncbi request reprint Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens
    Stephanie C Joachim
    Department of Ophthalmology, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 243:817-23. 2005
    ..The aim of this study was to analyze and compare the entire IgG autoantibody patterns against different ocular antigens (retina, optic nerve, and optic nerve head) in sera of glaucoma patients and healthy subjects...
  34. ncbi request reprint Comparison of dynamic contour tonometry and goldmann applanation tonometry in glaucoma patients and healthy subjects
    Lorenz Barleon
    Department of Ophthalmology, University of Mainz, Mainz, Germany
    Am J Ophthalmol 142:583-90. 2006
    ....
  35. doi request reprint Efficacy and tolerability of preservative-free eye drops containing a fixed combination of dorzolamide and timolol in glaucoma patients
    Giulia Renieri
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    J Ocul Pharmacol Ther 26:597-603. 2010
    ..To evaluate the efficacy and tolerability of preservative-free eye drops (dorzolamide/timolol) in routine management of preservative-sensitive glaucoma patients...
  36. doi request reprint Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography
    Andreas Schulze
    Department of Ophthalmology, University Medical Center Mainz, Langenbeckstrase 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1039-45. 2011
    ..To evaluate the diagnostic ability of Fourier-domain optical coherence tomography (FD-OCT) measurements in glaucoma patients, patients with ocular hypertension, and normal subjects...
  37. pmc Prevalence and Cardiovascular Associations of Diabetic Retinopathy and Maculopathy: Results from the Gutenberg Health Study
    Philipp Raum
    Department of Ophthalmology, University Medical Center, Mainz, Germany
    PLoS ONE 10:e0127188. 2015
    ..Diabetic retinopathy (DR) is the leading cause of blindness in people of working age. The purpose of this paper is to report the prevalence and cardiovascular associations of diabetic retinopathy and maculopathy (DMac) in Germany...
  38. doi request reprint Effect of the M1 Muscarinic Acetylcholine Receptor on Retinal Neuron Number Studied with Gene-Targeted Mice
    Panagiotis Laspas
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131, Mainz, Germany
    J Mol Neurosci 56:472-9. 2015
    ..The present findings suggest that the M1 receptor is not essential for the survival of retinal neurons in vivo. ..
  39. doi request reprint Neuroprotection of medical IOP-lowering therapy
    Norbert Pfeiffer
    Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany
    Cell Tissue Res 353:245-51. 2013
    ..To date, evidence for a neuroprotective effect independent of IOP regulation in human glaucoma is scarce and has only been shown to be likely for the α2-adrenergic receptor agonist, brimonidine. ..
  40. pmc Risk factors of a reduced response to ranibizumab treatment for neovascular age-related macular degeneration--evaluation in a clinical setting
    Christina Korb
    Department of Ophthalmology, University Medical Centre, Johannes Gutenberg University, Langenbeckstr, 1, Mainz 55131, Germany
    BMC Ophthalmol 13:84. 2013
    ..To identify risk factors for being a "reduced responder" to ranibizumab treatment in a clinical setting in patients with neovascular age-related macular degeneration...
  41. doi request reprint Irregularity of the posterior corneal surface after curved interface femtosecond laser-assisted versus microkeratome-assisted descemet stripping automated endothelial keratoplasty
    Jan M Vetter
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Cornea 32:118-24. 2013
    ..We compared morphological and functional outcomes after DSAEK using both cutting techniques...
  42. doi request reprint Intraocular pressure measurements during flap preparation using 2 femtosecond lasers and 1 microkeratome in human donor eyes
    Jan M Vetter
    Departments of Ophthalmology, Medical Centre of the Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 38:2011-8. 2012
    ..To evaluate and compare intraocular pressures (IOPs) during flap preparations performed using 2 femtosecond lasers and a mechanical microkeratome in human donor globes...
  43. doi request reprint Flap suture--a simple technique for the revision of hypotony maculopathy following trabeculectomy with mitomycin C
    Judith Eha
    Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:869-74. 2008
    ..We describe a new simple surgical technique for the treatment of hypotony maculopathy following trabeculectomy with MMC...
