Alexander Munchau

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Implementation of visuospatial cues in response selection
    Thilo van Eimeren
    NeuroImage Nord, Department of Neurology, University Medical Center Hamburg Eppendorf, Germany
    Neuroimage 29:286-94. 2006
  2. doi request reprint Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
    Melanie Jonas
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:991-9. 2010
  3. ncbi request reprint MEP latency shift after implantation of deep brain stimulation systems in the subthalamic nucleus in patients with advanced Parkinson's disease
    Ute Hidding
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Germany
    Mov Disord 21:1471-6. 2006
  4. doi request reprint Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:2828-37. 2010
  5. pmc Activity parameters of subthalamic nucleus neurons selectively predict motor symptom severity in Parkinson's disease
    Andrew Sharott
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurology, University Medical Center Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany, and Department of Neurosurgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 34:6273-85. 2014
  6. ncbi request reprint Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex
    Alexander Peinemann
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munich, Germany
    Clin Neurophysiol 115:1519-26. 2004
  7. ncbi request reprint Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
    Tobias Bäumer
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Neuroimage 20:550-60. 2003
  8. doi request reprint Charting the excitability of premotor to motor connections while withholding or initiating a selected movement
    Johan Kroeger
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Neurosci 32:1771-9. 2010
  9. doi request reprint Waking up the brain: a case study of stimulation-induced wakeful unawareness during anaesthesia
    Christian K E Moll
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prog Brain Res 177:125-45. 2009
  10. doi request reprint Action inhibition in Tourette syndrome
    Christos Ganos
    Department of Neurology, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lubeck, Lubeck, Germany
    Mov Disord 29:1532-8. 2014

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Implementation of visuospatial cues in response selection
    Thilo van Eimeren
    NeuroImage Nord, Department of Neurology, University Medical Center Hamburg Eppendorf, Germany
    Neuroimage 29:286-94. 2006
    ..We propose that the latter set of dorsal parieto-frontal areas subserves rapid implementation of spatial information during visually guided response selection...
  2. doi request reprint Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
    Melanie Jonas
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:991-9. 2010
    ..Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients...
  3. ncbi request reprint MEP latency shift after implantation of deep brain stimulation systems in the subthalamic nucleus in patients with advanced Parkinson's disease
    Ute Hidding
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Germany
    Mov Disord 21:1471-6. 2006
    ..These TMS effects need to be considered when interpreting results of excitability measurements in PD patients after implantation of STN electrodes...
  4. doi request reprint Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:2828-37. 2010
    ..Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC...
  5. pmc Activity parameters of subthalamic nucleus neurons selectively predict motor symptom severity in Parkinson's disease
    Andrew Sharott
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurology, University Medical Center Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany, and Department of Neurosurgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 34:6273-85. 2014
    ..Our results demonstrate that the occurrence of alterations in the rate and pattern of basal ganglia neurons could partly underlie the variability in parkinsonian phenotype...
  6. ncbi request reprint Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex
    Alexander Peinemann
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munich, Germany
    Clin Neurophysiol 115:1519-26. 2004
    ..To study the after effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) on corticospinal excitability...
  7. ncbi request reprint Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
    Tobias Bäumer
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Neuroimage 20:550-60. 2003
    ....
  8. doi request reprint Charting the excitability of premotor to motor connections while withholding or initiating a selected movement
    Johan Kroeger
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Neurosci 32:1771-9. 2010
    ..Thus, the left premotor cortex is engaged not only in action selection but also in withholding and releasing a preselected movement generated by the right motor cortex...
  9. doi request reprint Waking up the brain: a case study of stimulation-induced wakeful unawareness during anaesthesia
    Christian K E Moll
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prog Brain Res 177:125-45. 2009
    ....
  10. doi request reprint Action inhibition in Tourette syndrome
    Christos Ganos
    Department of Neurology, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lubeck, Lubeck, Germany
    Mov Disord 29:1532-8. 2014
    ..In the latter the supplementary motor area is probably a key relay of inhibitory processes mediating both suppression of tics and inhibition of voluntary action...
  11. doi request reprint Deep brain stimulation of the ventrolateral thalamic base and posterior subthalamic area in dystonic head tremor
    Carsten Buhmann
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Acta Neurochir Suppl 117:67-72. 2013
    ..Chronic stimulation improved not only head tremor but also CD. These findings suggest that DBS at the base of VL thalamus and the adjacent PSA should undergo further investigation as a potential target for patients with DHT...
