Winfried L Neuhuber

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment
    Kristin Seiler
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Headache Pain 14:74. 2013
  2. ncbi request reprint Lung sensors: complex functions require complex structures
    Winfried L Neuhuber
    Anatomy Institute, University of Erlangen Nuremberg, Germany
    Am J Respir Cell Mol Biol 28:265-6. 2003
  3. ncbi request reprint Innervation of immune cells: evidence for neuroimmunomodulation in the liver
    Winfried L Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:884-92. 2004
  4. ncbi request reprint Innervation of the mammalian esophagus
    Winfried L Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Adv Anat Embryol Cell Biol 185:1-73, back cover. 2006
  5. doi request reprint Autonomic control of the eye and the iris
    Winfried Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Germany
    Auton Neurosci 165:67-79. 2011
  6. doi request reprint The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice
    Irena Kroeger
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Hepatol 51:342-53. 2009
  7. ncbi request reprint Enteric co-innervation of motor endplates in the esophagus: state of the art ten years after
    Jürgen Wörl
    Anatomy Institute, University of Erlangen Nuremberg, Krankenhausstrasse 9, D 91054, Erlangen, Germany
    Histochem Cell Biol 123:117-30. 2005
  8. doi request reprint Enteric co-innervation of esophageal striated muscle fibers: a phylogenetic study
    Christina Hempfling
    Institute of Anatomy, University of Erlangen Nuremberg, Krankenhausstrasse 9, D 91054 Erlangen, Germany
    Auton Neurosci 151:135-41. 2009
  9. ncbi request reprint Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse
    Tobias Kraus
    Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Neurosci Lett 360:53-6. 2004
  10. ncbi request reprint Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage
    Renate Bang
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Pharmacol Exp Ther 308:1174-80. 2004

Collaborators

Detail Information

Publications45

  1. pmc Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment
    Kristin Seiler
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Headache Pain 14:74. 2013
    ..In the present study we examined changes in immunofluorescence of CGRP receptor components (CLR and RAMP1) and soluble guanylyl cyclase (sGC), the intracellular receptor for NO, in rat trigeminal ganglia after pretreatment with GTN...
  2. ncbi request reprint Lung sensors: complex functions require complex structures
    Winfried L Neuhuber
    Anatomy Institute, University of Erlangen Nuremberg, Germany
    Am J Respir Cell Mol Biol 28:265-6. 2003
  3. ncbi request reprint Innervation of immune cells: evidence for neuroimmunomodulation in the liver
    Winfried L Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:884-92. 2004
    ..Modulation of autonomic nervous system functions may open novel therapeutic strategies in immune and inflammatory liver diseases...
  4. ncbi request reprint Innervation of the mammalian esophagus
    Winfried L Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Adv Anat Embryol Cell Biol 185:1-73, back cover. 2006
    ..In addition, other molecules, e.g., ATP, GABA and probably also inflammatory cytokines, may modulate these neuronal functions...
  5. doi request reprint Autonomic control of the eye and the iris
    Winfried Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Germany
    Auton Neurosci 165:67-79. 2011
    ..This review across the vertebrate classes outfolds the complex neuronal regulatory underpinnings across vertebrates that ensure proper visual function...
  6. doi request reprint The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice
    Irena Kroeger
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Hepatol 51:342-53. 2009
    ..Its role in inflammatory diseases of other organs is controversial and poorly investigated regarding liver inflammation, although the organ is innervated by CGRP containing primary sensory nerve fibers...
  7. ncbi request reprint Enteric co-innervation of motor endplates in the esophagus: state of the art ten years after
    Jürgen Wörl
    Anatomy Institute, University of Erlangen Nuremberg, Krankenhausstrasse 9, D 91054, Erlangen, Germany
    Histochem Cell Biol 123:117-30. 2005
    ..The aim of this review is to summarize current knowledge about enteric co-innervation of esophageal striated muscle and to provide some hints as to its functional significance...
  8. doi request reprint Enteric co-innervation of esophageal striated muscle fibers: a phylogenetic study
    Christina Hempfling
    Institute of Anatomy, University of Erlangen Nuremberg, Krankenhausstrasse 9, D 91054 Erlangen, Germany
    Auton Neurosci 151:135-41. 2009
    ..These results demonstrate that enteric co-innervation, in spite of varying co-innervation rates, is conserved through vertebrate evolution, and underline the significance of this newly discovered innervation component...