  44. doi request reprint Effect of contact lenses on the protein composition in tear film: a ProteinChip study
    Christina Kramann
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Langenbeckstr 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:233-43. 2011
    ..The aim of this study was to analyze and compare the effects of rigid gas permeable and soft contact lenses on the protein composition in the tear film of contact lens wearers...
  45. doi request reprint Neuroprotective effects of antibodies on retinal ganglion cells in an adolescent retina organ culture
    Katharina Bell
    Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Neurochem 139:256-269. 2016
    ..This could be shown with an increase of rgc numbers. This effect results through reduced stress levels and the shift of glutamine synthetase localization...
  46. doi request reprint Prevalence of diabetic retinopathy in screening-detected diabetes mellitus: results from the Gutenberg Health Study (GHS)
    Katharina A Ponto
    Department of Ophthalmology, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
    Diabetologia 59:1913-9. 2016
    ..We aimed to determine the prevalence of diabetic retinopathy in patients with newly diagnosed (screening-detected) type 2 diabetes...
  47. doi request reprint Distribution of Anterior Chamber Angle Width and Correlation With Age, Refraction, and Anterior Chamber Depth-The Gutenberg Health Study
    Alexander K Schuster
    Department of Ophthalmology University Medical Center Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 57:3740-6. 2016
    ..We report the population-based distribution of the anterior chamber angle width using this noncontact imaging technique and investigate associated factors...
  48. doi request reprint Prevalence of age-related macular degeneration in a large European cohort: results from the population-based Gutenberg Health Study
    Christina A Korb
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 252:1403-11. 2014
    ..The aim of this study was to describe the sex- and age-specific prevalence of age-related macular degeneration (AMD) and its correlation with urban or rural residence in a large and relatively young European cohort...
  49. doi request reprint Myopia and level of education: results from the Gutenberg Health Study
    Alireza Mirshahi
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany Electronic address
    Ophthalmology 121:2047-52. 2014
    ..To analyze the association between myopia and educational level in an adult European cohort...
  50. pmc Role of the M3 muscarinic acetylcholine receptor subtype in murine ophthalmic arteries after endothelial removal
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 55:625-31. 2014
    ..We tested the hypothesis that the M3 muscarinic acetylcholine receptor subtype mediates cholinergic responses in murine ophthalmic arteries after endothelial removal...
  51. doi request reprint Health- and vision-related quality of life in patients with ocular hypertension or primary open-angle glaucoma
    Christian Wolfram
    Department of Ophthalmology, University Medical Center, DE 55131 Mainz, Germany
    Ophthalmologica 229:227-34. 2013
    ..The main objective of this analysis was to assess the impact of severity of disease on the quality of life (QoL) of patients with ocular hypertension (OHT) and early, moderate, or advanced primary open-angle glaucoma (POAG)...
  52. pmc Standard automated perimetry versus matrix frequency doubling technology perimetry in subjects with ocular hypertension and healthy control subjects
    Julia Lamparter
    Department of Ophthalmology, University Medical Centre Mainz, Mainz, Germany
    PLoS ONE 8:e57663. 2013
    ..To evaluate the relationship and agreement between standard automated perimetry (SAP) and Matrix frequency doubling technology (Matrix-FDT) in subjects with ocular hypertension and healthy control subjects...
  53. doi request reprint Distribution of intraocular pressure and its association with ocular features and cardiovascular risk factors: the Gutenberg Health Study
    Rene Hoehn
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
    Ophthalmology 120:961-8. 2013
    ..To describe the distribution of intraocular pressure (IOP) and its association with ocular features and cardiovascular risk factors in an adult European cohort...
  54. doi request reprint Autoimmune biomarkers in glaucoma patients
    Oliver W Gramlich
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Curr Opin Pharmacol 13:90-7. 2013
    ..This article highlights recent advances in understanding of autoimmune mechanisms in the pathogenesis of glaucoma...
  55. pmc Serum and antibodies of glaucoma patients lead to changes in the proteome, especially cell regulatory proteins, in retinal cells
    Katharina Bell
    Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 7:e46910. 2012
    ..As pathogenesis of glaucoma still is unknown the aim of this study was to analyze if the serum and antibodies of glaucoma patients interact with neuroretinal cells...
