Genomes and Genes
Affiliation: University of Erlangen-Nuremberg
- Dialysis-associated acquired cystic kidney disease imitating autosomal dominant polycystic kidney disease in a patient receiving long-term peritoneal dialysisDaniel Neureiter
Department of Pathology, University of Erlangen, Heidelberg, Germany
Nephrol Dial Transplant 17:500-3. 2002
- Detection of Chlamydia pneumoniae but not of Helicobacter pylori in symptomatic atherosclerotic carotids associated with enhanced serum antibodies, inflammation and apoptosis rateDaniel Neureiter
Institute of Pathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, Germany
Atherosclerosis 168:153-62. 2003..Therefore, we evaluated the detection rate of C. pneumoniae and H. pylori in normal carotids vs. atherosclerotic carotids and compared these findings with serology, plaque morphology, inflammatory cell infiltrates and apoptosis rate...
- Overexpression of MMP9 and tissue factor in unstable carotid plaques associated with Chlamydia pneumoniae, inflammation, and apoptosisSebastian Stintzing
Institute of Pathology, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
Ann Vasc Surg 19:310-9. 2005..This process is associated with local inflammatory cell infiltrates and apoptosis, which might be influenced by infectious agents such as C. pneumoniae...
- CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failureValentina Campean
Department of Pathology, University of Erlangen Nurnberg, Germany
Atherosclerosis 190:156-66. 2007..The data indicate a higher inflammatory status of coronary lesions as well as involvement of the CD40-CD154 signaling cascade in CRF patients, especially in cases of calcified atherosclerotic lesions...
- Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 tumor model in rabbitsJohannes Hansler
Department of Medicine I, Institute of Pathology, and Institute of Diagnostic Radiology, Friedrich Alexander University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Radiology 230:169-74. 2004..To evaluate survival, metastases, tumor necrosis, and prediction of local recurrence after percutaneous ultrasonographically (US) guided radiofrequency (RF) thermal ablation with electrodes perfused continuously with isotonic saline...
- The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cellsMatthias Ocker
Department of Medicine I, University of Erlangen Nuernberg, Ulmenweg 18, 91054, Erlangen, Germany
J Cancer Res Clin Oncol 131:385-94. 2005..The use of the triple combination could optimize treatment results in vivo and needs further evaluation...
- Hepatic transit time of an echo enhancer: an indicator of metastatic spread to the liverThomas Bernatik
Department of Medicine I, Friedrich Alexander University, Erlangen Nuremberg, Germany
Eur J Gastroenterol Hepatol 16:313-7. 2004..Can sonographic measurements of the transit time of an echo enhancer from the hepatic artery to the hepatic vein discriminate between patients with and without liver metastases?..
- Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesionsThomas Aigner
Institute of Pathology, University of Leipzig, Liebigstr 26, D 04103 Leipzig, Germany
Atherosclerosis 196:37-41. 2008..Occasionally, however, chondrocytic differentiation markers occur within atherosclerotic lesions. This most likely represents a metaplastic event associated, but not causative for atherosclerotic vessel degeneration and calcification...
- Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of miceGabriele Sass
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
Int J Cancer 123:1269-77. 2008..Livers and kidneys of treated animals did not reveal signs of damage by this treatment. In conclusion, a specific knockdown of HO-1 might represent a novel therapeutic approach in HCC therapy...
- Different capabilities of morphological pattern formation and its association with the expression of differentiation markers in a xenograft model of human pancreatic cancer cell linesDaniel Neureiter
Department of Pathology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Pancreatology 5:387-97. 2005..The aim of our study was to investigate the possibility of differentiation pathways of human pancreatic cancer cell lines in vivo...
- Role of the receptor for advanced glycation end products in hepatic fibrosisChristina Lohwasser
Department of Medicine I, University of Erlangen Nuremberg, Erlangen Nurnberg, D 91054, Germany
World J Gastroenterol 15:5789-98. 2009..To study the role of advanced glycation end products (AGE) and their specific receptor (RAGE) in the pathogenesis of liver fibrogenesis...
- Prognostic relevance of cell biologic and biochemical features in conventional chondrosarcomasThomas Aigner
Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
Cancer 94:2273-81. 2002..Currently, tumor grade is the only parameter of prognostic significance besides stage and, possibly, resection margins. Additional independent prognostic markers therefore would be highly valuable for patient management...
- Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer modelsDaniel Neureiter
Institute of Pathology, Landeskliniken Salzburg, Salzburg, Austria
Scand J Gastroenterol 42:103-16. 2007....
- Activation of tumor-specific T lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbitsThaddäus Till Wissniowski
Department of Medicine I, Friedrich Alexander University, Erlangen Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
Cancer Res 63:6496-500. 2003..Therefore, in addition to destroying tumor tissue, RFA induces an immune response against tumor antigens that may be exploited in multimodal antitumor strategies...
- Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivoSteffen Zopf
Department of Medicine 1, University Hospital Erlangen, D 91054, Erlangen, Germany
Int J Oncol 31:1391-402. 2007..0 on the extrinsic cell death pathway through activation of TRAIL and its signalling pathway indicate that A-423378.0 may be a potent new therapeutic compound for the treatment of advanced colorectal cancer...
- The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude miceKinya Okamoto
Department of Medicine 1, University Hospital Erlangen, D 91054 Erlangen, Germany
Int J Oncol 33:733-42. 2008..Except for a reversible skin reaction and weight loss, no signs of toxicity were observed. AEE788 is a promising new option for the treatment of HCC...
- The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alphaChristina Lohwasser
Department of Medicine I, University of Erlangen Nuernberg, Germany
J Invest Dermatol 126:291-9. 2006..We conclude that in HFFs, AGE-RAGE interactions may influence the process of skin aging through mild stimulation of ECM gene expression...
- Intravascular lymphomatosis mimicking disseminated encephalomyelitis and encephalomyelopathyCharly Gaul
Neurologische Klinik, Friedrich Alexander Universitat, Erlangen Nurnberg, Germany Neurologische Klinik, Martin Luther Universitat, Halle Wittenberg, Germany
Clin Neurol Neurosurg 108:486-9. 2006..A biopsy of different organs including the brain and leptomeninges should not be delayed to ensure ante mortem diagnosis and to initiate chemotherapy...
- bcl-2-specific siRNAs restore gemcitabine sensitivity in human pancreatic cancer cellsKinya Okamoto
Department of Medicine 1, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
J Cell Mol Med 11:349-61. 2007..Our results demonstrate that siRNA-mediated silencing of anti-apoptotic bcl-2 enhances chemotherapy sensitivity in human pancreatic cancer cells in vitro and might lead to improved therapy responses in advanced stages of this disease...
- Gastrointestinal cancer - only a deregulation of stem cell differentiation? (Review)Daniel Neureiter
Institute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, Austria
Int J Mol Med 17:483-9. 2006..Here, we review the current knowledge on the roles of stem cells in gastrointestinal cancer formation and the implication on future diagnostic and therapeutic strategies...