N Peters

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    J Neurol Sci 260:100-5. 2007
  2. doi request reprint [Vascular dementia]
    N Peters
    Neurologische Klinik und Poliklinik, Klinikum Groshadern, Ludwig Maximilians Universitat Munchen, Marchioninistrase 15, 81377, Munchen, Deutschland
    Nervenarzt 81:1245-53; quiz 1254-5. 2010
  3. doi request reprint Ischemic stroke of the cortical "hand knob" area: stroke mechanisms and prognosis
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol 256:1146-51. 2009
  4. doi request reprint Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL
    Nils Peters
    Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 255:1203-8. 2008
  5. doi request reprint Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting
    S Muller-Schunk
    Department of Neuroradiology, Ludwig Maximilians University, Munich, Germany
    AJNR Am J Neuroradiol 29:786-91. 2008
  6. ncbi request reprint Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study
    Martin Dichgans
    Department of NeurologyKlinikum Grosshadern, Ludwig Maximilians University, Munchen, Germany
    Stroke 33:67-71. 2002
  7. ncbi request reprint Ischemic stroke and peripheral arterial thromboembolism in a patient with Crohn's disease: a case presentation
    Tobias Freilinger
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol Sci 266:177-9. 2008
  8. ncbi request reprint The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Am J Psychiatry 162:2078-85. 2005
  9. doi request reprint Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 39:1496-500. 2008
  10. doi request reprint A case of Sturge-Weber syndrome with symptomatic hemiplegic migraine: clinical and multimodality imaging data during a prolonged attack
    Tobias Freilinger
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    J Neurol Sci 287:271-4. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    J Neurol Sci 260:100-5. 2007
    ..CADASIL is a monogenic form of SVD caused by mutations in the Notch3 gene. Treatment options are limited and little is known about the therapeutic role of statins in CADASIL...
  2. doi request reprint [Vascular dementia]
    N Peters
    Neurologische Klinik und Poliklinik, Klinikum Groshadern, Ludwig Maximilians Universitat Munchen, Marchioninistrase 15, 81377, Munchen, Deutschland
    Nervenarzt 81:1245-53; quiz 1254-5. 2010
    ..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic variant of SIVD, represents an important differential diagnosis and may serve as a model of SIVD...
  3. doi request reprint Ischemic stroke of the cortical "hand knob" area: stroke mechanisms and prognosis
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol 256:1146-51. 2009
    ..It mostly reflects first ever ischemic stroke, and follow-up data suggest a rather benign course...
  4. doi request reprint Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL
    Nils Peters
    Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 255:1203-8. 2008
    ..Vasoreactivity induced by L-arginine, which is the substrate for endothelial nitric oxide synthase, is a parameter of endothelial function and has been shown to be altered in patients with cerebrovascular disease...
  5. doi request reprint Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting
    S Muller-Schunk
    Department of Neuroradiology, Ludwig Maximilians University, Munich, Germany
    AJNR Am J Neuroradiol 29:786-91. 2008
    ..We analyzed platelet function in a near-patient setting to determine the effects of antiplatelet treatment in neurologic patients and correlated the results with clinical outcome after stent placement...
  6. ncbi request reprint Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study
    Martin Dichgans
    Department of NeurologyKlinikum Grosshadern, Ludwig Maximilians University, Munchen, Germany
    Stroke 33:67-71. 2002
    ..Our purposes were (1) to determine the frequency, extent, and pattern of MBs in CADASIL; (2) to analyze the relationship between MBs and T2-hyperintense lesions; and (3) to evaluate the histopathology of brain tissue affected by MBs...
  7. ncbi request reprint Ischemic stroke and peripheral arterial thromboembolism in a patient with Crohn's disease: a case presentation
    Tobias Freilinger
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol Sci 266:177-9. 2008
    ..A pathophysiological model explaining this cooccurrence as well as the significance of prothrombotic risk factors ("hypercoaguable state") in the setting of inflammatory bowel disease and stroke are discussed...
  8. ncbi request reprint The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Am J Psychiatry 162:2078-85. 2005
    ..Mutation carriers almost invariably develop cognitive deficits and eventually dementia. The current study describes the profile of cognitive abnormalities in CADASIL subjects...
  9. doi request reprint Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 39:1496-500. 2008
    ..The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO...
  10. doi request reprint A case of Sturge-Weber syndrome with symptomatic hemiplegic migraine: clinical and multimodality imaging data during a prolonged attack
    Tobias Freilinger
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    J Neurol Sci 287:271-4. 2009
    ..A pathophysiological model explaining both the association between SWS/HM and the observed imaging changes is presented...
  11. ncbi request reprint Cortical hypometabolism and crossed cerebellar diaschisis suggest subcortically induced disconnection in CADASIL: an 18F-FDG PET study
    Klaus Tatsch
    Department of Nuclear Medicine, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    J Nucl Med 44:862-9. 2003
    ..The purpose of this study was to evaluate with (18)F-FDG PET whether regional cerebral metabolic rate of glucose (rCMRglc) is altered in CADASIL patients and, if so, whether there is evidence of subcortically induced disconnection...