  56. doi request reprint Longitudinal analysis of taurine induced effects on the tear proteome of contact lens wearers and dry eye patients using a RP-RP-Capillary-HPLC-MALDI TOF/TOF MS approach
    Sebastian Funke
    Dept of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz, Germany
    J Proteomics 75:3177-90. 2012
    ..Since levels of these proteins differentiate from those of a healthy non-contact lens wearer reference they are supposed to be involved in contact lens induced dry eye and should be focused on in further studies...
  57. ncbi request reprint Repeatability and reproducibility of optic nerve head topography using the retinal thickness analyzer
    Esther M Hoffmann
    Department of Ophthalmology, University of Mainz, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 244:192-8. 2006
    ..The objective was to determine the reproducibility and repeatability of topographic disk parameters with the retinal thickness analyzer (RTA)...
  58. doi request reprint Intraocular pressure during corneal flap preparation: comparison among four femtosecond lasers in porcine eyes
    Jan M Vetter
    Department of Ophthalmology, Medical Center of the Johanes Gutenbery University, Mainz, Germany
    J Refract Surg 27:427-33. 2011
    ..To compare the course of intraocular pressure (IOP) during corneal flap preparation using four different femtosecond lasers in porcine globes...
  59. pmc Analysis of the effects of preservative-free tafluprost on the tear proteome
    Sebastian Funke
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Germany
    Am J Transl Res 8:4025-4039. 2016
    ..Together with improved clinical parameters the study output proposes beneficial effects of PFT glaucoma therapy...
  60. ncbi request reprint PREVALENCE AND ASSOCIATIONS OF MYELINATED RETINAL NERVE FIBERS: Results From the Population-Based Gutenberg Health Study
    Hisham Elbaz
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom Department of Ophthalmology, Philipps University of Marburg, Marburg, Germany Center for Thrombosis and Hemostasis CTH, University Medical Center Mainz, Mainz, Germany Department of Biostatistics, University Medical Center Mainz, Mainz, Germany and Dardenne Eye Hospital, Bonn Bad Godesberg, Germany
    Retina 36:2364-2370. 2016
    ..To determine the prevalence, ocular, and systemic associations of myelinated retinal nerve fibers (MRNF) in a Caucasian cohort...
  61. pmc Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma
    Oliver W Gramlich
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131, Mainz, Germany
    J Neuroinflammation 13:82. 2016
    ..This study aimed to identify if intermittent IOP elevations in vivo (i) elicit neurodegeneration, (ii) provokes an immune response and (iii) whether progression of RGC loss can be attenuated by the B lymphocyte inhibitor Belimumab...
  62. pmc Glaucoma related Proteomic Alterations in Human Retina Samples
    Sebastian Funke
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Sci Rep 6:29759. 2016
    ..The workflow allowed a detailed view into the human retina proteome highlighting new molecular players ANT3, DFS70 and MeCp2 associated to glaucoma. ..
  63. pmc Associations between depression and diabetes in the community: do symptom dimensions matter? Results from the Gutenberg Health Study
    Jorg Wiltink
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 9:e105499. 2014
    ..While a bidirectional relationship between diabetes and depression has been established, there is little knowledge if the associations are due to somatic-affective or cognitive-affective dimensions of depression...
  64. doi request reprint Autoimmunity and glaucoma
    Franz H Grus
    Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Glaucoma 17:79-84. 2008
    ..Considering that these changes in natural autoimmunity can be found consistently among different study populations, it might be a promising new tool for glaucoma detection...
  65. ncbi request reprint Effect of a closed foldable equator ring on capsular bag shrinkage in cataract surgery
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 32:1615-20. 2006
    ..To evaluate the effect of a closed foldable equator ring (CFER) versus a conventional capsular tension ring (CTR) on capsular bag shrinkage...
  66. doi request reprint Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries
    Adrian Gericke
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:4795-9. 2011
    ..To identify the α(1)-adrenoceptor (α(1)-AR) subtypes mediating vascular adrenergic responses in murine ophthalmic arteries...
