U Muller-Ladner

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint [Are "biologics" in the treatment of rheumatoid arthritis really cost effective?]
    U Muller-Ladner
    Bereich Rheumatologie Klinische Immunologie, Klinik und Poliklinik für Innere Medizin I der Universität Regensburg
    Internist (Berl) 45:1402-6. 2004
  2. ncbi request reprint Gene transfer as a future therapy for rheumatoid arthritis
    Ulf Müller-Ladner
    Department of Internal Medicine I, University of Regensburg, FJS Allee 11, D 93042 Regensburg, Germany
    Expert Opin Biol Ther 3:587-98. 2003
  3. pmc MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Germany
    Ann Rheum Dis 61:957-9. 2002
  4. ncbi request reprint Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee11, D 93042, Regensburg, Germany
    Biochim Biophys Acta 1628:64-70. 2003
  5. ncbi request reprint Laser-mediated microdissection facilitates analysis of area-specific gene expression in rheumatoid synovium
    M Judex
    University of Regensburg, Regensburg, Germany
    Arthritis Rheum 48:97-102. 2003
  6. ncbi request reprint Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway
    E Neumann
    Department of Internal Medicine I, University of Regensburg, Germany
    Gene Ther 9:1508-19. 2002
  7. ncbi request reprint Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction
    E Neumann
    University of Regensburg, Germany
    Arthritis Rheum 46:52-63. 2002
  8. ncbi request reprint Activation of the IL-4 STAT pathway in rheumatoid synovium
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol 164:3894-901. 2000
  9. ncbi request reprint Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042, Regensburg, Germany
    FEBS Lett 545:103-4. 2003
  10. ncbi request reprint Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Biochim Biophys Acta 1630:123-9. 2003