  9. ncbi request reprint Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse
    Tobias Kraus
    Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Neurosci Lett 360:53-6. 2004
    ..This may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated muscle fibers...
  10. ncbi request reprint Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage
    Renate Bang
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Pharmacol Exp Ther 308:1174-80. 2004
    ..Because NK-1 receptor antagonists not only suppress the proinflammatory cytokine response in the liver but also prevent liver cell apoptosis in vivo, they might be suitable drugs for treatment of immune-mediated liver disease...
  11. ncbi request reprint Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagus
    Marion Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Auton Neurosci 108:22-31. 2003
    ..This concurs with their proposed function as vagal mechanosensors crucial for reflex peristalsis...
  12. ncbi request reprint Heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase
    Bernd Kallmünzer
    Institute of Anatomy, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054, Erlangen, Germany
    Cell Tissue Res 324:181-8. 2006
    ....
  13. doi request reprint Innervation pattern of the preocular human central retinal artery
    Antonio Bergua
    Dept of Ophthalmology, University Erlangen Nuremberg, Erlangen, Germany
    Exp Eye Res 110:142-7. 2013
    ..Remarkably, a peptidergic primary afferent innervation was missing. Since clinical results suggest an autoregulation of intraretinal vessels, further studies are needed to clarify the impact of CRA innervation for retinal perfusion...
  14. doi request reprint Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis
    Matthias A Engel
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Dig Liver Dis 44:24-9. 2012
    ..SP levels increase whilst CGRP levels decrease in colon specimens from patients with inflammatory bowel disease; thus suggesting the pro- and anti-inflammatory roles, respectively, of these neuropeptides...
  15. doi request reprint The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages
    Falk Schroedl
    Department of Anatomy I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:5222-9. 2008
    ..To date, there is no report on its expression in the posterior human uvea. The purpose of this study was to investigate the expression of LYVE-1 in normal human choroids...
  16. ncbi request reprint Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury
    Gabriele Sass
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Hepatology 40:1128-35. 2004
    ..g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma). In conclusion, HO-1-induced prolongation of survival, but not the protection from liver damage, seems to be dependent on down-regulation of cytokine synthesis...
  17. pmc Spiny versus stubby: 3D reconstruction of human myenteric (type I) neurons
    Tobias M Lindig
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Histochem Cell Biol 131:1-12. 2009
    ..2 in spiny and 1:0.3 in stubby neurons. In conclusion, 3D reconstruction revealed new differences between stubby and spiny neurons and allowed estimations of volumetric data of these neuron populations...
  18. ncbi request reprint Vasoactive intestinal and calcitonin gene-related peptides, tyrosine hydroxylase and nitrergic markers in the innervation of the rat central retinal artery
    Antonio Bergua
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Exp Eye Res 77:367-74. 2003
    ..Tyrosine hydroxylase positive innervation indicates the presence of sympathetic activity, and calcitonin gene-related peptide positive fibers indicate sensory innervation by trigeminal primary efferents...
  19. ncbi request reprint Development of neuromuscular junctions in the mouse esophagus: morphology suggests a role for enteric coinnervation during maturation of vagal myoneural contacts
    Christian Breuer
    Anatomy Institute, University of Erlangen Nuremberg, Krankenhausstrasse 9, D 91054 Erlangen, Germany
    J Comp Neurol 475:47-69. 2004
    ....
  20. doi request reprint Deletion of Pax7 changes the tunica muscularis of the mouse esophagus from an entirely striated into a mixed phenotype
    Jürgen Wörl
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Dev Dyn 238:864-74. 2009
    ..We conclude that Pax7-dependent myogenic progenitor cells are of prime importance for striated muscle formation and the degree of smooth-to-striated muscle conversion during esophageal ontogeny...
  21. doi request reprint Increase in CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of an NO donor
    Anne Dieterle
    Institute of Physiology and Pathophysiology, University of Erlangen Nuernberg, Universitaetsstrasse 17, Erlangen, Germany
    Cephalalgia 31:31-42. 2011
    ..Increases in plasma CGRP and NO metabolites have also been found in spontaneous migraine attacks. In a rat model of meningeal nociception, infusion of NO donors induced activity of neurons in the spinal trigeminal nucleus...