  67. doi request reprint Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays
    Nils Boehm
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:7725-30. 2011
    ..However, the exact details of the pathomechanisms are still unknown. In this study, the expression patterns of proinflammatory cytokines in the tears of patients with different subtypes of dry eye were analyzed...
  68. ncbi request reprint Effect of additive preoperative latanoprost treatment on the outcome of filtration surgery
    Silke Berthold
    Department of Ophthalmology, University Hospital of Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 244:1029-34. 2006
    ..It was the goal of our study to investigate whether additive preoperative treatment with latanoprost has an effect on the outcome of subsequent trabeculectomy...
  69. ncbi request reprint Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels
    Susanne Marx-Gross
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 31:1372-6. 2005
    ..To evaluate the influence of dapiprazole versus brimonidine on pupil size at various illumination levels...
  70. doi request reprint Surface topographies of glaucoma drainage devices and their influence on human tenon fibroblast adhesion
    Lars Choritz
    BiomaTiCS Research Group, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 51:4047-53. 2010
    ..This study was performed to investigate the surface topography of different glaucoma drainage devices and to determine the effects of surface roughness on cell adhesion of cultured human tenon fibroblasts...
  71. doi request reprint Reproducibility of ocular response analyzer measurements and their correlation with central corneal thickness
    Joanna Wasielica-Poslednik
    Department of Ophthalmology of the University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1617-22. 2010
    ..To evaluate the inter- and intraobserver variability of ocular response analyzer (ORA) measurements, namely corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH)...
  72. ncbi request reprint Biaxial microincision versus coaxial small-incision clear cornea cataract surgery
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Ophthalmology 113:1818-26. 2006
    ..To compare clinical outcomes of biaxial microincision (1.5 mm) and coaxial small-incision (2.75 mm) clear cornea cataract surgery...
  73. pmc γ-Synuclein antibodies have neuroprotective potential on neuroretinal cells via proteins of the mitochondrial apoptosis pathway
    Corina Wilding
    Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 9:e90737. 2014
    ..We hypothesize that the down-regulation of autoantibodies found in glaucoma patients lead to a loss of protective autoimmunity. ..
  74. doi request reprint Comparison of the effects of different lens-cleaning solutions on the protein profiles of human conjunctival cells
    Katharina Bell
    Experimental Ophthalmology, Department of Ophthalmology of the Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 250:1627-36. 2012
    ..Therefore, the aim of this study was to detect the influence of different lens solutions on conjunctival cells, cells also involved in tear film composition...
  75. doi request reprint Modulation of central corneal thickness by various riboflavin eyedrop compositions in porcine corneas
    Jan M Vetter
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    J Cataract Refract Surg 38:525-32. 2012
    ..To evaluate the modulatory effect of various riboflavin 0.1% and 0.2% compositions on the central corneal thickness (CCT) in fresh porcine corneas...
  76. doi request reprint Clinical relevance of thyroid-stimulating immunoglobulins in graves' ophthalmopathy
    Katharina A Ponto
    Department of Ophthalmology, University Medical Center, Mainz, Germany
    Ophthalmology 118:2279-85. 2011
    ..Thyroid-stimulating immunoglobulins (TSIs) likely mediate Graves' ophthalmopathy (GO). The clinical relevance of these functional autoantibodies was assessed in GO...
  77. ncbi request reprint Is homelessness a risk factor for eye disease? Results of a German screening study
    Susanne Pitz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Ophthalmologica 219:345-9. 2005
    ..However, only scarce data are available on whether this also applies to the incidence of eye disease. The present study was carried out to evaluate the prevalence of ocular disease in homeless people in Germany...
  78. pmc Cholinergic responses of ophthalmic arteries in M3 and M5 muscarinic acetylcholine receptor knockout mice
    Adrian Gericke
    Department of Ophthalmology, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 50:4822-7. 2009
    ..To determine the functional role of M(3) and M(5) muscarinic acetylcholine receptor subtypes in ophthalmic arteries using gene-targeted mice...