Collaborators

Detail Information

Publications34

  1. ncbi request reprint [Are "biologics" in the treatment of rheumatoid arthritis really cost effective?]
    U Muller-Ladner
    Bereich Rheumatologie Klinische Immunologie, Klinik und Poliklinik für Innere Medizin I der Universität Regensburg
    Internist (Berl) 45:1402-6. 2004
    ..However, when all current data are summarized, the cost for a TNF-inhibitor in regard of one quality-adjusted life-year ranges below the internationally recommended critical amount of 40,000 euro...
  2. ncbi request reprint Gene transfer as a future therapy for rheumatoid arthritis
    Ulf Müller-Ladner
    Department of Internal Medicine I, University of Regensburg, FJS Allee 11, D 93042 Regensburg, Germany
    Expert Opin Biol Ther 3:587-98. 2003
    ..Future strategies will also examine the potential of novel long-term expression vectors such as lentiviruses and cytomegalovirus (CMV)-based viruses as a basis for future clinical trials in RA...
  3. pmc MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Germany
    Ann Rheum Dis 61:957-9. 2002
  4. ncbi request reprint Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee11, D 93042, Regensburg, Germany
    Biochim Biophys Acta 1628:64-70. 2003
    ..The present data provide the basis for further investigation of the CORS-26 gene regulation in the context of mesenchymal tissue development, chondrocyte/adipocyte function and bone or skeletal disease...
  5. ncbi request reprint Laser-mediated microdissection facilitates analysis of area-specific gene expression in rheumatoid synovium
    M Judex
    University of Regensburg, Regensburg, Germany
    Arthritis Rheum 48:97-102. 2003
    ..The present study was undertaken to establish parameters for this technique and assess its usefulness for gene expression analysis...
  6. ncbi request reprint Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway
    E Neumann
    Department of Internal Medicine I, University of Regensburg, Germany
    Gene Ther 9:1508-19. 2002
    ....
  7. ncbi request reprint Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction
    E Neumann
    University of Regensburg, Germany
    Arthritis Rheum 46:52-63. 2002
    ..A combination of RNA arbitrarily primed-polymerase chain reaction (RAP-PCR) and complementary DNA (cDNA) array with defined genes was used for a highly sensitive differential screening using small amounts of RNA...
  8. ncbi request reprint Activation of the IL-4 STAT pathway in rheumatoid synovium
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol 164:3894-901. 2000
    ....
  9. ncbi request reprint Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042, Regensburg, Germany
    FEBS Lett 545:103-4. 2003
    ..0001) and positively (regression analysis: r=0.86) associated with HDL-cholesterol levels in type 2 diabetes...
  10. ncbi request reprint Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Biochim Biophys Acta 1630:123-9. 2003
    ..The present data provide the basis for further investigation of CORS-26 gene regulation in the context of mesenchymal tissue development and in the pathogenesis of bone or skeletal disease...
  11. ncbi request reprint Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 112:383-9. 2004
    ..Adiponectin represents an adipocyte-specific secretory protein that has been discussed recently as candidate gene and promising new drug target to restore insulin sensitivity in diabetes mellitus type 2...
  12. ncbi request reprint Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1678:150-6. 2004
    ..Pit-1 and PPARgamma can bind specifically to the promoter and might play an additive functional role in gene regulation of murine CORS-26...
  13. ncbi request reprint Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach
    P Harle
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Rheumatology (Oxford) 44:426-33. 2005
    ..Therefore, this review focuses on the multidisciplinary aspects of neuroendocrine-immune changes in RA...
  14. ncbi request reprint [Diagnosis and therapy of rheumatoid arthritis]
    U Muller-Ladner
    Bereich Rheumatologie Klinische Immunologie, Klinik und Poliklinik für Innere Medizin I der Universität Regensburg
    Dtsch Med Wochenschr 129:1318-21. 2004
    ..Finally, the current therapeutic standard includes also the ongoing clinical and scientific exchange with the orthopedic surgeon to optimize the long-term treatment for the individual patient...
  15. pmc Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis
    J Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, D 93042 Regensburg, Germany
    Ann Rheum Dis 63:1205-11. 2004
    ..To investigate the expression of maspin in RA synovial tissue and compare it with the expression in osteoarthritis (OA) and normal synovial tissue (NS)...
  16. ncbi request reprint Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis
    O Distler
    Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatol Int 19:39-46. 1999
    ..RANTES may be involved in early pathogenesis of SSc as well as in fibrosis pathways, either by chemoattraction of immunocompetent cells and/or by modulation of collagen production...
  17. doi request reprint RAP-PCR fingerprinting reveals time-dependent expression of matrix-related molecules following stem-cell based TGFβ1-induced chondrocyte development
    J Schedel
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany
    Int J Mol Med 27:519-23. 2011
    ..The results suggest that using RAP-PCR for differential display fingerprinting is a useful tool to investigate the differentiation process of bone marrow-derived stem cells following TGF-β1-stimulation...
  18. ncbi request reprint Molecular imaging: novel tools in visualizing rheumatoid arthritis
    A Wunder
