Bjorn Nashan

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 93:1075-85. 2012
  2. doi request reprint Is acute rejection the key predictor for long-term outcomes after renal transplantation when comparing calcineurin inhibitors?
    Bjorn Nashan
    Department of Hepatobiliary and Transplant Surgery, Universitatsklinikum Hamburg Eppendorf, D 20251 Hamburg, Germany
    Transplant Rev (Orlando) 23:47-52. 2009
  3. doi request reprint Pharmacokinetics, efficacy, and safety of mycophenolate mofetil in combination with standard-dose or reduced-dose tacrolimus in liver transplant recipients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Liver Transpl 15:136-47. 2009
  4. doi request reprint Donor quality of life up to two years after living donor liver transplantation: a prospective study
    Sylvia Kroencke
    1 Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Hamburg, Germany 2 Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany 3 Department of Psychosomatics and Psychotherapy, Erlangen University Hospital, Erlangen, Germany 4 Address correspondence to Prof Karl Heinz Schulz, M D, Ph D, Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Martinistr 52, W26, 20246 Hamburg, Germany
    Transplantation 97:582-9. 2014
  5. doi request reprint Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
    Florian Ewald
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 133:2065-76. 2013
  6. doi request reprint Immediate postoperative intensive care treatment of pediatric combined liver-kidney transplantation: outcome and prognostic factors
    Egmont Harps
    Department of Pediatrics, Pediatric Intensive Care Unit, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 91:1127-31. 2011
  7. doi request reprint Role of the Fyn -93A>G polymorphism (rs706895) in acute rejection after liver transplantation
    Hansjörg Thude
    University Medical Center Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistrase 52, 20246 Hamburg, Germany Electronic address
    Hum Immunol 76:657-62. 2015
  8. doi request reprint Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
    Florian Ewald
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg, 20246, Germany
    Invest New Drugs 32:1144-54. 2014
  9. doi request reprint Induction therapy and mTOR inhibition: minimizing calcineurin inhibitor exposure in de novo renal transplant patients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Eppendorf, Hamburg, Germany
    Clin Transplant 27:16-29. 2013
  10. doi request reprint Four-year allograft survival in a highly sensitized combined liver-kidney transplant patient despite unsuccessful anti-HLA antibody reduction with rituximab, splenectomy, and bortezomib
    Martina Koch
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, UKE, Hamburg, Germany
    Transpl Int 26:e64-8. 2013