  79. doi request reprint Learning curve and fatigue effect of flicker defined form perimetry
    Julia Lamparter
    Department of Ophthalmology, University Medical Center, Mainz University, Langenbeckstrasse 1, Mainz, Germany
    Am J Ophthalmol 151:1057-1064.e1. 2011
    ..To evaluate the learning curve and fatigue effect of flicker defined form (FDF) perimetry...
  80. ncbi request reprint Effects of intraocular cefotaxime on the human corneal endothelium
    C Kramann
    Department of Ophthalmology, Johannes Gutenberg-University, Mainz, Germany
    J Cataract Refract Surg 27:250-5. 2001
    ..With its broad spectrum of antibiotic activity, cefotaxime might be an appropriate alternative to other intraocularly administered antibiotics in anterior segment surgery for prophylaxis and management of infection...
  81. ncbi request reprint [Agreement between clinical evaluation, Heidelberg-Retina-Tomograph (HRT) and Nerve Fiber Analyzer (GDx) in glaucoma diagnosis]
    A Troost
    Augenklinik und Poliklinik, Johannes Gutenberg Universitat, Mainz
    Klin Monbl Augenheilkd 221:757-61. 2004
    ..We have made a comparison of clinical evaluation, Heidelberg-Retina-Tomograph (HRT) and Nerve Fiber Analyzer (GDx) in diagnosing glaucoma...
  82. doi request reprint Public health relevance of Graves' orbitopathy
    Katharina A Ponto
    Department of Ophthalmology, Johannes Gutenberg University Medical Centre, 55101 Mainz, Germany
    J Clin Endocrinol Metab 98:145-52. 2013
    ..Disfiguring proptosis and functional impairment in patients with Graves' orbitopathy (GO) may lead to impaired earning capacity and to considerable indirect/direct costs...
  83. doi request reprint Confocal laser-scanning microscopy allows differentiation between Fabry disease and amiodarone-induced keratopathy
    Joanna Wasielica-Poslednik
    Department of Ophthalmology, University Medical Center of Johannes Gutenberg University Mainz, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1689-96. 2011
    ..The aim of this work is to compare the microstructure of cornea verticillata in Fabry disease with amiodarone-induced keratopathy by means of in vivo confocal laser-scanning microscopy (CLSM)...
  84. ncbi request reprint Refractive lens exchange with an array multifocal intraocular lens
    H Burkhard Dick
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Refract Surg 18:509-18. 2002
    ....
  85. doi request reprint Is gaze-dependent tonometry a useful tool in the differential diagnosis of Graves' ophthalmopathy?
    Daniel Herzog
    Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstr 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1737-41. 2008
    ..However, the question of erroneous IOP measurement due to applanation carried out on the peripheral cornea has never been addressed...
  86. ncbi request reprint Effects of multipurpose contact lens solutions on the protein composition of the tear film
    Franz H Grus
    Department of Ophthalmology, University of Mainz, Germany
    Cont Lens Anterior Eye 28:103-12. 2005
    ..Changes in tear film protein profiles of contact lens wearers who used several marketed brands of multipurpose contact lens care solutions, were assessed by ProteinChip analysis...
  87. ncbi request reprint The value of vision
    Christine Knauer
    Universitats Augenklinik, Langenbeckstrasse 1, Gebäude 102, 55131 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:477-82. 2008
    ..The purpose of this review is to find ophthalmologic utility values, and utility values affected by systemic diseases that correlate to the ophthalmologic ones...
  88. ncbi request reprint Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathy
    Verena B Gerl
    Department of Ophthalmology, University of Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 43:1104-8. 2002
    ..To determine the presence of activated complement components in eyes affected by diabetic retinopathy...
  89. ncbi request reprint Capsular bag shrinkage after implantation of a capsular bending or capsular tension ring
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 31:1915-20. 2005
    ..To evaluate the influence of a capsular bending ring (CBR) or tension ring (CTR) on capsular bag shrinkage...
  90. ncbi request reprint Endotoxins in ophthalmic viscosurgical devices
    H Burkhard Dick
    Department of Ophthalmology, Johannes Gutenberg University of Mainz, Germany
    Eur J Ophthalmol 13:176-84. 2003
    ..To measure the endotoxin concentration (EC) of 25 commercially available, hyaluronic acid- and hydroxypropylmethylcellulose-based (HPMC) ophthalmic viscosurgical devices (OVDs)...