  22. ncbi request reprint Intrinsic choroidal neurons in the human eye: projections, targets, and basic electrophysiological data
    Falk Schrödl
    Anatomy Institute I, Erlangen, Germany
    Invest Ophthalmol Vis Sci 44:3705-12. 2003
    ..Thus, this technique was used in the present study to help characterize the organization of the ICN in the human eye...
  23. ncbi request reprint Ultrastructural analysis of the smooth-to-striated transition zone in the developing mouse esophagus: emphasis on apoptosis of smooth and origin and differentiation of striated muscle cells
    Jürgen Wörl
    Anatomy Institute, University of Erlangen Nuremberg, Erlangen, Germany
    Dev Dyn 233:964-82. 2005
    ..Taken together, these results provide further evidence for distinct differentiation pathways of both muscle types during esophagus development...
  24. ncbi request reprint Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury
    Renate Bang
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Pharmacol Exp Ther 305:31-9. 2003
    ..NK-1 receptor antagonists might be potent drugs for treatment of inflammatory liver disease, most likely by inhibiting SP effects...
  25. pmc Morphologic indication for proprioception in the human ciliary muscle
    Cassandra Flügel-Koch
    Institute of Anatomy II, University of Erlangen Nurnberg, Universitätsstrasse 19, 91054 Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:5529-36. 2009
    ..To search for proprioceptive nerve terminals in human ciliary muscle...
  26. doi request reprint Release of calcitonin gene-related peptide from the jugular-nodose ganglion complex in rats--a new model to examine the role of cardiac peptidergic and nitrergic innervation
    Thomas Strecker
    Institute of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nurnberg, Universitätsstr 17, D 91054 Erlangen, Germany
    Neuropeptides 42:543-50. 2008
    ....
  27. ncbi request reprint Comparative anatomy of nitrergic intrinsic choroidal neurons (ICN) in various avian species
    Falk Schroedl
    Anatomisches Institut I, FAU Erlangen Nürnberg, Krankenhausstr 9, 91054 Erlangen, Germany
    Exp Eye Res 78:187-96. 2004
    ..The temporo-cranial accumulation of ICN in galliformes and the belt-like arrangement in anseriformes may reflect special functional requirements in regions of high visual acuity...
  28. pmc Somatostatin immunoreactivity in quail pterygopalatine ganglion
    Falk Schrödl
    Anatomisches Institut I, FAU Erlangen Nürnberg, Germany
    J Anat 206:249-55. 2005
    ..SOM may regulate the production of NO in pterygopalatine neurons and ICN, respectively, and is therefore involved in neuronal circuits regulating ocular homeostasis...
  29. ncbi request reprint Close apposition of dynorphin-positive nerve fibres to lymphocytes in the liver suggests opioidergic neuroimmunomodulation
    Matthias J T Kaiser
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhaustrasse 9, 91054 Erlangen, Germany
    Histochem Cell Biol 120:213-21. 2003
    ..Hence, sympathetic neurons innervating the liver may interfere with inflammatory processes, in addition to their well-established beta(2)-adrenergic effect, via an opioidergic action on immune cells...
  30. doi request reprint Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution
    Jochen K Lennerz
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    J Comp Neurol 507:1277-99. 2008
    ..Thus, in the trigeminovascular system CGRP receptor localization suggests multiple targets for CGRP in the pathogenesis of primary headaches...
  31. ncbi request reprint Glutamatergic functions of primary afferent neurons with special emphasis on vagal afferents
    Marion Raab
    Institut fur Anatomie, Universitat Erlangen Nurnberg, Erlangen, Germany
    Int Rev Cytol 256:223-75. 2007
    ..Thus, morphological analysis of the relationships of putative glutamatergic primary afferents with associated tissues may direct forthcoming studies on their functions...
  32. doi request reprint TRPA1 and substance P mediate colitis in mice
    Matthias A Engel
    Institute of Physiology and Pathophysiology, First Department of Medicine, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Gastroenterology 141:1346-58. 2011
    ..We investigated the mechanisms of colitis in 2 different models, the involvement of the irritant receptor transient receptor potential of the ankyrin type-1 (TRPA1), and the effects of CGRP and substance P...
  33. ncbi request reprint Development of neuromuscular junctions in the mouse esophagus: focus on establishment and reduction of enteric co-innervation
    Jürgen Wörl
    Anatomy Institute, University of Erlangen Nurnberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Anat Embryol (Berl) 205:141-52. 2002
    ..Thus, enteric co-innervation may subserve a functional role in the development and control of perinatal striated esophageal muscle rather than representing an unspecific "hangover" from the smooth muscle past of this organ...