  12. doi request reprint Mirror me: Imitative responses in adults with autism
    Odette Schunke
    University Medical Center Hamburg Eppendorf, Germany
    Autism 20:134-44. 2016
    ..Our results suggest imitative control deficits rather than global imitative system impairments. ..
  13. pmc Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders
    Ina Peiker
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 10:e0132531. 2015
    ..Thus, our data suggest that a disturbed excitatory-inhibitory balance underlies enhanced neural responses to coherent motion in ASD. ..
  14. doi request reprint Brain iron deposition fingerprints in Parkinson's disease and progressive supranuclear palsy
    Kai Boelmans
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 27:421-7. 2012
    ..Regional decreases of T2' relaxation times in parts of the basal ganglia reflecting increased brain iron load in these areas are characteristic for progressive supranuclear palsy but not PD patients...
  15. doi request reprint The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route
    Sergiu Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Hum Brain Mapp 33:419-30. 2012
    ..This paradigm opens up new possibilities to study context-dependent intrahemispheric PMd-to-M1(HAND) interactions in the intact human brain...
  16. doi request reprint Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome
    Gotz Thomalla
    Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Brain 132:765-77. 2009
    ..The negative correlation between higher regional FA values and fewer tics suggests that these alterations of white matter microstructure represent adaptive reorganization of somatosensory processing in GTS...
  17. doi request reprint Quantitative Sensory Testing in adults with Tourette syndrome
    Odette Schunke
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Parkinsonism Relat Disord 24:132-6. 2016
    ..Aberrant awareness of externally applied stimuli in terms of altered sensory perception thresholds might contribute to these sensory phenomena in GTS...
  18. pmc Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome
    Bastian Cheng
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Neuroimage Clin 4:174-81. 2014
    ..These findings are in line with the concept of GTS as a neurodevelopmental disorder of brain immaturity. ..
  19. doi request reprint Transcranial magnetic stimulation studies of sensorimotor networks in Tourette syndrome
    Michael Orth
    Department of Neurology, University of Ulm, Ulm, Germany
    Behav Neurol 27:57-64. 2013
    ..In GTS the gain of many motor circuits may be reduced and hence less sensitive to small changes in input from other areas. These cortical changes may constitute an adaptive response to abnormal basal ganglia-motor cortex inputs...
  20. doi request reprint The functional anatomy of Gilles de la Tourette syndrome
    Christos Ganos
    Department of Neurology, University Medical Centre Hamburg Eppendorf UKE, Hamburg 20246, Germany
    Neurosci Biobehav Rev 37:1050-62. 2013
    ....
  21. doi request reprint Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurophysiol 102:3180-90. 2009
    ..These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."..
  22. doi request reprint Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia families
    Simone Zittel
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:2405-12. 2010
    ..SN hyperechogenicity on TCS may represent an endophenotype in these patients. Pallidal DBS in two patients was unsatisfactory...
  23. ncbi request reprint Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp
    Tobias Bäumer
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Mov Disord 22:81-90. 2007
    ....
  24. doi request reprint Clinical and neurophysiological profile of four German families with spinocerebellar ataxia type 14
    Christos Ganos
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Cerebellum 13:89-96. 2014
    ..Other neurophysiological parameters did not differ between groups. SCA14 is a slowly progressive ataxia associated with mild dystonia and myoclonus. Reduced SICI reflects abnormalities of intracortical inhibitory circuits. ..
  25. doi request reprint Are premonitory urges a prerequisite of tic inhibition in Gilles de la Tourette syndrome?
    Christos Ganos
    Movement Disorders Research Group, Department of Neurology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Neurol Neurosurg Psychiatry 83:975-8. 2012
    ..We examined the relation of the trait of premonitory urges with tics and tic suppression. We hypothesised that patients with more urges would be more efficient at inhibiting tics...
  26. doi request reprint Arm tremor in cervical dystonia--is it a manifestation of dystonia or essential tremor?
    Sarah Schiebler
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 26:1789-92. 2011
    ..From this point of view, we outline this tremor debate and add some new clinical data...
  27. pmc Identification and functional analysis of novel THAP1 mutations
    Katja Lohmann
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
    Eur J Hum Genet 20:171-5. 2012
    ..Speech was affected in four mutation carriers. In conclusion, THAP1 mutations are rare in unselected dystonia patients and functional analysis is necessary to distinguish between benign variants and pathogenic mutations...