  91. ncbi request reprint Scanning laser polarimetry and retinal thickness analysis before and after laser in situ keratomileusis
    E M Hoffmann
    Department of Ophthalmology, University of Mainz, Mainz Germany
    Eur J Ophthalmol 15:434-40. 2005
    ..To evaluate changes in retinal nerve fiber layer (RNFL) thickness after laser in situ keratomileusis (LASIK) using a scanning laser polarimeter with fixed corneal compensation (GDx) and the retinal thickness analyzer (RTA)...
  92. ncbi request reprint [Systemic fibrinolytic therapy using urokinase in central retinal artery occlusion. A case study]
    M A von Mach
    II Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universität Mainz, Langenbeckstrasse 155131, Mainz
    Dtsch Med Wochenschr 130:1002-6. 2005
    ..In the present case study results and complications of systemic fibrinolysis should be investigated in patients with central retinal artery occlusion...
  93. ncbi request reprint Vacuoles in the Acrysof intraocular lens as factor of the presence of serum in aqueous humor
    H B Dick
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Ophthalmic Res 33:61-7. 2001
    ..To help clarify the influence of factors present under in vivo conditions on vacuole formation, the present experimental study examines the influence of aqueous humor components on the occurrence of vacuoles in Acrysof IOLs...
  94. ncbi request reprint [Laser in situ keratomileusis (LASIK) and scanning laser ophthalmoscopy]
    E M Hoffmann
    Univ Augenklinik Mainz
    Ophthalmologe 102:856-62. 2005
    ..To determine the influence of Laser in situ keratomileusis (LASIK) on the measurements of retinal thickness and optic nerve head topography using the Retinal Thickness Analyzer (RTA)...
  95. ncbi request reprint Intraocular pressure after small incision cataract surgery: temporal sclerocorneal versus clear corneal incision
    O Schwenn
    Department of Ophthalmology Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 27:421-5. 2001
    ..To compare intraocular pressure (IOP) after phacoemulsification and foldable intraocular lens (IOL) implantation using a temporal sclerocorneal or clear corneal incision...
  96. ncbi request reprint [Refraction, anterior chamber depth, decentration and tilt after implantation of monofocal and multifocal silicone lenses]
    H B Dick
    Universitats Augenklinik, Johannes Gutenberg Universitat Mainz
    Ophthalmologe 98:380-6. 2001
    ..We prospectively investigated changes in refraction, anterior chamber depth, decentration and tilt after implantation of multifocal (MIOL) and monofocal (MONO) intraocular lenses (IOL)...
  97. ncbi request reprint [Near vision after implantation of monofocal versus multifocal intraocular lenses]
    H B Dick
    Universitats Augenklinik, Langenbeckstr 1, 55131 Mainz
    Klin Monbl Augenheilkd 218:406-11. 2001
    ....
  98. pmc Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension
    O Schwenn
    Augenklinik der Johannes Gutenberg Universität Mainz Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Br J Ophthalmol 86:981-4. 2002
    ..Furthermore, the authors examined whether there were any correlations with blood pressure...
  99. ncbi request reprint Physicochemical surface properties of various intraocular lenses
    H B Dick
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Ophthalmic Res 33:303-9. 2001
    ..Therefore, we performed measurements of the contact angle and critical surface tension of several commercially available IOLs...
  100. ncbi request reprint Clinical comparison of two intraocular pressure measurement methods: SmartLens dynamic observing tonography versus Goldmann
    R Troost
    Coordination Centre for Clinical Trials, University of Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 239:889-92. 2001
    ..To compare intraocular pressure measurements obtained with SmartLens, a gonioscopic contact lens, to those from Goldmann applanation tonometry...
  101. pmc Corneal tattooing: an alternative treatment for disfiguring corneal scars
    S Pitz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Br J Ophthalmol 86:397-9. 2002
    ..The performance and results of corneal tattooing are described in a case series of 11 patients suffering from a disfiguring corneal scar using a technique similar to conventional dermatography...