  34. ncbi request reprint Enteric co-innervation of striated muscle in the esophagus: still enigmatic?
    Winfried L Neuhuber
    Institut für Anatomie I, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstraße 9, 91054, Erlangen, Germany
    Histochem Cell Biol 146:721-735. 2016
    ..doi: 10.1007/s00418-005-0764-7 , 2005a), is to summarize the current knowledge about enteric co-innervation of esophageal striated muscle and to provide some hints as to its functional significance...
  35. doi request reprint Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus
    Piet van der Keylen
    Institute of Anatomy I, Friedrich Alexander University Erlangen Nurnberg, Krankenhausstrasse 9, 91054, Erlangen, Germany
    Histochem Cell Biol 145:573-85. 2016
    ....
  36. doi request reprint Innervation of rat and human dura mater and pericranial tissues in the parieto-temporal region by meningeal afferents
    Markus Schueler
    Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany Department of Nephrology and Hypertensiology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Headache 54:996-1009. 2014
    ..To reinvestigate the innervation pattern of the dura mater of rat and human middle cranial fossa, the morpho-functional substrate of headache generation, and adjacent extracranial tissues with neuronal in vitro tracing...
  37. ncbi request reprint Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    Irith Baumann
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 46:191-201. 2002
    ..To investigate the fate of apoptotic cells in the germinal centers (GCs) of patients with systemic lupus erythematosus (SLE)...
  38. ncbi request reprint Site-specific gene expression of nNOS variants in distinct functional regions of rat gastrointestinal tract
    Dieter Saur
    Department of Internal Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G349-58. 2002
    ..These mechanisms could be involved in gastrointestinal motor diseases and may explain the phenotype of nNOSalpha knockout mice with gastric stasis and pyloric stenosis, due to a total loss of nNOS in the pyloric sphincter region...
  39. ncbi request reprint Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus
    Ammar Boudaka
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Eur J Pharmacol 556:157-65. 2007
    ..Taken together, the results suggest that piperine inhibits the vagally mediated striated muscle contraction in the mouse esophagus through its action on a TRPV1-dependent pathway as well as a TRPV1-independent site...
  40. ncbi request reprint The autonomic facial nerve pathway in birds: a tracing study in chickens
    Falk Schrödl
    The New England College of Optometry, Boston, 02115, USA
    Invest Ophthalmol Vis Sci 47:3225-33. 2006
    ..The purpose of this study was to find an extraorbital approach to the preganglionic part of cranial nerve VII and to reveal its peripheral terminals and its site of origin in the brain stem...
  41. ncbi request reprint Lymph heart in chick--somitic origin, development and embryonic oedema
    Petr Valasek
    School of Biological Sciences, University of Reading, Reading RG6 6AJ, UK
    Development 134:4427-36. 2007
    ..Finally, we assessed the function of the lymph heart during embryogenesis and demonstrate that it is responsible for preventing embryonic oedema in birds, a role previously thought to be played by body skeletal muscle contractions...
  42. ncbi request reprint PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons
    Seifollah Ahmadi
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Emil Fischer Zentrum, Fahrstrasse 17, D 91054 Erlangen, Germany
    Nat Neurosci 5:34-40. 2002
    ..Via this mechanism, PGE(2) may facilitate the transmission of nociceptive input through the spinal cord dorsal horn to higher brain areas where pain becomes conscious...
  43. ncbi request reprint Cardiac grafting of engineered heart tissue in syngenic rats
    Wolfram Hubertus Zimmermann
    Institute of Experimental and Clinical Pharmacology and Toxicology, Nuremberg, Germany
    Circulation 106:I151-7. 2002
    ..We hypothesize that survival and functional and electrical integration of grafts may be improved by engineering cardiac tissue constructs in vitro before grafting...
  44. ncbi request reprint Differences in responses to nociceptive stimulation of the oral and aboral oesophagus
    Thomas Hummel
    Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr 74, 01307 Dresden, Germany
    J Clin Neurosci 10:223-5. 2003
    ..These results suggest a contribution of vagal afferents to pseudoaffective responses elicited by noxious stimulation of the upper esophagus...
  45. ncbi request reprint Vagaries of adipose tissue innervation
    Hans Rudi Berthoud
    Am J Physiol Regul Integr Comp Physiol 291:R1240-2. 2006