  28. doi request reprint The cortical motor threshold reflects microstructural properties of cerebral white matter
    Stefan Kloppel
    Department of Neurology, Neurozentrum, University Clinic Freiburg, Freiburg, Germany
    Neuroimage 40:1782-91. 2008
    ....
  29. pmc Magnetic stimulation of human premotor or motor cortex produces interhemispheric facilitation through distinct pathways
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Germany
    J Physiol 572:857-68. 2006
    ..These may correspond to elements involved in the generation of I3 and I1 waves, respectively...
  30. doi request reprint Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
    ..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown...
  31. doi request reprint A novel computerized algorithm to detect microstructural brainstem pathology in Parkinson's disease using standard 3 Tesla MR imaging
    Kai Boelmans
    Department of Psychiatry, Memory Clinic, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neurol 261:1968-75. 2014
    ..Furthermore, absolute grey matter volume was significantly higher in the brainstem of the PD group compared to healthy controls. We conclude that this cluster may reflect α-synuclein induced microstructural brainstem pathology in PD...
  32. doi request reprint The pathophysiology of echopraxia/echolalia: relevance to Gilles de la Tourette syndrome
    Christos Ganos
    Department of Neurology, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany
    Mov Disord 27:1222-9. 2012
    ..The neural basis of echophenomena will also be addressed. © 2012 Movement Disorder Society...
  33. doi request reprint Cost of illness in patients with Gilles de la Tourette's syndrome
    Ines Dodel
    Department of Neurology, Philipps University Marburg, Rudolf Bultmann Str 8, Marburg, Germany
    J Neurol 257:1055-61. 2010
    ..Unfortunately, no cost of illness studies are available for comparison. Further health economic studies, especially cost-effectiveness studies, are necessary for a basis for rational resource allocation...
  34. doi request reprint Right temporoparietal gray matter predicts accuracy of social perception in the autism spectrum
    Nicole David
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Autism Dev Disord 44:1433-46. 2014
    ..Our findings suggest that social-perceptual difficulties in ASD cannot be reduced to deficits in spatial-temporal integration. ..
  35. doi request reprint Effects of DBS, premotor rTMS, and levodopa on motor function and silent period in advanced Parkinson's disease
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 24:672-6. 2009
    ..e., only partially reversed abnormal motor network activity...
  36. doi request reprint Subthalamotomy in cervical dystonia: A case study of lesion location and clinical outcome
    Christian K E Moll
    Department of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 23:1751-6. 2008
    ....
  37. doi request reprint Right hemisphere contributions to imitation tasks
    Katja Biermann-Ruben
    Department of Neurology, MEG Laboratory, Dusseldorf University Hospital, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Eur J Neurosci 27:1843-55. 2008
    ....
  38. ncbi request reprint Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy
    Jan Lewerenz
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Mov Disord 20:1071-5. 2005
    ..We suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension...
  39. doi request reprint ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome
    Anne Grünewald
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
    Neurobiol Aging 33:1843.e1-7. 2012
    ..These findings collectively suggest that ATP13A2 contributes to the maintenance of a healthy mitochondrial pool, supporting the hypothesis that impaired mitochondrial clearance represents an important pathogenic mechanism underlying KRS...
  40. ncbi request reprint Image-based classification of parkinsonian syndromes using T2'-atlases
    Nils Daniel Forkert
    Department of Medical Informatics, University Medical Center Hamburg Eppendorf, Germany
    Stud Health Technol Inform 169:465-9. 2011
    ..The evaluation using leave-one-out validation revealed that the proposed method achieves a classification accuracy of 91%. The presented method might serve as the basis for an improved automatic classification of PS in the future...
  41. ncbi request reprint Clinical and genetic features of myoclonus-dystonia in 3 cases: a video presentation
    Norman Kock
    Department of Neurology, University of Schleswig Holstein, Lubeck, Germany
    Mov Disord 19:231-4. 2004
    ..We describe 3 children with a similar clinical picture of autosomal dominant M-D and an SGCE mutation in only one of them, suggesting that M-D is genetically heterogeneous...
  42. ncbi request reprint Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene
    Michael Orth
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 22:2090-6. 2007
    ..The SGCE and the SLITRK1 gene were sequenced and investigated by gene dosage analysis in selected family members. Linkage to the SGCE, DYT15, DYT1, DRD2, and SLITRK1 loci was also tested...