  12. doi request reprint Internal carotid artery dissection and ischemic cerebral infarction in the setting of essential thrombocythemia
    T Freilinger
    Department of Neurology, Ludwig Maximilians Universitat, Klinikum Groshadern, Munich, Germany
    Clin Appl Thromb Hemost 17:E138-40. 2011
    ..In particular, we speculate that ET may increase the susceptibility of cervical vessels to spontaneous dissection, for example, by disturbing the microcirculation within the vessel wall...
  13. doi request reprint Reversible cerebral vasoconstriction syndrome associated with hormone therapy for intrauterine insemination
    T Freilinger
    Neurologische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Cephalalgia 30:1127-32. 2010
    ..A number of precipitating factors have been described in the literature, including recent childbirth and use of vasoactive substances...
  14. doi request reprint [Vasculitis and hereditary small vessel diseases]
    C Opherk
    Institut für Schlaganfall und Demenzforschung, Neurologische Klinik und Poliklinik, Ludwig Maximilians Universitat, Marchioninistrasse 15, 81377, Munchen, Deutschland
    Internist (Berl) 50:1200-9. 2009
    ..Their diagnosis which is based on family history, typical clinical features and genetic analysis often has implications for treatment and genetic counselling...
  15. ncbi request reprint Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease
    N Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Neurology 66:1517-22. 2006
    ..However, little is known about the role of brain atrophy and its clinical correlates in CADASIL...
  16. ncbi request reprint Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers
    Christian Opherk
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munchen, Germany
    Stroke 37:2684-9. 2006
    ..However, little is known about the factors that underlie this variability. We sought to quantify the contribution of modifying genetic effects to individual differences in the volume of cerebral ischemic lesions...
  17. ncbi request reprint A two-year clinical follow-up study in 80 CADASIL subjects: progression patterns and implications for clinical trials
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Stroke 35:1603-8. 2004
    ..The aim of this study was to explore the patterns of clinical progression in CADASIL, to check for prognostic variables, and to provide sample size estimates for future therapeutic trials...
  18. ncbi request reprint CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Exp Cell Res 299:454-64. 2004
    ..Moreover, the data suggest that ligand-induced receptor shedding may not be required for N3ECD deposition in CADASIL...
  19. doi request reprint CADASIL mutations enhance spontaneous multimerization of NOTCH3
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:2761-7. 2009
    ..Taken together, our results for the first time provide experimental evidence for N3 self-association and strongly argue for a neomorphic effect of CADASIL mutations in disease pathogenesis...
  20. ncbi request reprint Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients
    Christian Opherk
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 127:2533-9. 2004
    ..Our findings suggest possible genotype-phenotype correlations with regard to disease progression. The data presented may serve as source material for counselling CADASIL patients and for designing future interventional trials...
  21. ncbi request reprint Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies
    Nils Peters
    Department of Neurology, Neurogenetics Laboratory, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Arch Neurol 62:1091-4. 2005
    ..Mutations are typically located within epidermal growth factor-like repeat domains in the extracellular part of the Notch3 receptor. Identification of the mutation is critical for genetic counseling and testing of relatives at risk...
  22. ncbi request reprint Intrafamilial variability in fragile X-associated tremor/ataxia syndrome
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Mov Disord 21:98-102. 2006
    ..Also, their family history suggests further evidence of possible manifestation of FXTAS in women...
  23. ncbi request reprint Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study
    Markus Holtmannspotter
    Abteilung fur Neuroradiologie, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Stroke 36:2559-65. 2005
    ..In this study, we assessed the role of quantitative MRI (T2-lesion volume and diffusion tensor imaging [DTI]-derived metrics) in monitoring and predicting disease progression...
  24. ncbi request reprint Fusion imaging using a hybrid SPECT-CT camera improves port perfusion scintigraphy for control of hepatic arterial infusion of chemotherapy in colorectal cancer patients
    Timm Denecke
    Campus Virchow Klinikum, Charite Universitatsmedizin Berlin Klinik fur Strahlenheilkunde und PET Zentrum Berlin, Augustenburger Platz 1 Berlin, 13353 Berlin, Germany
    Eur J Nucl Med Mol Imaging 32:1003-10. 2005
    ..The aim of this study was to evaluate port perfusion scintigraphy in colorectal cancer patients using a hybrid SPECT-CT system for control of minimally invasive intra-arterial port systems within the scope of a phase II trial...
  25. ncbi request reprint In vivo assessment of the gastric mucosal tolerance dose after single fraction, small volume irradiation of liver malignancies by computed tomography-guided, high-dose-rate brachytherapy
    Florian Streitparth
    Department of Radiology, Charite Medical University Center, Campus Virchow Clinic, Humboldt University, Berlin, Germany
    Int J Radiat Oncol Biol Phys 65:1479-86. 2006
    ..The aim of this study was to assess the tolerance dose of gastric mucosa for single-fraction computed tomography (CT)-guided, high-dose-rate (HDR) brachytherapy of liver malignancies...
  26. ncbi request reprint Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL
    Eric Jouvent
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, and Université Paris VII, Paris, France
    Stroke 38:1786-90. 2007
    ..The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships between cerebral volume and different types of subcortical MRI lesions in CADASIL...