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatology (Oxford) 44:1341-9. 2005
    ..With regard to their applicability in rheumatic diseases, we discuss potential molecular targets, current experimental approaches and the future prospects for molecular imaging in rheumatoid arthritis...
  19. ncbi request reprint Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis
    J Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, Regensburg, Germany
    Scand J Immunol 60:514-23. 2004
    ..g. integrins: collagen/integrin alpha(2)beta(1)) and that higher numbers of OA-SF adhered to the cartilage and bone matrix proteins than did RA-SF...
  20. pmc Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia
    S Lechner
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Gut 52:1148-53. 2003
    ..To achieve this goal, a novel gene expression analysis strategy, screening for expressed transcripts in small histologically defined tissue samples, was performed...
  21. ncbi request reprint Activation of synoviocytes
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Germany
    Curr Opin Rheumatol 12:186-94. 2000
    ..Major topics include cellular and humoral interactions (frequently modulated by cytokines), intracellular signaling and upregulation of gene transcription, and the deleterious effects on articular homeostasis...
  22. ncbi request reprint Successful treatment of psoriatic onycho-pachydermo periostitis (POPP) with adalimumab
    T Bongartz
    University of Regensburg, Regensburg, Germany
    Arthritis Rheum 52:280-2. 2005
    ..Therefore, we consider a TNF-blocking strategy as promising for treatment of POPP...
  23. ncbi request reprint Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX
    C Fiehn
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Rheumatology (Oxford) 43:1097-105. 2004
    ..To evaluate the anti-arthritic effects of the new inflammation-targeted drug MTX-HSA and to investigate whether peripheral blood mononuclear cells (PBMC) are potential target cells for albumin-mediated drug delivery...
  24. pmc p53 in rheumatoid arthritis: friend or foe?
    U Muller-Ladner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Arthritis Res 2:175-8. 2000
    ....
  25. ncbi request reprint Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Horm Metab Res 36:702-7. 2004
    ..The physiological range of serum resistin levels, reference values or adjusted percentiles have not yet been determined, making the interpretation of serum resistin concentrations quite difficult...
  26. ncbi request reprint Treatment of active psoriatic arthritis with the PPARgamma ligand pioglitazone: an open-label pilot study
    T Bongartz
    Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatology (Oxford) 44:126-9. 2005
    ..Therefore, we studied the use of pioglitazone, a PPARgamma agonist originally developed for the treatment of diabetes, in patients with PsA...
  27. ncbi request reprint [Interdisciplinary management of pregnant women with connective tissue diseases]
    A G Wimmer
    Bereich Rheumatologie Klinische Immunologie, Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, Germany
    Z Geburtshilfe Neonatol 208:1-9. 2004
    ..Clinical aspects that are intensively discussed include immunosuppressive therapy during pregnancy, the management of antiphospholipid antibody-dependent problems and the prophylaxis and treatment options for congenital heart block...
  28. ncbi request reprint Leukoencephalopathy and chronic pancreatitis as concomitant manifestations of systemic lupus erythematosus related to anticardiolipin antibodies
    J Swol-Ben
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Rheumatol Int 24:177-81. 2004
    ..Subsequent complications of pancreatitis are responsible for the critical, life-threatening state of these patients and may be prevented by early identification of anticardiolipin antibodies and therapy for SLE...
  29. ncbi request reprint A 30 year history of panniculitis
    O Distler
    Department of Internal Medicine I, University of Regensburg, Germany
    J Rheumatol 27:507-9. 2000
    ..The wide spectrum of histological alterations of chronic erythema induratum as well as the sensitivity of polymerase chain reaction for Mycobacterium tuberculosis in erythema induratum lesions is discussed...
  30. ncbi request reprint Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Diabetes Obes Metab 7:570-8. 2005
    ....
  31. ncbi request reprint Role of nuclear factor kappaB in synovial inflammation
    Ulf Müller-Ladner
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Curr Rheumatol Rep 4:201-7. 2002
    ..The goal is to evolve these strategies from the therapies that have a wide spectrum of effects and side effects into rheumatoid arthritis-specific therapies designed to inhibit distinct molecular pathways within the synovium...
  32. ncbi request reprint Functional genomics of fibroblasts
    Elena Neumann
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Curr Opin Rheumatol 16:238-45. 2004
    ....
  33. ncbi request reprint Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings
    Sandra Lechner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Lab Invest 83:1321-31. 2003
    ..The mechanism underlying the loss of TR1-positive/CD3-positive/CD56-positive cells or the biologic consequence of this phenomenon observed in neoplastic colonic tissue remains to be clarified...
  34. ncbi request reprint Fatal outcome of constrictive pericarditis in rheumatoid arthritis
    Peter Härle
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee, 11, D 93042, Regensburg, Germany
    Rheumatol Int 23:312-4. 2003
    ..Further, we discuss risk factors, diagnostic caveats, diagnostic tests and therapy of hemodynamically relevant contrictive pericarditis...