Collaborators

Detail Information

Publications33

  1. doi request reprint Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 93:1075-85. 2012
    ..This review will summarize these studies to discuss whether mTOR inhibitor-based immunosuppressive therapy can reduce the magnitude of CMV-related complications in the de novo renal transplantation setting...
  2. doi request reprint Is acute rejection the key predictor for long-term outcomes after renal transplantation when comparing calcineurin inhibitors?
    Bjorn Nashan
    Department of Hepatobiliary and Transplant Surgery, Universitatsklinikum Hamburg Eppendorf, D 20251 Hamburg, Germany
    Transplant Rev (Orlando) 23:47-52. 2009
    ..In conclusion, the perception of better efficacy with tacrolimus vs cyclosporine based on the incidence of acute rejection is not supported by a difference in graft or patient survival after kidney transplantation...
  3. doi request reprint Pharmacokinetics, efficacy, and safety of mycophenolate mofetil in combination with standard-dose or reduced-dose tacrolimus in liver transplant recipients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Liver Transpl 15:136-47. 2009
    ..In conclusion, exposure to MPA is not a function of exposure to tacrolimus. The similar safety and efficacy seen with MMF plus standard or reduced doses of tacrolimus suggest that MMF could be combined with reduced doses of tacrolimus...
  4. doi request reprint Donor quality of life up to two years after living donor liver transplantation: a prospective study
    Sylvia Kroencke
    1 Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Hamburg, Germany 2 Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany 3 Department of Psychosomatics and Psychotherapy, Erlangen University Hospital, Erlangen, Germany 4 Address correspondence to Prof Karl Heinz Schulz, M D, Ph D, Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Martinistr 52, W26, 20246 Hamburg, Germany
    Transplantation 97:582-9. 2014
    ..There is a lack of longer-term prospective data on living liver donors' quality of life (QOL). This is the first prospective study examining QOL up to 2 years after donation...
  5. doi request reprint Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
    Florian Ewald
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 133:2065-76. 2013
    ..In summary, our preclinical data suggest that combined targeting of mTOR and AKT using RAD001 and MK-2206 might be a new, effective strategy for the treatment of CCA. ..
  6. doi request reprint Immediate postoperative intensive care treatment of pediatric combined liver-kidney transplantation: outcome and prognostic factors
    Egmont Harps
    Department of Pediatrics, Pediatric Intensive Care Unit, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 91:1127-31. 2011
    ..Studies reporting the immediate pediatric intensive care unit (PICU) treatment after combined liver-kidney transplantation (CLKT) are scarce, although this period is pivotal for survival and long-term outcome...
  7. doi request reprint Role of the Fyn -93A>G polymorphism (rs706895) in acute rejection after liver transplantation
    Hansjörg Thude
    University Medical Center Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistrase 52, 20246 Hamburg, Germany Electronic address
    Hum Immunol 76:657-62. 2015
    ..Thus our results provide no evidence that the Fyn -93A>G SNP contributes to the susceptibility to acute liver transplant rejection in a Caucasian population. ..
  8. doi request reprint Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
    Florian Ewald
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg, 20246, Germany
    Invest New Drugs 32:1144-54. 2014
    ..Our data suggest that a combination of inhibitors targeting those respective pathways may be a viable approach for future application in patients with cholangiocarcinoma...
  9. doi request reprint Induction therapy and mTOR inhibition: minimizing calcineurin inhibitor exposure in de novo renal transplant patients
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Eppendorf, Hamburg, Germany
    Clin Transplant 27:16-29. 2013
    ....
  10. doi request reprint Four-year allograft survival in a highly sensitized combined liver-kidney transplant patient despite unsuccessful anti-HLA antibody reduction with rituximab, splenectomy, and bortezomib
    Martina Koch
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, UKE, Hamburg, Germany
    Transpl Int 26:e64-8. 2013
    ..So far, patient and allograft survival has reached 4 years despite failure to achieve a permanent reduction of anti-HLA antibodies, and particularly nondonor directed antibodies...
  11. ncbi request reprint Wound healing complications and the use of mammalian target of rapamycin inhibitors in kidney transplantation: a critical review of the literature
    Bjorn Nashan
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Eppendorf, Hamburg, Germany
    Transplantation 94:547-61. 2012
    ..This review summarizes these studies to consider whether modern mTOR inhibitor-based immunosuppressive regimens exert and affect wound healing after kidney transplantation...
  12. pmc High expression of micro RNA-135A in hepatocellular carcinoma is associated with recurrence within 12 months after resection
    Johann von Felden
    I Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    BMC Cancer 17:60. 2017
    ..The aim of this study was to identify patients at high risk for early intrahepatic recurrence by expression profiling of selected micro RNAs...
  13. pmc Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
    Astrid Grottke
    Center for Experimental Medicine, Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    PLoS ONE 11:e0146370. 2016
    ....
  14. doi request reprint Developments in pediatric liver transplantation since implementation of the new allocation rules in Eurotransplant
    Uta Herden
    Department of Hepatobiliary and Transplant Surgery, University Medical Centre Hamburg Eppendorf, Germany
    Clin Transplant 28:1061-8. 2014
    ..Introduction of a MELD-based allocation system in ET with assignment of a granted score for pediatric recipients has led to a clear priorization of children resulting in a low wait-list mortality and good clinical outcome. ..
  15. doi request reprint Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients
    Hansjörg Thude
    University Medical Center Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistrase 52, 20246 Hamburg, Germany
    Hum Immunol 75:1123-7. 2014
    ..Our results do not suggest an important role of tested CD40 SNPs in the susceptibility to acute liver transplant rejection in a Caucasian population. ..
  16. doi request reprint Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients
    Hansjörg Thude
    University Hospital Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistrasse 52, 20246 Hamburg, Germany
    Hum Immunol 74:1041-5. 2013
    ..In conclusion, our results suggest that the tested SNPs may not be associated with susceptibility to acute liver transplant rejection in a Caucasian population...
  17. doi request reprint 14-bp ins/del polymorphism and +3142C>G SNP of the HLA-G gene have a significant impact on acute rejection after liver transplantation
    Hansjörg Thude
    University Medical Center Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistrase 52, 20246 Hamburg, Germany Electronic address
    Hum Immunol 77:1159-1165. 2016
    ..Thus genotyping of liver recipients for both polymorphisms might be useful to stratify liver transplant recipients according to the risk of acute liver transplant rejection...
  18. doi request reprint Anterior vertical mini-incision vs. retroperitoneoscopic nephrectomy in living kidney donation: a prospective study on donors' quality of life and clinical outcome
    Sylvia Kroencke
    Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Transplant 29:1029-38. 2015
    ..We evaluated clinical outcome and health-related quality of life (QOL) comparing anterior vertical mini-incision donor nephrectomy (MIDN) and retroperitoneoscopic donor nephrectomy (RPDN)...
  19. doi request reprint High B-cell activating factor is not associated with worse 3-year graft outcome in blood group-incompatible kidney transplantation with rituximab induction
    Anja M Lehnhardt
    Department of Hepatobiliary Surgery and Transplantation at University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of Pediatric Nephrology at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Transplant 29:359-64. 2015
    ..The use of rituximab in ABOi together with maintenance immunosuppression leads to significant elevation of sBAFF and lowering of B-cell numbers for more than 1 year, and this does not correlate with worse 3-year graft outcome. ..
  20. doi request reprint Association between a gain-of-function variant of PTPN22 and rejection in liver transplantation
    Raphael Dullin
    1 Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany 2 Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 99:431-7. 2015
    ..One SNP (rs2476601; 1858G>A) has emerged as a particularly potent risk factor for autoimmunity. We address the question whether PTPN22 polymorphisms are also associated with acute rejection after liver transplantation...
  21. doi request reprint Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma
    Kornelius Schulze
    I Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 133:2165-71. 2013
    ..050). Our study demonstrates frequent presence of EpCAM-positive CTC in patients with intermediate or advanced HCC and its prognostic value for OS with possible implications for future treatment stratification. ..
  22. doi request reprint Cost-effectiveness analysis of antiviral treatment in liver transplant recipients with HCV infection
    Christoph Logge
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transpl Int 26:527-34. 2013
    ..We conclude that Peg-IFN/RBV treatment is cost-effective post transplant. This may support treatment decision in individual cases...
  23. doi request reprint A prospective study on living related kidney donors' quality of life in the first year: choosing appropriate reference data
    Sylvia Kroencke
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Transplant 26:E418-27. 2012
    ..Future research needs to determine the length and the nature of the post-operative QoL impairment and further explore possible influencing factors...
  24. doi request reprint Monitoring of nuclear factor of activated T-cell-regulated gene expression in de novo and long-term liver transplant recipients treated with cyclosporine a
    Uta Herden
    Department of Hepatobiliary Surgery and Solid Organ Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ther Drug Monit 33:185-91. 2011
    ..The data suggest that CsA C2 concentrations, but not C0 concentrations, reflect the effect of CsA on downregulation of cytokine expression in both de novo and long-term liver transplant patients...
  25. doi request reprint Rat renal transplant model for mixed acute humoral and cellular rejection: Weak correlation of serum cytokines/chemokines with intragraft changes
    Anja Lemke
    Department of Hepatobilary and Transplant Surgery and Pediatric Nephrology, University Medical Center Hamburg Eppendorf, Hamburg, Germany University Childrens Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Transpl Immunol 33:95-102. 2015
    ..We established a rat RT model with exclusive and complete MHC-disparity to investigate pathomechanisms of acute rejection and evaluate serum multiplex assays as a diagnostic tool in this context...
  26. doi request reprint The influence of PEEP and positioning on central venous pressure and venous hepatic hemodynamics in patients undergoing liver resection
    Asi Ukere
    Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg Eppendorf, Martinistrase 52, 22087, Hamburg, Germany
    J Clin Monit Comput . 2016
    ..We further analyzed correlations between CVP and venous hepatic blood flow parameters...
  27. doi request reprint Prediction, prevention, and management of delayed graft function: where are we now?
    Bjorn Nashan
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Transplant 30:1198-1208. 2016
    ..With so many unanswered questions, substantial reductions in the toll of DGF in the near future seem unlikely but concentrated research on many levels offers long-term promise...
  28. pmc Associating liver partition and portal vein ligation for staged hepatectomy: From technical evolution to oncological benefit
    Jun Li
    Jun Li, Florian Ewald, Björn Nashan, Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    World J Gastrointest Surg 8:124-33. 2016
    ..Furthermore, we review the contemporary literature regarding indication and benefits, but also limitations of ALPPS. ..
  29. pmc Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial
    Alexander Stein
    University Medical Center Hamburg Eppendorf, and University Cancer Center Hamburg, Hamburg, Germany
    BMC Cancer 15:564. 2015
    ..Thus, evaluation of adjuvant chemotherapy in biliary tract cancer in a large randomized trial is warranted...
  30. pmc The diagnosis and treatment of cholangiocarcinoma
    Arndt Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, University Medical Center Hamburg Eppendorf, I Department of Internal Medicine, Hamburg, Department of Gastroenterology and Oncology, Klinikum Ludwigsburg, University Medical Center Hamburg Eppendorf, Department of Hepatobiliary and Transplant Surgery, Department of General, Visceral and Transplant Surgery, University Hospital RWTH Aachen
    Dtsch Arztebl Int 111:748-54. 2014
    ..In recent years, its prognosis has improved because of wider resections and the establishment of local treatment and chemotherapy in the palliative situation...
  31. doi request reprint Surgical complications after kidney transplantation: different impacts of immunosuppression, graft function, patient variables, and surgical performance
    Martina Koch
    Department of Hepatobiliary Surgery and Transplantation, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Transplant 29:252-60. 2015
    ....
  32. pmc Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
    Nicole Grabinski
    Center for Experimental Medicine, Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg 20246, Germany
    Mol Cancer 11:85. 2012
    ..In addition, we measured the feedback activation of each of the AKT isoforms after mTOR inhibition in HCC cell lines and their enzymatic activity in primary samples from HCC patients...
  33. ncbi request reprint Attention and executive functioning deficits in liver-transplanted children
    Tanja Kaller
    Institute of Medical Psychology, University Hospital Eppendorf, Hamburg, Germany
    Transplantation 90:1567-73. 2010
    ..Liver-transplanted children have an increased risk for serious developmental problems. We examined attention and executive functioning and their relation to intelligence and several disease-related variables after transplantation...